AR008195A1 - ALPHA GAMMA-DIAMINOBUTIRIC ACID (DAB) CONTAINING OLIGOPEPTIDIC DERIVATIVES. - Google Patents
ALPHA GAMMA-DIAMINOBUTIRIC ACID (DAB) CONTAINING OLIGOPEPTIDIC DERIVATIVES.Info
- Publication number
- AR008195A1 AR008195A1 ARP970104504A ARP970104504A AR008195A1 AR 008195 A1 AR008195 A1 AR 008195A1 AR P970104504 A ARP970104504 A AR P970104504A AR P970104504 A ARP970104504 A AR P970104504A AR 008195 A1 AR008195 A1 AR 008195A1
- Authority
- AR
- Argentina
- Prior art keywords
- dab
- derivatives
- agent
- gamma
- alpha
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 102000015636 Oligopeptides Human genes 0.000 abstract 3
- 108010038807 Oligopeptides Proteins 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- -1 alkyl amide Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000005859 cell recognition Effects 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000004960 subcellular localization Effects 0.000 abstract 1
- 238000001890 transfection Methods 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Polyamides (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Acido alfa, gamma-diaminobutírico (DAB) conteniendo derivados oligopetídicos de fórmula R-NH-A en donde: R es un agente de reconocimientode la célula, un agente permieabilizante de la membrana, un agente de localización subcelular o un agente enmascarante; A es un oligopéptidodesprovisto de un grupo amino, que contiene de 1 a 200 aminoácidos es el ácido alfa, gamma-diaminobutírico (DAB), y el grupo carboxilo terminal deloligopéptido se convierte en una amida, amida alquilo inferior, amida dialquilo inferior o hidrazida es de utilidad como portador para la transfección decélulas con un polinucleótido o cualquier otra macromolécula aniónica.Alpha, gamma-diaminobutyric acid (DAB) containing oligopeptide derivatives of the formula R-NH-A where: R is a cell recognition agent, a membrane permieabilizing agent, a subcellular localization agent or a masking agent; A is an oligopeptide devoid of an amino group, containing from 1 to 200 amino acids is alpha, gamma-diaminobutyric acid (DAB), and the terminal carboxyl group of the oligopeptide is converted to an amide, lower alkyl amide, lower dialkyl amide or hydrazide is Useful as a carrier for transfection of cells with a polynucleotide or any other anionic macromolecule.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96115784 | 1996-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008195A1 true AR008195A1 (en) | 1999-12-09 |
Family
ID=8223255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104504A AR008195A1 (en) | 1996-10-02 | 1997-09-30 | ALPHA GAMMA-DIAMINOBUTIRIC ACID (DAB) CONTAINING OLIGOPEPTIDIC DERIVATIVES. |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPH10147595A (en) |
| AR (1) | AR008195A1 (en) |
| BR (1) | BR9704955A (en) |
| CA (1) | CA2213257A1 (en) |
| MX (1) | MX9707319A (en) |
| TR (1) | TR199701091A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001323059A (en) * | 2000-05-18 | 2001-11-20 | Hisamitsu Pharmaceut Co Inc | Polypeptide derivative and carrier for nucleic acid |
-
1997
- 1997-08-18 CA CA 2213257 patent/CA2213257A1/en not_active Abandoned
- 1997-09-25 MX MX9707319A patent/MX9707319A/en unknown
- 1997-09-30 AR ARP970104504A patent/AR008195A1/en unknown
- 1997-10-01 BR BR9704955A patent/BR9704955A/en unknown
- 1997-10-01 JP JP9267594A patent/JPH10147595A/en active Pending
- 1997-10-02 TR TR97/01091A patent/TR199701091A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10147595A (en) | 1998-06-02 |
| BR9704955A (en) | 1998-10-27 |
| TR199701091A3 (en) | 1998-04-21 |
| CA2213257A1 (en) | 1998-04-02 |
| MX9707319A (en) | 1998-04-30 |
| TR199701091A2 (en) | 1998-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |