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AR005123A1 - DERIVATIVES OF CARBOXYLIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM AND USE OF SUCH DERIVATIVES - Google Patents

DERIVATIVES OF CARBOXYLIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM AND USE OF SUCH DERIVATIVES

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Publication number
AR005123A1
AR005123A1 ARP960105745A ARP960105745A AR005123A1 AR 005123 A1 AR005123 A1 AR 005123A1 AR P960105745 A ARP960105745 A AR P960105745A AR P960105745 A ARP960105745 A AR P960105745A AR 005123 A1 AR005123 A1 AR 005123A1
Authority
AR
Argentina
Prior art keywords
cycloalkyl
lower alkyl
hydrogen
heteroaryl
aryl
Prior art date
Application number
ARP960105745A
Other languages
Spanish (es)
Original Assignee
Agouron Pharma
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma, Hoffmann La Roche filed Critical Agouron Pharma
Publication of AR005123A1 publication Critical patent/AR005123A1/en

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Abstract

Derivados de acidos carboxilicos que responden a la formula (I), en donde: n es 0, 1 o 2; Y es hidroxilo o XONH-, donde X es hidrogeno o alquilo inferior;R1 es hidrogeno o alquilo inferior; R2 es hidrogeno, alquilo inferior, heteroalquilo,arilo, aralquilo, arilheteroalquilo, cicloalquilo,cicloalquilalquilo, heteroarilo, heteroalquilo, heteroarilheteroalquilo, heterociclo, heterociclo-alquilo inferior, heterociclo-heteroalquilo inferior oNR6R7, donde: R6 es hidrogeno, alquiloin ferior, cicloalquilo o cicloalquil alquilo, arilo, heteroarilo y heteroaralquilo; R7 es hidrogeno, alquiloinferior, cicloalquilo o cicloalquil alquilo, arilo, aralquilo, heteroarilo, heteroaralquilo, -C(O)NR8R9, -SO2NR8R9, -SO2R10,ariloxicarb onilo, oalcoxicarbonilo; o R6 y R7 junto con el atomo de nitrogeno al que estan unidos son un grupo heterociclo donde: R8 y R9 son independientemente hidrogeno,alquilo inferior, cicloalquilo, cicloalquilalquilo, arilo, aralquilo,heteroari lo, heteroaralquilo o heteroalquilo; y R10 es alquilo inferior,cicloalquilo, cicloalquilalquilo, arilo, aralquilo, heteroarilo, heteroaralquilo, heteroalquilo o heterociclo; o R1 y R2 junto con el atomo decarbono al queestan unidos re presentan un grupo cicloalquilo o heterociclo; R3 es hidrogeno, alquilo inferior, cicloalquilo, cicloalquilalquilo, arilo,aralquilo, heteroarilo, heteroaralquilo, heteroalquilo o alcoxilo inferior; R4 es hidrogeno, alquiloinferior, cicloalquilo o cicloalquilalquilo; o R2 y R3junto con los carbonos a los que estan unidos son un grupo cicloalquilo o heteroaciclo; o R3 y R4 junto con el carbono al que estan unidos son un grupocicloalquilo o heterociclo; y R5 esalquilo inferior, cicloalq uilo, cicloalquilalquilo, arilo, aralquilo, heteroarilo o heteroaralquilo; o salesDerivatives of carboxylic acids that respond to formula (I), where: n is 0, 1 or 2; Y is hydroxyl or XONH-, where X is hydrogen or lower alkyl, R1 is hydrogen or lower alkyl; R2 is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroalkyl, heteroarylheteroalkyl, heterocycle, heterocyclo-lower alkyl, heterocycloalkylalkyl or NR6R7, where: R6 is hydrogen, alkyl, alkyl alkyl, aryl, heteroaryl, and heteroaralkyl; R7 is hydrogen, lower alkyl, cycloalkyl or cycloalkyl alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, -C (O) NR8R9, -SO2NR8R9, -SO2R10, aryloxycarbonyl, oalkoxycarbonyl; or R6 and R7 together with the nitrogen atom to which they are attached are a heterocycle group where: R8 and R9 are independently hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or heteroalkyl; and R10 is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalkyl, or heterocycle; or R1 and R2 together with the carbon atom to which they are attached represent a cycloalkyl or heterocycle group; R3 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroalkyl, or lower alkoxy; R4 is hydrogen, lower alkyl, cycloalkyl, or cycloalkylalkyl; or R2 and R3 together with the carbons to which they are attached are a cycloalkyl or heterocyclo group; or R3 and R4 together with the carbon to which they are attached are a cycloalkyl or heterocycle group; and R5 is lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or you go out

ARP960105745A 1996-08-07 1996-12-18 DERIVATIVES OF CARBOXYLIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM AND USE OF SUCH DERIVATIVES AR005123A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2243996P 1996-08-07 1996-08-07

Publications (1)

Publication Number Publication Date
AR005123A1 true AR005123A1 (en) 1999-04-14

Family

ID=51929247

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105745A AR005123A1 (en) 1996-08-07 1996-12-18 DERIVATIVES OF CARBOXYLIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM AND USE OF SUCH DERIVATIVES

Country Status (1)

Country Link
AR (1) AR005123A1 (en)

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