AR006748A1 - Compuestos de acidos 4-amino-2-heterobiciclo¨(3.1.0)hexano-4,6-dicarboxilicos utiles como reguladores de la funcion metabotropica de los glutamato-receptores y formulaciones farmaceuticas que los comprenden - Google Patents
Compuestos de acidos 4-amino-2-heterobiciclo¨(3.1.0)hexano-4,6-dicarboxilicos utiles como reguladores de la funcion metabotropica de los glutamato-receptores y formulaciones farmaceuticas que los comprendenInfo
- Publication number
- AR006748A1 AR006748A1 ARP960105205A ARP960105205A AR006748A1 AR 006748 A1 AR006748 A1 AR 006748A1 AR P960105205 A ARP960105205 A AR P960105205A AR P960105205 A ARP960105205 A AR P960105205A AR 006748 A1 AR006748 A1 AR 006748A1
- Authority
- AR
- Argentina
- Prior art keywords
- aromatic
- group
- monocyclic
- heterocyclic
- condensed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuesto de ácidos 4-amino-2-heterabiciclo [3.1.0]-hexano-4,6- dicarboxílicos útiles como reguladores de la función metabotrópica de losglutamato-receptores que tienen la fórmula (I), en la que X es O, NRa, S, SO u SO2; R es unáto mo de hidrógeno, un grupo alquilo C1-C6, un grupoalquenilo C2-C6; un grupo alquinilo C2-C6, un grupo aromático opcionalmente sustituido, un grupo heteroaromático opcionalmente sustituido, un grupocarbocíclico no aromático, un grupoheterocíclico no aromático, un grupo carbocíclico monocíclico no aromático condensado con uno o dos gruposaromáticos o heteroaromáticos monocílicos, un grupo heterocíclico monocíclico no aromático condensado con uno o dos grupos aromáticoso heteroaromáti cosmonocíclicos; o un alquilo C1-C6, alquenilo C2-C6 o alquinilo C2-C6 que está sustituido con uno, dos o tres grupos seleccionados de formaindependiente entre un grupo aromático opcionalmente sustituido, un grupoheteroaromático opcion almente sustituido, un grupo carbocíclico no aromático,un grupo heterocíclico no aromático, un grupo carbocíclico monocíclico no aromático condensado con uno o dos grupos aromáticos o heteroaromáticosmonocíclicos y ungrupo heterocíclico mon ocíclico no aromático, condensado con uno o dos grupos aromáticos o heteroaromáticos monocíclicos; Ra eshidrógeno o un grupo de fórmula (CO)nRb; n es 0 o 1; y Rb es como se ha descripto para R; o uno de susésteres o amidas metabólicamen te lábiles notóxicos; o una de sus sales farmacéuticamente aceptables. También se proponen composiciones farmacéuticas que incluyen dichos compuestos de fórmula (I) comoagente activo para regular la funciónmencionada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US686495P | 1995-11-16 | 1995-11-16 | |
| GBGB9605434.1A GB9605434D0 (en) | 1996-03-15 | 1996-03-15 | Excitatory amino acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006748A1 true AR006748A1 (es) | 1999-09-29 |
Family
ID=26308935
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105205A AR006748A1 (es) | 1995-11-16 | 1996-11-15 | Compuestos de acidos 4-amino-2-heterobiciclo¨(3.1.0)hexano-4,6-dicarboxilicos utiles como reguladores de la funcion metabotropica de los glutamato-receptores y formulaciones farmaceuticas que los comprenden |
| ARP960105204A AR004602A1 (es) | 1995-11-16 | 1996-11-15 | Procedimiento para preparar compuestos de acidos 4-amino-2-heterobiciclo [3.1.0]hexan-4,6-dicarboxilicos, de sus sales farmaceuticamente aceptables yenantiomeros de los mismos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105204A AR004602A1 (es) | 1995-11-16 | 1996-11-15 | Procedimiento para preparar compuestos de acidos 4-amino-2-heterobiciclo [3.1.0]hexan-4,6-dicarboxilicos, de sus sales farmaceuticamente aceptables yenantiomeros de los mismos. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0774461B1 (es) |
| KR (1) | KR19990067598A (es) |
| CN (1) | CN1202167A (es) |
| AR (2) | AR006748A1 (es) |
| AT (1) | ATE319685T1 (es) |
| AU (1) | AU703409B2 (es) |
| BR (1) | BR9611511A (es) |
| CA (1) | CA2237910C (es) |
| CO (1) | CO4770955A1 (es) |
| CZ (1) | CZ150198A3 (es) |
| DE (1) | DE69635886T2 (es) |
| EA (1) | EA001617B1 (es) |
| ES (1) | ES2258771T3 (es) |
| HU (1) | HUP9903459A3 (es) |
| IL (1) | IL124487A (es) |
| NO (1) | NO982202D0 (es) |
| NZ (1) | NZ323205A (es) |
| PE (1) | PE17798A1 (es) |
| PL (1) | PL326695A1 (es) |
| TR (1) | TR199800877T2 (es) |
| WO (1) | WO1997018199A1 (es) |
| YU (1) | YU60796A (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6248798A (en) * | 1997-01-29 | 1998-08-18 | Eli Lilly And Company | Treatment for premenstrual dysphoric disorder |
| US6825211B1 (en) | 1997-07-18 | 2004-11-30 | Georgetown University | Bicyclic metabotropic glutamate receptor ligands |
| AU743899B2 (en) | 1997-07-18 | 2002-02-07 | Georgetown University | Bicyclic metabotropic glutamate receptor ligands |
| DE19801646A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte alpha,beta-annellierte Butyrolactone |
| DE19801647A1 (de) * | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte beta,gamma-annellierte Lactone |
| DE19801648A1 (de) * | 1998-01-17 | 1999-07-22 | Bayer Ag | alpha-Substituierte Lactone |
| DE19801636A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte bicyclische Lactone |
| GB2355982A (en) * | 1999-11-03 | 2001-05-09 | Lilly Co Eli | Heterocyclic amino acids |
| TWI315666B (en) * | 2002-06-11 | 2009-10-11 | Lilly Co Eli | Prodrugs of excitatory amino acids |
| US8497384B2 (en) | 2008-11-14 | 2013-07-30 | Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg | Process for the production of cyclopropane derivatives |
| WO2010111080A2 (en) | 2009-03-27 | 2010-09-30 | Eli Lilly And Company | Optimized treatment of schizophrenia |
| US8735397B2 (en) * | 2010-03-29 | 2014-05-27 | Vanderbilt University | Method for treating schizophrenia and related diseases |
| SI2721012T1 (sl) | 2011-06-17 | 2016-08-31 | Eli Lilly And Company | Derivati biciklo(3.1.0)heksan-2,6-dikarboksilne kisline kot agonisti mglu2 receptorja |
| AR089718A1 (es) | 2012-02-01 | 2014-09-10 | Lilly Co Eli | AGONISTAS DE mGlu2/3 |
| EA033889B1 (ru) | 2014-01-21 | 2019-12-05 | Янссен Фармацевтика Нв | Комбинация на основе лиганда sv2a и положительного аллостерического модулятора метаботропного глутаматергического рецептора 2 подтипа |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2572842A (en) * | 1947-08-05 | 1951-10-30 | Du Pont | The n-carboanhydride of 2-amino-4, 6, 6-trimethylheptanoic acid and polymers therefrom |
| US4536330A (en) * | 1982-09-23 | 1985-08-20 | International Flavors & Fragrances Inc. | 1-Hydroxymethyl-2-acyl cyclopropane derivatives and esters and cyclic condensation products thereof, organoleptic uses of same and processes for preparing same |
| PL182285B1 (pl) * | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| EP0776200A4 (en) * | 1994-08-12 | 2001-01-17 | Lilly Co Eli | AGENT AND METHOD FOR PROTECTING DRUG ADDICTION |
| PT776201E (pt) * | 1994-08-12 | 2002-03-28 | Lilly Co Eli | Composicao e metodo para tratar a ansiedade |
-
1996
- 1996-11-12 IL IL12448796A patent/IL124487A/xx not_active IP Right Cessation
- 1996-11-12 TR TR1998/00877T patent/TR199800877T2/xx unknown
- 1996-11-12 WO PCT/US1996/018112 patent/WO1997018199A1/en not_active Ceased
- 1996-11-12 AU AU77279/96A patent/AU703409B2/en not_active Ceased
- 1996-11-12 NZ NZ323205A patent/NZ323205A/xx unknown
- 1996-11-12 CN CN96198396A patent/CN1202167A/zh active Pending
- 1996-11-12 EA EA199800377A patent/EA001617B1/ru not_active IP Right Cessation
- 1996-11-12 CZ CZ981501A patent/CZ150198A3/cs unknown
- 1996-11-12 CA CA002237910A patent/CA2237910C/en not_active Expired - Fee Related
- 1996-11-12 HU HU9903459A patent/HUP9903459A3/hu unknown
- 1996-11-12 BR BR9611511A patent/BR9611511A/pt active Search and Examination
- 1996-11-12 PL PL96326695A patent/PL326695A1/xx unknown
- 1996-11-12 KR KR1019980703624A patent/KR19990067598A/ko not_active Ceased
- 1996-11-13 PE PE1996000813A patent/PE17798A1/es not_active Application Discontinuation
- 1996-11-13 CO CO96059738A patent/CO4770955A1/es unknown
- 1996-11-14 EP EP96308216A patent/EP0774461B1/en not_active Expired - Lifetime
- 1996-11-14 AT AT96308216T patent/ATE319685T1/de not_active IP Right Cessation
- 1996-11-14 ES ES96308216T patent/ES2258771T3/es not_active Expired - Lifetime
- 1996-11-14 DE DE69635886T patent/DE69635886T2/de not_active Expired - Lifetime
- 1996-11-15 AR ARP960105205A patent/AR006748A1/es unknown
- 1996-11-15 AR ARP960105204A patent/AR004602A1/es unknown
- 1996-11-15 YU YU60796A patent/YU60796A/sh unknown
-
1998
- 1998-05-14 NO NO982202A patent/NO982202D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL326695A1 (en) | 1998-10-26 |
| IL124487A (en) | 2001-01-11 |
| DE69635886D1 (de) | 2006-05-04 |
| CN1202167A (zh) | 1998-12-16 |
| IL124487A0 (en) | 1998-12-06 |
| NZ323205A (en) | 1999-06-29 |
| HUP9903459A2 (hu) | 2001-04-28 |
| AR004602A1 (es) | 1998-12-16 |
| ATE319685T1 (de) | 2006-03-15 |
| EP0774461A1 (en) | 1997-05-21 |
| CA2237910A1 (en) | 1997-05-22 |
| CA2237910C (en) | 2005-12-27 |
| NO982202L (no) | 1998-05-14 |
| ES2258771T3 (es) | 2006-09-01 |
| WO1997018199A1 (en) | 1997-05-22 |
| YU60796A (sh) | 1998-12-23 |
| EP0774461B1 (en) | 2006-03-08 |
| EA199800377A1 (ru) | 1998-10-29 |
| BR9611511A (pt) | 1999-05-04 |
| AU7727996A (en) | 1997-06-05 |
| HUP9903459A3 (en) | 2001-08-28 |
| CZ150198A3 (cs) | 1998-10-14 |
| CO4770955A1 (es) | 1999-04-30 |
| PE17798A1 (es) | 1998-04-18 |
| AU703409B2 (en) | 1999-03-25 |
| KR19990067598A (ko) | 1999-08-25 |
| EA001617B1 (ru) | 2001-06-25 |
| DE69635886T2 (de) | 2006-10-19 |
| TR199800877T2 (xx) | 1998-09-21 |
| NO982202D0 (no) | 1998-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |