AR008545A1 - Compuestos substituidos de indano o de dihidroindol; composicion farmaceutica que los contiene y uso de dichos compuestos en la preparacionde un medicamento. - Google Patents
Compuestos substituidos de indano o de dihidroindol; composicion farmaceutica que los contiene y uso de dichos compuestos en la preparacionde un medicamento.Info
- Publication number
- AR008545A1 AR008545A1 ARP970106065A ARP970106065A AR008545A1 AR 008545 A1 AR008545 A1 AR 008545A1 AR P970106065 A ARP970106065 A AR P970106065A AR P970106065 A ARP970106065 A AR P970106065A AR 008545 A1 AR008545 A1 AR 008545A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloalk
- group
- alk
- ring
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 240000001546 Byrsonima crassifolia Species 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical class C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 244000144980 herd Species 0.000 abstract 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000003441 thioacyl group Chemical group 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C5/00—Details of stores covered by group G11C11/00
- G11C5/02—Disposition of storage elements, e.g. in the form of a matrix array
- G11C5/025—Geometric lay-out considerations of storage- and peripheral-blocks in a semiconductor storage device
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- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
- G11C7/10—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
- G11C7/1048—Data bus control circuits, e.g. precharging, presetting, equalising
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Compuestos de indano o de dihidroindol sustituidos de formula (I), donde A es un grupo (II), Y es un grupo hidrocarburo que completa un anillo deindano, un grupo NR1 que completa un anillo de dihidroindol o un grupo N, que completa unanillo de dihidroindol ligado via la posicion 1; W es unenlace y n+m es 1, 2, 3, 4, 5 o 6; W es CO, SO, o SO2, n es 2, 3, 4 o 5 y m es 0, 1, 2, o 3 siempre que n+m no sea más de 6; o W es O, S, n es 2, 3, 4 o 5 ym es 0, 1, 2, o 3, siempre que n+mno sea m ás de 6; y cuando Y sea N completando un anillo de hidroindol ligado a la posicion 1, entonces m es 2,o 3 y cuando Y sea NR1 completando un anillo de dihidroindol ligado vía la posicion 2, entonces m es 1, 2 o 3, la línea depuntos, e manada a partir deX, indica un enlace opcional; cuando no indica un enlace X es N, CH o COH; y cuando indica un enlace X es C; R1 es: hidrogeno, alqu(en/in)ilo C1.6,cicloalqu(ilen/in)ilo C3-8, cicloalqu(en/in)ilo C3-8, alqu(en/in)ilo C1- 6, ar ilo, heteroarilo, arilo- alquilo C1-6, heteroarilo-alquilo C1-6, acilo,tioacilo, alquilsulfonilo C1-6, trifluormetilsulfonilo, arilsulfonilo, o heteroarilsulfonilo; R15 es VCO donde V es O o S y R15 es alqu(en/in)ilo C1-6,cicloalqu(en/in)ilo C 3-8, cicloalqu(en/in)ilo C3-8-alqu(en/in)ilo C1-6, arilo, heteroarilo; o un grupo R16R17 NCO- o R16R17 NCS- donde R16 y R17, sonindependientemente, hidrogeno, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, cicloalqu(en)iloC3-8-alqu(en/in)ilo C1-6 -arilo, heteroarilo; o R16 y R17juntos con el átomo N-, al cual los mismos se encuentran ligados, forman un grupo de pirrolidinilo, piperidinilo o de perhidrozepina; y R2, R3, R4 y R5son independientemente seleccionadosde hidrogeno, halogeno, c iano, nitro alqu(en/in)ilo C1-6, alcoxi C1-6, alquiltio C1-6, hidroxi, cicloalqu(en)ilo
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK151496 | 1996-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008545A1 true AR008545A1 (es) | 2000-01-19 |
Family
ID=8105631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970106065A AR008545A1 (es) | 1996-12-20 | 1997-12-19 | Compuestos substituidos de indano o de dihidroindol; composicion farmaceutica que los contiene y uso de dichos compuestos en la preparacionde un medicamento. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6262087B1 (es) |
| EP (1) | EP0946542B1 (es) |
| JP (1) | JP3251300B2 (es) |
| KR (1) | KR100432297B1 (es) |
| CN (3) | CN1244558C (es) |
| AR (1) | AR008545A1 (es) |
| AT (1) | ATE225784T1 (es) |
| AU (1) | AU731243B2 (es) |
| BG (1) | BG63968B1 (es) |
| BR (1) | BR9714039A (es) |
| CZ (1) | CZ297416B6 (es) |
| DE (1) | DE69716296T2 (es) |
| DK (1) | DK0946542T3 (es) |
| EA (1) | EA002158B1 (es) |
| ES (1) | ES2185058T3 (es) |
| HU (1) | HUP0000079A3 (es) |
| IL (1) | IL130133A (es) |
| IS (1) | IS2018B (es) |
| NO (2) | NO318978B1 (es) |
| NZ (1) | NZ335973A (es) |
| PL (1) | PL188418B1 (es) |
| PT (1) | PT946542E (es) |
| SK (1) | SK283678B6 (es) |
| TR (1) | TR199901407T2 (es) |
| UA (1) | UA66778C2 (es) |
| WO (1) | WO1998028293A1 (es) |
| ZA (1) | ZA9711376B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| TWI242011B (en) * | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
| PT1068199E (pt) * | 1998-04-08 | 2003-02-28 | Wyeth Corp | N-ariloxietil-indoli-alquilaminas para o tratamento da depressao |
| US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
| TW528754B (en) * | 1998-04-29 | 2003-04-21 | Wyeth Corp | Indolyl derivatibes as serotonergic agents |
| US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| WO1999064044A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel therapeutic agents that modulate 5-ht receptors |
| US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| WO1999064045A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel therapeutic agents for membrane transporters |
| JP2003521443A (ja) * | 1998-06-19 | 2003-07-15 | ハー・ルンドベック・アクチエゼルスカベット | ４，５，６及び７−インドール及びインドリン誘導体、その製造方法及びその使用方法 |
| HK1044339A1 (zh) | 1998-06-19 | 2002-10-18 | H‧隆德贝克有限公司 | 4，5，6和7-吲及二氢吲衍生物，它们的制备和应用 |
| EP0982030A3 (en) | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands |
| AR020773A1 (es) * | 1998-10-16 | 2002-05-29 | Duphar Int Res | Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto |
| EP1140886B1 (en) | 1998-12-23 | 2003-04-02 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
| KR100604156B1 (ko) | 1999-04-14 | 2006-07-25 | 하. 룬트벡 아크티에 셀스카브 | 시탈로프람의 제조방법 |
| JP2002544223A (ja) * | 1999-05-12 | 2002-12-24 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | 精神病性障害の治療方法 |
| AU5487300A (en) * | 1999-06-14 | 2001-01-02 | Neurogen Corporation | Benzylpiperazinyl-indolinylethanones |
| US6355644B1 (en) | 1999-06-14 | 2002-03-12 | Neurogen Corporation | Benzylpiperazinyl-indolinylethanones |
| WO2000078716A1 (en) * | 1999-06-24 | 2000-12-28 | Toray Industries, Inc. | α1B-ADRENERGIC RECEPTOR ANTAGONISTS |
| CZ298533B6 (cs) | 1999-08-23 | 2007-10-31 | Solvay Pharmaceuticals B. V. | Deriváty fenylpiperazinu, zpusob jejich prípravy a farmaceutické prostredky s jejich obsahem |
| US6476051B2 (en) | 1999-12-17 | 2002-11-05 | Bristol-Myers Squibb Company | Antipsychotic heterocycle compounds |
| UA74830C2 (en) * | 2000-06-14 | 2006-02-15 | Lundbeck & Co As H | Indole derivatives being useful for the treatment of cns disorders, a pharmaceutical composition and a method for the treatment of diseases |
| AR028685A1 (es) | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
| SI1294710T1 (en) * | 2000-06-14 | 2005-10-31 | H. Lundbeck A/S | Indole derivatives useful for the treatment of cns disorders |
| MXPA02012506A (es) * | 2000-06-29 | 2003-04-25 | Lundbeck & Co As H | Derivados de indol utiles para el tratamiento de enfermedades del sistema nervioso central. |
| IL144817A0 (en) | 2000-08-18 | 2002-06-30 | Lundbeck & Co As H | Method for the preparation of citalopram |
| AR032712A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| AR033287A1 (es) * | 2001-05-09 | 2003-12-10 | Lundbeck & Co As H | Tratamiento del adhd |
| WO2003080050A1 (en) * | 2002-03-27 | 2003-10-02 | H. Lundbeck A/S | The use of 3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]-6-chloro-1h-indole or its enantiomers for the treatment of diseases and disorders responsive to 5-ht (serotonin) re-uptake inhibition |
| WO2003102097A1 (en) * | 2002-05-31 | 2003-12-11 | H. Lundbeck A/S | The hydrochloride of (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole |
| AU2003243930A1 (en) * | 2002-07-05 | 2004-01-23 | H. Lundbeck A/S | Pharmaceutical composition comprising (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole |
| WO2004020437A1 (en) * | 2002-08-29 | 2004-03-11 | H. Lundbeck A/S | S-(+)-3-{1-[2-(2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof |
| WO2004080407A2 (en) * | 2003-03-07 | 2004-09-23 | Predix Pharmaceuticals Holdings, Inc. | New serotonin modulating compounds and uses therefor |
| US20070265300A1 (en) * | 2004-05-11 | 2007-11-15 | Egis Gyogyszergyar Rt. | Pyridine Derivatives of Alkyl Oxindoles as 5-Ht7 Receptor Active Agents |
| ATE537153T1 (de) * | 2004-09-09 | 2011-12-15 | Merck Sharp & Dohme | Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors |
| CN101084225B (zh) * | 2004-11-26 | 2011-03-02 | 詹森药业有限公司 | 具有改良的抗精神病和抗焦虑活性的异噁唑啉-吲哚衍生物 |
| TW200800960A (en) * | 2005-08-17 | 2008-01-01 | Lundbeck & Co As H | Novel 2,3-dihydroindole compounds |
| US7544685B2 (en) | 2005-08-17 | 2009-06-09 | H. Lundbeck A/S | 2,3-dihydroindole compounds |
| JP2009515833A (ja) * | 2005-10-24 | 2009-04-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター |
| WO2008015516A1 (en) * | 2006-07-28 | 2008-02-07 | Pfizer Products Inc. | Fused tricyclic heterocycles for the treatment of schizophrenia |
| ES2375417T3 (es) * | 2006-11-28 | 2012-02-29 | Valeant Pharmaceuticals International | Análogos 1,4-diamino bicíclicos de retigabina como moduladores de los canales de potasio. |
| PL395469A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego |
| US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
| WO2014102588A2 (en) * | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| EP3866927A4 (en) | 2018-10-17 | 2022-07-27 | Nikang Therapeutics, Inc. | Indane derivatives as hypoxia inducible factor-2(alpha) inhibitors |
| GB201919213D0 (en) * | 2019-12-23 | 2020-02-05 | Ucb Biopharma Sprl | Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds |
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|---|---|---|---|---|
| ATE81123T1 (de) * | 1987-11-20 | 1992-10-15 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
| FR2654104B1 (fr) | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| TW199152B (es) | 1990-11-01 | 1993-02-01 | Takeda Pharm Industry Co Ltd | |
| FR2670491B1 (fr) | 1990-12-14 | 1993-02-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| WO1994021627A1 (en) | 1993-03-18 | 1994-09-29 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
| GB9305641D0 (en) | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| CA2188949A1 (en) | 1994-04-28 | 1995-11-09 | Janusz Jozef Kulagowski | Benzofuran derivatives as d4 receptor antagonists |
| ZA954689B (en) * | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines |
| ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| JP2003521443A (ja) * | 1998-06-19 | 2003-07-15 | ハー・ルンドベック・アクチエゼルスカベット | ４，５，６及び７−インドール及びインドリン誘導体、その製造方法及びその使用方法 |
-
1997
- 1997-12-18 ZA ZA9711376A patent/ZA9711376B/xx unknown
- 1997-12-19 PL PL97334011A patent/PL188418B1/pl not_active IP Right Cessation
- 1997-12-19 CN CNB031088511A patent/CN1244558C/zh not_active Expired - Fee Related
- 1997-12-19 US US09/331,560 patent/US6262087B1/en not_active Expired - Fee Related
- 1997-12-19 IL IL13013397A patent/IL130133A/xx not_active IP Right Cessation
- 1997-12-19 AT AT97949998T patent/ATE225784T1/de not_active IP Right Cessation
- 1997-12-19 PT PT97949998T patent/PT946542E/pt unknown
- 1997-12-19 BR BR9714039-2A patent/BR9714039A/pt not_active Application Discontinuation
- 1997-12-19 HU HU0000079A patent/HUP0000079A3/hu unknown
- 1997-12-19 DK DK97949998T patent/DK0946542T3/da active
- 1997-12-19 ES ES97949998T patent/ES2185058T3/es not_active Expired - Lifetime
- 1997-12-19 UA UA99074138A patent/UA66778C2/uk unknown
- 1997-12-19 CN CNB971818134A patent/CN1146556C/zh not_active Expired - Fee Related
- 1997-12-19 SK SK813-99A patent/SK283678B6/sk not_active IP Right Cessation
- 1997-12-19 TR TR1999/01407T patent/TR199901407T2/xx unknown
- 1997-12-19 KR KR10-1999-7005622A patent/KR100432297B1/ko not_active Expired - Fee Related
- 1997-12-19 JP JP52826298A patent/JP3251300B2/ja not_active Expired - Fee Related
- 1997-12-19 DE DE69716296T patent/DE69716296T2/de not_active Expired - Fee Related
- 1997-12-19 AR ARP970106065A patent/AR008545A1/es active IP Right Grant
- 1997-12-19 CZ CZ0222799A patent/CZ297416B6/cs not_active IP Right Cessation
- 1997-12-19 EP EP97949998A patent/EP0946542B1/en not_active Expired - Lifetime
- 1997-12-19 CN CNB031088503A patent/CN1282644C/zh not_active Expired - Fee Related
- 1997-12-19 EA EA199900581A patent/EA002158B1/ru not_active IP Right Cessation
- 1997-12-19 AU AU53109/98A patent/AU731243B2/en not_active Ceased
- 1997-12-19 NZ NZ335973A patent/NZ335973A/xx unknown
- 1997-12-19 WO PCT/DK1997/000587 patent/WO1998028293A1/en not_active Ceased
-
1999
- 1999-05-28 IS IS5061A patent/IS2018B/is unknown
- 1999-06-14 NO NO19992895A patent/NO318978B1/no not_active IP Right Cessation
- 1999-07-07 BG BG103561A patent/BG63968B1/bg unknown
-
2001
- 2001-03-21 US US09/814,037 patent/US6352988B2/en not_active Expired - Fee Related
- 2001-03-21 US US09/813,480 patent/US6552044B2/en not_active Expired - Fee Related
-
2004
- 2004-10-21 NO NO20044514A patent/NO20044514L/no not_active Application Discontinuation
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