AP3521A - Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors - Google Patents

Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors

Info

Publication number: AP3521A
Authority: AP; ARIPO
Prior art keywords: benzoimidazole; indeno; hsd; carbonitrile; hexahydro
Prior art date: 2010-11-05

Application number

AP2013006902A

Other languages

English (en)

Other versions

AP2013006902A0 (en

Inventor

Matthias Eckhardt

Hans-Juergen Martin

Martin Schuehle

Sandra Sick

Bing-Shiou Yang

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-11-05

Filing date

2011-11-04

Publication date

2016-01-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3521(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-11-05 Priority claimed from PCT/US2010/055586 external-priority patent/WO2011057054A1/en

2011-11-04 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2013-06-30 Publication of AP2013006902A0 publication Critical patent/AP2013006902A0/xx

2016-01-11 Application granted granted Critical

2016-01-11 Publication of AP3521A publication Critical patent/AP3521A/xx

Links

QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title 1
101100451537 Caenorhabditis elegans hsd-1 gene Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2013006902A 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors AP3521A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/US2010/055586 WO2011057054A1 (en)	2009-11-06	2010-11-05	Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US201161484995P	2011-05-11	2011-05-11
PCT/US2011/059331 WO2012061708A1 (en)	2010-11-05	2011-11-04	Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Publications (2)

Publication Number	Publication Date
AP2013006902A0 AP2013006902A0 (en)	2013-06-30
AP3521A true AP3521A (en)	2016-01-11

Family

ID=44999935

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2013006902A AP3521A (en)	2010-11-05	2011-11-04	Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors

Country Status (36)

Country	Link
US (2)	US8686149B2 (xx)
EP (1)	EP2635563B1 (xx)
JP (1)	JP2013541592A (xx)
KR (1)	KR20130119939A (xx)
CN (1)	CN103228642B (xx)
AP (1)	AP3521A (xx)
AR (1)	AR083678A1 (xx)
AU (1)	AU2011323164B2 (xx)
BR (1)	BR112013011095A2 (xx)
CA (1)	CA2816136A1 (xx)
CL (1)	CL2013001221A1 (xx)
CO (1)	CO6781480A2 (xx)
CY (1)	CY1116043T1 (xx)
DK (1)	DK2635563T3 (xx)
EA (1)	EA022406B1 (xx)
EC (2)	ECSP12011788A (xx)
ES (1)	ES2533833T3 (xx)
GE (1)	GEP20166481B (xx)
HR (1)	HRP20150327T1 (xx)
IL (1)	IL225647A0 (xx)
ME (1)	ME02066B (xx)
MX (1)	MX2013005069A (xx)
NZ (1)	NZ609281A (xx)
PE (1)	PE20140123A1 (xx)
PH (1)	PH12013500879A1 (xx)
PL (1)	PL2635563T3 (xx)
PT (1)	PT2635563E (xx)
RS (1)	RS53900B1 (xx)
SG (1)	SG189859A1 (xx)
SI (1)	SI2635563T1 (xx)
SM (1)	SMT201500095B (xx)
TN (1)	TN2012000117A1 (xx)
TW (1)	TWI537258B (xx)
UA (1)	UA110807C2 (xx)
UY (1)	UY33701A (xx)
WO (1)	WO2012061708A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200927115A (en)	2007-11-16	2009-07-01	Boehringer Ingelheim Int	Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5711115B2 (ja)	2008-05-13	2015-04-30	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用
US8703765B2 (en)	2009-06-02	2014-04-22	Boehringer Ingelheim International Gmbh	Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
EP2440537A1 (en)	2009-06-11	2012-04-18	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
WO2011159760A1 (en)	2010-06-16	2011-12-22	Vitae Pharmaceuticals, Inc.	Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja)	2011-08-17	2014-09-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	インデノピリジン誘導体
IN2014DN08582A (xx) *	2012-05-09	2015-05-22	Boehringer Ingelheim Int
EP3235813A1 (en)	2016-04-19	2017-10-25	Cidqo 2012, S.L.	Aza-tetra-cyclo derivatives
EP3679027A1 (en)	2017-09-04	2020-07-15	C4 Therapeutics, Inc.	Dihydrobenzimidazolones
WO2020181232A1 (en)	2019-03-06	2020-09-10	C4 Therapeutics, Inc.	Heterocyclic compounds for medical treatment
CN118005644B (zh) *	2024-01-29	2025-12-16	中国科学院南海海洋研究所	十氢芴型生物碱及其制备方法和在制备抗菌药物中应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009063061A2 (en) *	2007-11-16	2009-05-22	Boehringer Ingelheim International Gmbh	Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL127995C (xx)	1963-12-20		Geigy Ag J R
US3341538A (en)	1965-06-18	1967-09-12	Geigy Chem Corp	Certain 2, 6-methano-3-benzazocines
DE1785124A1 (de)	1968-08-13	1971-11-11	Prym Werke William	Reissverschluss
DE2108954A1 (en)	1971-02-25	1972-09-07	Boehringer Sohn Ingelheim	2-(furylmethyl)-6,7-benzomorphans - useful as cns active agents
GB1304175A (xx)	1969-03-31	1973-01-24
DE2105743C3 (de)	1971-02-08	1979-11-29	Boehringer Sohn Ingelheim	2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
US3681349A (en)	1970-03-05	1972-08-01	Morton Norwich Products Inc	1-(substituted benzyl) tetrahydro-2-(1h) pyrimidones
US3657257A (en)	1970-08-31	1972-04-18	Robins Co Inc A H	3-aryl-8-carbamoyl nortropanes
DE2229695A1 (de)	1972-06-19	1974-01-31	Boehringer Sohn Ingelheim	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2338369A1 (de)	1973-07-26	1975-02-13	Schering Ag	Mikrobiologische hydroxylierung von 2,6-methano-3-benzazocinen
SU510999A3 (ru)	1973-10-27	1976-04-15	К.Х.Берингер Зон, (Фирма)	Способ получени (метоксиметил-фурилметил)6,7-бензоморфанов илиморфинанов
US4009171A (en)	1974-02-21	1977-02-22	Sterling Drug Inc.	N-acylated-11-oxygenated-2,6-methano-3-benzazocine intermediates
US4087532A (en)	1974-03-09	1978-05-02	Boehringer Ingelheim Gmbh	Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
DE2411382C3 (de)	1974-03-09	1979-09-06	C.H. Boehringer Sohn, 6507 Ingelheim	2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de)	1974-08-05	1976-02-26	Boehringer Sohn Ingelheim	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
US4108857A (en)	1975-08-18	1978-08-22	Sterling Drug Inc.	Imidazolylmethyl methanobenzazocines
DE2828039A1 (de)	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
GB9510459D0 (en)	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
GB9517622D0 (en)	1995-08-29	1995-11-01	Univ Edinburgh	Regulation of intracellular glucocorticoid concentrations
DE69730980T2 (de)	1996-07-31	2006-02-23	Nikken Chemicals Co., Ltd.	6-phenyltetrahydro-1,3-oxazin-2-on derivate und medizinische zusammensetzungen, die sie enthalten
GB9623944D0 (en)	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
US6514977B1 (en)	1997-05-22	2003-02-04	G.D. Searle & Company	Substituted pyrazoles as p38 kinase inhibitors
YU54202A (sh)	2000-01-18	2006-01-16	Agouron Pharmaceuticals Inc.	Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
WO2001055063A1 (en)	2000-01-25	2001-08-02	Idemitsu Petrochemical Co., Ltd.	Novel bisadamantane compounds, process for preparing the same, and novel biadamantane derivatives
DE10034623A1 (de)	2000-07-17	2002-01-31	Bayer Ag	Heterocyclisch substituierte Pyridine als Cytokin-Inhibitoren
WO2003097608A2 (en)	2002-05-17	2003-11-27	Jenken Biosciences, Inc.	Opioid and opioid-like compounds and uses thereof
US7135575B2 (en) *	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
JP2006521359A (ja)	2003-03-26	2006-09-21	メルク　エンド　カムパニー　インコーポレーテッド	メラノコルチン−４受容体作働薬としての二環式ピペリジン誘導体
US7700583B2 (en)	2003-04-11	2010-04-20	High Point Pharmaceuticals, Llc	11β-hydroxysteroid dehydrogenase type 1 active compounds
WO2004089896A1 (en)	2003-04-11	2004-10-21	Novo Nordisk A/S	11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS
WO2005108361A1 (en)	2004-05-07	2005-11-17	Janssen Pharmaceutica N.V.	Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
WO2006024628A1 (en)	2004-08-30	2006-03-09	Janssen Pharmaceutica N.V.	Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
WO2006040329A1 (en)	2004-10-12	2006-04-20	Novo Nordisk A/S	1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds
WO2006044174A2 (en)	2004-10-13	2006-04-27	Neurogen Corporation	Aryl substituted 8-azabicyclo[3.2.1]octane compounds as ligands of the melanin concentrating hormone receptor
US20090264650A1 (en)	2005-03-31	2009-10-22	Nobuo Cho	Prophylactic/Therapeutic Agent for Diabetes
CA2627306A1 (en)	2005-11-01	2007-05-10	Transtech Pharma, Inc.	Pharmaceutical use of substituted amides
JP2009513611A (ja)	2005-11-01	2009-04-02	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	置換アミドの医薬用途
JP2007140188A (ja)	2005-11-18	2007-06-07	Fujifilm Corp	ポジ型感光性組成物及びそれを用いたパターン形成方法
WO2007076055A2 (en)	2005-12-22	2007-07-05	Entremed, Inc.	Compositions and methods comprising proteinase activated receptor antagonists
AU2006335109B2 (en)	2005-12-30	2011-04-07	Merck Sharp & Dohme Corp.	Cholesteryl ester transfer protein inhibitors
KR20080091503A (ko)	2006-01-31	2008-10-13	인사이트 코포레이션	아미도 화합물 및 약제로서의 이의 용도
EP2016047B1 (en)	2006-04-21	2013-08-28	Eli Lilly And Company	Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
ES2346925T3 (es)	2006-04-24	2010-10-21	ELI LILLY & COMPANY	Pirrolidinonas sustituidas como inhibidores de la 11 beta-dihidroesteroide deshidrogenasa 1.
ATE471311T1 (de)	2006-04-25	2010-07-15	Lilly Co Eli	Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1
PE20080344A1 (es)	2006-06-27	2008-06-09	Sanofi Aventis	Compuestos 8-azabiciclo[3.2.1]oct-8-il-1,2,3,4-tetrahidroquinolina sustituidos como inhibidores 11b-hsd1
US8132151B2 (en)	2006-07-18	2012-03-06	Yahoo! Inc.	Action tags
EP2104665A2 (en)	2006-10-19	2009-09-30	F. Hoffmann-Roche AG	Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes
TW200829171A (en)	2006-11-17	2008-07-16	Nihon Nohyaku Co Ltd	Haloalkyl sulfonanilide derivatives or salts thereof, herbicide using it as effective constituent and use-method thereof
EP1935420A1 (en)	2006-12-21	2008-06-25	Merck Sante	2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors
JP5486928B2 (ja)	2007-02-26	2014-05-07	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックウレアおよびカルバメートインヒビター
JP2010520864A (ja)	2007-03-09	2010-06-17	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	ヒドロキシステロイドデヒドロゲナーゼインヒビターとしてのインドール−及びベンズイミダゾールアミド類
EP2183229B1 (en)	2007-07-26	2012-04-18	Vitae Pharmaceuticals, Inc.	Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
AR069207A1 (es)	2007-11-07	2010-01-06	Vitae Pharmaceuticals Inc	Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2714532A1 (en)	2008-02-11	2009-08-20	Vitae Pharmaceuticals, Inc.	1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
EP2245014B1 (en) *	2008-02-12	2011-11-02	Boehringer Ingelheim International GmbH	Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8598160B2 (en)	2008-02-15	2013-12-03	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2009117109A1 (en)	2008-03-18	2009-09-24	Vitae Pharmaceuticals, Inc.	Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CA2723034A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
ES2421537T3 (es)	2008-05-01	2013-09-03	Vitae Pharmaceuticals Inc	Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
US8846668B2 (en)	2008-07-25	2014-09-30	Vitae Pharmaceuticals, Inc.	Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
DK2324018T3 (da)	2008-07-25	2013-10-14	Boehringer Ingelheim Int	Cykliske inhibitorer af 11 beta-hydroxysteroid dehydrogenase 1
US8057970B2 (en)	2008-09-01	2011-11-15	D2S, Inc.	Method and system for forming circular patterns on a surface
US8680093B2 (en)	2009-04-30	2014-03-25	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TWI531571B (zh) *	2009-11-06	2016-05-01	維它藥物公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物

2011
- 2011-10-18 TW TW100137675A patent/TWI537258B/zh not_active IP Right Cessation
- 2011-11-01 UY UY0001033701A patent/UY33701A/es not_active Application Discontinuation
- 2011-11-01 AR ARP110104053A patent/AR083678A1/es unknown
- 2011-11-04 NZ NZ609281A patent/NZ609281A/en not_active IP Right Cessation
- 2011-11-04 EP EP11785232.7A patent/EP2635563B1/en active Active
- 2011-11-04 AP AP2013006902A patent/AP3521A/xx active
- 2011-11-04 HR HRP20150327TT patent/HRP20150327T1/hr unknown
- 2011-11-04 RS RS20150205A patent/RS53900B1/sr unknown
- 2011-11-04 JP JP2013537864A patent/JP2013541592A/ja active Pending
- 2011-11-04 PT PT117852327T patent/PT2635563E/pt unknown
- 2011-11-04 MX MX2013005069A patent/MX2013005069A/es unknown
- 2011-11-04 PH PH1/2013/500879A patent/PH12013500879A1/en unknown
- 2011-11-04 AU AU2011323164A patent/AU2011323164B2/en not_active Ceased
- 2011-11-04 SG SG2013026430A patent/SG189859A1/en unknown
- 2011-11-04 EA EA201390643A patent/EA022406B1/ru not_active IP Right Cessation
- 2011-11-04 UA UAA201307042A patent/UA110807C2/uk unknown
- 2011-11-04 KR KR1020137014295A patent/KR20130119939A/ko not_active Withdrawn
- 2011-11-04 BR BR112013011095A patent/BR112013011095A2/pt not_active IP Right Cessation
- 2011-11-04 WO PCT/US2011/059331 patent/WO2012061708A1/en not_active Ceased
- 2011-11-04 DK DK11785232.7T patent/DK2635563T3/en active
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- 2011-11-04 ES ES11785232.7T patent/ES2533833T3/es active Active
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- 2011-11-04 PE PE2013000949A patent/PE20140123A1/es not_active Application Discontinuation
2012
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2013
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009063061A2 (en) *	2007-11-16	2009-05-22	Boehringer Ingelheim International Gmbh	Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use

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Publication number	Publication date
TN2012000117A1 (en)	2013-09-19
HRP20150327T1 (hr)	2015-04-24
WO2012061708A1 (en)	2012-05-10
US20120157488A1 (en)	2012-06-21
ECSP12011788A (es)	2012-10-30
EA022406B1 (ru)	2015-12-30
ES2533833T3 (es)	2015-04-15
PL2635563T3 (pl)	2015-06-30
TW201242960A (en)	2012-11-01
US9120769B2 (en)	2015-09-01
SI2635563T1 (sl)	2015-04-30
EP2635563A1 (en)	2013-09-11
GEP20166481B (en)	2016-05-25
US8686149B2 (en)	2014-04-01
JP2013541592A (ja)	2013-11-14
PE20140123A1 (es)	2014-03-02
AP2013006902A0 (en)	2013-06-30
HK1184144A1 (en)	2014-01-17
BR112013011095A2 (pt)	2016-08-02
AU2011323164B2 (en)	2015-07-23
CY1116043T1 (el)	2017-01-25
ME02066B (me)	2015-05-20
MX2013005069A (es)	2013-08-29
RS53900B1 (sr)	2015-08-31
NZ609281A (en)	2015-02-27
IL225647A0 (en)	2013-06-27
TWI537258B (zh)	2016-06-11
CN103228642A (zh)	2013-07-31
UY33701A (es)	2012-05-31
KR20130119939A (ko)	2013-11-01
CA2816136A1 (en)	2012-05-10
EA201390643A1 (ru)	2013-11-29
SMT201500095B (it)	2015-07-09
CL2013001221A1 (es)	2013-11-08
PT2635563E (pt)	2015-04-13
AR083678A1 (es)	2013-03-13
SG189859A1 (en)	2013-06-28
UA110807C2 (uk)	2016-02-25
PH12013500879A1 (en)	2013-07-01
CN103228642B (zh)	2015-02-18
DK2635563T3 (en)	2015-02-02
AU2011323164A1 (en)	2013-05-02
US20140249174A1 (en)	2014-09-04
CO6781480A2 (es)	2013-10-31
ECSP13012664A (es)	2013-08-30
EP2635563B1 (en)	2015-01-14

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