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AR004494A1 - A CELL USEFUL FOR THE TREATMENT OF PAIN, A METHOD TO PRODUCE IT, A BIOARTIFICIAL ORGAN OF UNDERSTAND IT AND A METHOD TO PREPARE SUCH ORGANOBIOARTIFICIAL - Google Patents

A CELL USEFUL FOR THE TREATMENT OF PAIN, A METHOD TO PRODUCE IT, A BIOARTIFICIAL ORGAN OF UNDERSTAND IT AND A METHOD TO PREPARE SUCH ORGANOBIOARTIFICIAL

Info

Publication number
AR004494A1
AR004494A1 ARP960102993A AR10299396A AR004494A1 AR 004494 A1 AR004494 A1 AR 004494A1 AR P960102993 A ARP960102993 A AR P960102993A AR 10299396 A AR10299396 A AR 10299396A AR 004494 A1 AR004494 A1 AR 004494A1
Authority
AR
Argentina
Prior art keywords
pain
produce
treatment
organobioartificial
understand
Prior art date
Application number
ARP960102993A
Other languages
Spanish (es)
Original Assignee
Cytotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytotherapeutics Inc filed Critical Cytotherapeutics Inc
Publication of AR004494A1 publication Critical patent/AR004494A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Una línea de células obtenidas por ingeniería genética que producen por lo menos una catecolamina, por lo menos una endorfina, y por lo menos unaencefalina, para el tratamiento del dolor. Las células pueden administrarse directamente a un paciente que las necesite, o pueden encapsularse para formarun órgano bioartificial.A line of genetically engineered cells that produce at least one catecholamine, at least one endorphin, and at least one encephalin, for the treatment of pain. The cells can be administered directly to a patient in need of them, or they can be encapsulated to form a bioartificial organ.

ARP960102993A 1995-06-07 1996-06-06 A CELL USEFUL FOR THE TREATMENT OF PAIN, A METHOD TO PRODUCE IT, A BIOARTIFICIAL ORGAN OF UNDERSTAND IT AND A METHOD TO PREPARE SUCH ORGANOBIOARTIFICIAL AR004494A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48191795A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
AR004494A1 true AR004494A1 (en) 1998-12-16

Family

ID=23913905

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102993A AR004494A1 (en) 1995-06-07 1996-06-06 A CELL USEFUL FOR THE TREATMENT OF PAIN, A METHOD TO PRODUCE IT, A BIOARTIFICIAL ORGAN OF UNDERSTAND IT AND A METHOD TO PREPARE SUCH ORGANOBIOARTIFICIAL

Country Status (20)

Country Link
EP (1) EP0833935A1 (en)
JP (1) JPH11507530A (en)
KR (1) KR19990022414A (en)
CN (1) CN1192246A (en)
AR (1) AR004494A1 (en)
AU (1) AU6263696A (en)
BR (1) BR9608746A (en)
CA (1) CA2223246A1 (en)
CZ (1) CZ392497A3 (en)
EE (1) EE9700326A (en)
HU (1) HUP9901191A2 (en)
IL (1) IL122415A0 (en)
IN (1) IN181898B (en)
IS (1) IS4628A (en)
NO (1) NO975545L (en)
PL (1) PL323867A1 (en)
SK (1) SK167997A3 (en)
TR (1) TR199701520T1 (en)
WO (1) WO1996040959A1 (en)
ZA (1) ZA964880B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2311282A1 (en) * 1997-11-28 1999-06-10 Medical Research Council Yac vectors
AU6151899A (en) * 1998-09-23 2000-04-10 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods of treating chronic pain
US6372489B1 (en) 1998-10-27 2002-04-16 Anticancer, Inc. Method and model for hair pigmentation
AU1324100A (en) * 1998-10-27 2000-05-15 Anticancer, Inc. Method and model for hair pigmentation
US6903244B1 (en) 1999-02-26 2005-06-07 University Of Utah Research Foundation Mice which are +/− or −/− for the elastin gene as models for vascular disease
AU2002952993A0 (en) 2002-11-29 2002-12-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic and diagnostic agents
CA2551189A1 (en) 2003-12-24 2005-07-07 The Walter And Eliza Hall Institute Of Medical Research Therapeutic agents and uses therefor
EP1766389A4 (en) 2004-05-12 2008-08-27 Inst Medical W & E Hall CELL ISOLATION PROCEDURE
US8686110B2 (en) 2005-06-24 2014-04-01 The Walter And Eliza Hall Institute Of Medical Research Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same
AU2007275764B2 (en) 2006-07-18 2013-11-14 University Of Utah Research Foundation Methods for treating pain and screening analgesic compounds
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
EP3003344B1 (en) 2013-05-31 2020-11-25 University of Utah Research Foundation Conotoxin peptides, pharmaceutical compositions and uses thereof
US10617738B2 (en) 2015-10-27 2020-04-14 The University Of Queensland Mammalian EphA4 polypeptide derivatives lacking one or more N-glycosylation sites and method of use thereof
CN107964047B (en) * 2017-12-18 2018-11-02 哈尔滨工业大学 Chimeric peptide and its synthetic method based on Tyr-Pro-Trp-Phe-NH2 and neurotensin (8-13) and application
CN112891337A (en) * 2021-03-26 2021-06-04 河北医科大学 Application of galangin and its derivatives in preparing medicine for preventing and treating nervous system diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7568094A (en) * 1993-08-12 1995-03-14 Cytotherapeutics, Inc. Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules

Also Published As

Publication number Publication date
CA2223246A1 (en) 1996-12-19
KR19990022414A (en) 1999-03-25
SK167997A3 (en) 1998-05-06
WO1996040959A1 (en) 1996-12-19
HUP9901191A2 (en) 1999-08-30
EP0833935A1 (en) 1998-04-08
EE9700326A (en) 1998-06-15
NO975545L (en) 1998-02-04
JPH11507530A (en) 1999-07-06
AU6263696A (en) 1996-12-30
TR199701520T1 (en) 1998-04-21
IS4628A (en) 1997-12-04
CN1192246A (en) 1998-09-02
BR9608746A (en) 1999-05-11
ZA964880B (en) 1997-01-07
CZ392497A3 (en) 1998-12-16
IL122415A0 (en) 1998-06-15
NO975545D0 (en) 1997-12-02
PL323867A1 (en) 1998-04-27
IN181898B (en) 1998-10-24

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