AR005434A1 - Imidazoles sustituidos por cicloalquilos, un procedimiento para su preparacion, composicion farmaceutica que los comprende, uso de los mismos parala manufactura de un medicamento. - Google Patents
Imidazoles sustituidos por cicloalquilos, un procedimiento para su preparacion, composicion farmaceutica que los comprende, uso de los mismos parala manufactura de un medicamento.Info
- Publication number
- AR005434A1 AR005434A1 ARP970100105A ARP970100105A AR005434A1 AR 005434 A1 AR005434 A1 AR 005434A1 AR P970100105 A ARP970100105 A AR P970100105A AR P970100105 A ARP970100105 A AR P970100105A AR 005434 A1 AR005434 A1 AR 005434A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloalkyl
- manufacture
- preparation
- pharmaceutical composition
- same
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- -1 imidazole compound Chemical class 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004173 1-benzimidazolyl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N1* 0.000 abstract 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000004546 quinazolin-4-yl group Chemical group N1=CN=C(C2=CC=CC=C12)* 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
Abstract
Un compuesto imidazol sustituído por cicloalquilo, que comprende la fórmula (I) en la cual R1 es 4 piridilo, pirimidinilo, quinolilo, isoquinolinilo,quinazolin-4-ilo, 1-imidazolilo o 1-bencimidazolilo, anillo que está sustituído tal como figura enla memoria descriptiva; R4 es fenilo, naft-1-ilo onaft-2-ilo, o un heteroarilo, que está sustituído opcionalmente con 1 o 2 sustituyentes, cada uno de los cuales se selecciona independientemente tal comofigura en la memoria descriptiva. R2 esun cicloalquilo C3-7opcionalmente sustituído, o cicloalquil C3-7-alquilo C1-10; o una de sus salesfarmacéutiamente aceptables, un procedimiento para su preparación, composición farmacéutica que los compende, uso de los mismos para lamanufactura de unmedicamento para la inhibición de la síntesis de prostaglandinas endoperóxido- sintasa-2-(PGHS-2).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1001096P | 1996-01-11 | 1996-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005434A1 true AR005434A1 (es) | 1999-06-23 |
Family
ID=21743297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100105A AR005434A1 (es) | 1996-01-11 | 1997-01-10 | Imidazoles sustituidos por cicloalquilos, un procedimiento para su preparacion, composicion farmaceutica que los comprende, uso de los mismos parala manufactura de un medicamento. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6329526B1 (es) |
| EP (1) | EP0889726B1 (es) |
| JP (1) | JP2000503304A (es) |
| CN (1) | CN1213305A (es) |
| AP (1) | AP9700912A0 (es) |
| AR (1) | AR005434A1 (es) |
| AT (1) | ATE276248T1 (es) |
| AU (1) | AU715315B2 (es) |
| BR (1) | BR9708149A (es) |
| CZ (1) | CZ218198A3 (es) |
| DE (1) | DE69730704T2 (es) |
| ES (1) | ES2229335T3 (es) |
| HU (1) | HUP9901233A2 (es) |
| ID (1) | ID18759A (es) |
| IL (1) | IL125224A0 (es) |
| MA (1) | MA24055A1 (es) |
| MX (1) | MX9805628A (es) |
| NO (1) | NO983182L (es) |
| NZ (1) | NZ330889A (es) |
| PL (1) | PL327939A1 (es) |
| TR (1) | TR199801350T2 (es) |
| UY (1) | UY24434A1 (es) |
| WO (1) | WO1997025048A1 (es) |
| ZA (1) | ZA97173B (es) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
| ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
| US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| TR199801361T2 (xx) * | 1996-01-11 | 1998-10-21 | Smithkline Beecham Corporation | Yeni ikameli imidazol bile�imleri. |
| AP9700912A0 (en) | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
| US6235760B1 (en) * | 1996-03-25 | 2001-05-22 | Smithkline Beecham Corporation | Treatment for CNS injuries |
| WO1997035856A1 (en) * | 1996-03-25 | 1997-10-02 | Smithkline Beecham Corporation | Novel treatment for cns injuries |
| WO1998007425A1 (en) | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| US5929076A (en) * | 1997-01-10 | 1999-07-27 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
| US6087381A (en) | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| US20020156104A1 (en) | 1997-06-13 | 2002-10-24 | Jerry L. Adams | Novel pyrazole and pyrazoline substituted compounds |
| WO1998057966A1 (en) | 1997-06-19 | 1998-12-23 | Smithkline Beecham Corporation | Novel aryloxy substituted pyrimidine imidazole compounds |
| TW517055B (en) | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
| US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| AU8381098A (en) | 1997-07-02 | 1999-01-25 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
| CA2306077A1 (en) | 1997-10-08 | 1999-04-15 | Smithkline Beecham Corporation | Novel cycloalkenyl substituted compounds |
| JP2001526230A (ja) | 1997-12-19 | 2001-12-18 | スミスクライン・ビーチャム・コーポレイション | ヘテロアリール置換イミダゾール化合物、その医薬組成物および使用 |
| US6096899A (en) * | 1998-04-14 | 2000-08-01 | The Regents Of The University Of Michigan | Cylic imidazole compounds having relatively low hydrogen content and relatively high nitrogen content and polymers formed therefrom |
| GB9809869D0 (en) * | 1998-05-09 | 1998-07-08 | Medical Res Council | Inhibition of protein kinases |
| PL344330A1 (en) | 1998-05-22 | 2001-10-22 | Smithkline Beecham Corp | Novel 2-alkyl substituted imidazole compounds |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6599910B1 (en) | 1998-08-20 | 2003-07-29 | Smithkline Beecham Corporation | Substituted triazole compounds |
| ES2212657T3 (es) | 1998-11-04 | 2004-07-16 | Smithkline Beecham Corporation | Pirazinas sustituidas piridin-4-il o pirimidin-4-il. |
| US6239279B1 (en) | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
| US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
| JP2003516314A (ja) * | 1999-09-17 | 2003-05-13 | スミスクライン・ビーチャム・コーポレイション | ライノウイルス感染症におけるｃｓａｉｄの使用 |
| US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| WO2001038314A1 (en) | 1999-11-23 | 2001-05-31 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors |
| ES2249309T3 (es) | 1999-11-23 | 2006-04-01 | Smithkline Beecham Corp | Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa. |
| US7172769B2 (en) | 1999-12-08 | 2007-02-06 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| EP1534282B1 (en) | 2002-07-09 | 2006-12-27 | Boehringer Ingelheim Pharma GmbH & Co.KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| US20050004098A1 (en) * | 2003-03-20 | 2005-01-06 | Britten Nancy Jean | Dispersible formulation of an anti-inflammatory agent |
| MXPA05009978A (es) * | 2003-03-20 | 2005-11-04 | Pharmacia Corp | Formulacion dispersable de un agente antiinflamatorio. |
| US20050009931A1 (en) * | 2003-03-20 | 2005-01-13 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| US20040214753A1 (en) * | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| US7105467B2 (en) * | 2003-07-08 | 2006-09-12 | Pharmacore, Inc. | Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives |
| US7105707B2 (en) * | 2003-12-17 | 2006-09-12 | Pharmacore, Inc. | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| US20080119498A1 (en) * | 2004-12-06 | 2008-05-22 | Masatomo Kato | Therapeutic Agent for Pruritus Comprising P38 Map Kinase Inhibitor as the Active Ingredient |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| JP2007145819A (ja) * | 2005-10-28 | 2007-06-14 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| WO2007056016A2 (en) * | 2005-11-02 | 2007-05-18 | Kemia, Inc. | Bisamide cytokine inhibitors |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| EP2111861A1 (en) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
| ES2897740T3 (es) | 2011-12-28 | 2022-03-02 | Kyoto Prefectural Public Univ Corp | Normalización del cultivo de células endoteliales de la córnea |
| WO2015072580A1 (ja) | 2013-11-14 | 2015-05-21 | 学校法人同志社 | 細胞増殖促進または細胞障害抑制による角膜内皮治療薬 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP3691620B1 (en) | 2017-10-05 | 2022-07-27 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| US20240165148A1 (en) | 2021-03-15 | 2024-05-23 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2748119A (en) | 1954-06-23 | 1956-05-29 | Searle & Co | 6-furyl and 6-thienyl derivatives of 4-trifluoromethyl-2-pyrimidinamines |
| US3557114A (en) | 1968-12-23 | 1971-01-19 | Merck & Co Inc | 1-substituted-3-(2-pyrimidinyl) imidazolium salts |
| US3707475A (en) | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
| US3940486A (en) | 1971-05-10 | 1976-02-24 | Ciba-Geigy Corporation | Imidazole derivatives in the treatment of pain |
| US3929807A (en) | 1971-05-10 | 1975-12-30 | Ciba Geigy Corp | 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles |
| US4058614A (en) | 1973-12-04 | 1977-11-15 | Merck & Co., Inc. | Substituted imidazole compounds and therapeutic compositions therewith |
| US4199592A (en) | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
| GR75287B (es) | 1980-07-25 | 1984-07-13 | Ciba Geigy Ag | |
| US4503065A (en) | 1982-08-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl 1-2-halo imidazoles |
| US4565875A (en) | 1984-06-27 | 1986-01-21 | Fmc Corporation | Imidazole plant growth regulators |
| US4686231A (en) | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
| IL83467A0 (en) | 1986-08-15 | 1988-01-31 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same |
| JPH06504779A (ja) | 1990-12-13 | 1994-06-02 | スミスクライン・ビーチャム・コーポレイション | 新規ｃｓａｉｄｓ |
| ZA919797B (en) | 1990-12-13 | 1992-10-28 | Smithkline Beecham Corp | Bicyclo-5,6-dihydro-7h-pyrrolo-1,20-imidazol-7-ols and 7-ones |
| US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
| MX9300141A (es) * | 1992-01-13 | 1994-07-29 | Smithkline Beecham Corp | Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
| US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| US5593991A (en) * | 1993-07-16 | 1997-01-14 | Adams; Jerry L. | Imidazole compounds, use and process of making |
| IL110296A (en) | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
| US5670527A (en) * | 1993-07-16 | 1997-09-23 | Smithkline Beecham Corporation | Pyridyl imidazole compounds and compositions |
| AU7629594A (en) * | 1993-07-21 | 1995-02-20 | Smithkline Beecham Corporation | Imidazoles for treating cytokine mediated disease |
| WO1995009847A1 (en) | 1993-10-01 | 1995-04-13 | Ciba-Geigy Ag | Pyrimidineamine derivatives and processes for the preparation thereof |
| US5543520A (en) | 1993-10-01 | 1996-08-06 | Ciba-Geigy Corporation | Pyrimidine derivatives |
| DK0672041T3 (da) | 1993-10-01 | 2002-02-25 | Novartis Ag | Farmakologisk aktive pyridinderivater og fremgangsmåder til fremstilling deraf |
| US5705502A (en) | 1993-10-01 | 1998-01-06 | Novartis Corporation | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
| HUP0102677A3 (en) | 1995-01-12 | 2002-09-30 | Smithkline Beecham Corp | Trisubstituted imidazole derivatives, process for their preparation and pharmaceutical compositions containing them |
| US5658903A (en) * | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| US5739143A (en) * | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
| TR199801361T2 (xx) | 1996-01-11 | 1998-10-21 | Smithkline Beecham Corporation | Yeni ikameli imidazol bile�imleri. |
| ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
| AP9700912A0 (en) | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
| WO1997025047A1 (en) | 1996-01-11 | 1997-07-17 | Smithkline Beecham Corporation | Novel cycloalkyl substituded imidazoles |
| WO1997035856A1 (en) | 1996-03-25 | 1997-10-02 | Smithkline Beecham Corporation | Novel treatment for cns injuries |
| US6235760B1 (en) | 1996-03-25 | 2001-05-22 | Smithkline Beecham Corporation | Treatment for CNS injuries |
| EP0959886A4 (en) | 1996-11-20 | 2001-05-02 | Merck & Co Inc | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS |
-
1997
- 1997-01-02 AP AP9700912A patent/AP9700912A0/xx unknown
- 1997-01-08 UY UY24434A patent/UY24434A1/es unknown
- 1997-01-08 MA MA24456A patent/MA24055A1/fr unknown
- 1997-01-09 ZA ZA97173A patent/ZA97173B/xx unknown
- 1997-01-10 DE DE69730704T patent/DE69730704T2/de not_active Expired - Fee Related
- 1997-01-10 IL IL12522497A patent/IL125224A0/xx unknown
- 1997-01-10 TR TR1998/01350T patent/TR199801350T2/xx unknown
- 1997-01-10 NZ NZ330889A patent/NZ330889A/xx unknown
- 1997-01-10 US US09/101,416 patent/US6329526B1/en not_active Expired - Fee Related
- 1997-01-10 CZ CZ982181A patent/CZ218198A3/cs unknown
- 1997-01-10 AU AU22425/97A patent/AU715315B2/en not_active Ceased
- 1997-01-10 EP EP97905576A patent/EP0889726B1/en not_active Expired - Lifetime
- 1997-01-10 WO PCT/US1997/000619 patent/WO1997025048A1/en not_active Ceased
- 1997-01-10 JP JP9525466A patent/JP2000503304A/ja not_active Ceased
- 1997-01-10 BR BR9708149A patent/BR9708149A/pt unknown
- 1997-01-10 AT AT97905576T patent/ATE276248T1/de not_active IP Right Cessation
- 1997-01-10 ES ES97905576T patent/ES2229335T3/es not_active Expired - Lifetime
- 1997-01-10 AR ARP970100105A patent/AR005434A1/es unknown
- 1997-01-10 CN CN97192881A patent/CN1213305A/zh active Pending
- 1997-01-10 HU HU9901233A patent/HUP9901233A2/hu unknown
- 1997-01-10 PL PL97327939A patent/PL327939A1/xx unknown
- 1997-01-10 ID IDP970056A patent/ID18759A/id unknown
-
1998
- 1998-07-10 NO NO983182A patent/NO983182L/no not_active Application Discontinuation
- 1998-07-10 MX MX9805628A patent/MX9805628A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL125224A0 (en) | 1999-03-12 |
| MX9805628A (es) | 1998-11-29 |
| NZ330889A (en) | 2000-03-27 |
| EP0889726B1 (en) | 2004-09-15 |
| CZ218198A3 (cs) | 1999-09-15 |
| ZA97173B (en) | 1997-07-18 |
| ATE276248T1 (de) | 2004-10-15 |
| PL327939A1 (en) | 1999-01-04 |
| MA24055A1 (fr) | 1997-10-01 |
| US6329526B1 (en) | 2001-12-11 |
| DE69730704D1 (de) | 2004-10-21 |
| AU2242597A (en) | 1997-08-01 |
| EP0889726A1 (en) | 1999-01-13 |
| JP2000503304A (ja) | 2000-03-21 |
| HUP9901233A2 (hu) | 2000-04-28 |
| DE69730704T2 (de) | 2005-09-22 |
| AU715315B2 (en) | 2000-01-20 |
| TR199801350T2 (xx) | 1998-10-21 |
| CN1213305A (zh) | 1999-04-07 |
| AP9700912A0 (en) | 1997-01-31 |
| NO983182L (no) | 1998-09-09 |
| EP0889726A4 (en) | 1999-07-21 |
| ID18759A (id) | 1998-05-07 |
| WO1997025048A1 (en) | 1997-07-17 |
| ES2229335T3 (es) | 2005-04-16 |
| BR9708149A (pt) | 1999-07-27 |
| UY24434A1 (es) | 1997-06-06 |
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