AR004191A1 - POLYPEPTIDES TO INDUCE PROTECTIVE IMMUNITY AGAINST TUBERCULOSIS, DNA MOLECULES THAT CODES THEM, A VECTOR OF EXPRESSION, A HOST CELL, A VACCINE, A FUSION PROTEIN, A METHOD OF DETECTING TUBERCULOSIS - Google Patents
POLYPEPTIDES TO INDUCE PROTECTIVE IMMUNITY AGAINST TUBERCULOSIS, DNA MOLECULES THAT CODES THEM, A VECTOR OF EXPRESSION, A HOST CELL, A VACCINE, A FUSION PROTEIN, A METHOD OF DETECTING TUBERCULOSISInfo
- Publication number
- AR004191A1 AR004191A1 ARP960104202A AR10420296A AR004191A1 AR 004191 A1 AR004191 A1 AR 004191A1 AR P960104202 A ARP960104202 A AR P960104202A AR 10420296 A AR10420296 A AR 10420296A AR 004191 A1 AR004191 A1 AR 004191A1
- Authority
- AR
- Argentina
- Prior art keywords
- ala
- pro
- thr
- ser
- asp
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 201000008827 tuberculosis Diseases 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title 1
- 230000036039 immunity Effects 0.000 title 1
- 230000001681 protective effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- DEFJQIDDEAULHB-IMJSIDKUSA-N L-alanyl-L-alanine Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(O)=O DEFJQIDDEAULHB-IMJSIDKUSA-N 0.000 abstract 1
- 108010056243 alanylalanine Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un polipéptido caracterizado porque comprende una porción inmunogénica de un antígeno soluble de M.tuberculosis, ó una variante de dicho antígeno quedifiere sólo en sustituciones y/o modificaciones conservadoras, en el cual dicho antígeno tiene una secuencia de N-terminal seleccionado entre el grupoque consiste en: (a) Asp-Pro-Val-Asp-Ala-Val-Ile-Asn-Thr-Thr-Cys-Asn-Tyr-Gly-Gln-Val-Val-Ala-Ala-Leu (SEC.ID. N°120)(b) Ala-Val-Glu-Ser-Gly-Met-Leu-Ala-Leu-Gly-Thr-Pro-Ala-Pro-Ser (SEC.ID. N°121) (c) Ala-Ala-Met-Lys-Pro-Arg-Thr-Gly-Asp-Gly-Pro-Leu-Glu-Ala-Ala-Lys-Glu-Gly-Arg (SEC. ID. N°122) (d) Tyr-Tyr-Trp-Gys-Pro-Gly-Gln-Pro-Phe-Asp-Pro-Ala-Trp-Gly-Pro (SEC.ID. N°123)(e) Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp-Gln-Gln-Xaa-Ala-Val (SEC.ID.N°124) (f) Ala-Glu-Glu-Ser-Ile-Ser-Thr-Xaa-Glu-Xaa-Ile-Val-Pro (SEC.ID. N°125)(g) Asp-Pro-Glu-Pro-Ala-Pro-Pro-Val-Pro-Thr-Thr-Ala-Ala-Ser-Pro-Pro-Ser (SEC. ID N° |16)(h) Ala-Pro-Lys-Thr-Tyr-Naa-Glu-Glu-Leu-Lys-Gly-Thr-Asp-Thr-Gly (SEC.ID. N° 127)(i) Asp-Pro-Ala-Ser-Ala-Pro-Asp-Val-Pro-Thr-Ala-Ala-Gln-Leu-Thr-Ser-Leu-Leu- Asn-Ser-Leu-Ala-Asp-Pro-Asn-Val-Ser-Phe-Ala-Asn (SEC.ID. N° 128)(j) Xaa-Asp-Ser-Glu-Lys-Ser-Ala-Thr-Ile-Lys-Val-Thr-Asp-Ala-Ser (SEC.ID. N°134)donde Xaa puede ser cualquier aminoácido. Esos polipéptidos se pueden formular en vacunas y/o composiciones farmacéuticas para la inmunización contra laA polypeptide characterized in that it comprises an immunogenic portion of a soluble M. tuberculosis antigen, or a variant of said antigen that differs only in conservative substitutions and / or modifications, in which said antigen has an N-terminal sequence selected from the group consisting of in: (a) Asp-Pro-Val-Asp-Ala-Val-Ile-Asn-Thr-Thr-Cys-Asn-Tyr-Gly-Gln-Val-Val-Ala-Ala-Leu (SEQ ID N 120) (b) Ala-Val-Glu-Ser-Gly-Met-Leu-Ala-Leu-Gly-Thr-Pro-Ala-Pro-Ser (SEQ ID NO: 121) (c) Ala-Ala -Met-Lys-Pro-Arg-Thr-Gly-Asp-Gly-Pro-Leu-Glu-Ala-Ala-Lys-Glu-Gly-Arg (SEQ ID NO: 122) (d) Tyr-Tyr- Trp-Gys-Pro-Gly-Gln-Pro-Phe-Asp-Pro-Ala-Trp-Gly-Pro (SEQ ID NO: 123) (e) Asp-Ile-Gly-Ser-Glu-Ser-Thr -Glu-Asp-Gln-Gln-Xaa-Ala-Val (SEQ ID NO: 124) (f) Ala-Glu-Glu-Ser-Ile-Ser-Thr-Xaa-Glu-Xaa-Ile-Val- Pro (SEQ ID NO: 125) (g) Asp-Pro-Glu-Pro-Ala-Pro-Pro-Val-Pro-Thr-Thr-Ala-Ala-Ser-Pro-Pro-Ser (SEQ ID No. 16) (h) Ala-Pro-Lys-Thr-Tyr-Naa-Glu-Glu-Leu-Lys-Gly-Thr-Asp-Thr-Gly (SEQ ID NO: 12 7) (i) Asp-Pro-Ala-Ser-Ala-Pro-Asp-Val-Pro-Thr-Ala-Ala-Gln-Leu-Thr-Ser-Leu-Leu- Asn-Ser-Leu-Ala-Asp -Pro-Asn-Val-Ser-Phe-Ala-Asn (SEC.ID. No. 128) (j) Xaa-Asp-Ser-Glu-Lys-Ser-Ala-Thr-Ile-Lys-Val-Thr-Asp-Ala-Ser (SEC.ID. No. 134) where Xaa can be any amino acid. Those polypeptides can be formulated into vaccines and / or pharmaceutical compositions for immunization against
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52343695A | 1995-09-01 | 1995-09-01 | |
| US53363495A | 1995-09-22 | 1995-09-22 | |
| US62087496A | 1996-03-22 | 1996-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004191A1 true AR004191A1 (en) | 1998-11-04 |
Family
ID=51983135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104202A AR004191A1 (en) | 1995-09-01 | 1996-09-02 | POLYPEPTIDES TO INDUCE PROTECTIVE IMMUNITY AGAINST TUBERCULOSIS, DNA MOLECULES THAT CODES THEM, A VECTOR OF EXPRESSION, A HOST CELL, A VACCINE, A FUSION PROTEIN, A METHOD OF DETECTING TUBERCULOSIS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR004191A1 (en) |
-
1996
- 1996-09-02 AR ARP960104202A patent/AR004191A1/en unknown
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