[go: up one dir, main page]

AR004719A1 - Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n' - Google Patents

Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n'

Info

Publication number
AR004719A1
AR004719A1 ARP960105257A ARP960105257A AR004719A1 AR 004719 A1 AR004719 A1 AR 004719A1 AR P960105257 A ARP960105257 A AR P960105257A AR P960105257 A ARP960105257 A AR P960105257A AR 004719 A1 AR004719 A1 AR 004719A1
Authority
AR
Argentina
Prior art keywords
compounds
bridge
useful
pharmaceutical formulations
prepare
Prior art date
Application number
ARP960105257A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21725638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR004719(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR004719A1 publication Critical patent/AR004719A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Compuestos de bisindolilmaleimidas con un puente N, N y formulaciones farmacéuticas que los contienen, dichos compuestos también útiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente N, N. Se proponencompues tos de bisindolilmaleimidas con un puente N, Nde fórmula(I), donde R1 es bromo, yodo y además o-tosilo. Dichos compuestos son útiles como intermediarios para preparar otras bisindolilmaleimidas con unpuente N, N. Además, la invenciónproporciona for mulaciones farmacéuticas y los procedimientos de uso para preparar otras bisindolilmaleimidas y parainhibir la Proteína Quinasa C en mamíferos.
ARP960105257A 1995-11-20 1996-11-20 Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n' AR004719A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US734595P 1995-11-20 1995-11-20

Publications (1)

Publication Number Publication Date
AR004719A1 true AR004719A1 (es) 1999-03-10

Family

ID=21725638

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP960105256A AR004718A1 (es) 1995-11-20 1996-11-20 Procedimiento para preparar bisindolilmaleimidas con un puente n,n', utiles como inhibidores de la proteina c quinasa y procedimiento para preparar compuestos intermediarios de aplicacion en dicho procedimiento
ARP960105257A AR004719A1 (es) 1995-11-20 1996-11-20 Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n'

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP960105256A AR004718A1 (es) 1995-11-20 1996-11-20 Procedimiento para preparar bisindolilmaleimidas con un puente n,n', utiles como inhibidores de la proteina c quinasa y procedimiento para preparar compuestos intermediarios de aplicacion en dicho procedimiento

Country Status (31)

Country Link
EP (1) EP0776899B1 (es)
JP (2) JP4100708B2 (es)
KR (1) KR100342142B1 (es)
CN (1) CN1066734C (es)
AR (2) AR004718A1 (es)
AT (1) ATE191219T1 (es)
AU (1) AU701659B2 (es)
BR (1) BR9611709A (es)
CA (1) CA2237401C (es)
CO (1) CO4750824A1 (es)
CZ (1) CZ150398A3 (es)
DE (1) DE69607443T2 (es)
DK (1) DK0776899T3 (es)
EA (1) EA000639B1 (es)
ES (1) ES2145978T3 (es)
GR (1) GR3033729T3 (es)
HU (1) HU225716B1 (es)
IL (1) IL124415A (es)
MX (1) MX9803791A (es)
MY (1) MY118946A (es)
NO (1) NO310195B1 (es)
NZ (1) NZ323282A (es)
PE (1) PE17998A1 (es)
PL (1) PL184728B1 (es)
PT (1) PT776899E (es)
TR (1) TR199800876T2 (es)
TW (1) TW371661B (es)
UA (1) UA56145C2 (es)
WO (1) WO1997019080A1 (es)
YU (1) YU49316B (es)
ZA (1) ZA969645B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506868A (ja) * 1998-03-13 2002-03-05 ザ ユニバーシティー オブ ブリティッシュ コロンビア 癌治療において用いるためのグラニュラチミド誘導体
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6300106B1 (en) 2000-11-22 2001-10-09 Ppg Industries Ohio, Inc. Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate
EP2181999A1 (en) 2008-11-03 2010-05-05 Zentiva, A.S. Method of manufacturing ruboxistarin
CN119343136A (zh) * 2022-03-31 2025-01-21 4M治疗公司 作为激酶抑制剂的n-去甲基鲁伯斯塔
EP4654966A1 (en) * 2023-01-27 2025-12-03 Mellicell, Inc. Methods and compositions for treatment of obesity and diseases associated with fat cell enlargement

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
PT657458E (pt) 1993-12-07 2002-02-28 Lilly Co Eli Inibidores de proteina cinase c
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
HUP9901975A2 (hu) 1999-11-29
PL184728B1 (pl) 2002-12-31
NZ323282A (en) 1999-01-28
IL124415A (en) 2003-11-23
DE69607443T2 (de) 2000-08-10
PT776899E (pt) 2000-08-31
JP2008138006A (ja) 2008-06-19
NO310195B1 (no) 2001-06-05
GR3033729T3 (en) 2000-10-31
EA000639B1 (ru) 1999-12-29
AR004718A1 (es) 1999-03-10
ZA969645B (en) 1998-05-18
NO982105L (no) 1998-05-08
CA2237401C (en) 2003-10-21
IL124415A0 (en) 1998-12-06
YU61096A (sh) 1999-03-04
CN1207740A (zh) 1999-02-10
NO982105D0 (no) 1998-05-08
MY118946A (en) 2005-02-28
CN1066734C (zh) 2001-06-06
JP4100708B2 (ja) 2008-06-11
CA2237401A1 (en) 1997-05-29
EP0776899B1 (en) 2000-03-29
DE69607443D1 (de) 2000-05-04
PL326753A1 (en) 1998-10-26
WO1997019080A1 (en) 1997-05-29
TR199800876T2 (xx) 1998-08-21
TW371661B (en) 1999-10-11
UA56145C2 (uk) 2003-05-15
BR9611709A (pt) 1999-02-23
ATE191219T1 (de) 2000-04-15
ES2145978T3 (es) 2000-07-16
EA199800368A1 (ru) 1998-12-24
HUP9901975A3 (en) 2000-01-28
YU49316B (sh) 2005-06-10
KR19990067600A (ko) 1999-08-25
PE17998A1 (es) 1998-04-20
JP2000500496A (ja) 2000-01-18
MX9803791A (es) 1998-09-30
DK0776899T3 (da) 2000-07-10
KR100342142B1 (ko) 2002-08-22
HU225716B1 (en) 2007-07-30
CO4750824A1 (es) 1999-03-31
CZ150398A3 (cs) 1998-12-16
EP0776899A1 (en) 1997-06-04
AU701659B2 (en) 1999-02-04
AU7738896A (en) 1997-06-11

Similar Documents

Publication Publication Date Title
ES552627A0 (es) Procedimiento para la preparacion de carbamatos de fenilo
ES2100151T3 (es) Nuevos derivados de benzopirano, procedimientos para su preparacion y su uso y composiciones que contienen los compuestos.
ES520988A0 (es) Procedimiento para la preparacion de nuevos 6,11-dihidro-dibenzo-(b,e)-tiepin-11-n-alcohilnorescopin-eteres.
ES2068179T3 (es) Benzo(5,6)-ciclohepta-piridinas, composiciones y metodo de uso.
ES2144192T3 (es) Nuevos derivados de 1-fenil-2-dimetil-amino-metil-ciclohexan-1-ol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
EA199900381A1 (ru) Арил(тио)эфиры галогенпиримидина в качестве пестицидов
PT758248E (pt) Formulacoes para o factor ix
ES2138691T3 (es) Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina.
ES500876A0 (es) Procedimiento para la preparacion de nuevos transplantes de organos
CL2004001102A1 (es) Compuestos derivados de 2-amino-4-bicicloamino-1,3,5-triazinas; composicion herbicida que los contiene; procedimiento de preparacion; uso de dichos compuestos; y compuestos intermediarios.
DK173883D0 (da) Substituerede 8-phenylxanthiner
ES516648A0 (es) "procedimiento para la preparacion de n-(2-piridiloxifenil)-n-benzoilureas substituidas".
MX9204844A (es) Derivados de benzodioxano, procedimiento para su preparacion composiciones farmaceuticas que los contienen.
ES509871A0 (es) "procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil)-bencimidazolonas sustituidas".
MA19882A1 (fr) Derives d'acides w-amines, leur preparation et utilisation ainsi que les compositions contenant ces acides.
AR004719A1 (es) Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n'
FI892222A0 (fi) Peptidalkoholer med antikoagulantverkan.
EA199900241A1 (ru) ЗАМЕЩЕННЫЕ 1,2,3,4-ТЕТРАГИДРО-2-ДИБЕНЗОФУРАНАМИНЫ И 2-АМИНОЦИКЛОГЕПТА [b] БЕНЗОФУРАНЫ
EA200000365A1 (ru) Полиморфные модификации дофетилида
ES545004A0 (es) Un procedimiento para producir un acetileno.
ES2038163T3 (es) Procedimiento para preparar 1,3-dioxolanos trisustituidos en 2,4,4 y tetrasustituidos en 2,2,4,4.
EA199700223A1 (ru) Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции
MX9207264A (es) Compuestos de sulfonimidamida, procedimiento para su preparacion y formulaciones farmaceuticas que los contienen
ES478741A1 (es) Procedimiento para la preparacion de nuevos tetrahidrocarba-zoles y cis-hexahidrocarbazoles.
AR240042A1 (es) Derivados de acidos 7-ariloxi-naftil-2-oxi)-alcanacorboxilicos, procedimientos para su preparacion y composicones herbicidas que los contienen.