AR008764A1 - Sales hidratadas de n,n'-diacetilcistina, proceso para su preparacion, y composiciones terapeuticas que comprenden a dichas sales como ingredienteactivo. - Google Patents
Sales hidratadas de n,n'-diacetilcistina, proceso para su preparacion, y composiciones terapeuticas que comprenden a dichas sales como ingredienteactivo.Info
- Publication number
- AR008764A1 AR008764A1 ARP970102429A ARP970102429A AR008764A1 AR 008764 A1 AR008764 A1 AR 008764A1 AR P970102429 A ARP970102429 A AR P970102429A AR P970102429 A ARP970102429 A AR P970102429A AR 008764 A1 AR008764 A1 AR 008764A1
- Authority
- AR
- Argentina
- Prior art keywords
- salts
- preparation
- therapeutic compositions
- diacetilcistina
- active ingredient
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- YTPQSLLEROSACP-YUMQZZPRSA-N (2R)-2-acetamido-3-[[(2R)-2-acetamido-2-carboxyethyl]disulfanyl]propanoic acid Chemical class CC(=O)N[C@H](C(O)=O)CSSC[C@@H](C(O)=O)NC(C)=O YTPQSLLEROSACP-YUMQZZPRSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- UPABQMWFWCMOFV-UHFFFAOYSA-N benethamine Chemical compound C=1C=CC=CC=1CNCCC1=CC=CC=C1 UPABQMWFWCMOFV-UHFFFAOYSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 150000004683 dihydrates Chemical class 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- -1 sesquihydrate Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Sales hidratadas de N, N-diacetilcistina, que tienen la formula I en la cual la N, N-diacetilcistina es la formula D-, L-, o meso, o cualquier mezclade las mismas, R+ es la formula protonada de lisina, amoníaco o N-bencil-2- -feniletilamina,y x es 1; 1,5; o 2, que se designan monohidrato, sesquihidrato, y dihidrato, respectivamente, con la condicion de que cuando, y solo cuando , R+ sea la forma protonada de N-bencil-2-feniletilamina, X sea1,5. Además sedan a conocer un proceso parala preparacion de dichas sales, y composiciones terapéuticas que comprenden a dichas sales como ingredientes activos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9602416A SE9602416D0 (sv) | 1996-06-18 | 1996-06-18 | New forms of an organic salt of N'N-diacetylcystine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008764A1 true AR008764A1 (es) | 2000-02-23 |
Family
ID=20403068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102429A AR008764A1 (es) | 1996-06-18 | 1997-06-04 | Sales hidratadas de n,n'-diacetilcistina, proceso para su preparacion, y composiciones terapeuticas que comprenden a dichas sales como ingredienteactivo. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0906275B1 (es) |
| JP (1) | JP2000512991A (es) |
| AR (1) | AR008764A1 (es) |
| AT (1) | ATE202556T1 (es) |
| AU (1) | AU726083B2 (es) |
| CA (1) | CA2258205A1 (es) |
| DE (1) | DE69705405T2 (es) |
| ID (1) | ID17738A (es) |
| NO (1) | NO985929L (es) |
| NZ (1) | NZ333150A (es) |
| SE (1) | SE9602416D0 (es) |
| WO (1) | WO1997048679A1 (es) |
| ZA (1) | ZA974929B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9800932D0 (sv) * | 1998-03-20 | 1998-03-20 | Astra Ab | New compunds |
| US6926911B1 (en) | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| HK1042825A1 (zh) * | 1998-12-22 | 2002-08-30 | The University Of North Carolina At Chapel Hill | 治疗气道疾病的化合物和方法以及气道药物的给药方法 |
| SE9900438D0 (sv) * | 1999-02-10 | 1999-02-10 | Astra Ab | The pharmacological use of certian cystine derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
-
1996
- 1996-06-18 SE SE9602416A patent/SE9602416D0/xx unknown
-
1997
- 1997-06-04 AR ARP970102429A patent/AR008764A1/es not_active Application Discontinuation
- 1997-06-04 ZA ZA9704929A patent/ZA974929B/xx unknown
- 1997-06-05 ID IDP971910A patent/ID17738A/id unknown
- 1997-06-17 EP EP97928596A patent/EP0906275B1/en not_active Expired - Lifetime
- 1997-06-17 DE DE69705405T patent/DE69705405T2/de not_active Expired - Fee Related
- 1997-06-17 JP JP10502801A patent/JP2000512991A/ja not_active Ceased
- 1997-06-17 CA CA002258205A patent/CA2258205A1/en not_active Abandoned
- 1997-06-17 WO PCT/SE1997/001069 patent/WO1997048679A1/en not_active Ceased
- 1997-06-17 AT AT97928596T patent/ATE202556T1/de not_active IP Right Cessation
- 1997-06-17 NZ NZ333150A patent/NZ333150A/xx unknown
- 1997-06-17 AU AU32814/97A patent/AU726083B2/en not_active Ceased
-
1998
- 1998-12-17 NO NO985929A patent/NO985929L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2258205A1 (en) | 1997-12-24 |
| EP0906275B1 (en) | 2001-06-27 |
| WO1997048679A1 (en) | 1997-12-24 |
| DE69705405T2 (de) | 2001-11-08 |
| NO985929D0 (no) | 1998-12-17 |
| ZA974929B (en) | 1997-12-18 |
| NZ333150A (en) | 2000-03-27 |
| AU3281497A (en) | 1998-01-07 |
| AU726083B2 (en) | 2000-11-02 |
| ATE202556T1 (de) | 2001-07-15 |
| ID17738A (id) | 1998-01-22 |
| SE9602416D0 (sv) | 1996-06-18 |
| EP0906275A1 (en) | 1999-04-07 |
| NO985929L (no) | 1999-02-17 |
| JP2000512991A (ja) | 2000-10-03 |
| DE69705405D1 (de) | 2001-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |