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AR016785A1 - 1-FENIL-4-BENCILPIPERAZINAS: SPECIFIC LINKS OF DOPAMINE RECEPTORS SUBTIPOS - Google Patents

1-FENIL-4-BENCILPIPERAZINAS: SPECIFIC LINKS OF DOPAMINE RECEPTORS SUBTIPOS

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Publication number
AR016785A1
AR016785A1 ARP980103832A AR016785A1 AR 016785 A1 AR016785 A1 AR 016785A1 AR P980103832 A ARP980103832 A AR P980103832A AR 016785 A1 AR016785 A1 AR 016785A1
Authority
AR
Argentina
Prior art keywords
represent
alkyl
subtipos
bencilpiperazinas
fenil
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Priority to ARP980103832 priority Critical patent/AR016785A1/en
Publication of AR016785A1 publication Critical patent/AR016785A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un compuesto de formula (I) o sus sales de ácidos farmacéuticamente aceptables en donde: R1 es halogeno o alquilo C1-4; y Ra es hidrogeno; o R1 y Rajuntos representan alquileno C3-5 que contiene uno o dos átomos de oxígeno que junto con el grupo fenilo forma un anillo de cinco o seis miembrosque contiene uno o dos átomos de oxígeno; o R1 y Ra juntos representan (II); R2 y R3 son iguales o diferentes y representan hidrogeno, halogeno,alquilo C1-4, alcoxi C1-4 alquiltio, hidroxi, nitro, amino, monoalquilamino o dialquilamino o R2 y R3 juntos representan alquileno C3-5 o alquenileno quecontiene uno o dos átomos de oxígeno que junto con el fenilo forman un anillo de cinco o seis miembros sustituido con uno o dos átomos de oxígeno, con lacondicion de que R2 y R3 no pueden ser 2-isopropoxilo e hidrogeno respectivamente cuando R1 es bromo. Se describe también un método para el tratamientoo la prevencion de trastornos neuropsicologicos en dichos compuestos.A compound of formula (I) or its pharmaceutically acceptable acid salts wherein: R 1 is halogen or C 1-4 alkyl; and Ra is hydrogen; or R1 and Rajuntos represent C3-5 alkylene containing one or two oxygen atoms which together with the phenyl group forms a five or six membered ring containing one or two oxygen atoms; or R1 and Ra together represent (II); R2 and R3 are the same or different and represent hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy alkyl, hydroxy, nitro, amino, monoalkylamino or dialkylamino or R2 and R3 together represent C3-5 alkylene or alkenylene containing one or two atoms of oxygen which together with the phenyl form a five or six membered ring substituted with one or two oxygen atoms, with the proviso that R2 and R3 cannot be 2-isopropoxy and hydrogen respectively when R1 is bromine. A method for the treatment or prevention of neuropsychological disorders in said compounds is also described.

ARP980103832 1998-08-03 1998-08-03 1-FENIL-4-BENCILPIPERAZINAS: SPECIFIC LINKS OF DOPAMINE RECEPTORS SUBTIPOS AR016785A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP980103832 AR016785A1 (en) 1998-08-03 1998-08-03 1-FENIL-4-BENCILPIPERAZINAS: SPECIFIC LINKS OF DOPAMINE RECEPTORS SUBTIPOS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP980103832 AR016785A1 (en) 1998-08-03 1998-08-03 1-FENIL-4-BENCILPIPERAZINAS: SPECIFIC LINKS OF DOPAMINE RECEPTORS SUBTIPOS

Publications (1)

Publication Number Publication Date
AR016785A1 true AR016785A1 (en) 2001-08-01

Family

ID=45606225

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103832 AR016785A1 (en) 1998-08-03 1998-08-03 1-FENIL-4-BENCILPIPERAZINAS: SPECIFIC LINKS OF DOPAMINE RECEPTORS SUBTIPOS

Country Status (1)

Country Link
AR (1) AR016785A1 (en)

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