AR006876A1 - Procedimiento e intermedios para preparar el compuesto {2-(2-[1,2,4]- triazol-3-ilmetil)-1,2,3,4-tetrahidroisoquinolin-6-il} amida del acido 4'-trifluorometilbifenil-2-carboxilico - Google Patents
Procedimiento e intermedios para preparar el compuesto {2-(2-[1,2,4]- triazol-3-ilmetil)-1,2,3,4-tetrahidroisoquinolin-6-il} amida del acido 4'-trifluorometilbifenil-2-carboxilicoInfo
- Publication number
- AR006876A1 AR006876A1 ARP970101731A ARP970101731A AR006876A1 AR 006876 A1 AR006876 A1 AR 006876A1 AR P970101731 A ARP970101731 A AR P970101731A AR P970101731 A ARP970101731 A AR P970101731A AR 006876 A1 AR006876 A1 AR 006876A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- group
- formula
- trifluorometilbifenil
- tetrahidroisoquinolin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para preparar el compuesto de fórmula (I) que comprende tratar el compuesto de fórmula II en la que R es H o R2 y R2 se seleccionaentre el grupo que comprende alilo o un grupo metilo sustituido en el que los sustituyentes comprenden uno a tres grupos arilo C6-C10, en los que los gruposarilo están además sustituidos opcionalmente con uno o más sustituyentes seleccionados entre nitro y alcoxi C1-C6, a) con un compuesto de fórmula (X) enla que J es un grupo saliente, tal como un átomo de halógeno, un grupo azida, un grupo aciloxi C-C6 o un grupo a r c il o x i C8-C10 preferiblemente un átomode cloro o bromo; y b) cuando R es R2, tratar además el productos de la etapa a) con un ácido. Un compuesto de fórmula (II) en la que R es R1 y R1 es como seha definido anteriormente preferiblemente CH2OC2H4CH2- como intermediario.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1649596P | 1996-04-30 | 1996-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006876A1 true AR006876A1 (es) | 1999-09-29 |
Family
ID=21777423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101731A AR006876A1 (es) | 1996-04-30 | 1997-04-25 | Procedimiento e intermedios para preparar el compuesto {2-(2-[1,2,4]- triazol-3-ilmetil)-1,2,3,4-tetrahidroisoquinolin-6-il} amida del acido 4'-trifluorometilbifenil-2-carboxilico |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5998623A (es) |
| EP (1) | EP0902785B1 (es) |
| JP (1) | JPH11507959A (es) |
| KR (1) | KR20000065152A (es) |
| CN (1) | CN1216988A (es) |
| AR (1) | AR006876A1 (es) |
| AT (1) | ATE223400T1 (es) |
| AU (1) | AU711279B2 (es) |
| BR (1) | BR9709137A (es) |
| CA (1) | CA2252621C (es) |
| CZ (1) | CZ346498A3 (es) |
| DE (1) | DE69715188T2 (es) |
| DK (1) | DK0902785T3 (es) |
| ES (1) | ES2180935T3 (es) |
| HU (1) | HUP9902157A3 (es) |
| ID (1) | ID17294A (es) |
| IL (1) | IL126202A0 (es) |
| PL (1) | PL329739A1 (es) |
| PT (1) | PT902785E (es) |
| TR (1) | TR199802163T2 (es) |
| WO (1) | WO1997041111A1 (es) |
| YU (1) | YU16297A (es) |
| ZA (1) | ZA973696B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197798B1 (en) | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
| CA2324801A1 (en) * | 1999-11-10 | 2001-05-10 | Andrew Gordon Swick | Use of apo b secretion/mtp inhibitors and anti-obesity agents |
| CA2324800A1 (en) * | 1999-11-10 | 2001-05-10 | Mary Anne Hickman | Use of apo b secretion/mtp inhibitors |
| CO5271688A1 (es) * | 1999-11-10 | 2003-04-30 | Pfizer Prod Inc | Uso de inhibidor de secrecion de apoliproteinas b y/o de proteina de transferencia de trigliceridos microsmales |
| IL139450A0 (en) * | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Methods of administering apo b-secretion/mtp inhibitors |
| EP1259484B1 (en) * | 2000-01-18 | 2005-05-18 | Novartis AG | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion |
| WO2002014276A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| AU2001277728A1 (en) * | 2000-08-10 | 2002-02-25 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| JP5697296B2 (ja) | 2004-03-05 | 2015-04-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 高脂血症および高コレステロール血症に関連する障害または疾患を、副作用を最小限にしつつ処置するための方法 |
| WO2008075949A1 (en) * | 2006-12-20 | 2008-06-26 | Friesland Brands B.V. | Modulation of human microsomal triglyceride transfer protein (mtp or mttp) gene expression by food-grade/ingested dietary microorganisms |
| CN116322682A (zh) | 2020-07-29 | 2023-06-23 | 艾米琳制药有限责任公司 | 在治疗儿科患者的高脂血症和高胆固醇血症的方法中使用的洛美他派 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2091102C (en) * | 1992-03-06 | 2009-05-26 | John R. Ii Wetterau | Microsomal triglyceride transfer protein |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicyclic compounds and pharmaceutical compositions containing them |
| WO1996040640A1 (en) * | 1995-06-07 | 1996-12-19 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
| DK0832069T3 (da) * | 1995-06-07 | 2003-04-22 | Pfizer | Biphenyl-2-carboxylsyre-tetrahydroisoquinolin-6-ylamidderivater, deres fremstilling og deres anvendelse som inhibitorer af sekretion af mikrosomalt triglyceridoverførselsprotein og/eller apolipoprotein B (Apo B) |
-
1997
- 1997-03-13 DE DE69715188T patent/DE69715188T2/de not_active Expired - Fee Related
- 1997-03-13 CA CA002252621A patent/CA2252621C/en not_active Expired - Fee Related
- 1997-03-13 US US09/147,197 patent/US5998623A/en not_active Expired - Fee Related
- 1997-03-13 ES ES97905354T patent/ES2180935T3/es not_active Expired - Lifetime
- 1997-03-13 EP EP97905354A patent/EP0902785B1/en not_active Expired - Lifetime
- 1997-03-13 CN CN97194209A patent/CN1216988A/zh active Pending
- 1997-03-13 HU HU9902157A patent/HUP9902157A3/hu unknown
- 1997-03-13 PT PT97905354T patent/PT902785E/pt unknown
- 1997-03-13 DK DK97905354T patent/DK0902785T3/da active
- 1997-03-13 KR KR1019980708760A patent/KR20000065152A/ko not_active Ceased
- 1997-03-13 BR BR9709137A patent/BR9709137A/pt not_active Application Discontinuation
- 1997-03-13 PL PL97329739A patent/PL329739A1/xx unknown
- 1997-03-13 IL IL12620297A patent/IL126202A0/xx unknown
- 1997-03-13 AU AU22266/97A patent/AU711279B2/en not_active Ceased
- 1997-03-13 TR TR1998/02163T patent/TR199802163T2/xx unknown
- 1997-03-13 WO PCT/IB1997/000254 patent/WO1997041111A1/en not_active Ceased
- 1997-03-13 JP JP9538686A patent/JPH11507959A/ja active Pending
- 1997-03-13 AT AT97905354T patent/ATE223400T1/de not_active IP Right Cessation
- 1997-03-13 CZ CZ983464A patent/CZ346498A3/cs unknown
- 1997-04-25 AR ARP970101731A patent/AR006876A1/es unknown
- 1997-04-28 ID IDP971403A patent/ID17294A/id unknown
- 1997-04-29 YU YU16297A patent/YU16297A/sh unknown
- 1997-04-29 ZA ZA973696A patent/ZA973696B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1216988A (zh) | 1999-05-19 |
| IL126202A0 (en) | 1999-05-09 |
| ID17294A (id) | 1997-12-18 |
| TR199802163T2 (xx) | 1999-02-22 |
| CA2252621A1 (en) | 1997-11-06 |
| PL329739A1 (en) | 1999-04-12 |
| AU711279B2 (en) | 1999-10-07 |
| ATE223400T1 (de) | 2002-09-15 |
| AU2226697A (en) | 1997-11-19 |
| DE69715188T2 (de) | 2003-01-02 |
| WO1997041111A1 (en) | 1997-11-06 |
| DK0902785T3 (da) | 2002-10-07 |
| JPH11507959A (ja) | 1999-07-13 |
| HUP9902157A2 (hu) | 2000-04-28 |
| HUP9902157A3 (en) | 2000-07-28 |
| US5998623A (en) | 1999-12-07 |
| DE69715188D1 (de) | 2002-10-10 |
| BR9709137A (pt) | 1999-08-03 |
| YU16297A (sh) | 1999-09-27 |
| ZA973696B (en) | 1998-10-29 |
| PT902785E (pt) | 2002-12-31 |
| CZ346498A3 (cs) | 1999-09-15 |
| ES2180935T3 (es) | 2003-02-16 |
| EP0902785B1 (en) | 2002-09-04 |
| CA2252621C (en) | 2002-09-03 |
| KR20000065152A (ko) | 2000-11-06 |
| EP0902785A1 (en) | 1999-03-24 |
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