AR006719A1 - Derivados de bencilamina y formulacion farmaceutica que comprende a uno de dichos derivados. - Google Patents
Derivados de bencilamina y formulacion farmaceutica que comprende a uno de dichos derivados.Info
- Publication number
- AR006719A1 AR006719A1 ARP970101597A ARP970101597A AR006719A1 AR 006719 A1 AR006719 A1 AR 006719A1 AR P970101597 A ARP970101597 A AR P970101597A AR P970101597 A ARP970101597 A AR P970101597A AR 006719 A1 AR006719 A1 AR 006719A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- derivatives
- heteroarylalkyl
- cycloalkenyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000003939 benzylamines Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 1
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- -1 substituted Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
Se refiere a derivados de bencilamina de fórmula (I) en la cual R1 y R2, iguales o diferentes, son restos arilo, heteroarilo, arilalquilo,heteroarilalquilo, alquilo, cicloalquilo, cicloalquenilo, alquenilo, alquinilo, alcoxialquilosubs tituidos o no substituidos, o hidrógeno, o unode R1 y R2 es como se ha indicado precedentemente y el otro es hidroxi; R3 y R4 pueden ser iguales o diferentes, son restos arilo, heteroarilo,arilalquilo, heteroarilalquilo, alquilo,cicloalquilo , cicloalquilalquilo, cicloalquenilo, alquenilo, alquinilo, alcoxialquilo, haloalquilo,haloalquenilo, haloalquinilo, alquilcarboxi, carboxialquilo, substituidos o no substituidos, hidrógeno, ciano o carboxilo; o uno de R3 y R4junto con unode R 1 y R2 y el átomo de N al cual está unido forma un anillo heterocíclico de 5 o 6 miembros; R5 es halógeno, hidrógeno, alquilo y alcoxi; y R6 es unsubstituyente del anillo simple de fórmula (II), en donde la línea punteada es unenlace opcional; Y es oxígeno o -NR8 en donde R8 es hidrógeno o alquilo yR7 es uno o más substituyentes seleccionados entre hidrógeno, halógeno, haloalquilo, alquilo y alcoxi; o una sal o solvato farmacéuticamenteaceptable de los mismos.Estos compuestos se u tilizan en terapéutica médica, particularmente para el tratamiento de la depresión.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96201065 | 1996-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006719A1 true AR006719A1 (es) | 1999-09-08 |
Family
ID=8223896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101597A AR006719A1 (es) | 1996-04-19 | 1997-04-21 | Derivados de bencilamina y formulacion farmaceutica que comprende a uno de dichos derivados. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0898566B1 (es) |
| JP (1) | JP4008033B2 (es) |
| CN (1) | CN1139580C (es) |
| AR (1) | AR006719A1 (es) |
| AT (1) | ATE227278T1 (es) |
| AU (1) | AU725847B2 (es) |
| BR (1) | BR9708790A (es) |
| CA (1) | CA2251820C (es) |
| CZ (1) | CZ295747B6 (es) |
| DE (1) | DE69716896T2 (es) |
| DK (1) | DK0898566T3 (es) |
| ES (1) | ES2186888T3 (es) |
| HU (1) | HU224637B1 (es) |
| ID (1) | ID17723A (es) |
| IL (1) | IL120669A (es) |
| NO (1) | NO311976B1 (es) |
| NZ (1) | NZ332334A (es) |
| PL (1) | PL192561B1 (es) |
| PT (1) | PT898566E (es) |
| RU (1) | RU2179553C2 (es) |
| TR (1) | TR199802104T2 (es) |
| TW (1) | TW498070B (es) |
| WO (1) | WO1997040027A1 (es) |
| ZA (1) | ZA973209B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080773A (en) | 1997-10-14 | 2000-06-27 | Akzo Nobel, N.V. | Benzylamine derivatives which are useful in treating psychiatric disorders |
| US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| DK1216244T3 (da) * | 1999-09-14 | 2003-11-17 | Aventis Pharma Inc | Benzisoxazolyl-, pyridoisoxazolyl- og benzothienylphenoxyderivater som D4-antagonister |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| US7253165B2 (en) | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| JP2006502995A (ja) * | 2002-07-19 | 2006-01-26 | メモリー・ファーマシューティカルズ・コーポレイション | ホスホジエステラーゼ４阻害剤としての６−アミノ−１ｈ−インダゾール及び４−アミノベンゾフラン化合物 |
| DE602004025354D1 (de) * | 2003-08-14 | 2010-03-18 | Hoffmann La Roche | Gabanerge modulatoren |
| GB0321538D0 (en) * | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
| AU2007205114B2 (en) * | 2006-01-06 | 2012-11-08 | Sunovion Pharmaceuticals Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| EP1925305A1 (en) * | 2006-10-23 | 2008-05-28 | N.V. Organon | Ih channel inhibitors for the promotion of wakefulness |
| AU2009330745B2 (en) * | 2008-12-24 | 2012-04-05 | Astrazeneca Ab | Ethanamine compounds and their use for treating depression |
| WO2011003895A1 (en) | 2009-07-07 | 2011-01-13 | N.V. Organon | 2-(1,2-benzisoxazol-3-yl)benzylamine derivatives |
| CN102942464B (zh) * | 2012-12-06 | 2015-04-08 | 西北师范大学 | 化合物1-(2-卤苯基)-3-甲基-丁酮-1的合成方法 |
| CN112300061B (zh) * | 2020-10-06 | 2022-02-18 | 大连理工大学 | 一种含氮杂环二芳酮化合物的制备方法 |
| GB202103012D0 (en) | 2021-03-03 | 2021-04-14 | King S College London | Compounds |
| GB202103008D0 (en) | 2021-03-03 | 2021-04-14 | King S College London | Compounds |
| GB202103017D0 (en) | 2021-03-03 | 2021-04-14 | King S College London | Compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980365A (en) * | 1987-07-13 | 1990-12-25 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
| FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1997
- 1997-04-15 ZA ZA9703209A patent/ZA973209B/xx unknown
- 1997-04-15 CZ CZ19983349A patent/CZ295747B6/cs not_active IP Right Cessation
- 1997-04-15 CN CNB971947376A patent/CN1139580C/zh not_active Expired - Lifetime
- 1997-04-15 NZ NZ332334A patent/NZ332334A/en not_active IP Right Cessation
- 1997-04-15 DE DE69716896T patent/DE69716896T2/de not_active Expired - Lifetime
- 1997-04-15 TR TR1998/02104T patent/TR199802104T2/xx unknown
- 1997-04-15 HU HU9901434A patent/HU224637B1/hu not_active IP Right Cessation
- 1997-04-15 RU RU98120691/04A patent/RU2179553C2/ru not_active IP Right Cessation
- 1997-04-15 DK DK97919371T patent/DK0898566T3/da active
- 1997-04-15 PT PT97919371T patent/PT898566E/pt unknown
- 1997-04-15 IL IL12066997A patent/IL120669A/en not_active IP Right Cessation
- 1997-04-15 EP EP97919371A patent/EP0898566B1/en not_active Expired - Lifetime
- 1997-04-15 CA CA002251820A patent/CA2251820C/en not_active Expired - Lifetime
- 1997-04-15 AT AT97919371T patent/ATE227278T1/de active
- 1997-04-15 JP JP53769997A patent/JP4008033B2/ja not_active Expired - Lifetime
- 1997-04-15 ES ES97919371T patent/ES2186888T3/es not_active Expired - Lifetime
- 1997-04-15 BR BR9708790A patent/BR9708790A/pt not_active Application Discontinuation
- 1997-04-15 AU AU23870/97A patent/AU725847B2/en not_active Expired
- 1997-04-15 WO PCT/EP1997/001904 patent/WO1997040027A1/en not_active Ceased
- 1997-04-15 PL PL329348A patent/PL192561B1/pl not_active IP Right Cessation
- 1997-04-19 TW TW086105111A patent/TW498070B/zh not_active IP Right Cessation
- 1997-04-21 AR ARP970101597A patent/AR006719A1/es active IP Right Grant
- 1997-04-21 ID IDP971328A patent/ID17723A/id unknown
-
1998
- 1998-10-16 NO NO19984836A patent/NO311976B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |