AP3499A - Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors - Google Patents

Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors

Info

Publication number: AP3499A
Authority: AP; ARIPO
Prior art keywords: pyrazolospiroketone; acetyl; derivatives; coa carboxylase; carboxylase inhibitors
Prior art date: 2011-04-22

Application number

AP2013007129A

Other languages

English (en)

Other versions

AP2013007129A0 (en

Inventor

James Alfred Southers Jr

Robert Lee Dow

David Andrew Griffith

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-22

Filing date

2012-04-09

Publication date

2015-12-31

2012-04-09 Application filed by Pfizer filed Critical Pfizer

2013-09-30 Publication of AP2013007129A0 publication Critical patent/AP2013007129A0/xx

2015-12-31 Application granted granted Critical

2015-12-31 Publication of AP3499A publication Critical patent/AP3499A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Photographic Processing Devices Using Wet Methods (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Peptides Or Proteins (AREA)

AP2013007129A 2011-04-22 2012-04-09 Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors AP3499A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161478240P	2011-04-22	2011-04-22
PCT/IB2012/051732 WO2012143813A1 (fr)	2011-04-22	2012-04-09	Dérivés de pyrazolospirocétone destinés à être utilisés comme inhibiteurs d'acétyl-coa carboxylase

Publications (2)

Publication Number	Publication Date
AP2013007129A0 AP2013007129A0 (en)	2013-09-30
AP3499A true AP3499A (en)	2015-12-31

Family

ID=46025823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2013007129A AP3499A (en)	2011-04-22	2012-04-09	Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors

Country Status (42)

Country	Link
US (4)	US8802688B2 (fr)
EP (1)	EP2699576B1 (fr)
JP (1)	JP5657174B2 (fr)
KR (1)	KR101567659B1 (fr)
CN (2)	CN103492388A (fr)
AP (1)	AP3499A (fr)
AR (1)	AR086198A1 (fr)
AU (1)	AU2012245996B2 (fr)
CA (1)	CA2831380C (fr)
CL (1)	CL2013002794A1 (fr)
CO (1)	CO6801757A2 (fr)
CR (1)	CR20130464A (fr)
CU (1)	CU24164B1 (fr)
CY (1)	CY1117122T1 (fr)
DK (1)	DK2699576T3 (fr)
DO (1)	DOP2013000243A (fr)
EA (1)	EA022375B1 (fr)
EC (1)	ECSP13013038A (fr)
ES (1)	ES2561452T3 (fr)
GE (1)	GEP20166474B (fr)
GT (1)	GT201300258A (fr)
HR (1)	HRP20151397T1 (fr)
HU (1)	HUE028602T2 (fr)
IL (1)	IL228949A (fr)
MA (1)	MA35061B1 (fr)
ME (1)	ME02312B (fr)
MX (1)	MX348860B (fr)
MY (1)	MY162167A (fr)
NI (1)	NI201300111A (fr)
NZ (1)	NZ616156A (fr)
PE (1)	PE20141187A1 (fr)
PH (1)	PH12013501941A1 (fr)
PL (1)	PL2699576T3 (fr)
PT (1)	PT2699576E (fr)
RS (1)	RS54526B1 (fr)
SG (1)	SG194142A1 (fr)
SI (1)	SI2699576T1 (fr)
TN (1)	TN2013000393A1 (fr)
TW (1)	TWI464171B (fr)
UA (1)	UA107753C2 (fr)
UY (1)	UY34027A (fr)
WO (1)	WO2012143813A1 (fr)

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NZ599815A (en) *	2009-11-10	2013-04-26	Pfizer	N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
CN102491974B (zh) *	2011-12-12	2013-08-07	南京药石药物研发有限公司	1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
WO2014149819A1 (fr)	2013-03-14	2014-09-25	Kalyra Pharmaceuticals, Inc.	Composés analgésiques bicycliques
EP2994141A4 (fr)	2013-05-10	2016-11-23	Nimbus Apollo Inc	Inhibiteurs de l'acc et utilisations associées
MX2015015422A (es)	2013-05-10	2016-06-21	Nimbus Apollo Inc	Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos.
US9988399B2 (en) *	2013-05-10	2018-06-05	Gilead Apollo, Llc	Bicyclic compounds as ACC inhibitors and uses thereof
WO2015036892A1 (fr) *	2013-09-12	2015-03-19	Pfizer Inc.	Utilisation d'inhibiteurs de l'acétyl-coa carboxylase pour traiter l'acné vulgaire
WO2015056782A1 (fr)	2013-10-17	2015-04-23	塩野義製薬株式会社	Nouveau dérivé d'alkylène
CN108947867A (zh)	2013-12-12	2018-12-07	卡利拉制药公司	双环烷基化合物及合成
EP3114107B1 (fr)	2014-03-07	2020-07-22	Recurium IP Holdings, LLC	Dérivés de propellane et synthèse
US10457502B2 (en)	2014-05-22	2019-10-29	Symbotic Canada Ulc	Tool and method for layer depalletizing
EP3193855B1 (fr)	2014-09-17	2021-05-19	Recurium IP Holdings, LLC	Composés bicycliques
US11058703B2 (en) *	2015-12-31	2021-07-13	Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.	Application of triacetyl-3-hydroxyphenyladenosine in preparation of pharmaceutical drug for preventing or treating non-alcoholic fatty liver disease
CN106580986B (zh) *	2016-11-28	2017-09-15	王保亮	一种治疗少弱精子症的药物组合物
EP3628043A4 (fr)	2017-05-15	2021-04-28	Recurium IP Holdings, LLC	Composés analgésiques
ES2942463T3 (es) *	2017-11-21	2023-06-01	Pfizer	Sal cristalina 2-amino-2-(hidroximetil)propano-1,3-diol del ácido 4-(4-(1-isopropil-7-oxo-1,4,6,7-tetrahidroespiro[indazol-5,4'-piperidina]-1'-carbonil)-6-metoxipiridin-2-il)benzoico
CN111574530B (zh) *	2020-04-21	2022-07-26	徐州医科大学	一种acc抑制剂及其医药用途
CN120457124A (zh) *	2022-12-30	2025-08-08	苏州浦合医药科技有限公司	Prmt5-mta抑制剂
CN121241054A (zh) *	2023-04-14	2025-12-30	北京双鹤润创科技有限公司	氮杂环羰基稠环衍生物及其用途
WO2025036472A1 (fr) *	2023-08-16	2025-02-20	Pharmaengine, Inc.	Inhibiteur de prmt5 mta-coopératif spirocyclique

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2012
- 2012-04-09 MX MX2013012313A patent/MX348860B/es active IP Right Grant
- 2012-04-09 KR KR1020137030875A patent/KR101567659B1/ko not_active Expired - Fee Related
- 2012-04-09 MA MA36357A patent/MA35061B1/fr unknown
- 2012-04-09 CN CN201280019621.3A patent/CN103492388A/zh active Pending
- 2012-04-09 WO PCT/IB2012/051732 patent/WO2012143813A1/fr not_active Ceased
- 2012-04-09 PL PL12718387T patent/PL2699576T3/pl unknown
- 2012-04-09 HR HRP20151397TT patent/HRP20151397T1/hr unknown
- 2012-04-09 CA CA2831380A patent/CA2831380C/fr active Active
- 2012-04-09 DK DK12718387.9T patent/DK2699576T3/en active
- 2012-04-09 SI SI201230417T patent/SI2699576T1/sl unknown
- 2012-04-09 HU HUE12718387A patent/HUE028602T2/hu unknown
- 2012-04-09 CN CN201610487378.8A patent/CN106117205B/zh not_active Expired - Fee Related
- 2012-04-09 MY MYPI2013003372A patent/MY162167A/en unknown
- 2012-04-09 EA EA201391288A patent/EA022375B1/ru not_active IP Right Cessation
- 2012-04-09 GE GEAP201213267A patent/GEP20166474B/en unknown
- 2012-04-09 EP EP12718387.9A patent/EP2699576B1/fr active Active
- 2012-04-09 RS RS20160026A patent/RS54526B1/sr unknown
- 2012-04-09 NZ NZ616156A patent/NZ616156A/en not_active IP Right Cessation
- 2012-04-09 SG SG2013075148A patent/SG194142A1/en unknown
- 2012-04-09 PE PE2013002387A patent/PE20141187A1/es not_active Application Discontinuation
- 2012-04-09 ME MEP-2015-214A patent/ME02312B/me unknown
- 2012-04-09 AP AP2013007129A patent/AP3499A/xx active
- 2012-04-09 PT PT127183879T patent/PT2699576E/pt unknown
- 2012-04-09 JP JP2014505745A patent/JP5657174B2/ja active Active
- 2012-04-09 PH PH1/2013/501941A patent/PH12013501941A1/en unknown
- 2012-04-09 AU AU2012245996A patent/AU2012245996B2/en not_active Ceased
- 2012-04-09 ES ES12718387.9T patent/ES2561452T3/es active Active
- 2012-04-09 CU CU20130126A patent/CU24164B1/es active IP Right Grant
- 2012-04-18 TW TW101113766A patent/TWI464171B/zh not_active IP Right Cessation
- 2012-04-19 UY UY0001034027A patent/UY34027A/es not_active Application Discontinuation
- 2012-04-20 AR ARP120101364A patent/AR086198A1/es unknown
- 2012-04-21 US US13/452,839 patent/US8802688B2/en active Active
- 2012-09-04 UA UAA201311822A patent/UA107753C2/ru unknown
2013
- 2013-09-12 CR CR20130464A patent/CR20130464A/es unknown
- 2013-09-27 CL CL2013002794A patent/CL2013002794A1/es unknown
- 2013-09-27 TN TNP2013000393A patent/TN2013000393A1/fr unknown
- 2013-10-17 IL IL228949A patent/IL228949A/en active IP Right Grant
- 2013-10-18 NI NI201300111A patent/NI201300111A/es unknown
- 2013-10-18 GT GT201300258A patent/GT201300258A/es unknown
- 2013-10-21 DO DO2013000243A patent/DOP2013000243A/es unknown
- 2013-10-24 CO CO13252716A patent/CO6801757A2/es active IP Right Grant
- 2013-11-22 EC ECSP13013038 patent/ECSP13013038A/es unknown
2014
- 2014-07-08 US US14/325,420 patent/US20140323730A1/en not_active Abandoned
2015
- 2015-01-09 US US14/593,370 patent/US20150112068A1/en not_active Abandoned
- 2015-08-07 US US14/820,884 patent/US20150336958A1/en not_active Abandoned
2016
- 2016-01-14 CY CY20161100038T patent/CY1117122T1/el unknown

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WO2012042433A1 (fr) *	2010-09-30	2012-04-05	Pfizer Inc.	Inhibiteurs de n1-pyrazolospirocétone acétyl-coa carboxylase

Non-Patent Citations (1)

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Title
SCOTT W. BAGLEY ET AL.: "Synthesis of 7-Oxo-dihydrospiro[indazole-5,4'-piperidine] Acetyl-CoA Carboxylase Inhibitors", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 77, no. 3, 3 February 2012 (2012-02-03), pages 1497-1506, XP55030451 *

Also Published As

Publication number	Publication date
KR101567659B1 (ko)	2015-11-09
ME02312B (me)	2016-06-20
KR20140015511A (ko)	2014-02-06
IL228949A (en)	2016-11-30
DK2699576T3 (en)	2016-02-15
TN2013000393A1 (fr)	2015-01-20
NZ616156A (en)	2014-08-29
US20150112068A1 (en)	2015-04-23
GT201300258A (es)	2015-06-02
HRP20151397T1 (hr)	2016-01-15
PT2699576E (pt)	2016-03-09
AU2012245996A1 (en)	2013-10-03
SI2699576T1 (sl)	2016-02-29
IL228949A0 (en)	2013-12-31
CL2013002794A1 (es)	2013-12-27
CN106117205B (zh)	2018-09-21
CA2831380C (fr)	2016-04-05
PH12013501941A1 (en)	2021-06-23
EA022375B1 (ru)	2015-12-30
UY34027A (es)	2013-04-05
AP2013007129A0 (en)	2013-09-30
EA201391288A1 (ru)	2014-04-30
PL2699576T3 (pl)	2016-05-31
US8802688B2 (en)	2014-08-12
NI201300111A (es)	2014-02-12
US20140323730A1 (en)	2014-10-30
MX348860B (es)	2017-06-30
JP5657174B2 (ja)	2015-01-21
PE20141187A1 (es)	2014-09-18
CU20130126A7 (es)	2014-01-29
AU2012245996B2 (en)	2016-09-01
ES2561452T3 (es)	2016-02-26
EP2699576B1 (fr)	2015-12-09
SG194142A1 (en)	2013-11-29
DOP2013000243A (es)	2013-12-31
CN103492388A (zh)	2014-01-01
CN106117205A (zh)	2016-11-16
MX2013012313A (es)	2014-01-31
US20150336958A1 (en)	2015-11-26
CU24164B1 (es)	2016-03-31
MY162167A (en)	2017-05-31
UA107753C2 (xx)	2015-02-10
CO6801757A2 (es)	2013-11-29
RS54526B1 (sr)	2016-06-30
ECSP13013038A (es)	2014-01-31
HUE028602T2 (hu)	2016-12-28
US20120270893A1 (en)	2012-10-25
TWI464171B (zh)	2014-12-11
WO2012143813A1 (fr)	2012-10-26
CA2831380A1 (fr)	2012-10-26
MA35061B1 (fr)	2014-04-03
TW201305162A (zh)	2013-02-01
JP2014515755A (ja)	2014-07-03
AR086198A1 (es)	2013-11-27
CR20130464A (es)	2013-10-16
GEP20166474B (en)	2016-05-10
EP2699576A1 (fr)	2014-02-26
CY1117122T1 (el)	2017-04-05

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