AR003905A1 - THROMBIN PIRAZINONE INHIBITOR COMPOUNDS AND THEIR SALTS, PROCEDURE FOR THE PREPARATION OF SALTS, COMPOSITIONS OF THE SALES, METHODS FOR THE TREATMENT AND USE OF THE COMPOUND FOR THE MANUFACTURE OF MEDICINES. - Google Patents
THROMBIN PIRAZINONE INHIBITOR COMPOUNDS AND THEIR SALTS, PROCEDURE FOR THE PREPARATION OF SALTS, COMPOSITIONS OF THE SALES, METHODS FOR THE TREATMENT AND USE OF THE COMPOUND FOR THE MANUFACTURE OF MEDICINES.Info
- Publication number
- AR003905A1 AR003905A1 ARP970101649A ARP970101649A AR003905A1 AR 003905 A1 AR003905 A1 AR 003905A1 AR P970101649 A ARP970101649 A AR P970101649A AR P970101649 A ARP970101649 A AR P970101649A AR 003905 A1 AR003905 A1 AR 003905A1
- Authority
- AR
- Argentina
- Prior art keywords
- salts
- thrombin
- compositions
- manufacture
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- 108090000190 Thrombin Proteins 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229960004072 thrombin Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical compound OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 abstract 1
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos inhibidores pirazinona de trombina y sus sales, útiles para inhibir trombina de oclusiones trombóticas asociadas que tienen la estructura(I), en donde X es hidrógeno o halógeno; R3 es hidrógeno, alquilo, cicloalquilo otr ifluormetilo; W es hidrógeno, fenilo, fenilalquilo,piridilalquilo u otro sustituyente; y A es (II), en donde Y1 y Y2 son independientemente hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno otrifluormetilo; R4 es H, alquilo, alcoxi,halóge no u otro sustituyente; y R5 es hidrógeno, alquilo, alcoxi u otro sustituyente. La invención además serelaciona con un procedimiento para la preparación de sales, composiciones de las mismas métodos de tratamiento y uso del compuestopara la man ufactura demedicamentos.Pyrazinone thrombin inhibitor compounds and their salts, useful for inhibiting thrombin from associated thrombotic occlusions having structure (I), wherein X is hydrogen or halogen; R3 is hydrogen, alkyl, cycloalkyl, or other ifluormethyl; W is hydrogen, phenyl, phenylalkyl, pyridylalkyl or other substituent; and A is (II), where Y1 and Y2 are independently hydrogen, alkyl, alkoxy, cycloalkyl, halogen, otrifluoromethyl; R4 is H, alkyl, alkoxy, halogen no or other substituent; and R5 is hydrogen, alkyl, alkoxy, or other substituent. The invention furthermore relates to a process for the preparation of salts, compositions of the same methods of treatment and use of the compound for the manufacture of drugs.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1604196P | 1996-04-23 | 1996-04-23 | |
| US9609714A | 1996-05-09 | 1996-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003905A1 true AR003905A1 (en) | 1998-09-30 |
Family
ID=51983086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101649A AR003905A1 (en) | 1996-04-23 | 1997-04-23 | THROMBIN PIRAZINONE INHIBITOR COMPOUNDS AND THEIR SALTS, PROCEDURE FOR THE PREPARATION OF SALTS, COMPOSITIONS OF THE SALES, METHODS FOR THE TREATMENT AND USE OF THE COMPOUND FOR THE MANUFACTURE OF MEDICINES. |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR003905A1 (en) |
-
1997
- 1997-04-23 AR ARP970101649A patent/AR003905A1/en unknown
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