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AR006550A1 - METHOD OF PREPARATION OF PHOSPHODIESTERASE IV INHIBITORS - Google Patents

METHOD OF PREPARATION OF PHOSPHODIESTERASE IV INHIBITORS

Info

Publication number
AR006550A1
AR006550A1 ARP970101372A ARP970101372A AR006550A1 AR 006550 A1 AR006550 A1 AR 006550A1 AR P970101372 A ARP970101372 A AR P970101372A AR P970101372 A ARP970101372 A AR P970101372A AR 006550 A1 AR006550 A1 AR 006550A1
Authority
AR
Argentina
Prior art keywords
phosphodiesterase
inhibitors
preparation
phenyl
alkyl
Prior art date
Application number
ARP970101372A
Other languages
Spanish (es)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612083.7A external-priority patent/GB9612083D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR006550A1 publication Critical patent/AR006550A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un procedimiento para la preparación de inhibidores de fosfodiessterasa IV de fórmula estructural I en donde R1 es alquil, alquenil fenil o fenilsustituido, que comprende la adición de P1 a un intermediario 2, mediante el tratamiento de 2 con (r1)3M seguido por remoción reductiva del grupo sulfinilo.A process for the preparation of phosphodiesterase IV inhibitors of structural formula I where R1 is alkyl, alkenyl phenyl or phenyl substituted, comprising the addition of P1 to an intermediate 2, by treating 2 with (r1) 3M followed by reductive removal of the sulfinyl group.

ARP970101372A 1996-04-17 1997-04-07 METHOD OF PREPARATION OF PHOSPHODIESTERASE IV INHIBITORS AR006550A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1568796P 1996-04-17 1996-04-17
GBGB9612083.7A GB9612083D0 (en) 1996-06-10 1996-06-10 Method of preparing phosphodiesterase IV inhibitors

Publications (1)

Publication Number Publication Date
AR006550A1 true AR006550A1 (en) 1999-09-08

Family

ID=26309476

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101372A AR006550A1 (en) 1996-04-17 1997-04-07 METHOD OF PREPARATION OF PHOSPHODIESTERASE IV INHIBITORS

Country Status (10)

Country Link
EP (1) EP0898564A1 (en)
CN (1) CN1216532A (en)
AR (1) AR006550A1 (en)
AU (1) AU2459297A (en)
BR (1) BR9708684A (en)
CZ (1) CZ333298A3 (en)
EA (1) EA000877B1 (en)
SK (1) SK143198A3 (en)
TW (1) TW426669B (en)
WO (1) WO1997038976A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE217611T1 (en) * 1996-09-17 2002-06-15 Merck & Co Inc METHOD FOR PRODUCING PHOSPHODIESTERASE IV INHIBITORS
TW508353B (en) * 1996-09-17 2002-11-01 Merck & Co Inc Method of preparing phosphodiesterase IV inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263495B (en) * 1992-12-23 1995-11-21 Celltech Ltd
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process

Also Published As

Publication number Publication date
CZ333298A3 (en) 1999-03-17
EA000877B1 (en) 2000-06-26
WO1997038976A1 (en) 1997-10-23
CN1216532A (en) 1999-05-12
EP0898564A1 (en) 1999-03-03
AU2459297A (en) 1997-11-07
BR9708684A (en) 1999-08-03
TW426669B (en) 2001-03-21
SK143198A3 (en) 1999-06-11
EA199800931A1 (en) 1999-04-29

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