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AR002536A1 - PROCEDURE FOR THE SYNTHESIS OF (1S) -AMINO- (2R) -INDANOL, AND OF INTERMEDIARY COMPOUNDS, AND PURE CULTIVATION OF PSEUDOMONAS PUTIDA. - Google Patents

PROCEDURE FOR THE SYNTHESIS OF (1S) -AMINO- (2R) -INDANOL, AND OF INTERMEDIARY COMPOUNDS, AND PURE CULTIVATION OF PSEUDOMONAS PUTIDA.

Info

Publication number
AR002536A1
AR002536A1 ARP960103234A AR10323496A AR002536A1 AR 002536 A1 AR002536 A1 AR 002536A1 AR P960103234 A ARP960103234 A AR P960103234A AR 10323496 A AR10323496 A AR 10323496A AR 002536 A1 AR002536 A1 AR 002536A1
Authority
AR
Argentina
Prior art keywords
indanol
amino
synthesis
procedure
pseudomonas putida
Prior art date
Application number
ARP960103234A
Other languages
Spanish (es)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602938.4A external-priority patent/GB9602938D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR002536A1 publication Critical patent/AR002536A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para sintetizar (1S)-amino-(2R)-indanol, que comprende tratar indeno con una dioxigenasa para formar (1S,2R)-indandiol que a su vezse trata con acetonitrilo en presencia de un ácido fuerte. El intermediario (1S,2R)-indandiolpuede ser purificado y enriquecido enantioméricamentemediante cristalización específica quiral o por tratamiento con una dihidrodiol dihidrogenasa.A method of synthesizing (1S) -amino- (2R) -indanol, which comprises treating indene with a dioxygenase to form (1S, 2R) -indandiol which in turn is treated with acetonitrile in the presence of a strong acid. The intermediate (1S, 2R) -indandiol can be purified and enantiomerically enriched by chiral specific crystallization or by treatment with a dihydrodiol dihydrogenase.

ARP960103234A 1995-06-20 1996-06-20 PROCEDURE FOR THE SYNTHESIS OF (1S) -AMINO- (2R) -INDANOL, AND OF INTERMEDIARY COMPOUNDS, AND PURE CULTIVATION OF PSEUDOMONAS PUTIDA. AR002536A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36095P 1995-06-20 1995-06-20
GBGB9602938.4A GB9602938D0 (en) 1996-02-13 1996-02-13 Conversion of indene

Publications (1)

Publication Number Publication Date
AR002536A1 true AR002536A1 (en) 1998-03-25

Family

ID=26308684

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103234A AR002536A1 (en) 1995-06-20 1996-06-20 PROCEDURE FOR THE SYNTHESIS OF (1S) -AMINO- (2R) -INDANOL, AND OF INTERMEDIARY COMPOUNDS, AND PURE CULTIVATION OF PSEUDOMONAS PUTIDA.

Country Status (5)

Country Link
CN (1) CN1194006A (en)
AR (1) AR002536A1 (en)
AU (1) AU6180096A (en)
BR (1) BR9608804A (en)
WO (1) WO1997000966A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420067D0 (en) * 1994-10-05 1994-11-16 Zeneca Ltd Process
US5858737A (en) * 1995-06-20 1999-01-12 Merck & Co., Inc. Conversion of indene to (1S)-amino-(2R)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
US5824540A (en) * 1995-06-20 1998-10-20 Merck & Co., Inc. Pseudomonas putida strain with dioxygenase activity
US6057479A (en) * 1996-01-12 2000-05-02 Nippon Steel Chemical Co., Ltd. Process for preparing indan derivatives
NL1005832C2 (en) * 1997-04-17 1998-10-20 Dsm Nv Optically active cis-(1S,2R)-amino-indanol preparation
GB2336841A (en) 1998-04-28 1999-11-03 Merck & Co Inc Preparation of cis-(is,2r)-indanediol by the microbial reduction of 1,2-indanedione
WO2000009659A1 (en) * 1998-08-13 2000-02-24 Lonza Ag Method for producing indane derivatives
NL1010354C2 (en) * 1998-10-20 2000-04-25 Dsm Biotech Gmbh Preparation of amino alcohols.
PT3320912T (en) * 2008-04-17 2021-05-24 Io Biotech Aps INDOLEAMINE 2,3-DIOXYGENASE-BASED IMMUNOTHERAPY

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols
US5420353A (en) * 1994-03-11 1995-05-30 Merck & Co., Inc. Regiospecific process to make cis-1-amino-2-alkanol from epoxide
GB9420067D0 (en) * 1994-10-05 1994-11-16 Zeneca Ltd Process

Also Published As

Publication number Publication date
WO1997000966A1 (en) 1997-01-09
AU6180096A (en) 1997-01-22
CN1194006A (en) 1998-09-23
BR9608804A (en) 1999-02-17

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