AR018010A1 - Secretagogos de la hormona del crecimiento y compuestos intermediarios utiles en la preparacion de dichos compuestos - Google Patents
Secretagogos de la hormona del crecimiento y compuestos intermediarios utiles en la preparacion de dichos compuestosInfo
- Publication number
- AR018010A1 AR018010A1 ARP980104068A ARP980104068A AR018010A1 AR 018010 A1 AR018010 A1 AR 018010A1 AR P980104068 A ARP980104068 A AR P980104068A AR P980104068 A ARP980104068 A AR P980104068A AR 018010 A1 AR018010 A1 AR 018010A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- cyclohexyl
- alkylidenyl
- nhr1
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 43
- 125000003118 aryl group Chemical group 0.000 abstract 13
- -1 naphthanyl Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
- 101150009274 nhr-1 gene Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000001422 pyrrolinyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004532 benzofuran-3-yl group Chemical group O1C=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004197 benzothien-3-yl group Chemical group [H]C1=C(*)C2=C([H])C([H])=C([H])C([H])=C2S1 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000000580 secretagogue effect Effects 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se trata de compuestos no péptidos denominados genéricamente secretagogos que poseen actividad secretora de la hormona del crecimiento de formula (I) en laque: A es alquilo C1-6, arilo, (alquil C1-6)arilo, (alquil C1-6)(O)(alquil C1-6)arilo, -SH, -OH, indolilo, indolinilo, tienilo, benzotienilo, benzofuranilo,naftanilo, ciclohexilo, (alquil C1-6)indol-3-ilo, (alquil C1-6)benzotien-3-ilo, (alquil C1-6)naftan-2-ilo, (alquil C1-6)benzofuran-3-ilo y (alquil C1-6)ciclohexilo; B es NH2, NHR1, (alquilC1-6)-NH2, (alquil C1-6)-NHR1, (alquil C1-6)aril-NH2, (alquil C1-6)aril-NR1, (alquil C1-6)ciclohexil NH2, (alquil C1-6)ciclohexil NHR1, R1-piperidin-3-il,(alquil C1-6), R1-piperidin-2-il, (alquil C1-6), R1-piperidin-4-il (alquil C1-6), R1-quinolin-2-il,(alquil C1-6),R1-(2,4-dihidroquinolin-2-il,(alquil C1-6),R1-isoquinolin-2-il, (alquil C1-6) y R1-(2,4-dihidroisoquinolin-2-il), (alquil C1-6); R1 es hidrogeno,alquilo C1-6 (alquilC1-6)OH o (alquilidenil C1-6)(OH); R2 es alquilo C1-6 alquenilo C1-6(alquil C1-6)(O)(alquilo C1-6), C(O)-O-alquilo C1-6, arilo o (alquil C1-6)arilo; X es unenlace, alquilidenilo C1-6 O, S, NH o N(alquilo C1-6); V es un grupo de formulas (I), W es S. O, NH o CH2; Y es N o Ch; Z es N o CH; Y es N, S, CH2, O; Z esN, CH2; R4 y R5 son, de forma independiente, hidrogeno, alquilo C1-6, arilo, (alquil C1-C6)arilo, C(O)O(alquilo C1-6), C(O)ON(alquilo C1-6)2 o (alquil C1-6)COR7; R7 es hidrogeno, alquilo C1-6, pirrolidinilo, peperidinilo, homoprolina o prolina; D es C(O)R6, (alquil C1-6)OH, (alquil C1-6)C(O)R6, (alquil C1-6)R6,arilo, CH2NHSO2(alquilo C1-6), R6 es H, alquilo C1-6, arilo, (alquil C1-6)arilo, acetilo, NH2, NH(alquilo C1-6), NH(alquilidenil C1-6)OCH3, NH(alquil C1-6)arilo, N(alquilo C1-6)2, N(alquil C1-6)arilo, N(alquil C1-6)(alquil C1-6)arilo, O(alquilo C1-6), piperidinilo o piperidinilo opcionalmente sustituido,pirrolidinilo o pirrolidinilo opcionalmente sustituido, pirrolinilo o pirrolinilo opcionalmente sustituido, morfolino, hexametilenimino, heptametilenimino,quinolinilo, 2,4-dihidroquinolinilo, isoquinolinilo, 2,4-dihidroisoquinolinilo, un aminoácido seleccionado entre el grupo de prolina, homoprolina, glicina,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5614297P | 1997-08-19 | 1997-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018010A1 true AR018010A1 (es) | 2001-10-31 |
Family
ID=22002443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104068A AR018010A1 (es) | 1997-08-19 | 1998-08-18 | Secretagogos de la hormona del crecimiento y compuestos intermediarios utiles en la preparacion de dichos compuestos |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0933365A3 (es) |
| JP (1) | JP2001515046A (es) |
| KR (1) | KR20010027947A (es) |
| CN (1) | CN1243567C (es) |
| AR (1) | AR018010A1 (es) |
| AU (1) | AU738204B2 (es) |
| BR (1) | BR9811948A (es) |
| CA (1) | CA2302467A1 (es) |
| CO (1) | CO5121066A1 (es) |
| EA (1) | EA002746B1 (es) |
| HR (1) | HRP20000090A2 (es) |
| HU (1) | HUP0002392A3 (es) |
| ID (1) | ID25000A (es) |
| IL (1) | IL134596A0 (es) |
| MY (1) | MY138258A (es) |
| NO (1) | NO20000823L (es) |
| NZ (1) | NZ502947A (es) |
| PE (1) | PE115999A1 (es) |
| PL (1) | PL338883A1 (es) |
| TR (1) | TR200000930T2 (es) |
| TW (1) | TW577879B (es) |
| UA (1) | UA58472C2 (es) |
| WO (1) | WO1999008699A1 (es) |
| ZA (1) | ZA987385B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| WO2000010565A1 (en) * | 1998-08-18 | 2000-03-02 | Eli Lilly And Company | Growth hormone secretagogues |
| CO5160260A1 (es) * | 1999-02-19 | 2002-05-30 | Lilly Co Eli | Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido |
| US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
| US6417397B1 (en) * | 1999-10-04 | 2002-07-09 | The Regents Of The University Of California, San Diego | N-substituted alkylamino acids for use as amino-protecting groups |
| WO2001091752A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Melanocortin receptor agonists |
| GT200100147A (es) * | 2000-07-31 | 2002-06-25 | Derivados de imidazol | |
| US6756385B2 (en) * | 2000-07-31 | 2004-06-29 | Pfizer Inc. | Imidazole derivatives |
| WO2002032878A1 (en) * | 2000-10-13 | 2002-04-25 | Eli Lilly And Company | Resolution process for preparation of substantially pure (r) and (s) enantiomers of 2-(4-nitroimidazolyl)-4-methoxyphenylpropionic acid and salts thereof |
| US7125840B2 (en) | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
| WO2003087069A2 (en) | 2002-04-09 | 2003-10-23 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
| US7365082B2 (en) * | 2002-12-18 | 2008-04-29 | Bayer Cropscience Ag | N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines |
| ATE399155T1 (de) | 2004-03-23 | 2008-07-15 | Pfizer Prod Inc | Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen |
| EA200800659A1 (ru) | 2005-09-22 | 2008-08-29 | Пфайзер Продактс Инк. | Соединения имидазола для лечения неврологических нарушений |
| US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| US7615556B2 (en) | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| ES2604943T3 (es) | 2007-02-09 | 2017-03-10 | Ocera Therapeutics, Inc. | Moduladores macrocíclicos del receptor de la grelina y procedimientos de uso de los mismos |
| TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
| US8642622B2 (en) | 2010-06-16 | 2014-02-04 | Bristol-Myers Squibb Company | Piperidinyl compound as a modulator of chemokine receptor activity |
| US8546416B2 (en) | 2011-05-27 | 2013-10-01 | Novartis Ag | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists |
| KR20150003771A (ko) | 2012-05-03 | 2015-01-09 | 노파르티스 아게 | 그렐린 수용체 효능제로서의 2,7-디아자-스피로[4.5]데스-7-일 유도체의 l-말레이트 염 및 그의 결정질 형태 |
| CA2918284A1 (en) | 2013-07-18 | 2015-01-22 | Novartis Ag | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| CN107540617B (zh) * | 2014-08-29 | 2020-12-18 | 东京应化工业株式会社 | 咪唑化合物、金属表面处理液、金属的表面处理方法、及层合体的制造方法 |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| CN107286041A (zh) * | 2016-04-01 | 2017-10-24 | 成都川科化工有限公司 | 一种n,n-二乙基甲酰胺的制备方法 |
| CN108299218A (zh) * | 2017-01-12 | 2018-07-20 | 南京红杉生物科技有限公司 | 一种4-溴-d-苯丙氨酸的合成方法 |
| CN110128285B (zh) * | 2019-06-24 | 2022-03-01 | 华北制药股份有限公司 | D-苯甘氨酸甲酯盐酸盐/d-二氢苯基甘氨酸甲酯盐酸盐的制备方法 |
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|---|---|---|---|---|
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| HUT72076A (en) * | 1992-12-11 | 1996-03-28 | Merck & Co Inc | Process for preparing spiro piperidines and homologs which promote release of growth hormone and pharmaceutical compositions containing them |
| AU8083694A (en) * | 1993-10-19 | 1995-05-08 | Merck & Co., Inc. | Combination of bisphosphonates and growth hormone secretagogues |
| US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| CA2203428A1 (en) * | 1995-08-21 | 1997-02-27 | Philip Arthur Hipskind | 2-acylaminopropanamides as growth hormone secretagogues |
| ZA966891B (en) * | 1995-08-21 | 1998-02-16 | Lilly Co Eli | 2-acylaminopropanamines as growth hormone secretagogues. |
-
1998
- 1998-08-17 ZA ZA9807385A patent/ZA987385B/xx unknown
- 1998-08-18 MY MYPI98003772A patent/MY138258A/en unknown
- 1998-08-18 TW TW087113593A patent/TW577879B/zh not_active IP Right Cessation
- 1998-08-18 EP EP98306622A patent/EP0933365A3/en not_active Withdrawn
- 1998-08-18 AR ARP980104068A patent/AR018010A1/es unknown
- 1998-08-18 CO CO98047011A patent/CO5121066A1/es unknown
- 1998-08-19 NZ NZ502947A patent/NZ502947A/en unknown
- 1998-08-19 ID IDW20000306A patent/ID25000A/id unknown
- 1998-08-19 PE PE1998000748A patent/PE115999A1/es not_active Application Discontinuation
- 1998-08-19 CA CA002302467A patent/CA2302467A1/en not_active Abandoned
- 1998-08-19 WO PCT/US1998/017229 patent/WO1999008699A1/en not_active Ceased
- 1998-08-19 HU HU0002392A patent/HUP0002392A3/hu unknown
- 1998-08-19 IL IL13459698A patent/IL134596A0/xx unknown
- 1998-08-19 JP JP2000509436A patent/JP2001515046A/ja active Pending
- 1998-08-19 EA EA200000239A patent/EA002746B1/ru not_active IP Right Cessation
- 1998-08-19 UA UA2000020987A patent/UA58472C2/uk unknown
- 1998-08-19 KR KR1020007001645A patent/KR20010027947A/ko not_active Ceased
- 1998-08-19 AU AU90256/98A patent/AU738204B2/en not_active Ceased
- 1998-08-19 TR TR2000/00930T patent/TR200000930T2/xx unknown
- 1998-08-19 HR HR20000090A patent/HRP20000090A2/hr not_active Application Discontinuation
- 1998-08-19 BR BR9811948-6A patent/BR9811948A/pt not_active IP Right Cessation
- 1998-08-19 PL PL98338883A patent/PL338883A1/xx unknown
- 1998-08-19 CN CNB988102390A patent/CN1243567C/zh not_active Expired - Fee Related
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2000
- 2000-02-18 NO NO20000823A patent/NO20000823L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UA58472C2 (uk) | 2003-08-15 |
| HUP0002392A2 (hu) | 2000-10-28 |
| TR200000930T2 (tr) | 2000-11-21 |
| PE115999A1 (es) | 1999-11-26 |
| EP0933365A3 (en) | 2003-03-19 |
| CA2302467A1 (en) | 1999-02-25 |
| EA002746B1 (ru) | 2002-08-29 |
| EP0933365A2 (en) | 1999-08-04 |
| KR20010027947A (ko) | 2001-04-06 |
| BR9811948A (pt) | 2000-08-22 |
| NO20000823L (no) | 2000-04-12 |
| AU9025698A (en) | 1999-03-08 |
| ZA987385B (en) | 2000-04-18 |
| HUP0002392A3 (en) | 2000-11-28 |
| EA200000239A1 (ru) | 2000-10-30 |
| JP2001515046A (ja) | 2001-09-18 |
| MY138258A (en) | 2009-05-29 |
| NO20000823D0 (no) | 2000-02-18 |
| CO5121066A1 (es) | 2002-01-30 |
| TW577879B (en) | 2004-03-01 |
| AU738204B2 (en) | 2001-09-13 |
| ID25000A (id) | 2000-09-07 |
| NZ502947A (en) | 2001-11-30 |
| CN1243567C (zh) | 2006-03-01 |
| PL338883A1 (en) | 2000-11-20 |
| HRP20000090A2 (en) | 2001-04-30 |
| WO1999008699A1 (en) | 1999-02-25 |
| IL134596A0 (en) | 2001-04-30 |
| CN1276727A (zh) | 2000-12-13 |
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