AR008177A1 - Nuevas bisindolilmaleimidas, sales de las mismas, procesos para su preparacion intermediarios, su uso para la fabricacion de medicamentos, metodode tratamiento y composicion farmaceutica. - Google Patents
Nuevas bisindolilmaleimidas, sales de las mismas, procesos para su preparacion intermediarios, su uso para la fabricacion de medicamentos, metodode tratamiento y composicion farmaceutica.Info
- Publication number
- AR008177A1 AR008177A1 ARP970104132A ARP970104132A AR008177A1 AR 008177 A1 AR008177 A1 AR 008177A1 AR P970104132 A ARP970104132 A AR P970104132A AR P970104132 A ARP970104132 A AR P970104132A AR 008177 A1 AR008177 A1 AR 008177A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- manufacture
- processes
- preparation
- new
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- DQYBRTASHMYDJG-UHFFFAOYSA-N Bisindolylmaleimide Chemical compound C1=CC=C2C(C=3C(=O)NC(C=3C=3C4=CC=CC=C4NC=3)=O)=CNC2=C1 DQYBRTASHMYDJG-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- FNKKANADPBOGGN-UHFFFAOYSA-N C1=CC=C2NC([N])=CC2=C1 Chemical compound C1=CC=C2NC([N])=CC2=C1 FNKKANADPBOGGN-UHFFFAOYSA-N 0.000 abstract 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 150000003924 bisindolylmaleimides Chemical class 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nuevas bisindolilmaleimidas que comprenden la fórmula (I) R20-(CH2)n-R , en donde R20 es una porción de bisindolilmaleimida ligada al grupo -CH2- a travésde un indolil nitrógeno, n es 0 o 1, R es un anillo carbocíclico o heterocíclicoar omático de 5 o 6 miembros, conteniendo el anillo heterocíclicoN o S, R es sustituido por R1 y hasta cuatro de R2, R3, R4 y R5, en donde R1 es aminometilo, (N-(C1-4-alquil)amino)metilo, (N,N-di(C1-4-alquil)amino)metilo, opiridiniometilo, y R2, R3,y R 4, y R5 (si están presentes), que pueden ser iguales o diferentes, son cada uno hidrógeno, hidroxi, C1-6-alcoxi,C1-6-alquilo, tri(C1-4-alquil)silil(C1-4-alcoxi)(C1-4-alcoxi), o halógeno, o R2 cuando se encuentra en una posición contigua alenlac e que conecta R al grupo-(CH2)n-, y n es 1, puede, junto con el átomo 2 carbono en el indol al que el grupo -(CH2)n- está adherido, formar un anillo, y sales farmacéuticamenteaceptables de los mismos, que son inhibidoras de quinasa C deproteína (P KC), procesos para su preparación, intermediarios para los mismos, su uso en lafabricación de medicamentos y composiciones farmacéuticas que los comprenden.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9603283A SE9603283D0 (sv) | 1996-09-10 | 1996-09-10 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008177A1 true AR008177A1 (es) | 1999-12-09 |
Family
ID=20403828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104132A AR008177A1 (es) | 1996-09-10 | 1997-09-10 | Nuevas bisindolilmaleimidas, sales de las mismas, procesos para su preparacion intermediarios, su uso para la fabricacion de medicamentos, metodode tratamiento y composicion farmaceutica. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6153641A (es) |
| EP (1) | EP0925296A1 (es) |
| AR (1) | AR008177A1 (es) |
| AU (1) | AU718844B2 (es) |
| CA (1) | CA2264236A1 (es) |
| NZ (1) | NZ334201A (es) |
| SE (1) | SE9603283D0 (es) |
| WO (1) | WO1998011102A1 (es) |
| ZA (1) | ZA977807B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR017200A1 (es) | 1997-12-23 | 2001-08-22 | Astrazeneca Ab | Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos |
| US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
| SE9800835D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| US6346625B1 (en) | 1999-06-23 | 2002-02-12 | Astrazeneca Ab | Protein kinase inhibitors |
| CA2431166A1 (en) | 2000-12-08 | 2002-06-13 | Ortho-Mcneil Pharmaceutical, Inc. | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| AU2003217596A1 (en) * | 2002-03-08 | 2003-09-22 | Eli Lilly And Company | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors |
| WO2003103663A2 (en) | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| CN1671694A (zh) * | 2002-06-05 | 2005-09-21 | 詹森药业有限公司 | 作为激酶抑制剂的二吲哚基－顺丁烯二酰亚胺衍生物 |
| EA200600032A1 (ru) | 2003-06-13 | 2006-06-30 | Янссен Фармацевтика Н.В. | Замещённые производные индазолил (индолил) малеимида в качестве ингибиторов киназ |
| EP1734952A1 (en) * | 2004-04-08 | 2006-12-27 | Novartis AG | Protein kinase c inhibitors for the treatment of autoimmune diseases and of transplant rejection |
| RS51826B (sr) | 2005-02-09 | 2012-02-29 | Arqule Inc. | Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera |
| EP2392574B1 (en) * | 2007-06-22 | 2013-12-18 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| AU2008268613A1 (en) * | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| CA2690799C (en) * | 2007-06-22 | 2015-06-16 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| US8871807B2 (en) | 2008-03-28 | 2014-10-28 | Ecolab Usa Inc. | Detergents capable of cleaning, bleaching, sanitizing and/or disinfecting textiles including sulfoperoxycarboxylic acids |
| US20170209488A1 (en) | 2014-07-17 | 2017-07-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for treating neuromuscular junction-related diseases |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| CN106565517B (zh) * | 2016-10-18 | 2018-08-17 | 湖南大学 | 一种由芳基甲烷衍生物和腈制备酰胺的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US28973A (en) * | 1860-07-03 | Potato-parer | ||
| USRE28973E (en) | 1965-10-23 | 1976-09-21 | A. H. Robins Company, Incorporated | 3-(Omega-substituted alkyl)-indoles |
| US3821387A (en) * | 1965-10-23 | 1974-06-28 | Robins Co Inc A H | The treatment of parkinsonism with 3-(omega-substituted alkyl)-indoles |
| US3821389A (en) * | 1969-10-31 | 1974-06-28 | Sherwin Williams Co | Microbiocidal use of 1,2-benzisothiazolin-3-ones |
| FR2182915A1 (en) * | 1972-03-30 | 1973-12-14 | Nelson Res & Dev | Substd indoles, benzimidazoles - as anti-immune agents , antitumour agents, serotonin inhibitors, hypnotics |
| US4031221A (en) * | 1974-06-17 | 1977-06-21 | American Hoechst Corporation | Method of treating pain and hypertension |
| GB1500176A (en) * | 1975-06-03 | 1978-02-08 | Wyeth John & Brother Ltd | Reduction process for the preparation of 1-unsubstituted 3-(2-hydroxyethyl)-indole derivatives |
| DE3132882A1 (de) * | 1981-08-20 | 1983-03-03 | Cassella Ag, 6000 Frankfurt | Neue piperazinone, ihre herstellung und verwendung |
| US4727044A (en) * | 1984-05-18 | 1988-02-23 | Semiconductor Energy Laboratory Co., Ltd. | Method of making a thin film transistor with laser recrystallized source and drain |
| CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| PT93947B (pt) * | 1989-05-05 | 1996-11-29 | Goedecke Ag | Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem |
| GB9413975D0 (en) * | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
| US5077293A (en) * | 1990-06-29 | 1991-12-31 | Bristol-Myers Squibb Co. | 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines |
| US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| JPH07504673A (ja) * | 1992-03-20 | 1995-05-25 | ザ・ウエルカム・ファウンデーション・リミテッド | 抗ウイルス活性を有するインドール誘導体 |
| US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5545636A (en) * | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| ATE290378T1 (de) * | 1993-12-23 | 2005-03-15 | Lilly Co Eli | Proteinkinase c-inhibitoren |
| CA2144940A1 (en) * | 1994-03-18 | 1995-09-19 | Chikara Murakata | Therapeutic agent for thrombocytopenia and indolocarbazole derivatives |
| US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| TW472045B (en) * | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
| US5854285A (en) * | 1997-04-03 | 1998-12-29 | Natpro, Inc. | Protein kinase inhibitor |
-
1996
- 1996-09-10 SE SE9603283A patent/SE9603283D0/xx unknown
-
1997
- 1997-08-29 ZA ZA9707807A patent/ZA977807B/xx unknown
- 1997-09-08 NZ NZ334201A patent/NZ334201A/en unknown
- 1997-09-08 EP EP97939316A patent/EP0925296A1/en not_active Withdrawn
- 1997-09-08 WO PCT/SE1997/001504 patent/WO1998011102A1/en not_active Ceased
- 1997-09-08 US US08/981,003 patent/US6153641A/en not_active Expired - Fee Related
- 1997-09-08 CA CA002264236A patent/CA2264236A1/en not_active Abandoned
- 1997-09-08 AU AU41431/97A patent/AU718844B2/en not_active Ceased
- 1997-09-10 AR ARP970104132A patent/AR008177A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998011102A1 (en) | 1998-03-19 |
| ZA977807B (en) | 1998-03-10 |
| CA2264236A1 (en) | 1998-03-19 |
| AU718844B2 (en) | 2000-04-20 |
| NZ334201A (en) | 2001-02-23 |
| EP0925296A1 (en) | 1999-06-30 |
| AU4143197A (en) | 1998-04-02 |
| SE9603283D0 (sv) | 1996-09-10 |
| US6153641A (en) | 2000-11-28 |
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