AR004777A1 - Uso de derivados de 2-tioxo-imidazolidin-4-ona para la preparacion de medicamentos y medicamentos que los contiene. - Google Patents
Uso de derivados de 2-tioxo-imidazolidin-4-ona para la preparacion de medicamentos y medicamentos que los contiene.Info
- Publication number
- AR004777A1 AR004777A1 ARP960105360A ARP960105360A AR004777A1 AR 004777 A1 AR004777 A1 AR 004777A1 AR P960105360 A ARP960105360 A AR P960105360A AR P960105360 A ARP960105360 A AR P960105360A AR 004777 A1 AR004777 A1 AR 004777A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- drugs
- imidazolidin
- thioxo
- alkynyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229920001774 Perfluoroether Polymers 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 235000012000 cholesterol Nutrition 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UGWULZWUXSCWPX-UHFFFAOYSA-N 2-sulfanylideneimidazolidin-4-one Chemical class O=C1CNC(=S)N1 UGWULZWUXSCWPX-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Uso de derivados de 2-tioxo-imidazolidin-4-ona para preparar un medicamento para incrementar la concentración de colesterol HDL en la sangre de un mamíferoque necesite una concentración elevada de colesterol HDL en la sangre, que comprende una cantidad terapéuticamente efectiva, de un compuesto de fórmula(I), en donde R es alquilo; un heterociclo N, O ó S aromático substituido o no substituido; arilo substituido o no substituido, arilalquilo, benzhidrilo óindanilo, en los que los substituyentes son uno a tres miembros independientemente seleccionado del grupo que consiste en alquilo, alcoxi,alquiltio, alquenilo, alquinilo, halo, perfluoralquilo, perfluoralcoxi o hidroxi; y R1 es arilo, alquilo, alquenilo, alquinilo, o arilo substituidodonde los substituyentes son uno a tres miembros independientemente seleccionados del grupo que consiste en alquilo, alcoxi, alquiltio, alquenilo,alquinilo, halo, perfluoralquilo, perfluoralcoxi o hidroxi, y al menos un vehículo farmacéuticamente aceptable; y medicamentos que los contienen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/563,325 US5554607A (en) | 1995-11-28 | 1995-11-28 | Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004777A1 true AR004777A1 (es) | 1999-03-10 |
Family
ID=24250053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960105360A AR004777A1 (es) | 1995-11-28 | 1996-11-27 | Uso de derivados de 2-tioxo-imidazolidin-4-ona para la preparacion de medicamentos y medicamentos que los contiene. |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US5554607A (es) |
| AR (1) | AR004777A1 (es) |
| ZA (1) | ZA969973B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1127697A (en) * | 1995-11-28 | 1997-06-19 | American Home Products Corporation | 2-thioxo-imidazolidin-4-one derivatives and their use for increasing hdl cholesterol concentration |
| US5821372A (en) * | 1995-11-28 | 1998-10-13 | American Home Products Corporation | 2-thioxo-imidazolidin-4-one derivatives |
| CA2238812A1 (en) * | 1995-11-28 | 1997-06-05 | Theodore Sylvester Sulkowski | 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives |
| EP0885197A1 (en) * | 1996-03-07 | 1998-12-23 | American Home Products Corporation | 2-thioxotetrahydropyrimidin-4-one derivatives |
| WO1998021190A1 (en) * | 1996-11-14 | 1998-05-22 | American Home Products Corporation | Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as anti-atherosclerotic agents |
| FR2823209B1 (fr) * | 2001-04-04 | 2003-12-12 | Fournier Lab Sa | Nouvelles thiohydantoines et leur utilisation en therapeutique |
| US7709517B2 (en) * | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| AU2013205325B2 (en) * | 2006-03-27 | 2016-03-24 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
| SI2656841T1 (sl) * | 2006-03-27 | 2016-11-30 | The Regents Of The University Of California | Modulator androgenih receptorjev za zdravljanje raka prostate in bolezni, povezanih z androgenimi receptorji |
| AU2016201061B2 (en) * | 2006-03-27 | 2017-03-02 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
| EP3020706A1 (en) | 2006-03-29 | 2016-05-18 | The Regents Of The University Of California | Diarylthiohydantoin compounds useful for the treatment of a hyperproliferative disorder |
| AR069039A1 (es) * | 2007-10-26 | 2009-12-23 | Univ California | Compuestos de diarilhidantoina, composicion farmaceutica, proceso de obtencion del compuesto, utiles para desordenes hiperproliferativos |
| ES2440001T3 (es) | 2009-05-12 | 2014-01-27 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos |
| LT3124481T (lt) | 2010-02-16 | 2018-06-11 | Aragon Pharmaceuticals, Inc. | Androgeno receptorių moduliatoriai ir jų panaudojimas |
| AU2013323861C1 (en) | 2012-09-26 | 2024-05-02 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
| JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| CN111479560A (zh) | 2017-10-16 | 2020-07-31 | 阿拉贡药品公司 | 用于治疗非转移性去势难治性前列腺癌的抗雄激素 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4887030A (es) * | 1972-02-24 | 1973-11-16 | ||
| US5137904A (en) * | 1989-05-30 | 1992-08-11 | G. D. Searle & Co. | Thiohydantoin inhibitors of collagen-induced and ADP-induced platelet aggregation |
| US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
| JPH04297461A (ja) * | 1991-03-27 | 1992-10-21 | Otsuka Pharmaceut Factory Inc | ２−チオヒダントイン誘導体 |
| DE4207254A1 (de) * | 1992-03-07 | 1993-09-09 | Cassella Ag | 4-oxo-2-thioxoimidazolidin-derivate |
| FR2694290B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
| DE4228717A1 (de) * | 1992-08-28 | 1994-03-03 | Cassella Ag | Imidazolidin-Derivate |
| WO1994020460A1 (en) * | 1993-03-11 | 1994-09-15 | Smithkline Beecham Corporation | Chemical compounds |
-
1995
- 1995-11-28 US US08/563,325 patent/US5554607A/en not_active Expired - Lifetime
-
1996
- 1996-11-27 ZA ZA9609973A patent/ZA969973B/xx unknown
- 1996-11-27 AR ARP960105360A patent/AR004777A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5554607A (en) | 1996-09-10 |
| ZA969973B (en) | 1998-05-27 |
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