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AR017066A1 - Cristales de glicoproteina, de enlazamiento cruzado con carbohidrato - Google Patents

Cristales de glicoproteina, de enlazamiento cruzado con carbohidrato

Info

Publication number
AR017066A1
AR017066A1 ARP980104437A ARP980104437A AR017066A1 AR 017066 A1 AR017066 A1 AR 017066A1 AR P980104437 A ARP980104437 A AR P980104437A AR P980104437 A ARP980104437 A AR P980104437A AR 017066 A1 AR017066 A1 AR 017066A1
Authority
AR
Argentina
Prior art keywords
crystals
cross
glycoprotein
linked
carbohydrate
Prior art date
Application number
ARP980104437A
Other languages
English (en)
Original Assignee
Altus Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altus Biologics Inc filed Critical Altus Biologics Inc
Publication of AR017066A1 publication Critical patent/AR017066A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invencion se relaciona con el campo de cristales de glicoproteína de enlazamiento cruzado con carbohidrato. De manera ventajosa, dichoscristales de glicoproteína de enlazamiento cruzado muestran estabilidad en condiciones severas de medioambiente, a la vez que mantienen la integridadestructural y funcional del nucleo de la glicoproteína. De acuerdo a una configuracion, esta invencion se refiere a métodos para la concentracion de proteínasque han sido modificadas por medio de carbohidratos y para la liberacion de su actividad en tasas controladas. Esta invencion también provee métodos para laproduccion de los cristales de glicoproteína de enlazamiento cruzado con carbohidrato y métodos para su uso en formulaciones farmacéuticas,vacunas,inmunoterapéutica, composicion para el cuidado personal, incluyendo cosméticos, vacunas y composiciones farmacéuticas veterinarias, alimentos, forraje,diagnostico, agentes de limpieza, incluyendo formulaciones para descontaminacion y detergentes. Las características físicas y químicas de los cristales deglicoproteína de enlazamiento cruzado con carbohidrato hacen de ellos particularmente utiles como absorbentes para separadores, tal como cromatografía quiral ocromatografía de afinidad:las cuales están basadas en interacciones específicas entre la posicion del enlazamiento activo del componente de glicoproteína delos cristales y la sustancia o molécula de interés. Tales características también hacen los cristales de glicoproteínade enlazamiento cruzado con carbohidratoutiles como componentes de enlace y catalíticos para la produccion de dispositivos de biodeteccion.
ARP980104437A 1997-09-05 1998-09-04 Cristales de glicoproteina, de enlazamiento cruzado con carbohidrato AR017066A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92627997A 1997-09-05 1997-09-05

Publications (1)

Publication Number Publication Date
AR017066A1 true AR017066A1 (es) 2001-08-22

Family

ID=25452985

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980104437A AR017066A1 (es) 1997-09-05 1998-09-04 Cristales de glicoproteina, de enlazamiento cruzado con carbohidrato

Country Status (11)

Country Link
US (2) US6359118B2 (es)
EP (2) EP1956085A2 (es)
AR (1) AR017066A1 (es)
AT (1) ATE397013T1 (es)
AU (1) AU8772498A (es)
DE (1) DE69839563D1 (es)
DK (1) DK1009759T3 (es)
ES (1) ES2306477T3 (es)
PE (1) PE130399A1 (es)
WO (1) WO1999012959A1 (es)
ZA (1) ZA987378B (es)

Families Citing this family (21)

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US6500933B1 (en) 1997-09-05 2002-12-31 Altus Biologics Inc. Methods of preparing carbohydrate crosslinked glycoprotein crystals
ES2306477T3 (es) * 1997-09-05 2008-11-01 Altus Pharmaceuticals Inc. Cristales de glicoproteina reticulados por carbohidratos.
KR100902966B1 (ko) * 2000-10-30 2009-06-15 마이크로소프트 코포레이션 비교를 위해 스트링을 맵핑하는 방법 및 시스템
AU2002220047A1 (en) * 2000-10-30 2002-05-15 Wayne State University Novel fish chemokine and methods for use
EP1333087A1 (en) * 2002-02-05 2003-08-06 Avantium International B.V. Crosslinked enzyme aggregates and crosslinking agent therefore
EP1549675B1 (en) * 2002-08-31 2008-02-13 CJ Corp Glycosylated human interferon alpha isoform
FR2848847B1 (fr) * 2002-12-18 2005-10-14 Coletica Composition cosmetique ou dermopharmaceutique comprenant une enzyme insoluble en milieu aqueux, ainsi que ses utilisations
BR0317888A (pt) 2002-12-31 2005-12-06 Altus Pharmaceuticals Inc Cristais do hormÈnio do crescimento humano e processos para preparação dos mesmos
EP1585771A4 (en) * 2002-12-31 2006-11-29 Altus Pharmaceuticals Inc COMPLEXES OF PROTEIN CRYSTALS AND IONIC POLYMERS
WO2005066341A1 (en) * 2004-01-01 2005-07-21 Council Of Scientific & Industrial Research A method for the preparation of cross linked protein crystals
WO2006044529A1 (en) 2004-10-14 2006-04-27 Altus Pharmaceuticals Inc. Compositions containing lipase; protease and amylase for treating pancreatic insufficiency
US8835143B2 (en) 2004-10-28 2014-09-16 Clea Technologies Bv Method for preparing hybrid cross-linked enzyme-silica aggregates
NL1027360C2 (nl) * 2004-10-28 2006-05-01 Clea Technologies B V Werkwijze voor de bereiding van vernette enzymaggregaten met verbeterde eigenschappen.
AU2006330833A1 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
EP1991273B2 (en) 2006-02-10 2022-01-05 Life Technologies Corporation Labeling and detection of post translationally modified proteins
US20110288360A1 (en) * 2007-08-13 2011-11-24 Sunrez Corporation Compositions for neutralization and decontamination of toxic chemical and biological agents
JP5758920B2 (ja) * 2010-03-02 2015-08-05 プロタリクス リミテッド 安定化α−ガラクトシダーゼおよびその使用
US20150246146A1 (en) 2012-10-25 2015-09-03 Life Technologies Corporation Methods and compositions for enzyme-mediated site-specific radiolabeling of glycoproteins
WO2014089578A1 (en) * 2012-12-07 2014-06-12 Cornell University Crosslinked thermoset resins and methods thereof
CN110095485B (zh) * 2018-01-29 2024-01-30 中国科学院上海有机化学研究所 一种蛋白质微小晶体冷冻样品的制备及结构解析的方法
CA3212187A1 (en) 2021-04-09 2022-10-13 Marcus Wolf William HARTMANN Purification of proteins

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Also Published As

Publication number Publication date
US20020137899A1 (en) 2002-09-26
DK1009759T3 (da) 2008-08-04
US6359118B2 (en) 2002-03-19
EP1956085A2 (en) 2008-08-13
ES2306477T3 (es) 2008-11-01
ATE397013T1 (de) 2008-06-15
US20010008934A1 (en) 2001-07-19
WO1999012959A1 (en) 1999-03-18
EP1009759B1 (en) 2008-05-28
PE130399A1 (es) 1999-12-22
ZA987378B (en) 2000-02-17
EP1009759A1 (en) 2000-06-21
DE69839563D1 (de) 2008-07-10
AU8772498A (en) 1999-03-29

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