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AR009301A1 - Procedimiento para preparar un cemento oseo o un material de sustitucion osea que contiene sustancias activas o el correspondiente deposito implantablede liberacion sostenida de farmacos, y un set para preparar un cemento oseo que promueve la liberacion de la sustancia activa - Google Patents

Procedimiento para preparar un cemento oseo o un material de sustitucion osea que contiene sustancias activas o el correspondiente deposito implantablede liberacion sostenida de farmacos, y un set para preparar un cemento oseo que promueve la liberacion de la sustancia activa

Info

Publication number
AR009301A1
AR009301A1 ARP970103817A ARP970103817A AR009301A1 AR 009301 A1 AR009301 A1 AR 009301A1 AR P970103817 A ARP970103817 A AR P970103817A AR P970103817 A ARP970103817 A AR P970103817A AR 009301 A1 AR009301 A1 AR 009301A1
Authority
AR
Argentina
Prior art keywords
bone cement
bone
release
preparing
active substances
Prior art date
Application number
ARP970103817A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR009301A1 publication Critical patent/AR009301A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Se refiere a un procedimiento para preparar un cemento oseo que contiene sustancias activas y también un material de sustitucion osea o un depositoimplantable de liberacion sostenida de fármacos, obtenido a partir de este cemento, a base de polímeros de ésteres de acrilato y/o metacrilato, pormezclado de: un componente solido (i), compuesto sustancialmente de un polímero de ésteres de acrilato y/o metacrilato en una proporcion del 50 al75% en peso -referido al cemento oseo - y de una o varias sustancias activas farmacéuticas, con un componente líquido (ii), compuesto sustancialmente de unéster de acrilato y/o monomérico en una proporcion del 25 al 50% en peso; hasta obtener una pasta polimerizable entre líquida y semisolida, la cual puede sereventualmente moldeada y endurecida, procedimiento en donde se disuelve el componente líquido (ii) con un disolvente orgánico cuya proporcion no superael 50% en peso - referido a (ii) -, y se mezcla esta solucion con elcomponente solido (i). También se refiere a un set para preparar un cementooseo que promueve la liberacion de la sustancia activa. Mediante el nuevo procedimiento se alcanza una liberacion de la sustancia activasignificativamente mayor,se logra una preparacion sencilla del cemento oseo y se emplean cantidades pequenas de sustancia activa.
ARP970103817A 1996-08-22 1997-08-22 Procedimiento para preparar un cemento oseo o un material de sustitucion osea que contiene sustancias activas o el correspondiente deposito implantablede liberacion sostenida de farmacos, y un set para preparar un cemento oseo que promueve la liberacion de la sustancia activa AR009301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19641775A DE19641775A1 (de) 1996-08-22 1996-08-22 Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen

Publications (1)

Publication Number Publication Date
AR009301A1 true AR009301A1 (es) 2000-04-12

Family

ID=7808364

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103817A AR009301A1 (es) 1996-08-22 1997-08-22 Procedimiento para preparar un cemento oseo o un material de sustitucion osea que contiene sustancias activas o el correspondiente deposito implantablede liberacion sostenida de farmacos, y un set para preparar un cemento oseo que promueve la liberacion de la sustancia activa

Country Status (10)

Country Link
US (1) US6160033A (es)
EP (1) EP0920341B1 (es)
JP (1) JP2001503290A (es)
AR (1) AR009301A1 (es)
AT (1) ATE234124T1 (es)
AU (1) AU4015597A (es)
DE (2) DE19641775A1 (es)
ES (1) ES2193393T3 (es)
WO (1) WO1998007456A1 (es)
ZA (1) ZA977524B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713527B2 (en) 1997-02-07 2004-03-30 Queen's University At Kingston Anaesthetic bone cement
ES2197525T3 (es) * 1998-12-14 2004-01-01 Ao Research Institute Procedimiento y aparato para la preparacion de cemento oseo.
DE19918295C2 (de) * 1999-04-22 2003-09-25 Coripharm Medizinprodukte Gmbh Kompatibles Implantat-Baustein-System in Form eines Baukastensystems für Implantationsmaterialien, Verfahren zur Herstellung derselben und ihre Verwendung
DE19939403B4 (de) * 1999-08-19 2004-02-12 fzmb Forschungszentrum für Medizintechnik und Biotechnologie e.V. Biologisch abbaubares Kompositmaterial
DE50006026D1 (de) 2000-08-01 2004-05-13 Coripharm Medizinprodukte Gmbh Wirkstoffhaltiges implantat-baustein-system und verfahren zu dessen herstellung
US6800245B1 (en) 2000-11-28 2004-10-05 Vita Special Purpose Corporation Sterile polymerizable systems and kits and methods of their manufacture and use
US7175336B2 (en) 2001-01-26 2007-02-13 Depuy Acromed, Inc. Graft delivery system
US7008433B2 (en) 2001-02-15 2006-03-07 Depuy Acromed, Inc. Vertebroplasty injection device
DE10129845C2 (de) 2001-06-15 2003-08-21 Bam Bundesanstalt Matforschung Verfahren zur Herstellung eines temporären Adhäsivs für Metall-Metall- und Metall-Keramik-Bindungen und Adhäsiv-Kit
DE10129842C1 (de) * 2001-06-15 2003-04-24 Bam Bundesanstalt Matforschung Verfahren zur Herstellung eines bioaktiven Knochenzements und Knochenzement-Kit
US20050203217A1 (en) * 2002-04-30 2005-09-15 Pomrink Gregory J. Stabilizers for polymerizable biocompatible materials
EP2314259B1 (en) 2003-03-14 2015-07-29 Depuy Spine, Inc. Hydraulic device for injection of bone cement in percutaneous vertebroplasty
US8066713B2 (en) 2003-03-31 2011-11-29 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
ES2220216B1 (es) * 2003-05-23 2006-03-01 Consejo Sup. De Invest. Cientificas Formulaciones acrilicas bioactivas inyectables para aplicacion en cirugia minimamente invasiva.
US8415407B2 (en) 2004-03-21 2013-04-09 Depuy Spine, Inc. Methods, materials, and apparatus for treating bone and other tissue
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
WO2005030034A2 (en) 2003-09-26 2005-04-07 Depuy Spine, Inc. Device for delivering viscous material
EP1786343B1 (en) 2004-07-30 2012-05-02 Depuy Spine, Inc. Apparatus for treating bone and other tissue
JP2008511405A (ja) * 2004-08-30 2008-04-17 アリーン、ネビル 靱帯および腱の処置のために移植片を用いる方法
WO2006026731A1 (en) 2004-08-30 2006-03-09 Spineovations, Inc. Method of treating spinal internal disk derangement
DE102004049121B4 (de) * 2004-10-07 2008-01-10 Heraeus Kulzer Gmbh Antibiotikum-/Antibiotika enthaltender PMMA-Knochenzement
DE102005023094A1 (de) * 2005-05-13 2006-11-16 Nies, Berthold, Dr. Bioaktiver Knochenzement und seine Herstellung
US8512724B2 (en) 2005-06-10 2013-08-20 The Board Of Regents Of The University Of Texas System Antiseptic compositions
DE102005033210B4 (de) * 2005-06-22 2008-04-30 Heraeus Kulzer Gmbh Polymethylmethacrylat-Knochenzement
DE102005032110B3 (de) * 2005-07-07 2006-08-17 Heraeus Kulzer Gmbh Gefärbter Polymethylmethacrylat-Knochenzement und Verfahren zu seiner Herstellung
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US8360629B2 (en) 2005-11-22 2013-01-29 Depuy Spine, Inc. Mixing apparatus having central and planetary mixing elements
DE102006006510A1 (de) * 2006-02-10 2007-08-23 Heraeus Kulzer Gmbh Lokales Wirkstofffreisetzungssystem und ein Verfahren zu seiner Herstellung
US9642932B2 (en) 2006-09-14 2017-05-09 DePuy Synthes Products, Inc. Bone cement and methods of use thereof
CA2665995C (en) 2006-10-19 2011-11-29 Oren Globerman Fluid delivery system
WO2008051864A2 (en) * 2006-10-24 2008-05-02 Neville Alleyne Method of treating spinal internal disk derangement
DE102006060938A1 (de) * 2006-12-20 2008-06-26 Wolter, Dietmar F., Prof. Dr. Materialdepot zur Abgabe eines antibakteriellen Wirkstoffmaterials
DE102007004968B4 (de) * 2007-01-26 2011-03-10 Heraeus Kulzer Gmbh Revisions-Polymethylmethacrylat-Knochenzement
US20100233225A1 (en) * 2007-02-09 2010-09-16 Bingyun Li Method of surface coating devices to incorporate bioactive molecules
KR20090125141A (ko) * 2007-03-02 2009-12-03 신세스 게엠바하 적합한 기계적 특성을 가지는 골 시멘트
DE102007015698B4 (de) * 2007-03-27 2009-05-14 Innotere Gmbh Implantatmaterial auf Basis eines Polymersystems und dessen Verwendung sowie Applikationsset
US20080299172A1 (en) * 2007-06-04 2008-12-04 Stuart Young Tissue repair implant
US20100004700A1 (en) * 2008-03-05 2010-01-07 Neville Alleyne Method of treating tissue with a suspenson of tricalcium hydroxyapatite microspheres
US8469961B2 (en) * 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
DE102009004368A1 (de) * 2009-01-08 2010-07-15 Heraeus Kulzer Gmbh Dentalmaterialien enthaltend antimikrobielle Wirkstoffe zur Verhinderung von Plaque-Anlagerungen
PT2402040T (pt) 2009-02-25 2016-07-28 Univ Kyoto Composição de cimento ósseo, método para a produzir e kit para a produzir
CN102333553B (zh) * 2009-02-25 2014-06-04 国立大学法人京都大学 骨水泥组合物和骨水泥组合物试剂盒以及骨水泥固化体的形成方法
CN102596272A (zh) * 2009-09-01 2012-07-18 斯恩蒂斯有限公司 含骨髓的骨水泥
KR101851410B1 (ko) 2010-03-05 2018-04-23 신세스 게엠바하 골 증강용 골 시멘트 시스템
US8834772B2 (en) 2011-12-07 2014-09-16 Biomet Manufacturing, Llc Antimicrobial methacrylate cements
KR102024447B1 (ko) 2015-01-16 2019-11-14 스파인오베이션즈, 인크. 척추 디스크를 치료하기 위한 작용제 및 작용제를 포함하는 의료 키트
DE102015102210A1 (de) * 2015-02-16 2016-08-18 Heraeus Medical Gmbh Antimykotischer polymerisierbarer Knochenzement und ein Verfahren zu seiner Herstellung
US12318508B2 (en) 2023-06-02 2025-06-03 33 Medical, Inc. Compositions for treatment of discogenic pain, and processes for making and using the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3245956A1 (de) * 1982-12-11 1984-06-14 Beiersdorf Ag, 2000 Hamburg Chirurgisches material
US4722948A (en) * 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
EP0164483B1 (de) * 1984-06-12 1989-08-16 Oscobal Ag Verfahren zur Herstellung von Knochenersatzmaterial
DE3738422A1 (de) * 1987-11-12 1989-05-24 Beiersdorf Ag Chirurgisches material
DE4433201A1 (de) * 1994-09-17 1996-03-21 Merck Patent Gmbh Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen
DE4435680A1 (de) * 1994-10-06 1996-04-11 Merck Patent Gmbh Poröse Knochenersatzmaterialien

Also Published As

Publication number Publication date
DE19641775A1 (de) 1998-02-26
AU4015597A (en) 1998-03-06
ATE234124T1 (de) 2003-03-15
JP2001503290A (ja) 2001-03-13
EP0920341A1 (de) 1999-06-09
US6160033A (en) 2000-12-12
EP0920341B1 (de) 2003-03-12
ZA977524B (en) 1998-02-19
DE59709515D1 (de) 2003-04-17
ES2193393T3 (es) 2003-11-01
WO1998007456A1 (de) 1998-02-26

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