[go: up one dir, main page]

AR016108A1 - Un derivado de bencimidazol y una composicion farmaceutica que lo contiene. - Google Patents

Un derivado de bencimidazol y una composicion farmaceutica que lo contiene.

Info

Publication number
AR016108A1
AR016108A1 ARP980103128A ARP980103128A AR016108A1 AR 016108 A1 AR016108 A1 AR 016108A1 AR P980103128 A ARP980103128 A AR P980103128A AR P980103128 A ARP980103128 A AR P980103128A AR 016108 A1 AR016108 A1 AR 016108A1
Authority
AR
Argentina
Prior art keywords
group
aromatic
alkyl
alkenyl
alkyloxy
Prior art date
Application number
ARP980103128A
Other languages
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of AR016108A1 publication Critical patent/AR016108A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de benzimidazol, representado por la siguiente formula (I), o una sal del mismo: I donde R1 representa un átomo de hidrogeno, un grupo alquiloinferior, un grupo alcoxi inferior, o un grupo alquiltio inferior; R2 representa un grupo alquilo inferior aromático, que puede estar sustituido con uno o másgrupos seleccionados entre un átomo de halogeno, un grupo alquilo, un grupo haloalquilo inferior, un grupo nitro, un grupo alcoxicarbonilo inferior, un grupoaromático, un grupo alquiloxiinferior aromático, un grupo alquilo inferior cicloalquiloxi inferior, un grupo alquilo inferior aromático, un grupo alqueniloinferior aromático, un grupo alquinilo inferior aromático, un grupo alquiloxi inferior aromático, un grupo alquiloxi inferior cicloalquilo inferior, un grupoalquenilo, un grupo alcoxi inferior, un grupo alquiltio inferior, un grupo alcansulfinilo inferior, un grupo alcansulfonilo inferior, y un grupoalcansulfonilcarbamoilo inferior; R3 representa un grupo alquilo, un grupo hidroxialquilo inferior, un grupo alquenilo, un grupo aromático, un grupo aromáticohalogenado, un grupo aromático alquilo inferior, un grupo alquenilo inferior aromático, un grupo alquilo inferior aromático o un grupo alquenilo inferioraromático;y -X- es un grupo de entrecruzamiento representado por cualquiera de las siguientes formulas II a VI; composicion farmacéutica que comprende elderivado de bencimidazol que posee actividad depresora del nivel de azucar sanguíneo o actividad inhibidorade la PDES.
ARP980103128A 1997-06-27 1998-06-26 Un derivado de bencimidazol y una composicion farmaceutica que lo contiene. AR016108A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18769697 1997-06-27
JP7635798 1998-03-25

Publications (1)

Publication Number Publication Date
AR016108A1 true AR016108A1 (es) 2001-06-20

Family

ID=26417500

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103128A AR016108A1 (es) 1997-06-27 1998-06-26 Un derivado de bencimidazol y una composicion farmaceutica que lo contiene.

Country Status (14)

Country Link
US (1) US6420409B1 (es)
EP (1) EP1020452A4 (es)
KR (1) KR20010014166A (es)
CN (1) CN1135224C (es)
AR (1) AR016108A1 (es)
AU (1) AU748541B2 (es)
BR (1) BR9811273A (es)
CA (1) CA2294505A1 (es)
HU (1) HUP0002324A3 (es)
IL (1) IL133674A0 (es)
RU (1) RU2243968C2 (es)
TR (1) TR199903277T2 (es)
TW (1) TW453999B (es)
WO (1) WO1999000373A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9810456A (pt) * 1997-06-27 2001-09-25 Fujisawa Pharmaceutical Co Composto de sulfonamida, método para sua obtenção e seu uso farmacêutico
EP1070705A4 (en) * 1998-04-06 2002-04-17 Fujisawa Pharmaceutical Co INDOLE DERIVATIVES
EP1132087A4 (en) * 1998-11-13 2002-06-26 Fujisawa Pharmaceutical Co REMEDIES FOR POLYKYSTIC OVARY SYNDROME
US6869950B1 (en) * 1998-12-24 2005-03-22 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
US6525067B1 (en) 1999-11-23 2003-02-25 Pfizer Inc Substituted heterocyclic derivatives
EP1149583A3 (en) * 2000-04-13 2001-11-14 Pfizer Products Inc. Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
US6943171B2 (en) 2001-11-09 2005-09-13 Schering Corporation Polycyclic guanine derivative phosphodiesterase V inhibitors
CA2468827A1 (en) * 2001-12-03 2003-06-12 Takeda Chemical Industries, Ltd. Insulin resistance improving agents
FR2833948B1 (fr) * 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
NZ560368A (en) * 2002-05-03 2008-11-28 Israel Inst Biolog Res Methods and compostions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
AU2003902860A0 (en) * 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
SE0302573D0 (sv) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
TW200533336A (en) * 2004-03-02 2005-10-16 Fujisawa Pharmaceutical Co Concomitant drugs
US20070232673A1 (en) * 2006-01-19 2007-10-04 Roth Gregory P 2-Imino-benzimidazoles
WO2011063339A1 (en) * 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
AU2010328230B2 (en) 2009-12-07 2016-06-02 Cardioxyl Pharmaceuticals, Inc. Bis-acylated hydroxylamine derivatives
US20110144067A1 (en) * 2009-12-07 2011-06-16 Toscano John P N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives
JP5990106B2 (ja) * 2011-01-28 2016-09-07 佐藤製薬株式会社 縮環化合物
SG11201804359SA (en) * 2015-12-11 2018-06-28 Teijin Pharma Ltd Aminoazole derivative
WO2017192728A1 (en) 2016-05-03 2017-11-09 Virginia Commonwealth University Heteroatom -doped porous carbons for clean energy applications and methods for their synthesis
US12234205B1 (en) 2024-05-22 2025-02-25 King Saud University Sulfonylhydrazide derivatives as anticancer agents

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE676196C (de) 1936-08-21 1939-05-30 I G Farbenindustrie Akt Ges Verfahren zur Herstellung von Imidazolverbindungen
US3152142A (en) 1962-05-24 1964-10-06 Dow Chemical Co Benzimidazole compounds
FR2291749A1 (fr) 1974-11-20 1976-06-18 Delalande Sa Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique
JPS51133267A (en) 1975-05-08 1976-11-18 Lilly Co Eli Substituted 11sulphonyl benzimidazole
US4179505A (en) 1977-03-30 1979-12-18 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
US4243806A (en) 1979-06-13 1981-01-06 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
GB2053215B (en) 1979-06-25 1983-04-07 May & Baker Ltd Benzimidazole derivatives
JPS625966A (ja) 1985-07-03 1987-01-12 Nippon Shinyaku Co Ltd ベンズイミダゾ−ル誘導体
NZ221729A (en) 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
ZA899367B (en) * 1988-12-22 1990-08-29 Yamanouchi Pharma Co Ltd 4,5,6,7-tetrahydrobenzimidazole derivatives
CA2004911A1 (en) 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU7759591A (en) 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5703110A (en) 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
DE4023369A1 (de) * 1990-07-23 1992-01-30 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU1836357C (ru) 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
PT98674B (pt) * 1990-08-15 1999-01-29 British Bio Technology Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios
US5614519A (en) 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
US5594003A (en) 1991-02-06 1997-01-14 Dr. Karl Thomae Gmbh Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists
SI9210098B (sl) 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5602127A (en) 1991-02-06 1997-02-11 Karl Thomae Gmbh (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5407835A (en) 1991-07-31 1995-04-18 Abbott Laboratories Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids
GB9121776D0 (en) 1991-10-14 1991-11-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives and process for preparation thereof
DE4237557A1 (de) 1992-11-06 1994-05-11 Bayer Ag Substituierte Benzimidazole
JPH0853424A (ja) 1994-08-11 1996-02-27 Kureha Chem Ind Co Ltd ベンズイミダゾールスルホン酸アミド誘導体
GB9423910D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
DK0882718T3 (da) 1995-12-28 2005-12-12 Astellas Pharma Inc Benzimidazolderivater

Also Published As

Publication number Publication date
AU7934698A (en) 1999-01-19
BR9811273A (pt) 2000-07-18
US6420409B1 (en) 2002-07-16
HUP0002324A3 (en) 2001-07-30
EP1020452A1 (en) 2000-07-19
KR20010014166A (ko) 2001-02-26
CA2294505A1 (en) 1999-01-07
EP1020452A4 (en) 2003-04-02
WO1999000373A1 (en) 1999-01-07
CN1268123A (zh) 2000-09-27
HUP0002324A2 (hu) 2001-05-28
AU748541B2 (en) 2002-06-06
IL133674A0 (en) 2001-04-30
HK1028246A1 (en) 2001-02-09
RU2243968C2 (ru) 2005-01-10
TR199903277T2 (xx) 2000-07-21
WO1999000373A8 (en) 2000-07-20
TW453999B (en) 2001-09-11
CN1135224C (zh) 2004-01-21

Similar Documents

Publication Publication Date Title
AR016108A1 (es) Un derivado de bencimidazol y una composicion farmaceutica que lo contiene.
PE20050346A1 (es) Glucopiranosiloxi-pirazoles como inhibidores del co-transportador de glucosa dependiente de sodio (sglt2)
NO20005237D0 (no) Heterocyklisk substituerte amider anvendt som calpain- inhibitorer
PE20050615A1 (es) Derivados de 2-cianobencenosulfonamidas
CO5640136A2 (es) Derivados de hexahidropiridoisoquinolinas inhibidores de dpp-iv y composiciones farmaceuticas que los contienen
ES2053609T3 (es) Derivados de urea inhibidores de lipoxigenasa.
ES2531660T3 (es) Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio
AR042273A1 (es) Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen
AR019427A1 (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa, procedimiento para su preparacion, su uso para la preparacion de medicamentos, composiciones farmaceuticas y compuestos intermediarios utiles para su preparacion
AR054799A1 (es) Derivados de oxindol
AR038717A1 (es) Ciclopropil-azol-carboxamidas
AR013746A1 (es) Sustitucion bioisosterica de catecol por indazol en compuesto terapeuticos activos
DOP2006000063A (es) Derivados de ciclopropanocarboxamida
ES2032899T3 (es) Agente cosmetico para aplicacion externa y su uso.
DK1598340T3 (da) 1-(4-piperidinyl)-1,3-dihydro-2H-benzoxazol -2-on derivater og beslægtede forbindelser som nociceptin analoger og ORL1 ligander til behandling af smerte
ES2051771T3 (es) Pirimidinas substituidas.
ES2074191T3 (es) Oxazolidinonas.
AR023886A1 (es) Benzoilcetonas sustituidas, procedimiento para su obtencion, compuestos para su uso en el procedimiento, composiciones herbicidas, empleo de dichos compuestos para la lucha contra las plantas indeseables.
DE69232484D1 (de) Hydroisochinolinderivate
AR021992A1 (es) Mezcla fungicida.
MX9301863A (es) Morfolin y tiomorfolin 4-ilamidas
MX9202994A (es) Derivados de 2-aminoacetamida.
ATE75399T1 (de) Therapeutikum zur behandlung von magengeschwueren.
DK54484D0 (da) Substituerede alkanthiocarboxylsyre-derivater,fremgangsmaade til deres fremstilling samt deres anvendelse som herbicider
ES2041644T3 (es) Derivados de n-(piperidilaminocarbonil) quinoleincarboxamida que tienen actividad psicotropica.

Legal Events

Date Code Title Description
FB Suspension of granting procedure