AR002204A1 - Compuestos piridiniminil-1,2-bencisoxazoles y bencisotiazoles utiles como agentes para aliviar la disfuncion de la memoria, compuestos intermediarios,procedimientos de preparacion, composiciones que hacen uso de dichos compuestos e intermediarios. - Google Patents
Compuestos piridiniminil-1,2-bencisoxazoles y bencisotiazoles utiles como agentes para aliviar la disfuncion de la memoria, compuestos intermediarios,procedimientos de preparacion, composiciones que hacen uso de dichos compuestos e intermediarios.Info
- Publication number
- AR002204A1 AR002204A1 ARP960102883A AR10288396A AR002204A1 AR 002204 A1 AR002204 A1 AR 002204A1 AR P960102883 A ARP960102883 A AR P960102883A AR 10288396 A AR10288396 A AR 10288396A AR 002204 A1 AR002204 A1 AR 002204A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- formula
- intermediate compounds
- compositions
- lower alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
- 230000007074 memory dysfunction Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical group C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se describen compuestos de fórmula (1), donde R1 es hidrógeno, alquilo inferior, alquenilo inferior, alquinilo inferior, cicloalquilo inferior,-C(=O)O- alquilo inferior, 1,3-dioxolano, fenilo, cinamilo, fenilo substituido por alquilo inferior,alcoxi inferior, halógeno, hidroxilo, nitro otrifluorometilo; Q es hidrógeno, halógeno, alquilo inferior o nitro; X es oxígeno o azufre; Z es hidrógeno, alquilo inferior, alcoxi inferior, hidroxilo,halógeno, nitro o trifluormetilo; n es 1 a 12;los isómeros geométricos, isómeros ópticos o sales farmacéuticamente aceptables del mismo. Los compuestosde fórmula (1) se preparan por medio de alquilación de compuestos de Fórmula (2) con un compuesto de fórmula Hal-(CH2)nR1. Los compuestos de fórmula 1 y loscompuestos intermediarios de fórmula 2 se utilizan en composiciones para aliviar la disfunción de la memoria y en la depresión de mamíferos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46602195A | 1995-06-06 | 1995-06-06 | |
| US08/637,091 US5668154A (en) | 1995-06-06 | 1996-05-02 | Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002204A1 true AR002204A1 (es) | 1998-01-07 |
Family
ID=23850131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102883A AR002204A1 (es) | 1995-06-06 | 1996-06-04 | Compuestos piridiniminil-1,2-bencisoxazoles y bencisotiazoles utiles como agentes para aliviar la disfuncion de la memoria, compuestos intermediarios,procedimientos de preparacion, composiciones que hacen uso de dichos compuestos e intermediarios. |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US5668154A (es) |
| EP (1) | EP0848713B1 (es) |
| KR (1) | KR100309215B1 (es) |
| AR (1) | AR002204A1 (es) |
| AT (1) | ATE197153T1 (es) |
| AU (1) | AU708843B2 (es) |
| CA (1) | CA2224171A1 (es) |
| DE (1) | DE69610778T2 (es) |
| DK (1) | DK0848713T3 (es) |
| ES (1) | ES2153584T3 (es) |
| GR (1) | GR3035249T3 (es) |
| HU (1) | HUP9802571A3 (es) |
| NO (1) | NO975682L (es) |
| NZ (1) | NZ308831A (es) |
| PT (1) | PT848713E (es) |
| TW (1) | TW355710B (es) |
| ZA (1) | ZA964565B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083932A (en) * | 1997-04-18 | 2000-07-04 | Cv Technologies Inc. | Pharmaceutical compositions derived from ginseng and methods of treatment using same |
| GT199900185A (es) * | 1998-11-06 | 2001-04-18 | Novedosa pirimidin-4-enamina como fungicida. | |
| US6123554A (en) * | 1999-05-28 | 2000-09-26 | Berg Technology, Inc. | Connector cover with board stiffener |
| US9907751B2 (en) | 2016-03-10 | 2018-03-06 | RxOMEG Therapeutics LLC | Composition and method of use of colchicine oral liquid |
| US10226423B1 (en) | 2017-12-20 | 2019-03-12 | RxOMEG Therapeutics LLC | Colchicine drug-to-drug interactions |
| CN110117278B (zh) * | 2018-02-07 | 2022-07-19 | 石家庄以岭药业股份有限公司 | 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途 |
| WO2023083445A1 (en) | 2021-11-10 | 2023-05-19 | Symrise Ag | Compositions comprising trpm8 agonistic cooling agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
-
1996
- 1996-05-02 US US08/637,091 patent/US5668154A/en not_active Expired - Lifetime
- 1996-05-14 DE DE69610778T patent/DE69610778T2/de not_active Expired - Lifetime
- 1996-05-14 AU AU58677/96A patent/AU708843B2/en not_active Ceased
- 1996-05-14 HU HU9802571A patent/HUP9802571A3/hu unknown
- 1996-05-14 KR KR1019970708744A patent/KR100309215B1/ko not_active Expired - Fee Related
- 1996-05-14 NZ NZ308831A patent/NZ308831A/en unknown
- 1996-05-14 PT PT96920335T patent/PT848713E/pt unknown
- 1996-05-14 EP EP96920335A patent/EP0848713B1/en not_active Expired - Lifetime
- 1996-05-14 DK DK96920335T patent/DK0848713T3/da active
- 1996-05-14 ES ES96920335T patent/ES2153584T3/es not_active Expired - Lifetime
- 1996-05-14 CA CA002224171A patent/CA2224171A1/en not_active Abandoned
- 1996-05-14 AT AT96920335T patent/ATE197153T1/de not_active IP Right Cessation
- 1996-05-29 TW TW085106396A patent/TW355710B/zh active
- 1996-06-03 ZA ZA964565A patent/ZA964565B/xx unknown
- 1996-06-04 AR ARP960102883A patent/AR002204A1/es unknown
-
1997
- 1997-02-26 US US08/806,981 patent/US5728717A/en not_active Expired - Lifetime
- 1997-10-30 US US08/961,298 patent/US5948798A/en not_active Expired - Lifetime
- 1997-12-05 NO NO975682A patent/NO975682L/no not_active Application Discontinuation
-
2001
- 2001-01-17 GR GR20010400069T patent/GR3035249T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0848713T3 (da) | 2000-12-18 |
| HUP9802571A3 (en) | 1999-11-29 |
| KR100309215B1 (ko) | 2001-12-28 |
| ES2153584T3 (es) | 2001-03-01 |
| US5728717A (en) | 1998-03-17 |
| EP0848713A1 (en) | 1998-06-24 |
| MX9709450A (es) | 1998-06-28 |
| PT848713E (pt) | 2001-02-28 |
| NO975682L (no) | 1998-02-05 |
| AU5867796A (en) | 1996-12-24 |
| KR19990022265A (ko) | 1999-03-25 |
| US5948798A (en) | 1999-09-07 |
| EP0848713B1 (en) | 2000-10-25 |
| ATE197153T1 (de) | 2000-11-15 |
| CA2224171A1 (en) | 1996-12-12 |
| DE69610778T2 (de) | 2001-06-13 |
| DE69610778D1 (de) | 2000-11-30 |
| GR3035249T3 (en) | 2001-04-30 |
| HUP9802571A2 (hu) | 1999-08-30 |
| NZ308831A (en) | 1998-11-25 |
| ZA964565B (en) | 1996-12-12 |
| TW355710B (en) | 1999-04-11 |
| AU708843B2 (en) | 1999-08-12 |
| US5668154A (en) | 1997-09-16 |
| NO975682D0 (no) | 1997-12-05 |
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