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AR009786A1 - FUSED PYROLCARBOXAMIDES, A NEW KIND OF GABA LEAN BRAIN RECEPTORS - Google Patents

FUSED PYROLCARBOXAMIDES, A NEW KIND OF GABA LEAN BRAIN RECEPTORS

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Publication number
AR009786A1
AR009786A1 ARP970104225A AR009786A1 AR 009786 A1 AR009786 A1 AR 009786A1 AR P970104225 A ARP970104225 A AR P970104225A AR 009786 A1 AR009786 A1 AR 009786A1
Authority
AR
Argentina
Prior art keywords
brain receptors
compounds
pyrolcarboxamides
gaba
lean
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Priority to ARP970104225 priority Critical patent/AR009786A1/en
Publication of AR009786A1 publication Critical patent/AR009786A1/en

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Abstract

Compuestos que tienen la formula (I) o sus sales farmacéuticamente aceptables donde: W representa fenilo substituido o no substituido; T eshidrogeno, halogeno, hidroxilo, amino o alquilo; X es hidrogeno, hidroxi, o alquilo inferior; mes 0,1 o 2; n es 0,1 o 2; R3 y R4 representan residuosorgánicos substituídos o no substituídos. Estos compuestos son agonistas, antagonistas o agonistas inversos altamente selectivos para los receptorescerebrales GABAa o prodrogas deagonistas, a ntagonistas o agonistas inversos para receptores cerebrales GABAa. Estos compuestos son utiles para eldiagnostico y tratamiento de ansiedad, desordenes del sueno y ataques apoléticos, sobredosis de drogas de benzodiazepinay para mejorar la memoria.Compounds having formula (I) or their pharmaceutically acceptable salts where: W represents substituted or unsubstituted phenyl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alkyl; month 0.1 or 2; n is 0.1 or 2; R3 and R4 represent substituted or unsubstituted organic residues. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or deagonist prodrugs, to antagonist ntagonists or inverse agonists for GABAa brain receptors. These compounds are useful for diagnosing and treating anxiety, sleep disorders and apoleptic seizures, benzodiazepine drug overdoses to improve memory.

ARP970104225 1997-09-15 1997-09-15 FUSED PYROLCARBOXAMIDES, A NEW KIND OF GABA LEAN BRAIN RECEPTORS AR009786A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP970104225 AR009786A1 (en) 1997-09-15 1997-09-15 FUSED PYROLCARBOXAMIDES, A NEW KIND OF GABA LEAN BRAIN RECEPTORS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP970104225 AR009786A1 (en) 1997-09-15 1997-09-15 FUSED PYROLCARBOXAMIDES, A NEW KIND OF GABA LEAN BRAIN RECEPTORS

Publications (1)

Publication Number Publication Date
AR009786A1 true AR009786A1 (en) 2000-05-03

Family

ID=45724612

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104225 AR009786A1 (en) 1997-09-15 1997-09-15 FUSED PYROLCARBOXAMIDES, A NEW KIND OF GABA LEAN BRAIN RECEPTORS

Country Status (1)

Country Link
AR (1) AR009786A1 (en)

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