AR002744A1 - Guanidinas de acido alquenilcarboxilico, sustituidas con fluorofenilo, procedimiento para su preparacion, su utilizacion como medicamento o agente dediagnostico, asi como medicamento que las contiene. - Google Patents
Guanidinas de acido alquenilcarboxilico, sustituidas con fluorofenilo, procedimiento para su preparacion, su utilizacion como medicamento o agente dediagnostico, asi como medicamento que las contiene.Info
- Publication number
- AR002744A1 AR002744A1 ARP960102622A AR10262296A AR002744A1 AR 002744 A1 AR002744 A1 AR 002744A1 AR P960102622 A ARP960102622 A AR P960102622A AR 10262296 A AR10262296 A AR 10262296A AR 002744 A1 AR002744 A1 AR 002744A1
- Authority
- AR
- Argentina
- Prior art keywords
- well
- substituted
- procedure
- preparation
- guanidines
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 150000002357 guanidines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Surgery (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Guanidinas de ácido alquenilcarboxílico, sustituidas con flurofenilo, procedimiento para su preparación, su utilización como medicamento o agentede diagnóstico, así como medicamento que las contiene. Los compuestos de la fórmula (I), en laque los sustituyentes R(1) a R(7) tienen los significadosindicados en las reivindicaciones, así como sus sales farmacéuticamente compatibles son inhibidores eficaces del antitransportador celular de protonesde sodio (intercambiador deNa(+)/H (+). Por lo tanto, son extraordinariamente indicados para el tratamiento de todas las enfermedades atribuibles a unintercambio de Na(+)/H(+) aumentado. R(6) es hidrógeno, alquilo, cicloalquilo o fenilo, estando sustituido o nó por F, Cl,CF3, metil o, metoxi y NR(9)R(10);R(9) y R(10) son hidrógeno, alquilo o perfluoro-alquilo; R(7) definido independientemente como R(6); R(1), R(2), R(3), R(4) y R(5), son hidrógeno o F;debiendo ser, sin embargo, al menos uno de los radicalesR(1), R(2), R(3), R(4) y R(5) fluor; así como sus sales farmacéuticamente compatibles.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19518796A DE19518796A1 (de) | 1995-05-22 | 1995-05-22 | Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002744A1 true AR002744A1 (es) | 1998-04-29 |
Family
ID=7762597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102622A AR002744A1 (es) | 1995-05-22 | 1996-05-20 | Guanidinas de acido alquenilcarboxilico, sustituidas con fluorofenilo, procedimiento para su preparacion, su utilizacion como medicamento o agente dediagnostico, asi como medicamento que las contiene. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20010020042A1 (es) |
| EP (1) | EP0744397B1 (es) |
| JP (1) | JP3924018B2 (es) |
| KR (1) | KR960041152A (es) |
| CN (1) | CN1063437C (es) |
| AR (1) | AR002744A1 (es) |
| AT (1) | ATE192431T1 (es) |
| AU (1) | AU701493B2 (es) |
| BR (1) | BR9602394A (es) |
| CA (1) | CA2177007C (es) |
| CZ (1) | CZ291622B6 (es) |
| DE (2) | DE19518796A1 (es) |
| DK (1) | DK0744397T3 (es) |
| ES (1) | ES2147629T3 (es) |
| GR (1) | GR3033416T3 (es) |
| HR (1) | HRP960230B1 (es) |
| HU (1) | HUP9601358A3 (es) |
| IL (1) | IL118327A (es) |
| MY (1) | MY113803A (es) |
| NO (1) | NO305552B1 (es) |
| NZ (1) | NZ286622A (es) |
| PL (1) | PL183431B1 (es) |
| PT (1) | PT744397E (es) |
| RU (1) | RU2164913C2 (es) |
| SI (1) | SI0744397T1 (es) |
| SK (1) | SK281527B6 (es) |
| TR (1) | TR199600421A2 (es) |
| TW (1) | TW415936B (es) |
| ZA (1) | ZA964035B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011059A (en) * | 1997-12-24 | 2000-01-04 | Bristol-Myers Squibb Company | Acyl guanidine sodium/proton exchange inhibitors and method |
| US6160134A (en) * | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
| WO2000064445A1 (en) | 1999-04-23 | 2000-11-02 | Bristol-Myers Squibb Company | Bicyclic acyl guanidine sodium/proton exchange inhibitors and method |
| DE10046993A1 (de) | 2000-09-22 | 2002-04-11 | Aventis Pharma Gmbh | Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament |
| BRPI0411900B8 (pt) * | 2003-06-26 | 2021-05-25 | Biotron Ltd | compostos e composições farmacêuticas compreendendo os mesmos |
| DK1902017T3 (da) | 2005-06-24 | 2014-06-30 | Biotron Ltd | Antivirale acylguanidinforbindelser |
| AU2013205388B2 (en) * | 2005-06-24 | 2016-05-05 | Biotron Limited | Antiviral compounds and methods |
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| RU2015107019A (ru) | 2012-08-21 | 2016-10-10 | Эрделикс Инк. | Соединения и способы для ингибирования nhe-опосредованного антипорта в лечении расстройств, ассоциированных с задержкой жидкости или солевой перегрузкой и заболеваний желудочно-кишечного тракта |
| MX382203B (es) | 2013-04-12 | 2025-03-11 | Ardelyx Inc | Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir transporte de fosfato. |
| UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
| JP2020505333A (ja) | 2017-01-09 | 2020-02-20 | アルデリックス， インコーポレイテッド | Ｎｈｅ媒介性アンチポートの阻害薬 |
| KR20240144491A (ko) | 2017-08-04 | 2024-10-02 | 알데릭스, 인코포레이티드 | 고칼륨혈증 치료를 위한 글리시레틴산 유도체 |
| EP4234016B1 (en) | 2019-02-07 | 2025-06-18 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| CN121159798A (zh) * | 2025-11-21 | 2025-12-19 | 北京大学口腔医学院 | 一种用于高效防治龋病的共价有机框架及其制备方法和应用 |
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| US6024748A (en) * | 1996-07-23 | 2000-02-15 | United States Surgical Corporation | Singleshot anastomosis instrument with detachable loading unit and method |
| US6109500A (en) * | 1996-10-04 | 2000-08-29 | United States Surgical Corporation | Lockout mechanism for a surgical stapler |
| JP2002514100A (ja) * | 1996-10-24 | 2002-05-14 | スピナル コンセプツ，インク． | 脊椎を固定するための方法および装置 |
| US5766250A (en) * | 1996-10-28 | 1998-06-16 | Medicinelodge, Inc. | Ligament fixator for a ligament anchor system |
| US5954057A (en) * | 1997-02-12 | 1999-09-21 | Li Medical Technologies, Inc. | Soft tissue suspension clip, clip assembly, emplacement tool and method |
| US5904692A (en) * | 1997-04-14 | 1999-05-18 | Mitek Surgical Products, Inc. | Needle assembly and method for passing suture |
| US5960522A (en) * | 1997-05-21 | 1999-10-05 | Micron Electronics, Inc. | Ribbon cable alligator clamp |
| US6099552A (en) * | 1997-11-12 | 2000-08-08 | Boston Scientific Corporation | Gastrointestinal copression clips |
| JP2002514463A (ja) * | 1998-05-12 | 2002-05-21 | サイムド ライフ システムズ， インコーポレイテッド | 手動骨アンカ配置デバイス |
-
1995
- 1995-05-22 DE DE19518796A patent/DE19518796A1/de not_active Withdrawn
-
1996
- 1996-05-14 DK DK96107622T patent/DK0744397T3/da active
- 1996-05-14 EP EP96107622A patent/EP0744397B1/de not_active Expired - Lifetime
- 1996-05-14 ES ES96107622T patent/ES2147629T3/es not_active Expired - Lifetime
- 1996-05-14 SI SI9630198T patent/SI0744397T1/xx unknown
- 1996-05-14 DE DE59605101T patent/DE59605101D1/de not_active Expired - Lifetime
- 1996-05-14 AT AT96107622T patent/ATE192431T1/de not_active IP Right Cessation
- 1996-05-14 PT PT96107622T patent/PT744397E/pt unknown
- 1996-05-15 PL PL96314252A patent/PL183431B1/pl unknown
- 1996-05-17 RU RU96109699/04A patent/RU2164913C2/ru not_active IP Right Cessation
- 1996-05-17 SK SK651-96A patent/SK281527B6/sk unknown
- 1996-05-20 AU AU52373/96A patent/AU701493B2/en not_active Ceased
- 1996-05-20 NZ NZ286622A patent/NZ286622A/xx unknown
- 1996-05-20 HU HU9601358A patent/HUP9601358A3/hu unknown
- 1996-05-20 TR TR96/00421A patent/TR199600421A2/xx unknown
- 1996-05-20 CN CN96100265A patent/CN1063437C/zh not_active Expired - Fee Related
- 1996-05-20 CZ CZ19961450A patent/CZ291622B6/cs not_active IP Right Cessation
- 1996-05-20 HR HR960230A patent/HRP960230B1/xx not_active IP Right Cessation
- 1996-05-20 AR ARP960102622A patent/AR002744A1/es unknown
- 1996-05-20 IL IL11832796A patent/IL118327A/en not_active IP Right Cessation
- 1996-05-21 ZA ZA9604035A patent/ZA964035B/xx unknown
- 1996-05-21 CA CA002177007A patent/CA2177007C/en not_active Expired - Fee Related
- 1996-05-21 JP JP12523696A patent/JP3924018B2/ja not_active Expired - Fee Related
- 1996-05-21 KR KR1019960017109A patent/KR960041152A/ko not_active Ceased
- 1996-05-21 NO NO962063A patent/NO305552B1/no not_active IP Right Cessation
- 1996-05-21 BR BR9602394A patent/BR9602394A/pt not_active Application Discontinuation
- 1996-05-22 MY MYPI96001926A patent/MY113803A/en unknown
- 1996-06-14 TW TW085107133A patent/TW415936B/zh not_active IP Right Cessation
-
2000
- 2000-05-16 GR GR20000401106T patent/GR3033416T3/el not_active IP Right Cessation
-
2001
- 2001-02-08 US US09/778,899 patent/US20010020042A1/en not_active Abandoned
- 2001-12-20 US US10/024,388 patent/US6504057B2/en not_active Expired - Fee Related
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