AR008939A1 - Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos. - Google Patents
Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos.Info
- Publication number
- AR008939A1 AR008939A1 ARP970105862A ARP970105862A AR008939A1 AR 008939 A1 AR008939 A1 AR 008939A1 AR P970105862 A ARP970105862 A AR P970105862A AR P970105862 A ARP970105862 A AR P970105862A AR 008939 A1 AR008939 A1 AR 008939A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- pgd2
- pharmaceutical
- benzotiofencarboxamides
- preparation
- Prior art date
Links
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title abstract 3
- 101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title abstract 3
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 3
- 125000002622 PGD2 group Chemical group 0.000 title 1
- 210000003630 histaminocyte Anatomy 0.000 abstract 2
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 abstract 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000008736 Systemic mastocytosis Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 210000003979 eosinophil Anatomy 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000009284 tracheal contraction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se propoircionan derivados y sales farmacéuticamente aceptable e hidratos de los mismos que tienen actividad antagonista de PGD2, actividad inhibitoriade la infiltracion de eosinofilos y utiles para preparar composiciones para el tratamiento ded plencias tales como mastocitosis sistémica e irregularidadesde la activacion sistémica de células mastoides (mast cells), contracciones traqueales, asma, rinitis alérgica, conjuntivitis alérgica, urticaria, danosisquémicos de la reperfusion,infl amacion y dermatitis atopicas, que tienen la formula (I); Se proponen composiciones farmacéuticas y antagonistas de la PGD2formuladas con dichos derivados y compuestos intermediarios para la síntesis de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33349596 | 1996-12-13 | ||
| JP25400197 | 1997-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008939A1 true AR008939A1 (es) | 2000-02-23 |
Family
ID=26541496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105862A AR008939A1 (es) | 1996-12-13 | 1997-12-12 | Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6083974A (es) |
| EP (1) | EP0944614B1 (es) |
| JP (1) | JP3215441B2 (es) |
| KR (1) | KR100433568B1 (es) |
| CN (2) | CN1105112C (es) |
| AR (1) | AR008939A1 (es) |
| AT (1) | ATE223911T1 (es) |
| AU (1) | AU718958B2 (es) |
| BR (1) | BR9714016A (es) |
| CA (1) | CA2274591C (es) |
| CZ (1) | CZ297324B6 (es) |
| DE (1) | DE69715448T2 (es) |
| DK (1) | DK0944614T3 (es) |
| ES (1) | ES2181039T3 (es) |
| HU (1) | HU226458B1 (es) |
| ID (1) | ID22753A (es) |
| IL (1) | IL130660A (es) |
| NO (1) | NO992838L (es) |
| NZ (1) | NZ336143A (es) |
| PL (1) | PL191760B1 (es) |
| PT (1) | PT944614E (es) |
| RU (1) | RU2161617C1 (es) |
| TR (1) | TR199901280T2 (es) |
| TW (1) | TW438790B (es) |
| WO (1) | WO1998025919A1 (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2186065C1 (ru) | 1998-03-31 | 2002-07-27 | Сионоги Энд Ко., Лтд. | Способ получения производных 5-гидрокси-бензо[b]тиофен-3-карбоновой кислоты (варианты) и производные бензо[b]тиофеновой кислоты |
| AU747860B2 (en) * | 1998-03-31 | 2002-05-23 | Shionogi & Co., Ltd. | Process for producing benzothiophenecarboxylic acid amide derivatives |
| ES2241283T3 (es) * | 1998-06-03 | 2005-10-16 | SHIONOGI & CO., LTD. | Remedios para el tratamiento del prurito que contienen antagonistas de pgd2. |
| EP1193243B1 (en) | 1999-07-02 | 2008-08-13 | Shionogi & Co., Ltd. | Novel process for producing bicyclic amino alcohol |
| JP4292742B2 (ja) | 2000-03-09 | 2009-07-08 | 小野薬品工業株式会社 | インドール誘導体、その製造方法および用途 |
| CA2405233A1 (en) * | 2000-04-12 | 2001-10-25 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Method and compositions for the treatment of allergic conditions using pgd2 receptor antagonists |
| US6410583B1 (en) * | 2000-07-25 | 2002-06-25 | Merck Frosst Canada & Co. | Cyclopentanoindoles, compositions containing such compounds and methods of treatment |
| US7217725B2 (en) | 2000-09-14 | 2007-05-15 | Allergan, Inc. | Prostaglandin D2 antagonist |
| US7273883B2 (en) | 2000-09-14 | 2007-09-25 | Allergan, Inc. | Prostaglandin EP4 antagonist |
| US6693203B2 (en) | 2000-10-17 | 2004-02-17 | Shionogi & Co., Ltd | Process for the preparation of PGD2 antagonist |
| AU2001296013A1 (en) * | 2000-11-01 | 2002-05-15 | Shionogi And Co., Ltd. | Pgd2 receptor antagonistic pharmaceutical compositions |
| AR038136A1 (es) | 2002-01-24 | 2004-12-29 | Merck Frosst Canada Inc | Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento |
| CA2479352A1 (en) * | 2002-03-19 | 2003-09-25 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid compound and a pharmaceutical agent comprising the compound as an active ingredient |
| EP1598065A2 (en) * | 2002-07-12 | 2005-11-23 | Japan Science and Technology Agency | Drugs for improving prognosis of brain injury |
| US20050215609A1 (en) * | 2002-09-30 | 2005-09-29 | Masaaki Yoshikawa | Novel uses of prostaglandin d2, prostaglandin d2 agonist and prostaglandin d2 antagonist |
| PL376440A1 (en) | 2002-10-30 | 2005-12-27 | Merck Frosst Canada Ltd. | Pyridopyrrolizine and pyridoindolizine derivatives |
| ES2304010T3 (es) | 2004-03-11 | 2008-09-01 | Actelion Pharmaceuticals Ltd. | Derivados de tetrahidropiridoindol. |
| WO2006068162A1 (ja) * | 2004-12-24 | 2006-06-29 | Shionogi & Co., Ltd. | 慢性閉塞性肺疾患の治療剤 |
| TW200716093A (en) * | 2005-04-28 | 2007-05-01 | Shionogi & Co | An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist |
| TWI410410B (zh) | 2007-08-10 | 2013-10-01 | Ono Pharmaceutical Co | Phenylacetic acid compounds |
| KR20120098908A (ko) | 2009-12-23 | 2012-09-05 | 아이언우드 파마슈티컬스, 인코포레이티드 | Ｃｒｔｈ２ 조절제 |
| US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| DK2588465T3 (en) | 2010-06-30 | 2017-05-01 | Ironwood Pharmaceuticals Inc | SGC stimulators |
| WO2012009134A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| WO2012009137A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| CN107266433A (zh) | 2010-11-09 | 2017-10-20 | 铁木医药有限公司 | sGC刺激剂 |
| US9139564B2 (en) | 2011-12-27 | 2015-09-22 | Ironwood Pharmaceuticals, Inc. | 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators |
| WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2897953B8 (en) | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
| KR102502937B1 (ko) | 2013-03-15 | 2023-02-23 | 사이클리온 테라퓨틱스, 인크. | ｓＧＣ 자극인자 |
| EP3092231B1 (en) | 2013-12-11 | 2018-06-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP3094327A1 (en) | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
| AU2015317824A1 (en) | 2014-09-17 | 2017-03-23 | Cyclerion Therapeutics, Inc. | Pyrazole derivatives as sGC stimulators |
| WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| CA2961489A1 (en) | 2014-09-17 | 2016-03-24 | Glen Robert RENNIE | Sgc stimulators |
| US20180021302A1 (en) | 2015-02-13 | 2018-01-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus |
| BR112019000290B1 (pt) | 2016-07-07 | 2022-10-18 | Cyclerion Therapeutics, Inc | Prófármacos de fósforo dos estimuladores da sgc |
| EA039753B1 (ru) | 2016-07-07 | 2022-03-10 | Сайклерион Терапьютикс, Инк. | ТВЕРДЫЕ ФОРМЫ СТИМУЛЯТОРА sGC |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8406906D0 (en) * | 1984-03-16 | 1984-04-18 | Akzo Nv | Benzo-thiazole and benzothiophene derivatives |
| US4560343A (en) * | 1984-06-11 | 1985-12-24 | Honeywell Inc. | Functional check for a hot surface ignitor element |
| JPS6149A (ja) * | 1984-06-12 | 1986-01-06 | Ono Pharmaceut Co Ltd | 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤 |
| CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
| CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
| US5356926A (en) * | 1992-02-24 | 1994-10-18 | Warner-Lambert Company | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion |
| CA2113787A1 (en) * | 1993-01-29 | 1994-07-30 | Nobuyuki Hamanaka | Carbocyclic sulfonamides |
| DE4317076A1 (de) * | 1993-05-21 | 1994-11-24 | Bayer Ag | Benzthiophencarbonsäureamid-S-oxide |
| US5863936A (en) * | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
| CZ285870B6 (cs) * | 1995-06-21 | 1999-11-17 | Shionogi & Co., Ltd. | Bicyklické aminoderiváty a antagonist PGD2, který je obsahuje |
| US5792763A (en) * | 1996-10-08 | 1998-08-11 | Eli Lilly And Company | Serotonin 5-HT1F agonists |
-
1997
- 1997-12-10 NZ NZ336143A patent/NZ336143A/en unknown
- 1997-12-10 CA CA002274591A patent/CA2274591C/en not_active Expired - Fee Related
- 1997-12-10 IL IL13066097A patent/IL130660A/en not_active IP Right Cessation
- 1997-12-10 TR TR1999/01280T patent/TR199901280T2/xx unknown
- 1997-12-10 EP EP97947866A patent/EP0944614B1/en not_active Expired - Lifetime
- 1997-12-10 JP JP52649298A patent/JP3215441B2/ja not_active Expired - Fee Related
- 1997-12-10 ID IDW990472A patent/ID22753A/id unknown
- 1997-12-10 KR KR10-1999-7005154A patent/KR100433568B1/ko not_active Expired - Fee Related
- 1997-12-10 CZ CZ0206599A patent/CZ297324B6/cs not_active IP Right Cessation
- 1997-12-10 DK DK97947866T patent/DK0944614T3/da active
- 1997-12-10 US US09/308,176 patent/US6083974A/en not_active Expired - Lifetime
- 1997-12-10 PT PT97947866T patent/PT944614E/pt unknown
- 1997-12-10 HU HU0002869A patent/HU226458B1/hu not_active IP Right Cessation
- 1997-12-10 AT AT97947866T patent/ATE223911T1/de not_active IP Right Cessation
- 1997-12-10 BR BR9714016-3A patent/BR9714016A/pt active Search and Examination
- 1997-12-10 RU RU99115766/04A patent/RU2161617C1/ru not_active IP Right Cessation
- 1997-12-10 AU AU54097/98A patent/AU718958B2/en not_active Ceased
- 1997-12-10 PL PL334072A patent/PL191760B1/pl not_active IP Right Cessation
- 1997-12-10 ES ES97947866T patent/ES2181039T3/es not_active Expired - Lifetime
- 1997-12-10 CN CN97180628A patent/CN1105112C/zh not_active Expired - Fee Related
- 1997-12-10 WO PCT/JP1997/004527 patent/WO1998025919A1/en not_active Ceased
- 1997-12-10 DE DE69715448T patent/DE69715448T2/de not_active Expired - Lifetime
- 1997-12-11 TW TW086118667A patent/TW438790B/zh not_active IP Right Cessation
- 1997-12-12 AR ARP970105862A patent/AR008939A1/es active IP Right Grant
-
1999
- 1999-06-10 NO NO992838A patent/NO992838L/no unknown
-
2002
- 2002-06-11 CN CNB021227608A patent/CN1185226C/zh not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR008939A1 (es) | Compuestos de benzotiofencarboxamidas, composiciones farmaceuticas y antagonistas de la pgd2 que los contienen, y compuestos intermediarios de aplicacion en la preparacion de dichos compuestos. | |
| BRPI0407508B8 (pt) | compostos derivados de bifenila, composição farmacêutica e uso dos mesmos | |
| PA8615701A1 (es) | Derivados de dihidrobenzofuranilo alcanamina y metodos para su uso. | |
| DK0889877T3 (da) | Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer | |
| DE60005485D1 (de) | Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten | |
| CO5271700A1 (es) | Composicion farmaceutica que comprende acido 3-[2,4-dimetil-5-(2-oxo-1,2-dihidro-indol-3-ilidenmetil)-1h-pirrol-3-il]-propionico, uno o mas compuestos polihidrocarbilo y un vehiculo farmaceuticamente aceptable | |
| DE69912581D1 (de) | Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren | |
| ES2192213T3 (es) | Arilalquil-diazinonas como inhibidores de fosfodiesterasa iv. | |
| ATE339408T1 (de) | Terphenylderivate, deren herstellung und zusammensetzungen, die diese enthalten | |
| AR004320A1 (es) | Nuevos compuestos de pirimidina condensados biciclicos; un procedimiento para su preparacion; composiciones farmaceuticas que los contienen y su usocomo agentes terapeuticos, en particular como inhibidores de la tirosina quinasa. | |
| AR029210A1 (es) | DERIVADOS DE N-(5-SULFAMOIL-1,3-TIAZOL-2-IL) ACETAMIDA, PROCEDIMIENTO PARA SU PREPARACIoN, COMPUESTOS INTERMEDIARIOS, COMPOSICIoN FARMACÉUTICA, Y EL USO DE DICHOS DERIVADOS PARA LA PRODUCCIoN DE MEDICAMENTOS | |
| UY27870A1 (es) | Nuevos derivados de quinuclidina-amida | |
| ES2158814A1 (es) | Antagonistas iii del receptor ccr-3. | |
| AR028833A1 (es) | Compuestos inhibidores de metaloproteasas, composiciones farmaceuticas, uso para la manufactura de medicamentos, metodo de tratamiento y procedimiento para su preparacion | |
| BRPI0313942B8 (pt) | derivados de benzimidazol úteis como agentes antiproliferativos, seus processos de preparação, composição farmacêutica compreendendo os mesmos e usos dos referidos compostos nas preparações de composições farmacêuticas | |
| PE20110854A1 (es) | DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 | |
| AR063158A1 (es) | Asenapina amorfa,p rocesos para prepararla, composiciones farmaceuticas solidas que la contienen y su uso para tratar trastornos del sistema nervioso central. | |
| MA28279A1 (fr) | Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 | |
| DE60045508D1 (de) | Dalda-analoge und ihre verwendung | |
| ES2102994T3 (es) | Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa. | |
| ATE340795T1 (de) | Benzolsulfonsäureester-indol-5-yl als 5-ht6 rezeptor-antagonisten | |
| AR008614A1 (es) | UN PROCEDIMIENTO PARA LA FABRICACIoN DE UNA COMPOSICION FARMACEUTICA QUE CONTIENE UN COMPUESTO DE PIRIMIDINA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DELMISMO, QUE TIENE ACTIVIDAD INHIBITORIA DE LA TIROSINA QUINASA, COMPUESTOS DE PIRIMIDINA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y UN PROCEDIMI | |
| ES2159717T3 (es) | Derivados de acido 5-(piperidinil-1 sustituido en posicion 4)-3-aril-pentanoico como antagonistas de los receptores de taquiquinina. | |
| ATE277010T1 (de) | Bis-indolederivate und ihre verwendung als entzündungshemmende mittel | |
| AU8998298A (en) | Compounds having (2.2.1)bicyclo skeleton |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |