AR003123A1 - Una composicion sinergica de por lo menos un compuesto de actividad antimicrobiana y de por lo menos un monoalquileter de glicerol y utilizacionesde los mismos como agentes antimicrobianos en una composicion cosmetica o farmaceutica como asi tambien en la preparacion de composiciones farmaceuticas - Google Patents
Una composicion sinergica de por lo menos un compuesto de actividad antimicrobiana y de por lo menos un monoalquileter de glicerol y utilizacionesde los mismos como agentes antimicrobianos en una composicion cosmetica o farmaceutica como asi tambien en la preparacion de composiciones farmaceuticasInfo
- Publication number
- AR003123A1 AR003123A1 ARP960102556A AR10255696A AR003123A1 AR 003123 A1 AR003123 A1 AR 003123A1 AR P960102556 A ARP960102556 A AR P960102556A AR 10255696 A AR10255696 A AR 10255696A AR 003123 A1 AR003123 A1 AR 003123A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- cosmetic
- compound
- glycerol
- utilizations
- Prior art date
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title abstract 5
- 239000002537 cosmetic Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002195 synergetic effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- -1 glycerol monoalkyl ether Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invención se refiere a una composición sinérgica de por lo menos un compuesto de actividad antimicrobiana y de por lo menos un monoalquiléter deglicerol, utilizada especialmente en calidad de agente antimicrobiano en una composicióncosmét ica o farmacéutica. Esta composición encuentra una aplicaciónmuy particular en los campos cosméticos o farmacéuticos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9505866A FR2734158B1 (fr) | 1995-05-17 | 1995-05-17 | Association d'un compose a activite anti-microbienne et d'un monoalkylether de glycerol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003123A1 true AR003123A1 (es) | 1998-07-08 |
Family
ID=9479089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102556A AR003123A1 (es) | 1995-05-17 | 1996-05-14 | Una composicion sinergica de por lo menos un compuesto de actividad antimicrobiana y de por lo menos un monoalquileter de glicerol y utilizacionesde los mismos como agentes antimicrobianos en una composicion cosmetica o farmaceutica como asi tambien en la preparacion de composiciones farmaceuticas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5736574A (es) |
| EP (1) | EP0747047B1 (es) |
| JP (1) | JP2898246B2 (es) |
| AR (1) | AR003123A1 (es) |
| AT (1) | ATE168266T1 (es) |
| AU (1) | AU686943B2 (es) |
| BR (1) | BR9601693A (es) |
| CA (1) | CA2176840C (es) |
| DE (1) | DE69600431T2 (es) |
| ES (1) | ES2123323T3 (es) |
| FR (1) | FR2734158B1 (es) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3615894B2 (ja) * | 1997-01-20 | 2005-02-02 | 株式会社ノエビア | 抗菌性低刺激化粧料 |
| FR2767697B1 (fr) * | 1997-09-01 | 2000-05-05 | Boots Co Plc | Composition dermatologique permettant d'eviter l'apparition de symptomes d'hypersensibilite et d'intolerance cutanee |
| US6685965B1 (en) * | 1997-10-22 | 2004-02-03 | Industria E Comercio De Cosmeticos Natura Ltda. | Process for stabilizing levogyre ascorbic acid (laa), a stable aqueous laa composition, a process for preparing a stable topical solution, an emulsion, a vitamin product, and a method for cosmetic, pharmaceutical or nutritional treatment |
| US6147120A (en) * | 1999-02-16 | 2000-11-14 | Ecolab Inc. | Synergistic antimicrobial skin washing compositions |
| US6224579B1 (en) * | 1999-03-31 | 2001-05-01 | The Trustees Of Columbia University In The City Of New York | Triclosan and silver compound containing medical devices |
| AU7057700A (en) * | 1999-08-18 | 2001-03-13 | Atairgin Technologies, Inc. | Compounds which modulate the activity of an lpa receptor |
| DE19959000B4 (de) | 1999-12-08 | 2018-07-05 | Cognis Ip Management Gmbh | Verwendung primärer Monoalkylether von Eigenkondensationsprodukten des Glycerins |
| DE10028638A1 (de) * | 2000-06-09 | 2001-12-20 | Schuelke & Mayr Gmbh | Lagerstabile Zusammensetzungen von Glycerinmonoalkylethern |
| US7329412B2 (en) | 2000-12-22 | 2008-02-12 | The Trustees Of Columbia University In The City Of New York | Antimicrobial medical devices containing chlorhexidine free base and salt |
| US6846846B2 (en) * | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
| DE10163838A1 (de) * | 2001-12-22 | 2003-07-03 | Beiersdorf Ag | Gegen Bakterien, Mycota und Viren wirksame Wirkstoffkombinationen auf der Basis von dialkylsubstituierten Essigsäuren und Glycerinalkylethern |
| US7879365B2 (en) * | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
| US7745425B2 (en) * | 2002-02-07 | 2010-06-29 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
| AU2003216213B2 (en) | 2002-02-07 | 2008-10-02 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
| DE10224978A1 (de) * | 2002-06-05 | 2003-12-24 | Schuelke & Mayr Gmbh | Glycerinether als Konservierungsmittel für Kühlschmierstoffe |
| DE10224979B4 (de) * | 2002-06-05 | 2004-07-15 | Schülke & Mayr GmbH | Verwendung von synergistischen Zubereitungen auf Basis von Gemischen von Glycerinether mit aromatischem Alkohol zur Bekämpfung von Mykobakterien |
| US20040001797A1 (en) * | 2002-06-21 | 2004-01-01 | Abel Saud | Antimicrobial compositions, products and methods employing same |
| US7569530B1 (en) | 2003-06-20 | 2009-08-04 | The Procter & Gamble Company | Antimicrobial compositions, products and methods employing same |
| EP1466960B1 (en) * | 2003-04-08 | 2009-03-18 | Kao Corporation | Liquid detergent composition |
| US20040208908A1 (en) * | 2003-04-16 | 2004-10-21 | The Trustees Of Columbia University In The City Of New York | Antimicrobial medical articles containing a synergistic combination of anti-infective compounds and octoxyglycerin |
| US7214391B2 (en) * | 2003-06-30 | 2007-05-08 | Usana Health Sciences, Inc. | Botanical extract compositions and process for preparing same |
| CN102319409A (zh) * | 2003-07-17 | 2012-01-18 | 纽约市哥伦比亚大学托管会 | 含有季铵化合物及精油和/或精油成分的协同组合的抗微生物组合物 |
| MXPA06002715A (es) * | 2003-09-09 | 2006-06-05 | 3M Innovative Properties Co | Composiciones antimicrobianas concentradas y metodos. |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| JP2007505125A (ja) * | 2003-09-09 | 2007-03-08 | スリーエム イノベイティブ プロパティズ カンパニー | 抗菌性組成物および方法 |
| US20050089488A1 (en) * | 2003-10-27 | 2005-04-28 | Kim Joo W. | Deodorant composition with monocyclic, unsaturated sequiterpene alcohols and glyceryl monoalkyl ethers as synergistic active deodorant agents |
| KR20050072899A (ko) * | 2004-01-07 | 2005-07-12 | 주식회사 엘지생활건강 | 항균비누 조성물 |
| US20050260243A1 (en) * | 2004-04-26 | 2005-11-24 | The Procter & Gamble Company | Method of treating microbial plant diseases |
| CA2598985A1 (en) * | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Antimicrobial pet wipes and methods |
| US20060229364A1 (en) * | 2005-03-10 | 2006-10-12 | 3M Innovative Properties Company | Antiviral compositions and methods of use |
| KR20070113281A (ko) * | 2005-03-10 | 2007-11-28 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 항미생물성 조성물 및 방법 |
| JP2008533048A (ja) * | 2005-03-10 | 2008-08-21 | スリーエム イノベイティブ プロパティズ カンパニー | 耳の感染症の治療方法 |
| BRPI0608690B8 (pt) * | 2005-03-10 | 2021-05-25 | 3M Innovative Properties Co | uso de uma composição antimicrobiana |
| DE102005012123A1 (de) | 2005-03-16 | 2006-09-28 | Schülke & Mayr GmbH | Isothiazolon-haltiges Konservierungsmittel mit verbesserter Wirksamkeit |
| US20060257347A1 (en) * | 2005-05-13 | 2006-11-16 | Kim Joo W | Self-preservation system |
| US7759327B2 (en) * | 2006-01-06 | 2010-07-20 | The Trustees Of Columbia University In The City Of New York | Compositions containing zinc salts for coating medical articles |
| US20080108674A1 (en) * | 2006-05-01 | 2008-05-08 | Enturia, Inc. | Cationic antiseptic and dye formulation |
| US20070253909A1 (en) * | 2006-05-01 | 2007-11-01 | Medi-Flex, Inc. | Aqueous Antiseptic Solution and Compatible Cationic Dye for Staining Skin |
| US20070254854A1 (en) * | 2006-05-01 | 2007-11-01 | Medi-Flex, Inc. | Aqueous Antiseptic Solution and Compatible Anionic Dye for Staining Skin |
| US20080075793A1 (en) * | 2006-09-21 | 2008-03-27 | Dunshee Wayne K | Antiviral compositions and methods of use |
| US9981069B2 (en) | 2007-06-20 | 2018-05-29 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
| JP4944843B2 (ja) * | 2007-07-18 | 2012-06-06 | ローム アンド ハース カンパニー | 殺微生物組成物 |
| AU2013270575B2 (en) * | 2007-07-18 | 2015-04-16 | Rohm And Haas Company | Microbicidal composition |
| FR2921558B1 (fr) * | 2007-09-28 | 2009-11-20 | Nuxe Lab | Composition antimicrobienne utilisable en cosmetique et en dermatologie. |
| FR2923159B1 (fr) * | 2007-11-07 | 2010-02-26 | Oreal | Utilisation d'un monoalkyle ether de glycerol a titre d'agent anti-oxydant |
| ES2582555T3 (es) | 2007-11-29 | 2016-09-13 | Inolex Investment Corporation | Conservantes para composiciones cosméticas, de tocador y farmacéuticas |
| EP2161016A1 (en) * | 2008-09-05 | 2010-03-10 | KPSS-Kao Professional Salon Services GmbH | Conditioning composition for hair |
| US20100249247A1 (en) * | 2009-03-31 | 2010-09-30 | Jeffrey Fallin Andrews | Antimicrobial compositions |
| CA2675184C (en) | 2009-08-10 | 2015-12-22 | Knowlton Development Corporation Inc. | Stable solid deodorant product and method for manufacturing same |
| FR2949643B1 (fr) * | 2009-09-08 | 2012-09-28 | Fonds De Dev Des Filieres Des Oleagineux Et Proteagineux Fidop | Utilisation d'ethers de glycerol comme activateurs des effets herbicides d'une substance herbicide |
| US20130101530A1 (en) * | 2011-10-25 | 2013-04-25 | Galaxy Surfactants Ltd. | Antimicrobial preservative compositions for personal care products |
| US9302127B2 (en) | 2013-03-07 | 2016-04-05 | Knowlton Development Corporation Inc. | Deodorant with improved endurance and stability |
| EP2807925A1 (en) | 2013-05-26 | 2014-12-03 | Symrise AG | Antimicrobial compositions |
| US10015963B2 (en) | 2014-03-10 | 2018-07-10 | GNA Surfactants Ltd. | Microemulsions of lipidated glycines and phenoxy ethanol for preservation of personal care products |
| JP6407839B2 (ja) * | 2015-11-12 | 2018-10-17 | 株式会社Adeka | 化粧料の抗菌方法 |
| FR3101543B1 (fr) * | 2019-10-02 | 2022-05-06 | Oreal | Mélange antimicrobien d’un sucre alkylé en C6-C30 et d’amide alkylé en C6-C20, et composition le contenant |
| EP4262708A1 (en) | 2020-12-17 | 2023-10-25 | Evonik Dr. Straetmans GmbH | N-heptyl-glyceryl ether and synergistically active preservatives |
| EP4509491A4 (en) | 2022-10-07 | 2025-10-15 | Adeka Corp | Process for producing bio-derived branched alkyl glyceryl ether and bio-derived branched alkyl glyceryl ether produced by said process |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2224169A1 (en) * | 1973-04-04 | 1974-10-31 | Astruc Jean | Antimicrobial fatty acid/amino acid compounds - for use against microorganisms (bacteria, fungi, viruses) in humans, animals and plants |
| FR2411006A1 (fr) * | 1977-12-08 | 1979-07-06 | Mill Edmond De | Nouvelles compositions therapeutiques destinees aux traitements de certaines affections cutanees et des voies respiratoires d'origines bacteriennes, fongiques et virales |
| DE4140474C2 (de) * | 1991-12-09 | 1995-07-13 | Schuelke & Mayr Gmbh | Hautpflegeadditiv |
| DE4240674C2 (de) * | 1992-11-26 | 1999-06-24 | Schuelke & Mayr Gmbh | Desodorierende Wirkstoffe |
-
1995
- 1995-05-17 FR FR9505866A patent/FR2734158B1/fr not_active Expired - Lifetime
-
1996
- 1996-04-09 AT AT96400763T patent/ATE168266T1/de not_active IP Right Cessation
- 1996-04-09 EP EP96400763A patent/EP0747047B1/fr not_active Revoked
- 1996-04-09 ES ES96400763T patent/ES2123323T3/es not_active Expired - Lifetime
- 1996-04-09 DE DE69600431T patent/DE69600431T2/de not_active Revoked
- 1996-05-03 AU AU52048/96A patent/AU686943B2/en not_active Ceased
- 1996-05-14 AR ARP960102556A patent/AR003123A1/es not_active Application Discontinuation
- 1996-05-16 JP JP8121864A patent/JP2898246B2/ja not_active Expired - Lifetime
- 1996-05-16 CA CA002176840A patent/CA2176840C/fr not_active Expired - Fee Related
- 1996-05-17 US US08/649,192 patent/US5736574A/en not_active Expired - Lifetime
- 1996-05-17 BR BR9601693A patent/BR9601693A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2176840A1 (fr) | 1996-11-18 |
| FR2734158B1 (fr) | 1997-06-27 |
| DE69600431D1 (de) | 1998-08-20 |
| AU5204896A (en) | 1996-11-28 |
| FR2734158A1 (fr) | 1996-11-22 |
| DE69600431T2 (de) | 1998-11-26 |
| JP2898246B2 (ja) | 1999-05-31 |
| JPH08310947A (ja) | 1996-11-26 |
| AU686943B2 (en) | 1998-02-12 |
| ATE168266T1 (de) | 1998-08-15 |
| EP0747047A1 (fr) | 1996-12-11 |
| BR9601693A (pt) | 1998-03-31 |
| ES2123323T3 (es) | 1999-01-01 |
| EP0747047B1 (fr) | 1998-07-15 |
| CA2176840C (fr) | 2003-03-18 |
| US5736574A (en) | 1998-04-07 |
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