AR016968A1 - Derivados de 1,2-benzisotiazol 2-sustituidos y uso para la obtencion de medicamentos. - Google Patents
Derivados de 1,2-benzisotiazol 2-sustituidos y uso para la obtencion de medicamentos.Info
- Publication number
- AR016968A1 AR016968A1 ARP980105243A ARP980105243A AR016968A1 AR 016968 A1 AR016968 A1 AR 016968A1 AR P980105243 A ARP980105243 A AR P980105243A AR P980105243 A ARP980105243 A AR P980105243A AR 016968 A1 AR016968 A1 AR 016968A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- branched
- unbranched
- independently
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Derivados de 1,2-benzisotiazol 2-sustituidos de la formula I donde R1, R2 significan, cada uno independientemente del otro C1-6 alquilo, R3, R4 significan,cada uno independientemente del otro, hidrogeno, C1-6 alquilo ramificado o sin ramificar,OH,O-C1-5-alquilo ramificado o sin ramificar, F, Cl, Br, I, trifluorometilo, NR5R6, CO2R7,nitro, ciano, pirrol, un radical fenilalquilo, con C1-4, que a su vez puede estar sustituido en el aromático por F, Cl,Br,I,C1-4-alquilo,C1-4 alcoxi,trifluorometilo,hidroxi, amino, ciano o nitro R5, R6 significan, cada uno independientemente del otro, H, C1-6 alquilo ramificado o sin ramificarCOPh, CO2tBu, CO-(C1-4)-alquilo o forman juntos un anillo de 5 a 6 miembros, que eventualmente contiene otro nitrogeno (por ej. piperacina), R7 significahidrogeno, y C1-6 alquilo ramificado o sin ramificar A significa un C1-10-alquileno ramificado o sin ramificar o un C2-10-alquileno lineal o ramificado, quecomprende al menos un grupo Z, que está seleccionado de entreO, S, NR7, ciclopropilo, CHOH o un doble o triple enlace, B significa 4-piperidina, 4-tetrahidro-1,2,3,6-piridina, 4-piperacina y los compuestos anulares correspondientes ampliados por un grupo metileno, realizandose el enlace entre A y B por vía del átomode nitrogeno, y Ar significa fenilo, que eventualmente está sustituido por C1-6 alquilo ramificado o sin ramificar, O-(C1-6)-alquilo ramificado o sinramificar, OH, F, Cl, Br, I, trifluorometilo, NR5R6, CO2R7, ciano o fenilo, tetralina, indano, aromáticos de alto grado de condensacion, como por ej. naftalinaque eventualmente está sustituida por C1-4 alquilo o O(C1-4)alquilo, antraceno o heterociclos aromáticos de 5-6 miembros con 1 a 2 heteroátomos, seleccionadosindependientemente de O yN, y que pueden estar anelados con otros radicales aromáticos, y sus enantioneros y diastereomeros, sus formas tautomeras. así comosus sales con ácidos fisiologicamente tolerados. Uso de los compuestos descriptos para la obtencion de medicamentos para el tratamiento de depresiones yenfermedades similares como antagonistas selectivos de 5HT1b y 5HT1a. Dicho antagonismo selectivo de serotonina va acompanado de una inhibicion de serotonina-
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19746612A DE19746612A1 (de) | 1997-10-22 | 1997-10-22 | 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016968A1 true AR016968A1 (es) | 2001-08-01 |
Family
ID=7846266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980105243A AR016968A1 (es) | 1997-10-22 | 1998-10-21 | Derivados de 1,2-benzisotiazol 2-sustituidos y uso para la obtencion de medicamentos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6346622B1 (es) |
| EP (1) | EP1034170A1 (es) |
| JP (1) | JP2001520224A (es) |
| KR (1) | KR20010031297A (es) |
| CN (1) | CN1277607A (es) |
| AR (1) | AR016968A1 (es) |
| AU (1) | AU748613B2 (es) |
| BG (1) | BG104332A (es) |
| BR (1) | BR9812948A (es) |
| CA (1) | CA2307199A1 (es) |
| CO (1) | CO4980863A1 (es) |
| DE (1) | DE19746612A1 (es) |
| HR (1) | HRP980555A2 (es) |
| HU (1) | HUP0003758A3 (es) |
| IL (1) | IL135256A0 (es) |
| NO (1) | NO20001937L (es) |
| NZ (1) | NZ503604A (es) |
| PL (1) | PL340033A1 (es) |
| SK (1) | SK4572000A3 (es) |
| TR (1) | TR200001080T2 (es) |
| TW (1) | TW517052B (es) |
| WO (1) | WO1999020616A1 (es) |
| ZA (1) | ZA989571B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19900544A1 (de) * | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Verbindungen der Formel I zur Prophylaxe und Therapie der zerebralen Ischämie |
| AP2005003250A0 (en) * | 2002-09-17 | 2005-03-31 | Warner Lambert Co | Heterocyclic substituted piperazines for the treatment of schizophrenia. |
| US20040127501A1 (en) * | 2002-09-24 | 2004-07-01 | Zhengming Chen | Therapeutic agents useful for treating pain |
| ATE479683T1 (de) | 2002-11-05 | 2010-09-15 | Glaxo Group Ltd | Antibakterielle mittel |
| KR100472988B1 (ko) | 2002-11-27 | 2005-03-10 | 씨제이 주식회사 | 조직감, 취반성 및 안전성이 우수한 발아 현미의 제조방법및 이로부터 얻은 발아 현미 |
| CN101151249B (zh) * | 2005-03-31 | 2011-04-06 | 辉瑞产品公司 | 环戊吡啶及四氢喹啉衍生物 |
| EP2376453B1 (en) * | 2008-12-11 | 2019-11-20 | VIIV Healthcare Company | Intermediates for carbamoylpyridone hiv integrase inhibitors |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8601494A (nl) | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
| DE3620643A1 (de) * | 1985-06-22 | 1987-01-22 | Sandoz Ag | Thiazole, ihre herstellung und verwendung |
| FR2662696A2 (fr) * | 1989-12-13 | 1991-12-06 | Rhone Poulenc Sante | Antagonistes de la serotonine, leur preparation et medicaments les contenant. |
| FR2675800A1 (fr) * | 1991-04-26 | 1992-10-30 | Rhone Poulenc Rorer Sa | Derives heterocycliques antiserotonines leur preparation et les medicaments les contenant. |
| JPH0912562A (ja) * | 1995-06-22 | 1997-01-14 | Suntory Ltd | 置換ベンゾチアジン誘導体 |
-
1997
- 1997-10-22 DE DE19746612A patent/DE19746612A1/de not_active Withdrawn
-
1998
- 1998-10-05 SK SK457-2000A patent/SK4572000A3/sk unknown
- 1998-10-05 IL IL13525698A patent/IL135256A0/xx unknown
- 1998-10-05 WO PCT/EP1998/006300 patent/WO1999020616A1/de not_active Ceased
- 1998-10-05 AU AU11497/99A patent/AU748613B2/en not_active Ceased
- 1998-10-05 CN CN98810529A patent/CN1277607A/zh active Pending
- 1998-10-05 NZ NZ503604A patent/NZ503604A/en unknown
- 1998-10-05 JP JP2000516958A patent/JP2001520224A/ja active Pending
- 1998-10-05 EP EP98954330A patent/EP1034170A1/en not_active Withdrawn
- 1998-10-05 KR KR1020007004286A patent/KR20010031297A/ko not_active Withdrawn
- 1998-10-05 CA CA002307199A patent/CA2307199A1/en not_active Abandoned
- 1998-10-05 PL PL98340033A patent/PL340033A1/xx unknown
- 1998-10-05 BR BR9812948-1A patent/BR9812948A/pt not_active IP Right Cessation
- 1998-10-05 TR TR2000/01080T patent/TR200001080T2/xx unknown
- 1998-10-05 US US09/529,828 patent/US6346622B1/en not_active Expired - Lifetime
- 1998-10-05 HU HU0003758A patent/HUP0003758A3/hu unknown
- 1998-10-20 TW TW087117331A patent/TW517052B/zh active
- 1998-10-20 CO CO98060934A patent/CO4980863A1/es unknown
- 1998-10-21 ZA ZA9809571A patent/ZA989571B/xx unknown
- 1998-10-21 AR ARP980105243A patent/AR016968A1/es not_active Application Discontinuation
- 1998-10-21 HR HR19746612.5A patent/HRP980555A2/hr not_active Application Discontinuation
-
2000
- 2000-04-11 BG BG104332A patent/BG104332A/xx unknown
- 2000-04-13 NO NO20001937A patent/NO20001937L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ503604A (en) | 2002-03-01 |
| CA2307199A1 (en) | 1999-04-29 |
| JP2001520224A (ja) | 2001-10-30 |
| BR9812948A (pt) | 2000-08-08 |
| WO1999020616A1 (de) | 1999-04-29 |
| AU1149799A (en) | 1999-05-10 |
| HRP980555A2 (en) | 1999-08-31 |
| PL340033A1 (en) | 2001-01-15 |
| NO20001937D0 (no) | 2000-04-13 |
| HUP0003758A1 (hu) | 2001-10-28 |
| US6346622B1 (en) | 2002-02-12 |
| CN1277607A (zh) | 2000-12-20 |
| ZA989571B (en) | 2000-04-25 |
| IL135256A0 (en) | 2001-05-20 |
| TW517052B (en) | 2003-01-11 |
| NO20001937L (no) | 2000-04-13 |
| BG104332A (en) | 2001-02-28 |
| CO4980863A1 (es) | 2000-11-27 |
| DE19746612A1 (de) | 1999-04-29 |
| KR20010031297A (ko) | 2001-04-16 |
| SK4572000A3 (en) | 2000-10-09 |
| AU748613B2 (en) | 2002-06-06 |
| EP1034170A1 (en) | 2000-09-13 |
| TR200001080T2 (tr) | 2001-01-22 |
| HUP0003758A3 (en) | 2001-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |