AR002510A1 - Un procedimiento para la preparacion de derivados de 1-(3-trialquilsilil- fenil)-2,2,2-trifluorometiletanona que son utiles en el tratamiento de laenfermedad de alzheimer y demencia senil y procedimiento para la purificacion de dicho derivado con dicho procedimiento de preparacion. - Google Patents
Un procedimiento para la preparacion de derivados de 1-(3-trialquilsilil- fenil)-2,2,2-trifluorometiletanona que son utiles en el tratamiento de laenfermedad de alzheimer y demencia senil y procedimiento para la purificacion de dicho derivado con dicho procedimiento de preparacion.Info
- Publication number
- AR002510A1 AR002510A1 ARP960103193A AR10319396A AR002510A1 AR 002510 A1 AR002510 A1 AR 002510A1 AR P960103193 A ARP960103193 A AR P960103193A AR 10319396 A AR10319396 A AR 10319396A AR 002510 A1 AR002510 A1 AR 002510A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- preparation
- trifluorometiletanona
- trialquilsilil
- fenil
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 title 2
- 206010039966 Senile dementia Diseases 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 9
- 239000000203 mixture Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 238000000605 extraction Methods 0.000 abstract 2
- JZVUAOCDNFNSGQ-UHFFFAOYSA-N 7-methoxy-2-phenyl-1h-quinolin-4-one Chemical compound N=1C2=CC(OC)=CC=C2C(O)=CC=1C1=CC=CC=C1 JZVUAOCDNFNSGQ-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/0827—Syntheses with formation of a Si-C bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/083—Syntheses without formation of a Si-C bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de 1-(3-trialquilsililfenil)-2,2,2- trifluormetiletanonas que comprende las etapas de adición de un 1-halo-3-trialquilsilanilbenceno a una mezcla de un exceso de magnesio en un solvente adecuado, posterior adición de un exceso de trifluoroacetato de litio yposterior adición de una solución adecuada de interrupción. La presente invención también incluye un procedimiento de purificación del productoobtenido 1-(3-trialquilsililfenil)-2,2,2-trifluorometiletonona, que comprende las etapas de lavado de una solución de dicho producto con metanol/agua 50/50 v/v, extracción con una mezcla metanol/agua 80/20 vv, concentración de extracto metanol/agua de un 13% a un 18% en peso de dichocompuesto y extracción de la mezcla concentrada con solvente orgánico adecuado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95401478A EP0749972A1 (en) | 1995-06-21 | 1995-06-21 | A process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002510A1 true AR002510A1 (es) | 1998-03-25 |
Family
ID=8221501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103193A AR002510A1 (es) | 1995-06-21 | 1996-06-19 | Un procedimiento para la preparacion de derivados de 1-(3-trialquilsilil- fenil)-2,2,2-trifluorometiletanona que son utiles en el tratamiento de laenfermedad de alzheimer y demencia senil y procedimiento para la purificacion de dicho derivado con dicho procedimiento de preparacion. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5760267A (es) |
| EP (2) | EP0749972A1 (es) |
| JP (1) | JPH11508255A (es) |
| AR (1) | AR002510A1 (es) |
| AU (1) | AU6165696A (es) |
| CA (1) | CA2224598A1 (es) |
| HU (1) | HUP9901070A3 (es) |
| IL (1) | IL122433A0 (es) |
| NO (1) | NO975961L (es) |
| NZ (1) | NZ310793A (es) |
| TW (1) | TW411343B (es) |
| WO (1) | WO1997000877A1 (es) |
| ZA (1) | ZA965167B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
| US6997031B2 (en) | 2003-05-01 | 2006-02-14 | Waters Corporation | Fraction collector for composition analysis |
| WO2005072713A2 (en) | 2004-01-27 | 2005-08-11 | The Feinstein Institute For Medical Research | Cholinesterase inhibitors for treating inflammation |
| EP1812007B1 (en) * | 2004-11-02 | 2011-09-07 | Northwestern University | Pyridazine compounds and methods |
| WO2007127474A2 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0403713A1 (en) | 1989-06-22 | 1990-12-27 | Merrell Dow Pharmaceuticals Inc. | Novel acetylcholinesterase inhibitors |
| TW393475B (en) * | 1992-10-16 | 2000-06-11 | Chugai Pharmaceutical Co Ltd | 4-alkoxyl-2,6-di-t-butyl phenol derivatives |
| US5523442A (en) * | 1993-02-16 | 1996-06-04 | Merrell Pharmaceuticals Inc. | Silylated acetylcholinesterase inhibitors |
| US5554780A (en) * | 1994-05-05 | 1996-09-10 | Merrell Pharmaceuticals Inc. | Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives |
| US5679820A (en) * | 1996-12-16 | 1997-10-21 | General Electric Company | Silylated ultraviolet light absorbers having resistance to humidity |
-
1995
- 1995-06-21 EP EP95401478A patent/EP0749972A1/en not_active Withdrawn
-
1996
- 1996-06-06 WO PCT/US1996/009750 patent/WO1997000877A1/en not_active Ceased
- 1996-06-06 AU AU61656/96A patent/AU6165696A/en not_active Abandoned
- 1996-06-06 CA CA002224598A patent/CA2224598A1/en not_active Abandoned
- 1996-06-06 JP JP9503865A patent/JPH11508255A/ja active Pending
- 1996-06-06 HU HU9901070A patent/HUP9901070A3/hu unknown
- 1996-06-06 NZ NZ310793A patent/NZ310793A/en unknown
- 1996-06-06 EP EP96919277A patent/EP0833829A1/en not_active Withdrawn
- 1996-06-06 IL IL12243396A patent/IL122433A0/xx unknown
- 1996-06-18 TW TW085107356A patent/TW411343B/zh not_active IP Right Cessation
- 1996-06-18 US US08/666,715 patent/US5760267A/en not_active Expired - Fee Related
- 1996-06-18 ZA ZA965167A patent/ZA965167B/xx unknown
- 1996-06-19 AR ARP960103193A patent/AR002510A1/es unknown
-
1997
- 1997-12-18 NO NO975961A patent/NO975961L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL122433A0 (en) | 1998-06-15 |
| ZA965167B (en) | 1997-07-23 |
| US5760267A (en) | 1998-06-02 |
| CA2224598A1 (en) | 1997-01-09 |
| JPH11508255A (ja) | 1999-07-21 |
| NO975961D0 (no) | 1997-12-18 |
| WO1997000877A1 (en) | 1997-01-09 |
| EP0749972A1 (en) | 1996-12-27 |
| EP0833829A1 (en) | 1998-04-08 |
| HUP9901070A2 (hu) | 1999-07-28 |
| MX9710414A (es) | 1998-07-31 |
| HUP9901070A3 (en) | 1999-11-29 |
| TW411343B (en) | 2000-11-11 |
| NZ310793A (en) | 1999-10-28 |
| NO975961L (no) | 1998-02-20 |
| AU6165696A (en) | 1997-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kaur et al. | A water-soluble, nitroso-aromatic spin-trap | |
| ES2177796T3 (es) | Extraccion por disolvente de polihidroxialcanoatos a partir de biomasafacilitada por el uso de un no disolvente marginal para pha. | |
| ES2196181T3 (es) | Derivados de purina y proceso para su preparacion. | |
| AR029898A1 (es) | Un metodo para la preparacion de un producto citalopram purificado | |
| ES8802273A1 (es) | Procedimiento para la inactivacion de germenes patogenos filtrables,capaces de reproducirse,en productos sanguineos | |
| ES2087916T3 (es) | Derivado de pirimidina biciclico, metodo para producir el mismo, y preparacion farmaceutica que contiene el mismo como ingrediente activo. | |
| ES2013067A6 (es) | Un procedimiento para producir un derivado de piperazina. | |
| CO4950563A1 (es) | Nuevos compuestos | |
| AU5377100A (en) | Process for extraction and purification of paclitaxel from natural sources | |
| PE103799A1 (es) | Procedimiento de purificacion de mesilato de alatrofloxacino | |
| AR002510A1 (es) | Un procedimiento para la preparacion de derivados de 1-(3-trialquilsilil- fenil)-2,2,2-trifluorometiletanona que son utiles en el tratamiento de laenfermedad de alzheimer y demencia senil y procedimiento para la purificacion de dicho derivado con dicho procedimiento de preparacion. | |
| ATE428730T1 (de) | Verfahren zur herstellung einer alpha-1- antitrypsinlösung | |
| Peters | Photochemistry of zearalenone and its derivatives | |
| US5406005A (en) | Method for the production of D-chiroinositol | |
| Tymiak et al. | Structures of Kelletinins I and II, antibacterial metabolites of the marine mollusk Kelletia kelletii | |
| DE69016683D1 (de) | Natrium-N-acetylneuraminat-trihydrat und Verfahren zu dessen Herstellung. | |
| MX9300203A (es) | Compuestos policiclicos disubstituidos y composicion farmaceutica que los contiene. | |
| FR2617476B1 (fr) | Nouveaux derives polycycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique | |
| MX9300205A (es) | Compuestos policiclicos disubstituidos y composicion farmaceutica que los contiene. | |
| ATE167871T1 (de) | Verfahren zur herstellung von vancomycin | |
| ES2143973T3 (es) | Procedimiento para la preparacion de acidos 7-(3-amino- asi como 3-aminometil-1-pirrolidinil)-3-quinoloncarboxilicos asi como -naftiridoncarboxilicos. | |
| ES2103151T3 (es) | Nuevos procedimientos para la preparacion de derivados de clonidina. | |
| Okura et al. | The bulky side chain of antillatoxin is important for potent toxicity: rational design of photoresponsive cytotoxins based on SAR studies | |
| Chambers et al. | A stable cis-azobenzene in aqueous solution | |
| JPS5536403A (en) | Preparation of 1-benzazonine derivative |