AP9901637A0 - Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid. - Google Patents
Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid.Info
- Publication number
- AP9901637A0 AP9901637A0 APAP/P/1999/001637A AP9901637A AP9901637A0 AP 9901637 A0 AP9901637 A0 AP 9901637A0 AP 9901637 A AP9901637 A AP 9901637A AP 9901637 A0 AP9901637 A0 AP 9901637A0
- Authority
- AP
- ARIPO
- Prior art keywords
- sodium salt
- phenylpyrrolidin
- indole
- dichloro
- oxo
- Prior art date
Links
- 159000000000 sodium salts Chemical class 0.000 title abstract 2
- VDIRQCDDCGAGET-DHZHZOJOSA-N 4,6-dichloro-3-[(e)-(2-oxo-1-phenylpyrrolidin-3-ylidene)methyl]-1h-indole-2-carboxylic acid Chemical compound OC(=O)C=1NC2=CC(Cl)=CC(Cl)=C2C=1\C=C(C1=O)/CCN1C1=CC=CC=C1 VDIRQCDDCGAGET-DHZHZOJOSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A crystalline hydrated form of the sodium salt of the compound of formula (i), processes for its preparation and its use in therapy.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9704498.6A GB9704498D0 (en) | 1997-03-05 | 1997-03-05 | Chemical compound |
| PCT/EP1998/001146 WO1998039327A1 (en) | 1997-03-05 | 1998-03-03 | Crystalline hydrated sodium salt of (e)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1h-indole-2-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP9901637A0 true AP9901637A0 (en) | 1999-09-30 |
Family
ID=10808697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1999/001637A AP9901637A0 (en) | 1997-03-05 | 1998-03-03 | Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid. |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0966463A1 (en) |
| JP (1) | JP2001513796A (en) |
| KR (1) | KR20000075907A (en) |
| CN (1) | CN1249750A (en) |
| AP (1) | AP9901637A0 (en) |
| AR (1) | AR011178A1 (en) |
| AU (1) | AU6825198A (en) |
| BG (1) | BG103779A (en) |
| BR (1) | BR9808305A (en) |
| CA (1) | CA2282851A1 (en) |
| CO (1) | CO4940415A1 (en) |
| EA (1) | EA199900710A1 (en) |
| EE (1) | EE9900387A (en) |
| GB (1) | GB9704498D0 (en) |
| HR (1) | HRP980114A2 (en) |
| HU (1) | HUP0002109A2 (en) |
| ID (1) | ID24207A (en) |
| IL (1) | IL131489A0 (en) |
| IS (1) | IS5166A (en) |
| NO (1) | NO994303L (en) |
| NZ (1) | NZ337315A (en) |
| OA (1) | OA11154A (en) |
| PE (1) | PE51399A1 (en) |
| PL (1) | PL335652A1 (en) |
| SK (1) | SK119699A3 (en) |
| TR (1) | TR199902117T2 (en) |
| WO (1) | WO1998039327A1 (en) |
| YU (1) | YU43499A (en) |
| ZA (1) | ZA981791B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9704499D0 (en) * | 1997-03-05 | 1997-04-23 | Glaxo Wellcome Spa | Method of manufacture |
| GB9825988D0 (en) | 1998-11-27 | 1999-01-20 | Pfizer Ltd | Indole derivatives |
| GB9915231D0 (en) | 1999-06-29 | 1999-09-01 | Pfizer Ltd | Pharmaceutical complex |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| AU2018284335A1 (en) | 2017-06-12 | 2020-01-30 | Glytech Llc. | Treatment of depression with NMDA antagonists and D2/5HT2A or selective 5HT2A antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
-
1997
- 1997-03-05 GB GBGB9704498.6A patent/GB9704498D0/en active Pending
-
1998
- 1998-03-03 NZ NZ337315A patent/NZ337315A/en unknown
- 1998-03-03 PE PE1998000149A patent/PE51399A1/en not_active Application Discontinuation
- 1998-03-03 AP APAP/P/1999/001637A patent/AP9901637A0/en unknown
- 1998-03-03 HU HU0002109A patent/HUP0002109A2/en unknown
- 1998-03-03 WO PCT/EP1998/001146 patent/WO1998039327A1/en not_active Ceased
- 1998-03-03 AR ARP980100948A patent/AR011178A1/en unknown
- 1998-03-03 CN CN98803053A patent/CN1249750A/en active Pending
- 1998-03-03 JP JP53813598A patent/JP2001513796A/en active Pending
- 1998-03-03 YU YU43499A patent/YU43499A/en unknown
- 1998-03-03 AU AU68251/98A patent/AU6825198A/en not_active Abandoned
- 1998-03-03 TR TR1999/02117T patent/TR199902117T2/en unknown
- 1998-03-03 EA EA199900710A patent/EA199900710A1/en unknown
- 1998-03-03 BR BR9808305-8A patent/BR9808305A/en not_active Application Discontinuation
- 1998-03-03 ZA ZA9801791A patent/ZA981791B/en unknown
- 1998-03-03 IL IL13148998A patent/IL131489A0/en unknown
- 1998-03-03 EP EP98913613A patent/EP0966463A1/en not_active Withdrawn
- 1998-03-03 KR KR1019997007987A patent/KR20000075907A/en not_active Withdrawn
- 1998-03-03 PL PL98335652A patent/PL335652A1/en unknown
- 1998-03-03 SK SK1196-99A patent/SK119699A3/en unknown
- 1998-03-03 CO CO98011404A patent/CO4940415A1/en unknown
- 1998-03-03 ID IDW990976A patent/ID24207A/en unknown
- 1998-03-03 EE EEP199900387A patent/EE9900387A/en unknown
- 1998-03-03 CA CA002282851A patent/CA2282851A1/en not_active Abandoned
- 1998-03-04 HR HR9704498.6A patent/HRP980114A2/en not_active Application Discontinuation
-
1999
- 1999-08-27 IS IS5166A patent/IS5166A/en unknown
- 1999-09-02 OA OA9900201A patent/OA11154A/en unknown
- 1999-09-03 NO NO994303A patent/NO994303L/en not_active Application Discontinuation
- 1999-10-04 BG BG103779A patent/BG103779A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ337315A (en) | 2001-02-23 |
| SK119699A3 (en) | 2000-05-16 |
| YU43499A (en) | 2000-12-28 |
| PL335652A1 (en) | 2000-05-08 |
| PE51399A1 (en) | 1999-06-07 |
| CO4940415A1 (en) | 2000-07-24 |
| WO1998039327A1 (en) | 1998-09-11 |
| NO994303L (en) | 1999-11-03 |
| EE9900387A (en) | 2000-04-17 |
| IS5166A (en) | 1999-08-27 |
| CA2282851A1 (en) | 1998-09-11 |
| HUP0002109A2 (en) | 2001-04-28 |
| TR199902117T2 (en) | 2000-03-21 |
| AU6825198A (en) | 1998-09-22 |
| BG103779A (en) | 2000-06-30 |
| KR20000075907A (en) | 2000-12-26 |
| GB9704498D0 (en) | 1997-04-23 |
| OA11154A (en) | 2003-04-16 |
| NO994303D0 (en) | 1999-09-03 |
| EA199900710A1 (en) | 2000-04-24 |
| IL131489A0 (en) | 2001-01-28 |
| ZA981791B (en) | 1999-09-03 |
| JP2001513796A (en) | 2001-09-04 |
| EP0966463A1 (en) | 1999-12-29 |
| HRP980114A2 (en) | 1998-12-31 |
| ID24207A (en) | 2000-07-13 |
| BR9808305A (en) | 2000-05-16 |
| AR011178A1 (en) | 2000-08-02 |
| CN1249750A (en) | 2000-04-05 |
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