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AR004822A1 - Proceso mejorado en la produccion de n-[3-[3-cianopirazolo[1,5-a]pirimidin- 7-il)fenil]-n-etil-acetamida - Google Patents

Proceso mejorado en la produccion de n-[3-[3-cianopirazolo[1,5-a]pirimidin- 7-il)fenil]-n-etil-acetamida

Info

Publication number
AR004822A1
AR004822A1 ARP960105438A ARP960105438A AR004822A1 AR 004822 A1 AR004822 A1 AR 004822A1 AR P960105438 A ARP960105438 A AR P960105438A AR P960105438 A ARP960105438 A AR P960105438A AR 004822 A1 AR004822 A1 AR 004822A1
Authority
AR
Argentina
Prior art keywords
ethyl
acetamide
phenyl
production
pirimidin
Prior art date
Application number
ARP960105438A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR004822A1 publication Critical patent/AR004822A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención consiste en una mejora del proceso para la producción de N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-N-etil-acetamida que es útilcomo un ansiolítico, antiepiléptico, agente sedativo-hipnótico y relajante músculoesquelét ico. La mejora del proceso se caracteriza por la adición deagua a la reacción de 3-dimetilamino-1-(3-N-etil-N-acetil-aminofenil)-2-propen- a-ona con 3-aminopirazol-4-carbonitrilo en ácido acético.
ARP960105438A 1995-12-01 1996-11-29 Proceso mejorado en la produccion de n-[3-[3-cianopirazolo[1,5-a]pirimidin- 7-il)fenil]-n-etil-acetamida AR004822A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US785995P 1995-12-01 1995-12-01

Publications (1)

Publication Number Publication Date
AR004822A1 true AR004822A1 (es) 1999-03-10

Family

ID=21728482

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105438A AR004822A1 (es) 1995-12-01 1996-11-29 Proceso mejorado en la produccion de n-[3-[3-cianopirazolo[1,5-a]pirimidin- 7-il)fenil]-n-etil-acetamida

Country Status (25)

Country Link
US (1) US5714607A (es)
EP (1) EP0776898B1 (es)
JP (1) JP4112032B2 (es)
KR (1) KR100439282B1 (es)
CN (1) CN1057525C (es)
AR (1) AR004822A1 (es)
AT (1) ATE227290T1 (es)
AU (1) AU718310B2 (es)
BR (1) BR9605760A (es)
CA (1) CA2191647C (es)
CY (1) CY2440B1 (es)
CZ (1) CZ292253B6 (es)
DE (1) DE69624657T2 (es)
DK (1) DK0776898T3 (es)
ES (1) ES2184844T3 (es)
HU (1) HU226398B1 (es)
IL (1) IL119710A (es)
MX (1) MX9605974A (es)
NO (1) NO307181B1 (es)
NZ (1) NZ299848A (es)
PT (1) PT776898E (es)
RU (1) RU2178415C2 (es)
SK (1) SK281807B6 (es)
TW (1) TW382629B (es)
ZA (1) ZA9610008B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US20030091632A1 (en) * 1999-08-26 2003-05-15 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
CN1610682A (zh) * 2000-08-03 2005-04-27 Wyeth公司 扎来普隆多晶型物及其制备方法
EP1526136A1 (en) * 2000-08-03 2005-04-27 Wyeth Polymorphs of zaleplon and methods for the preparation thereof
AR029780A1 (es) 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
US20050032818A1 (en) * 2001-06-12 2005-02-10 Entire Interest N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon
EP1406871A4 (en) * 2001-06-12 2005-01-26 Biogal Gyogyszergyar PROCESS FOR THE PRODUCTION OF N- 3- (3-CYANOPYRAZOLO 1,5-A] PYRIMIDINE-7-YLE) PHENYL] -N-ETHYLACETAMIDE (ZALEPLON)
WO2003011228A2 (en) 2001-08-01 2003-02-13 Biogal Gyogyszergyar Rt Purification and crystalline forms of zaleplon
US7034155B2 (en) 2002-02-14 2006-04-25 Cilag Ag Method for producing n-ethyl-n-[3-(3-cyanopyrazolo[1,5a]pyrimidine-7-yl)phenyl]acetamide
WO2003068238A1 (en) * 2002-02-15 2003-08-21 Biogal Gyogyszergyar Rt. Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom
PL207322B1 (pl) * 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu
US7772394B2 (en) 2003-09-04 2010-08-10 Cipla Limited Zaleplon synthesis
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
DE602004025747D1 (de) * 2004-01-14 2010-04-08 Mallinckrodt Inc Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine
HUP0400325A3 (en) * 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
WO2005079851A2 (en) 2004-02-18 2005-09-01 Sepracor, Inc. Dopamine-agonist combination therapy with sedatives for improving sleep quality
WO2006070244A2 (en) * 2004-11-22 2006-07-06 Bakulesh Mafatlal Khamar A process for the preparation of zaleplon
WO2008021337A1 (en) 2006-08-15 2008-02-21 Wyeth Oxazinan-2-one derivatives useful as pr modulators
TW200815428A (en) * 2006-08-15 2008-04-01 Wyeth Corp Oxazolidone derivatives as PR modulators
WO2008021309A1 (en) * 2006-08-15 2008-02-21 Wyeth Imidazolidin-2-one derivatives useful as pr modulators
US7649007B2 (en) * 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
WO2008068600A2 (en) * 2006-12-06 2008-06-12 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of zaleplo
CZ2008468A3 (cs) 2008-07-31 2009-11-18 Farmak, A. S. Zpusob prípravy N-(1-benzo[b]thien-2-ylethyl)-N-hydroxymocoviny
CN102816163A (zh) * 2012-08-20 2012-12-12 四川禾邦阳光制药股份有限公司 扎来普隆的新晶型及制备方法

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US3907799A (en) * 1971-08-16 1975-09-23 Icn Pharmaceuticals Xanthine oxidase inhibitors
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
JPS62270584A (ja) * 1986-04-28 1987-11-24 Yoshitomi Pharmaceut Ind Ltd ４，７−ジヒドロピラゾロ〔１，５−ａ〕ピリミジン誘導体
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines
GB9321162D0 (en) * 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents

Also Published As

Publication number Publication date
PT776898E (pt) 2003-02-28
CZ350596A3 (en) 1997-09-17
AU718310B2 (en) 2000-04-13
NO307181B1 (no) 2000-02-21
HUP9603275A3 (en) 1997-10-28
DK0776898T3 (da) 2003-02-24
HUP9603275A2 (en) 1997-08-28
AU7409196A (en) 1997-06-05
CY2440B1 (en) 2004-11-12
ATE227290T1 (de) 2002-11-15
US5714607A (en) 1998-02-03
TW382629B (en) 2000-02-21
KR970042543A (ko) 1997-07-24
CA2191647A1 (en) 1997-06-02
KR100439282B1 (ko) 2004-08-31
RU2178415C2 (ru) 2002-01-20
CN1163893A (zh) 1997-11-05
MX9605974A (es) 1998-04-30
SK153696A3 (en) 1997-11-05
JP4112032B2 (ja) 2008-07-02
NZ299848A (en) 1998-09-24
DE69624657T2 (de) 2003-08-21
IL119710A0 (en) 1997-02-18
BR9605760A (pt) 1998-08-25
ES2184844T3 (es) 2003-04-16
JPH09216885A (ja) 1997-08-19
ZA9610008B (en) 1998-08-28
HU226398B1 (en) 2008-11-28
NO965084L (no) 1997-06-02
DE69624657D1 (de) 2002-12-12
CA2191647C (en) 2005-01-25
CZ292253B6 (cs) 2003-08-13
IL119710A (en) 1999-11-30
CN1057525C (zh) 2000-10-18
NO965084D0 (no) 1996-11-28
HU9603275D0 (en) 1997-01-28
EP0776898A1 (en) 1997-06-04
SK281807B6 (sk) 2001-08-06
EP0776898B1 (en) 2002-11-06

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