AR015248A1 - Aminoguanidinas ciclicas, un proceso para su produccion, compuesto de partida,una composicion farmaceutica que las comprende y el uso de los mismos parala preparacion de un medicamento - Google Patents
Aminoguanidinas ciclicas, un proceso para su produccion, compuesto de partida,una composicion farmaceutica que las comprende y el uso de los mismos parala preparacion de un medicamentoInfo
- Publication number
- AR015248A1 AR015248A1 ARP990101236A ARP990101236A AR015248A1 AR 015248 A1 AR015248 A1 AR 015248A1 AR P990101236 A ARP990101236 A AR P990101236A AR P990101236 A ARP990101236 A AR P990101236A AR 015248 A1 AR015248 A1 AR 015248A1
- Authority
- AR
- Argentina
- Prior art keywords
- denotes
- alkyl
- heterocyclyl
- pharmaceutical composition
- preparation
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 Cyclic aminoguanidines Chemical class 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 101100439664 Arabidopsis thaliana CHR8 gene Proteins 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000588914 Enterobacter Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000588621 Moraxella Species 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 241000191940 Staphylococcus Species 0.000 abstract 1
- 241000194017 Streptococcus Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Aminoguanidinas cíclicas, caracterizado porque comprende un compuesto de la formula (I) en donde W denota CH o N, V denota CH o NO, R1 denota nitrogeno,acilo, carboxilo, o alquilo, R3 denota hidrogeno o una fraccion de éster,R2 denota un grupo de laformulas (a),(a) (b), (c),(d) (e), (e) (f), o (g) en dondeX e Y, independientemente uno del otro, denotan cada uno alquileno (de 2 a 5 átomos de carbono), o alquenilo (de 2 a 5 átomos de carbono), en donde estápresente un doble enlace C=C-, o en elcaso de cuando menos alquileno de 4 átomos de carbono, en donde están presentes dos dobles enlaces -C=C, R4 denotahidrogeno o alquilo, R5 denota hidrogeno, alquilo o aminoiminometilo, R6 denota hidrogeno, alquilo, cicloalquilo, amino, hidroxi, alcoxi, heterociclilo, o ungrupo de la formula -N=CHR8, en donde: R8 denota alquilo, arilo, o heterociclilo, o R5 y R6, junto con los átomos de nitrogeno con los que están unidos,denotan heterociclilo, R6 denota alquilo, R7 denota hidrogeno, o R6 y R7, junto con el átomo de nitrogeno con el que están unidos forman heterociclilo,Aminoguanidinas cíclicas, un proceso para su produccion, compuestos de partida, una composicion farmacéutica que las comprende y el uso de los mismos para lapreparacion de un medicamento para enfermedades microbianas ocasionadas por bacterias seleccionadas a partir de Pseudomonas, Eschetichia, Enterobacter,KDlebsiella, Enteroccus, Moraxella, Streptococcus, Staphylococcus.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0051598A AT406772B (de) | 1998-03-23 | 1998-03-23 | Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015248A1 true AR015248A1 (es) | 2001-04-18 |
Family
ID=3492649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101236A AR015248A1 (es) | 1998-03-23 | 1999-03-19 | Aminoguanidinas ciclicas, un proceso para su produccion, compuesto de partida,una composicion farmaceutica que las comprende y el uso de los mismos parala preparacion de un medicamento |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6440957B1 (es) |
| EP (2) | EP1930335A1 (es) |
| JP (1) | JP2002507616A (es) |
| KR (1) | KR100696422B1 (es) |
| CN (1) | CN1188418C (es) |
| AR (1) | AR015248A1 (es) |
| AT (1) | AT406772B (es) |
| AU (1) | AU749735B2 (es) |
| BR (1) | BR9908960A (es) |
| CA (1) | CA2324953C (es) |
| CO (1) | CO5080739A1 (es) |
| HU (1) | HUP0101603A3 (es) |
| ID (1) | ID26567A (es) |
| IL (2) | IL138477A0 (es) |
| MY (1) | MY119841A (es) |
| NO (1) | NO20004760L (es) |
| NZ (1) | NZ506908A (es) |
| PE (1) | PE20000360A1 (es) |
| PL (1) | PL343094A1 (es) |
| RU (1) | RU2245884C2 (es) |
| SK (1) | SK14152000A3 (es) |
| TR (1) | TR200002749T2 (es) |
| TW (1) | TWI250983B (es) |
| WO (1) | WO1999048896A1 (es) |
| ZA (1) | ZA200004850B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020115852A1 (en) * | 1997-04-01 | 2002-08-22 | Gerd Ascher | Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates |
| DE102007052891A1 (de) | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Verfahren zur Stabilisierung von olefinisch ungesättigten Monomeren |
| DE102013204950A1 (de) | 2013-03-20 | 2014-09-25 | Evonik Industries Ag | Verfahren und Zusammensetzung zur Inhibierung der Polymerisation von Cyclopentadienverbindungen |
| EP2993164B1 (de) | 2014-09-08 | 2017-02-15 | Evonik Degussa GmbH | Phenolische (Thio)Acetale als Inhibitoren der Polymerisation von olefinisch ungesättigten Monomeren |
| TWI669317B (zh) | 2014-09-22 | 2019-08-21 | 德商贏創德固賽有限責任公司 | 反應性單體的改良製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE943408C (de) * | 1953-03-31 | 1956-05-17 | Bayer Ag | Verfahren zur Darstellung von Bisguanylhydrazonen |
| FI851934A7 (fi) * | 1984-05-30 | 1985-12-01 | Ici Plc | Kefalosporiinijohdannaisia. |
| GB8721568D0 (en) * | 1987-09-14 | 1987-10-21 | Fujisawa Pharmaceutical Co | Cephem compounds |
| DE69626389T2 (de) * | 1995-05-11 | 2003-10-09 | Biochemie Ges.M.B.H., Kundl | Antibakterielle cephalosporinverbindungen |
| DE69816057T2 (de) * | 1997-04-01 | 2004-04-15 | Biochemie Gesellschaft M.B.H. | Antibakterielle substituierte 7-acylamino-3-(methylhydrazono)methyl-cephalosporine und zwischenprodukte |
-
1998
- 1998-03-23 AT AT0051598A patent/AT406772B/de not_active IP Right Cessation
-
1999
- 1999-03-19 CA CA002324953A patent/CA2324953C/en not_active Expired - Fee Related
- 1999-03-19 RU RU2000126469/04A patent/RU2245884C2/ru not_active IP Right Cessation
- 1999-03-19 IL IL13847799A patent/IL138477A0/xx not_active IP Right Cessation
- 1999-03-19 WO PCT/EP1999/001853 patent/WO1999048896A1/en not_active Ceased
- 1999-03-19 HU HU0101603A patent/HUP0101603A3/hu unknown
- 1999-03-19 KR KR1020007010434A patent/KR100696422B1/ko not_active Expired - Fee Related
- 1999-03-19 EP EP07021394A patent/EP1930335A1/en not_active Withdrawn
- 1999-03-19 EP EP99916839A patent/EP1082326A1/en not_active Withdrawn
- 1999-03-19 AR ARP990101236A patent/AR015248A1/es not_active Application Discontinuation
- 1999-03-19 NZ NZ506908A patent/NZ506908A/xx unknown
- 1999-03-19 ZA ZA200004850A patent/ZA200004850B/en unknown
- 1999-03-19 SK SK1415-2000A patent/SK14152000A3/sk unknown
- 1999-03-19 CN CNB998043192A patent/CN1188418C/zh not_active Expired - Fee Related
- 1999-03-19 TR TR2000/02749T patent/TR200002749T2/xx unknown
- 1999-03-19 JP JP2000537879A patent/JP2002507616A/ja not_active Withdrawn
- 1999-03-19 BR BR9908960-2A patent/BR9908960A/pt not_active Application Discontinuation
- 1999-03-19 AU AU35188/99A patent/AU749735B2/en not_active Ceased
- 1999-03-19 ID IDW20001853A patent/ID26567A/id unknown
- 1999-03-19 CO CO99017143A patent/CO5080739A1/es unknown
- 1999-03-19 PL PL99343094A patent/PL343094A1/xx unknown
- 1999-03-22 MY MYPI99001068A patent/MY119841A/en unknown
- 1999-03-22 PE PE1999000232A patent/PE20000360A1/es not_active Application Discontinuation
- 1999-05-10 TW TW088107541A patent/TWI250983B/zh not_active IP Right Cessation
-
2000
- 2000-09-14 IL IL138477A patent/IL138477A/en unknown
- 2000-09-21 US US09/667,075 patent/US6440957B1/en not_active Expired - Fee Related
- 2000-09-22 NO NO20004760A patent/NO20004760L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK14152000A3 (sk) | 2001-05-10 |
| CN1294593A (zh) | 2001-05-09 |
| IL138477A0 (en) | 2001-10-31 |
| AT406772B (de) | 2000-08-25 |
| ATA51598A (de) | 2000-01-15 |
| KR100696422B1 (ko) | 2007-03-20 |
| IL138477A (en) | 2007-06-17 |
| EP1930335A1 (en) | 2008-06-11 |
| MY119841A (en) | 2005-07-29 |
| EP1082326A1 (en) | 2001-03-14 |
| KR20010074666A (ko) | 2001-08-08 |
| HUP0101603A2 (hu) | 2001-12-28 |
| TR200002749T2 (tr) | 2000-12-21 |
| ZA200004850B (en) | 2002-02-27 |
| NO20004760D0 (no) | 2000-09-22 |
| CO5080739A1 (es) | 2001-09-25 |
| CA2324953C (en) | 2008-05-13 |
| TWI250983B (en) | 2006-03-11 |
| NZ506908A (en) | 2003-04-29 |
| BR9908960A (pt) | 2000-12-05 |
| NO20004760L (no) | 2000-11-21 |
| ID26567A (id) | 2001-01-18 |
| WO1999048896A1 (en) | 1999-09-30 |
| PL343094A1 (en) | 2001-07-30 |
| JP2002507616A (ja) | 2002-03-12 |
| AU749735B2 (en) | 2002-07-04 |
| CN1188418C (zh) | 2005-02-09 |
| PE20000360A1 (es) | 2000-05-17 |
| HUP0101603A3 (en) | 2002-10-28 |
| CA2324953A1 (en) | 1999-09-30 |
| US6440957B1 (en) | 2002-08-27 |
| AU3518899A (en) | 1999-10-18 |
| RU2245884C2 (ru) | 2005-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |