AR009665A1 - Compuestos derivados de pirrolidinamida sustituidos con heterociclos, utiles como antagonistas de receptores de taquiquininas, composiciones farmaceuticas que incluyen dichos compuestos, usos en la preparacion de composiciones farmaceuticas para tratamiento de enfermedades y procedimiento de preprac - Google Patents
Compuestos derivados de pirrolidinamida sustituidos con heterociclos, utiles como antagonistas de receptores de taquiquininas, composiciones farmaceuticas que incluyen dichos compuestos, usos en la preparacion de composiciones farmaceuticas para tratamiento de enfermedades y procedimiento de prepracInfo
- Publication number
- AR009665A1 AR009665A1 ARP970105923A ARP970105923A AR009665A1 AR 009665 A1 AR009665 A1 AR 009665A1 AR P970105923 A ARP970105923 A AR P970105923A AR P970105923 A ARP970105923 A AR P970105923A AR 009665 A1 AR009665 A1 AR 009665A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- group
- pharmaceutical
- hydrogen
- tachyquin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Compuestos de formula (I), donde R1 es de 1 a 3 sustituyentes elegidos cada uno independientemente del grupo formado por hidrogeno, halogeno, -CF3,alquilo C1-C6, y alcoxi C1-C6; R2 se elige del grupo formado por hidrogeno, alquilo C1-C4, ya lcoxi C1-C4; R3 es un radical seleccionado del grupo formadopor formulas (II), donde R4 se selecciona del grupo formado por hidrogeno, alquilo C1-C4, y -CF3; Ar1 es un radical seleccionado del grupo formado porformulas (III), donde R5 es de 1a 3 sustituyentes elegidos cada uno independientemente del grupo formado por hidrogeno, halogeno, -CF3,alquilo C1-C6, y alcoxi C1-C6; R6 es de 1 a 2 sustituyentes elegidos cada uno independientemente del grupo formado por hidrogeno,haloge no, alquilo C1-C6, yalcoxi C1-C6; R7 y R8 son hidrogeno o junto con el nitrogeno al que están anclados forman un anillo de piperidina, morfolina, piperazina,4-metilpiperazina, o pirrolidina; y los estereoisomeros, y las sales farmacéuticamente aceptables de los mismos. Los compuestos se incluyen encomposiciones farmacéuticas y se usan en la fabricacion de las mismas para el tratamiento del asma, bronquitis, dolor, tos y otras enfermedades. Tambiénse describe elprocedimient o de preparacion de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76981296A | 1996-12-19 | 1996-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009665A1 true AR009665A1 (es) | 2000-04-26 |
Family
ID=25086573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105923A AR009665A1 (es) | 1996-12-19 | 1997-12-17 | Compuestos derivados de pirrolidinamida sustituidos con heterociclos, utiles como antagonistas de receptores de taquiquininas, composiciones farmaceuticas que incluyen dichos compuestos, usos en la preparacion de composiciones farmaceuticas para tratamiento de enfermedades y procedimiento de preprac |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0946548B1 (es) |
| JP (1) | JP4195512B2 (es) |
| KR (1) | KR100514263B1 (es) |
| CN (1) | CN1119344C (es) |
| AR (1) | AR009665A1 (es) |
| AT (1) | ATE214063T1 (es) |
| AU (1) | AU723966B2 (es) |
| BR (1) | BR9714057A (es) |
| CA (1) | CA2275527C (es) |
| DE (1) | DE69710921T2 (es) |
| DK (1) | DK0946548T3 (es) |
| ES (1) | ES2169881T3 (es) |
| HU (1) | HUP0000315A3 (es) |
| IL (1) | IL130223A (es) |
| NO (1) | NO317760B1 (es) |
| NZ (1) | NZ335975A (es) |
| PT (1) | PT946548E (es) |
| TW (1) | TW486477B (es) |
| WO (1) | WO1998027086A1 (es) |
| ZA (1) | ZA9711271B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| PL367944A1 (en) * | 2001-07-20 | 2005-03-07 | Pfizer Products Inc. | Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses |
| BRPI0815674A2 (pt) | 2007-08-22 | 2015-02-18 | Hoffmann La Roche | Aril-éter de pirrolidina como antagonista de receptor de nk3 |
| HRP20231608T1 (hr) | 2018-10-29 | 2024-03-15 | Boehringer Ingelheim International Gmbh | Derivati piridinil sulfonamida, njihovi farmaceutski pripravci i njihove uporabe |
| US12213970B2 (en) | 2018-10-29 | 2025-02-04 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DK0696280T3 (da) * | 1993-05-06 | 1998-01-12 | Merrell Pharma Inc | Substituerede pyrrolidin-3-yl-alkyl-piperidiner anvendelige som tachykinin-antagonister |
| DE69626321T2 (de) * | 1995-11-17 | 2003-08-14 | Aventis Pharmaceuticals Inc., Bridgewater | Substituierte 4-(1h-benzimidazol-2-yl-amino)piperidine zur behandlung allergischer erkrankungen |
-
1997
- 1997-11-03 DE DE69710921T patent/DE69710921T2/de not_active Expired - Lifetime
- 1997-11-03 HU HU0000315A patent/HUP0000315A3/hu unknown
- 1997-11-03 WO PCT/US1997/019884 patent/WO1998027086A1/en not_active Ceased
- 1997-11-03 EP EP97946443A patent/EP0946548B1/en not_active Expired - Lifetime
- 1997-11-03 KR KR10-1999-7005496A patent/KR100514263B1/ko not_active Expired - Fee Related
- 1997-11-03 JP JP52768298A patent/JP4195512B2/ja not_active Expired - Lifetime
- 1997-11-03 NZ NZ335975A patent/NZ335975A/xx unknown
- 1997-11-03 PT PT97946443T patent/PT946548E/pt unknown
- 1997-11-03 DK DK97946443T patent/DK0946548T3/da active
- 1997-11-03 CA CA002275527A patent/CA2275527C/en not_active Expired - Fee Related
- 1997-11-03 AU AU51607/98A patent/AU723966B2/en not_active Ceased
- 1997-11-03 BR BR9714057-0A patent/BR9714057A/pt not_active Application Discontinuation
- 1997-11-03 AT AT97946443T patent/ATE214063T1/de not_active IP Right Cessation
- 1997-11-03 CN CN97180825A patent/CN1119344C/zh not_active Expired - Fee Related
- 1997-11-03 IL IL13022397A patent/IL130223A/xx not_active IP Right Cessation
- 1997-11-03 ES ES97946443T patent/ES2169881T3/es not_active Expired - Lifetime
- 1997-12-15 ZA ZA9711271A patent/ZA9711271B/xx unknown
- 1997-12-16 TW TW086119004A patent/TW486477B/zh not_active IP Right Cessation
- 1997-12-17 AR ARP970105923A patent/AR009665A1/es active IP Right Grant
-
1999
- 1999-06-18 NO NO19993013A patent/NO317760B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2275527C (en) | 2003-09-23 |
| IL130223A0 (en) | 2000-06-01 |
| CN1241185A (zh) | 2000-01-12 |
| WO1998027086A1 (en) | 1998-06-25 |
| AU723966B2 (en) | 2000-09-07 |
| AU5160798A (en) | 1998-07-15 |
| HK1020947A1 (en) | 2000-05-26 |
| NO993013L (no) | 1999-08-18 |
| HUP0000315A2 (hu) | 2001-04-28 |
| BR9714057A (pt) | 2000-05-09 |
| NO993013D0 (no) | 1999-06-18 |
| DE69710921D1 (de) | 2002-04-11 |
| NZ335975A (en) | 2000-11-24 |
| KR100514263B1 (ko) | 2005-09-15 |
| ZA9711271B (en) | 1998-06-19 |
| CA2275527A1 (en) | 1998-06-25 |
| DK0946548T3 (da) | 2002-06-24 |
| JP2001506650A (ja) | 2001-05-22 |
| IL130223A (en) | 2005-09-25 |
| DE69710921T2 (de) | 2002-09-19 |
| EP0946548B1 (en) | 2002-03-06 |
| PT946548E (pt) | 2002-06-28 |
| ES2169881T3 (es) | 2002-07-16 |
| NO317760B1 (no) | 2004-12-13 |
| EP0946548A1 (en) | 1999-10-06 |
| KR20000057668A (ko) | 2000-09-25 |
| ATE214063T1 (de) | 2002-03-15 |
| HUP0000315A3 (en) | 2002-01-28 |
| TW486477B (en) | 2002-05-11 |
| CN1119344C (zh) | 2003-08-27 |
| JP4195512B2 (ja) | 2008-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2058630T3 (es) | Derivados de 2-(1-piperazinil)-4-fenilcicloalcanopiridinas, procedimientos de preparacion y composiciones farmaceuticas que los contienen. | |
| ES2053508T3 (es) | Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos. | |
| CO4650042A1 (es) | Derivados de 6-fenilpiridil-2-amina | |
| AR034268A1 (es) | Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion | |
| AR009938A1 (es) | Nuevos derivados de arilglicinamida, procedimientos para su preparacion y composiciones farmaceuticas que contienen estos compuestos | |
| HUP0002112A2 (hu) | Helyettesített 3-ciano-kinolinok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények | |
| AR035235A1 (es) | Derivados heterocicliloxi-,-tioxi- y -aminobenzazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica, y el uso de dichos derivados para la manufactura de un medicamento | |
| ES2031876T3 (es) | Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas. | |
| AR031526A1 (es) | Nuevas fenilpiperazinas, composiciones farmaceuticas que las contienen, metodos para preparar los compuestos y las composiciones y uso de los compuestos en la preparacion de un medicamento. | |
| AR035153A1 (es) | Derivados de carboxamidas y cetonas de dihidrobenzodioxina | |
| ES2123652T3 (es) | 7-(2-aminoetil)-benzotiazolonas. | |
| AR019167A1 (es) | Derivados heteroaromaticos de piperazinas di-n-sustituidas y piperidinas 1,4-disustituidas, composiciones farmaceuticas y el uso de los mismos para lapreparacion de medicamentos | |
| AR007108A1 (es) | Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes. | |
| NO812355L (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,1-benzoksazin-2-on-derivater | |
| ES2141763T3 (es) | Fenilcarbonatos y fenilureas sustituidos, su preparacion y su uso como antagonistas de 5-ht4. | |
| ES2012648A6 (es) | Procedimiento para la preparacion de nuevos derivados de 1,4-benzoxazina y 1,4-benzotiazina. | |
| AR009665A1 (es) | Compuestos derivados de pirrolidinamida sustituidos con heterociclos, utiles como antagonistas de receptores de taquiquininas, composiciones farmaceuticas que incluyen dichos compuestos, usos en la preparacion de composiciones farmaceuticas para tratamiento de enfermedades y procedimiento de preprac | |
| NO156526C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1-fenyl-2-aminocarbonylindol-forbindelser. | |
| PE20001460A1 (es) | DERIVADOS DE PIPERIDINA Y PIPERAZINA COMO INHIBIDORES DE LA FORMACION DEL PEPTIDO ß-AMILOIDE | |
| CO4230234A1 (es) | DERIVADOS DE 6-(HIDROXIFENIL)SULFONIL-BENZO[b]PIRANO, COMPO- SICIONES QUE CONTIENEN TALES DERIVADOS, USOS DE LOS MISMOS, PROCEDIMIENTOS DE PREPARACION E INTERMEDIOS EMPLEADOS EN LA PREPARACION DE TALES DERIVADOS | |
| ES2031894T3 (es) | Procedimiento para preparar derivados de 4(3h)-oxo-5,6,7,8-tetrahidropirido-(2,3-d)-pirimidina. | |
| MX9304190A (es) | Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo. | |
| AR009666A1 (es) | Compuestos derivados de carboxamida ciclicos sustituidos con carboxi, composicion farmaceutica, usos en la fabricacion de composiciones farmaceuticas para el asma, la tos y la bronquitis y procedimiento de preparacion | |
| ES2037758T3 (es) | Un metodo de uso de un derivado quinolincarboxilico y su procedimiento de preparacion. | |
| ES2056811T3 (es) | Derivados de cinolina, procedimiento para su preparacion y composiciones herbicidas que los contienen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |