AR006308A1 - Sistema dispensador; un metodo para estabilizar una composicion; una composicion acuosa y el uso del sistema dispensador. - Google Patents
Sistema dispensador; un metodo para estabilizar una composicion; una composicion acuosa y el uso del sistema dispensador.Info
- Publication number
- AR006308A1 AR006308A1 ARP970100422A ARP970100422A AR006308A1 AR 006308 A1 AR006308 A1 AR 006308A1 AR P970100422 A ARP970100422 A AR P970100422A AR P970100422 A ARP970100422 A AR P970100422A AR 006308 A1 AR006308 A1 AR 006308A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- biologically effective
- effective compound
- dispensing system
- aqueous
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 13
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 8
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- UOQFZGVGGMHGEE-UHFFFAOYSA-N 1,1-dihydroxypropan-2-one Chemical class CC(=O)C(O)O UOQFZGVGGMHGEE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000013011 aqueous formulation Substances 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1081—Arrangements for pumping several liquids or other fluent materials from several containers, e.g. for mixing them at the moment of pumping
- B05B11/1084—Arrangements for pumping several liquids or other fluent materials from several containers, e.g. for mixing them at the moment of pumping each liquid or other fluent material being pumped by a separate pump
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un sistemas dispensador que permite la aplicación de una composición acuosa que contiene un compuesto biológicamente efectivo estabilizadoadecuadamente. Se utiliza un sistema dispensador de dos cámaras en donde están contenidas de forma sseparada una composición que comprende uncompuesto biológicamente efectivo y una composición básica acuosa. El sistema dispensador entrega ambas composiciones simultáneamente, con lo cual lascomposiciones se mezclan para dar como resultado una composición final adecuada para una aplicación directa, de dicho compuesto biológicamenteefectivo en su forma activa. La primer y segunda composición se entregan en una relación que varía de 1:1 a 1:50. Adicionalmente la composición puedec omprenderotro ingrediente activo. También puede contener agentes para aumentar la viscosidad. El compuesto biológicamente activo son inestablesen la formulación acuosa final en la cual se debería aplicar. Preferentemente dichos compuestos pueden ser enzimas,antibióticos, vitaminas,dihidroxiacetonas, etc. Se refiere también a un método para estabilizar físicamente una composición que comprende adicionar un agente para aumentarla viscosidad a la composición de un compuesto biol ógicamente efectivoformulado en forma de partículas. Otro objeto es una composición acuosaque comprende el compuesto biológicamente efectivo. Finalmente describe el uso del sistema dispensador para el empleo de aplicaciones tópicas del compuesto biológicamenteefectivo.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200190 | 1996-01-31 | ||
| EP96200594 | 1996-03-08 | ||
| EP96201713 | 1996-06-21 | ||
| EP96202781 | 1996-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006308A1 true AR006308A1 (es) | 1999-08-25 |
Family
ID=27443289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100422A AR006308A1 (es) | 1996-01-31 | 1997-02-03 | Sistema dispensador; un metodo para estabilizar una composicion; una composicion acuosa y el uso del sistema dispensador. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6117433A (es) |
| EP (1) | EP0817613B1 (es) |
| JP (1) | JPH11503465A (es) |
| KR (1) | KR100517060B1 (es) |
| CN (1) | CN1140261C (es) |
| AR (1) | AR006308A1 (es) |
| AT (1) | ATE291897T1 (es) |
| AU (1) | AU1721697A (es) |
| BR (1) | BR9702049B1 (es) |
| CA (1) | CA2216169C (es) |
| DE (1) | DE69732881T2 (es) |
| ES (1) | ES2237789T3 (es) |
| ID (1) | ID18666A (es) |
| MX (1) | MX9707487A (es) |
| PT (1) | PT817613E (es) |
| WO (1) | WO1997027841A1 (es) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5947335A (en) * | 1996-10-15 | 1999-09-07 | Lever Brothers Company | Dual compartment package |
| US6082588A (en) * | 1997-01-10 | 2000-07-04 | Lever Brothers Company, Division Of Conopco, Inc. | Dual compartment package and pumps |
| EP0996428A2 (en) * | 1997-07-08 | 2000-05-03 | Dsm N.V. | Topical application of a combination of benzoyl peroxide and a second active ingredient |
| KR100351620B1 (ko) * | 1999-07-09 | 2002-09-10 | 주식회사대성미생물연구소 | 3차 결정구조의 내열성 효소 |
| KR100340086B1 (ko) * | 1999-08-27 | 2002-06-12 | 안용찬 | 비듬방지용 샴푸조성물 |
| US6585984B1 (en) * | 2000-03-03 | 2003-07-01 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Dual composition cosmetic product with a concentration sensitive and an incompatible active respectively placed within first and second compositions |
| AU2001255487A1 (en) * | 2000-04-21 | 2001-11-07 | Nature's Cure | Salicylic acid acne spray formulations and methods for treating acne with same |
| US20030206897A1 (en) * | 2000-09-13 | 2003-11-06 | The Procter & Gamble Company | Cosmetic compositions |
| EP1317249A1 (en) * | 2000-09-13 | 2003-06-11 | The Procter & Gamble Company | Cosmetic compositions |
| AU2000274827A1 (en) * | 2000-09-13 | 2002-03-26 | The Procter And Gamble Company | Cosmetic compositions |
| WO2002022100A1 (en) * | 2000-09-13 | 2002-03-21 | The Procter & Gamble Company | Cosmetic method |
| AU2000274825A1 (en) * | 2000-09-13 | 2002-03-26 | The Procter And Gamble Company | Cosmetic method |
| JP2004509861A (ja) * | 2000-09-13 | 2004-04-02 | ザ、プロクター、エンド、ギャンブル、カンパニー | 皮膚及び/又は毛髪を処理するための化粧方法 |
| JP2002326924A (ja) * | 2001-05-07 | 2002-11-15 | Hayashibara Biochem Lab Inc | 洗顔料 |
| US7364565B2 (en) * | 2001-07-27 | 2008-04-29 | Ramot At Tel Aviv University Ltd. | Controlled enzymatic removal and retrieval of cells |
| GB0126433D0 (en) * | 2001-11-03 | 2002-01-02 | Astrazeneca Ab | Compounds |
| ATE423104T1 (de) * | 2001-11-03 | 2009-03-15 | Astrazeneca Ab | Quinazolin derivate als antitumor-mittel |
| CA2416305A1 (en) * | 2002-01-31 | 2003-07-31 | Davies, John | Shaving, after-shave, and skin conditioning compositions |
| US20080152722A1 (en) * | 2002-01-31 | 2008-06-26 | Norburn Robert B | Skin care composition |
| US20080152613A1 (en) * | 2002-01-31 | 2008-06-26 | Norburn Robert B | Method for manufacturing a skin care composition |
| TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
| US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| FR2840215B1 (fr) * | 2002-06-03 | 2004-08-27 | Oreal | Composition contenant un actif susceptible d'etre oxyde par un hydroperoxyde, une lipoxygenase et un substrat et procede mettant en oeuvre cette composition |
| DE10241073A1 (de) * | 2002-09-05 | 2004-03-11 | Beiersdorf Ag | Kosmetikum mit aktivierbaren Pflegekomponenten |
| GB0309009D0 (en) * | 2003-04-22 | 2003-05-28 | Astrazeneca Ab | Quinazoline derivatives |
| GB0309850D0 (en) * | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
| CA2477922C (en) * | 2003-08-20 | 2010-10-26 | Seikagaku Corporation | Stabilizing agent for enzymes |
| DE10342211A1 (de) * | 2003-09-12 | 2005-04-07 | Beiersdorf Ag | Kosmetikum |
| GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
| JP2007505873A (ja) * | 2003-09-16 | 2007-03-15 | アストラゼネカ アクチボラグ | チロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
| US8318752B2 (en) * | 2003-09-19 | 2012-11-27 | Astrazeneca Ab | 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoyl-methyl)piperidin-4-yl]oxy}quinazoline, its pharmaceutically acceptable salts, and pharmaceutical compositions comprising the same |
| EP1670782B1 (en) * | 2003-09-19 | 2007-02-14 | AstraZeneca AB | Quinazoline derivatives |
| CA2540008A1 (en) * | 2003-09-25 | 2005-04-07 | Astrazeneca Ab | Quinazoline derivatives |
| WO2005032729A1 (ja) * | 2003-10-03 | 2005-04-14 | Kao Corporation | 吐出装置 |
| EA200600745A1 (ru) * | 2003-10-10 | 2006-10-27 | Космедикал Апс | Ингибирование роста волос |
| CN1870965A (zh) * | 2003-10-31 | 2006-11-29 | 宝洁公司 | 提供共混组合物的方法 |
| GB0326459D0 (en) * | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| JP2008501675A (ja) * | 2004-06-04 | 2008-01-24 | アストラゼネカ アクチボラグ | Erbb受容体型チロシンキナーゼとしてのキナゾリン誘導体 |
| JP2005350384A (ja) * | 2004-06-09 | 2005-12-22 | Blc:Kk | 基礎化粧方法 |
| CN101005853B (zh) | 2004-07-26 | 2011-05-04 | 莫茨药物股份两合公司 | 包含肉毒杆菌神经毒素的治疗组合物 |
| JP4881875B2 (ja) | 2004-12-14 | 2012-02-22 | アストラゼネカ アクチボラグ | 抗腫瘍剤としてのピラゾロピリミジン化合物 |
| KR20070107151A (ko) * | 2005-02-26 | 2007-11-06 | 아스트라제네카 아베 | 티로신 키나제 억제제로서의 퀴나졸린 유도체 |
| GB0504474D0 (en) * | 2005-03-04 | 2005-04-13 | Astrazeneca Ab | Chemical compounds |
| GB0508717D0 (en) * | 2005-04-29 | 2005-06-08 | Astrazeneca Ab | Chemical compounds |
| GB0508715D0 (en) * | 2005-04-29 | 2005-06-08 | Astrazeneca Ab | Chemical compounds |
| US7378084B2 (en) * | 2005-07-01 | 2008-05-27 | Playtex Products, Inc. | Sunless tanning composition and method of sunless tanning |
| EP1931362A2 (en) * | 2005-08-10 | 2008-06-18 | Maya-Biotech Ltd. | Drug delivery system for topical administration |
| DE602006018331D1 (de) * | 2005-09-20 | 2010-12-30 | Astrazeneca Ab | 4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs |
| USD543864S1 (en) | 2005-09-20 | 2007-06-05 | Cho Sean H | Dual dispenser package with single actuator |
| WO2007034143A1 (en) * | 2005-09-20 | 2007-03-29 | Astrazeneca Ab | Quinazoline derivatives as anticancer agents |
| USD543865S1 (en) | 2005-09-20 | 2007-06-05 | Walters Peter J | Dual dispenser package with dual actuators |
| WO2007063291A1 (en) * | 2005-12-02 | 2007-06-07 | Astrazeneca Ab | 4-anilino-substituted quinazoline derivatives as tyrosine kinase inhibitors |
| ATE443053T1 (de) * | 2005-12-02 | 2009-10-15 | Astrazeneca Ab | Als inhibitoren von erbb-tyrosinkinase verwendete chinazoleinderivate |
| EP1921070A1 (de) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| BRPI0807234A2 (pt) * | 2007-02-06 | 2014-06-03 | Boehringer Ingelheim Int | Heterociclos bicíclicos, composições farmacêuticas que contêm estes compostos, o uso dos mesmos e processos para a preparação dos mesmos |
| US8569221B2 (en) * | 2007-08-30 | 2013-10-29 | Kimberly-Clark Worldwide, Inc. | Stain-discharging and removing system |
| KR20100111291A (ko) * | 2008-02-07 | 2010-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 스피로사이클릭 헤테로사이클, 상기 화합물을 함유하는 약제, 이의 용도 및 이의 제조 방법 |
| MY183041A (en) | 2008-05-13 | 2021-02-08 | Astrazeneca Ab | Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- {[1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy}quinazoline |
| CA2733153C (en) * | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
| US20120076742A1 (en) * | 2010-04-21 | 2012-03-29 | Phillips D Howard | Topical drug delivery system with dual carriers |
| CN104254370A (zh) | 2011-12-20 | 2014-12-31 | 欧瑞莲研发有限公司 | 具有防衰老活性的化合物 |
| US9931656B2 (en) * | 2014-04-18 | 2018-04-03 | The Clorox Company | Dual chamber spray dispenser |
| CN107177567B (zh) * | 2016-02-16 | 2018-07-03 | 上海青瑞食品科技有限公司 | 一种液体酶制剂及制备方法 |
| EP3210630A1 (en) | 2016-02-29 | 2017-08-30 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical compositions |
| EP3231420A1 (en) | 2016-02-29 | 2017-10-18 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical compositions |
| EP3210596A1 (en) | 2016-02-29 | 2017-08-30 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical composition |
| FR3052035B1 (fr) | 2016-06-02 | 2020-10-09 | Oreal | Systeme de distribution d'un produit cosmetique |
| WO2018177730A1 (de) | 2017-03-27 | 2018-10-04 | Evonik Degussa Gmbh | Verfahren und erzeugnis zur herstellung ceramidhaltiger formulierungen |
| JP7080247B2 (ja) * | 2017-03-31 | 2022-06-03 | アモーレパシフィック コーポレーション | アメントフラボンの安定度が向上した透明または半透明の化粧料組成物 |
| WO2018195415A1 (en) * | 2017-04-21 | 2018-10-25 | Phi Therapeutics, Inc. | Compositions comprising propionibacterium acnes bacteriophages for treating acne |
| IT201900006994A1 (it) * | 2019-05-20 | 2020-11-20 | Biodermol Ambiente S R L | Ceppi batterici per uso industriale |
| US20230017360A1 (en) * | 2019-11-22 | 2023-01-19 | Samyang Holdings Corporation | Kit for preparing nanoparticle composition for drug delivery |
| KR20230029260A (ko) * | 2021-08-24 | 2023-03-03 | (주)아모레퍼시픽 | 효소 손상을 방지하는 화장료 조성물 및 이를 저장하는 화장품 용기 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR6318M (es) * | 1967-04-04 | 1968-09-23 | ||
| FR2032202A5 (es) * | 1969-02-21 | 1970-11-20 | Oreal | |
| US3834075A (en) * | 1973-02-12 | 1974-09-10 | Tre X Injector Syst Co | Tree trunk pressure feeding device |
| US3992813A (en) * | 1975-07-07 | 1976-11-23 | Freshel David C | Tree treating system |
| US4243543A (en) * | 1979-05-11 | 1981-01-06 | Economics Laboratory, Inc. | Stabilized liquid enzyme-containing detergent compositions |
| US4556554A (en) * | 1981-06-01 | 1985-12-03 | Germaine Monteil Cosmetiques Corp. | Immobilized enzymes |
| AU3667189A (en) * | 1988-06-23 | 1990-01-04 | Unilever Plc | Enzyme-containing liquid detergents |
| US4959179A (en) * | 1989-01-30 | 1990-09-25 | Lever Brothers Company | Stabilized enzymes liquid detergent composition containing lipase and protease |
| WO1991000094A1 (en) * | 1989-06-28 | 1991-01-10 | Finn Tranberg | A new papaverine injection system |
| ES2044718T3 (es) * | 1989-12-21 | 1994-01-01 | Novo Nordisk As | Preparacion que contiene enzimas y detergente que contiene dicha preparacion. |
| DE4023601A1 (de) * | 1990-07-25 | 1992-01-30 | Henkel Kgaa | Fluessige enzymzubereitung |
| DE4121820A1 (de) * | 1991-07-02 | 1993-01-07 | Basf Ag | Mikrokapseldispersionen |
| TW203552B (en) * | 1992-02-18 | 1993-04-11 | J Baroody Lloyd | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| US5252312A (en) * | 1992-09-30 | 1993-10-12 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Package effervescible composition |
| AU687803B2 (en) * | 1993-03-31 | 1998-03-05 | Schering-Plough Healthcare Products, Inc. | Sunless tanning method and apparatus |
| JPH09506127A (ja) * | 1993-12-03 | 1997-06-17 | バックマン・ラボラトリーズ・インターナショナル・インコーポレーテッド | ブロックコポリマーによる酵素安定化 |
| US5843409A (en) * | 1994-08-08 | 1998-12-01 | Colgate Palmolive Company | Two component dentifrice for the treatment of dentinal hypersensitivity |
| FR2725897B1 (fr) * | 1994-10-24 | 1996-12-06 | Oreal | Produit pour application topique contenant une lipase et un precurseur d'actif |
-
1997
- 1997-01-31 AU AU17216/97A patent/AU1721697A/en not_active Abandoned
- 1997-01-31 CA CA002216169A patent/CA2216169C/en not_active Expired - Fee Related
- 1997-01-31 BR BRPI9702049-4A patent/BR9702049B1/pt not_active IP Right Cessation
- 1997-01-31 KR KR1019970706871A patent/KR100517060B1/ko not_active Expired - Fee Related
- 1997-01-31 US US08/930,685 patent/US6117433A/en not_active Expired - Lifetime
- 1997-01-31 WO PCT/EP1997/000507 patent/WO1997027841A1/en not_active Ceased
- 1997-01-31 ID IDP970303A patent/ID18666A/id unknown
- 1997-01-31 JP JP9527321A patent/JPH11503465A/ja not_active Ceased
- 1997-01-31 AT AT97904378T patent/ATE291897T1/de not_active IP Right Cessation
- 1997-01-31 ES ES97904378T patent/ES2237789T3/es not_active Expired - Lifetime
- 1997-01-31 DE DE69732881T patent/DE69732881T2/de not_active Expired - Lifetime
- 1997-01-31 EP EP97904378A patent/EP0817613B1/en not_active Expired - Lifetime
- 1997-01-31 MX MX9707487A patent/MX9707487A/es not_active IP Right Cessation
- 1997-01-31 CN CNB971900523A patent/CN1140261C/zh not_active Expired - Fee Related
- 1997-01-31 PT PT97904378T patent/PT817613E/pt unknown
- 1997-02-03 AR ARP970100422A patent/AR006308A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MX9707487A (es) | 1997-11-29 |
| CN1140261C (zh) | 2004-03-03 |
| JPH11503465A (ja) | 1999-03-26 |
| PT817613E (pt) | 2005-06-30 |
| US6117433A (en) | 2000-09-12 |
| BR9702049A (pt) | 1998-01-13 |
| BR9702049B1 (pt) | 2010-08-10 |
| AU1721697A (en) | 1997-08-22 |
| DE69732881T2 (de) | 2006-04-06 |
| CN1178460A (zh) | 1998-04-08 |
| ATE291897T1 (de) | 2005-04-15 |
| KR19980703467A (ko) | 1998-11-05 |
| ES2237789T3 (es) | 2005-08-01 |
| DE69732881D1 (de) | 2005-05-04 |
| EP0817613A1 (en) | 1998-01-14 |
| WO1997027841A1 (en) | 1997-08-07 |
| KR100517060B1 (ko) | 2006-05-25 |
| CA2216169C (en) | 2007-01-23 |
| EP0817613B1 (en) | 2005-03-30 |
| CA2216169A1 (en) | 1997-08-07 |
| ID18666A (id) | 1998-04-30 |
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