AR009445A1 - N- (PIRIDINYLAMINE) COMPOUNDS ISOINDOLINES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF MEMORY DYSFUNCTION AND DEPRESSION, PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOUNDS - Google Patents

Abstract

Compounds of formula (I) where R is hydrogen, a group of formula R2O-, where R2 is hydrogen, lower alkyl, benzyl, a group of formula (R3) 3Si-, where R3 is lower alkyl, or a group of formula R4R5NCO -, where R4 and R5 are independently hydrogen, lower alkyl or benzyl; R4 and R5 taken together with the nitrogen atom to which they are attached form a group of formula (a); or a group of formula (b); R1 is hydrogen or lower alkyl, X is hydrogen, lower alkyl, halogen, hydroxy, lower alkoxy or trifluoromethyl; Y is hydrogen, lower alkyl, halogen, hydroxy, lower alkoxy, or trifluoromethyl; m is 1 or 2; n is 1, 2 or 3: p is 1 or 2; its optical isomers or its pharmaceutically acceptable salts. Intermediate compounds useful in the preparation of the compounds of formula (I) that have the formulas: (II), (III), (IV), (V), where R is hydrogen, a group of formula R2O-, where R2 is hydrogen, lower alkyl, benzyl or a deformula group (R3) 3Si-, where R3 is lower alkyl; X is hydrogen, lower alkyl, hydroxy, lower alkoxy, hydroxy, lower alkoxy, halogen, or trifluoromethyl; n is 1, 2 or 3; or its optical isomers. The compounds of formula (I) are included in pharmaceutical compositions and are used in the manufacture of drugs for the treatment of memory dysfunction and depression.