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AR006997A1 - PROCESS FOR THE PREPARATION OF UREIC DERIVATIVES AND INTERMEDIARY SYNTHESIS - Google Patents

PROCESS FOR THE PREPARATION OF UREIC DERIVATIVES AND INTERMEDIARY SYNTHESIS

Info

Publication number
AR006997A1
AR006997A1 ARP970101846A ARP970101846A AR006997A1 AR 006997 A1 AR006997 A1 AR 006997A1 AR P970101846 A ARP970101846 A AR P970101846A AR P970101846 A ARP970101846 A AR P970101846A AR 006997 A1 AR006997 A1 AR 006997A1
Authority
AR
Argentina
Prior art keywords
synthesis
derivatives
preparation
amino group
primary amino
Prior art date
Application number
ARP970101846A
Other languages
Spanish (es)
Original Assignee
Abres Associated Biotechnology Res S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abres Associated Biotechnology Res S R L filed Critical Abres Associated Biotechnology Res S R L
Publication of AR006997A1 publication Critical patent/AR006997A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un proceso para la síntesis de derivados ureicos (o de urea) con la fórmula (I), en la cual el anillo P es un heterociclo azoico de 5 o 6miembros, saturado o no saturado, que eventualmente contiene además uno o más heteroátomos seleccionados entre N, O y E, y en los cuales -L es elradical de un compuesto que contiene un grupo amínico primario; el proceso comprende la condensación de dicho heterociclo azoico PN_H y de dichocompuesto L-NH, que contiene un grupo amínico primario, con derivados cloro-carbonílicos; particularmente dicho proceso permite la síntesis conbajo impacto ambiental y en forma económicamente ventajosa de antibióticos Beta-lactámicos, utilizando nuevos intermediarios de síntesis.A process is described for the synthesis of urea derivatives (or urea) with the formula (I), in which the P ring is a 5- or 6-membered azo heterocycle, saturated or unsaturated, which eventually also contains one or more heteroatoms. selected from N, O and E, and in which -L is the radical of a compound containing a primary amino group; The process comprises the condensation of said azo heterocycle PN_H and said compound L-NH, which contains a primary amino group, with chlorocarbonyl derivatives; Particularly, this process allows the synthesis with low environmental impact and in an economically advantageous manner of Beta-lactam antibiotics, using new synthesis intermediates.

ARP970101846A 1996-05-03 1997-05-05 PROCESS FOR THE PREPARATION OF UREIC DERIVATIVES AND INTERMEDIARY SYNTHESIS AR006997A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000873A IT1282955B1 (en) 1996-05-03 1996-05-03 PROCESS FOR THE PREPARATION OF UREIDE DERIVATIVES AND SYNTHETIC INTERMEDIATEs

Publications (1)

Publication Number Publication Date
AR006997A1 true AR006997A1 (en) 1999-10-13

Family

ID=11374193

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101846A AR006997A1 (en) 1996-05-03 1997-05-05 PROCESS FOR THE PREPARATION OF UREIC DERIVATIVES AND INTERMEDIARY SYNTHESIS

Country Status (4)

Country Link
AR (1) AR006997A1 (en)
AU (1) AU2775597A (en)
IT (1) IT1282955B1 (en)
WO (1) WO1997042177A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2321153B1 (en) * 2007-10-11 2010-02-26 Astur Pharma S.A. INTERMEDIATE FOR THE SYNTHESIS OF PIPERACILINA.
CN101857574A (en) * 2010-07-05 2010-10-13 山东鑫泉医药中间体有限公司 Synthesizing method of N-ethyl-2,3-dioxygen piperazine
CN103360343B (en) * 2012-03-30 2017-04-19 凯惠药业(上海)有限公司 Preparation method of piperazine amide compound
CN104910178B (en) * 2015-05-22 2017-06-13 华北制药集团先泰药业有限公司 A kind of preparation method of Piperacillin acid
CN109438476A (en) * 2018-12-24 2019-03-08 常州红太阳药业有限公司 The preparation method of Piperacillin acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3065012D1 (en) * 1979-04-25 1983-11-03 Biochemie Gmbh Process for the production of phenylglycyl chloride hydrochlorides
KR830001969B1 (en) * 1981-10-06 1983-09-29 김영설 6- ｛D-(-) α- (4-ethyl-2.3-dioxo-1 piperazinocarbonylamino) phenyl (or hydroxyphenyl) acetamido peniclanic acid and a method for preparing the salt thereof
DE3619562A1 (en) * 1986-06-11 1987-12-17 Basf Ag METHOD FOR PRODUCING 2,3-DIOXO-4-OXICARBONYLPIPERAZINE DERIVATIVES, NEW 2,3-DIOXO-4-OXICARBONYLPIPERAZINE DERIVATIVES AND THE USE THEREOF
ES2005450A6 (en) * 1987-11-16 1989-03-01 Gema Sa N,N'-carboxyl-bis-(4-ethyl-2,3-dioxo)-piperazine, process for the preparation thereof and use thereof.

Also Published As

Publication number Publication date
IT1282955B1 (en) 1998-04-02
ITMI960873A0 (en) 1996-05-03
WO1997042177A1 (en) 1997-11-13
AU2775597A (en) 1997-11-26
ITMI960873A1 (en) 1997-11-03

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