AP3382A - Tuberculosis drug based on 4-thioureido-iminomethylpyridinium perchlorate: method of preparation andtreatment - Google Patents

Tuberculosis drug based on 4-thioureido-iminomethylpyridinium perchlorate: method of preparation andtreatment

Info

Publication number: AP3382A
Authority: AP; ARIPO
Prior art keywords: andtreatment; thioureido; preparation; drug based; tuberculosis drug
Prior art date: 2010-04-20

Application number

AP2012006486A

Other languages

English (en)

Other versions

AP2012006486A0 (en

Inventor

Tatiana Ivanovna Vinogradova

Aleksander Sergeevich Gushchin

Petr Kazimirovich Yablonskiy

Original Assignee

Pharmasyntez

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-04-20

Filing date

2011-04-12

Publication date

2015-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44645750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3382(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-04-12 Application filed by Pharmasyntez filed Critical Pharmasyntez

2012-10-31 Publication of AP2012006486A0 publication Critical patent/AP2012006486A0/xx

2015-07-31 Application granted granted Critical

2015-07-31 Publication of AP3382A publication Critical patent/AP3382A/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Pyridine Compounds (AREA)

AP2012006486A 2010-04-20 2011-04-12 Tuberculosis drug based on 4-thioureido-iminomethylpyridinium perchlorate: method of preparation andtreatment AP3382A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
RU2010115705/15A RU2423977C1 (ru)	2010-04-20	2010-04-20	Противотуберкулезное лекарственное средство на основе 4-тиоуреидоиминометилпиридиния перхлората, способ его получения и способ лечения
PCT/IB2011/051566 WO2011132114A2 (en)	2010-04-20	2011-04-12	Tuberculosis drug based on 4-thioureido-iminomethylpyridinium perchlorate: method of preparation and treatment

Publications (2)

Publication Number	Publication Date
AP2012006486A0 AP2012006486A0 (en)	2012-10-31
AP3382A true AP3382A (en)	2015-07-31

Family

ID=44645750

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2012006486A AP3382A (en)	2010-04-20	2011-04-12	Tuberculosis drug based on 4-thioureido-iminomethylpyridinium perchlorate: method of preparation andtreatment

Country Status (17)

Country	Link
US (1)	US9750727B2 (es)
EP (1)	EP2560630A2 (es)
KR (1)	KR20130079387A (es)
CN (2)	CN105147679A (es)
AP (1)	AP3382A (es)
AU (2)	AU2011244054A1 (es)
BR (1)	BR112012027000A2 (es)
CA (1)	CA2794439C (es)
CL (1)	CL2012002924A1 (es)
EA (1)	EA023213B1 (es)
MX (1)	MX339367B (es)
PE (1)	PE20130202A1 (es)
PH (1)	PH12012502094A1 (es)
RU (1)	RU2423977C1 (es)
UA (1)	UA102970C2 (es)
WO (1)	WO2011132114A2 (es)
ZA (1)	ZA201207189B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2735468C1 (ru) *	2019-05-06	2020-11-02	Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт туберкулеза" Министерства здравоохранения Российской Федерации (ФГБУ "ННИИТ" Минздрава России)	Способ диагностики туберкулеза почек

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GB820196A (en) *	1956-11-28	1959-09-16	Geigy Ag J R	Improvements in and relating to therapeutic compositions
US3039925A (en) *	1957-04-24	1962-06-19	Bayer Ag	Compositions for the treatment of tuberculosis
US3079303A (en) *	1958-12-11	1963-02-26	Smith Kline French Lab	Basic tablet granulation and process of using same
JPS5946208A (ja) *	1982-08-30	1984-03-15	Daito Koeki Kk	抗菌性組成物
SU1621449A1 (ru) *	1989-04-24	1996-09-10	Иркутский институт органической химии СО АН СССР	Перхлорат 4-тиоуреидоиминометилпиридиния, обладающий туберкулостатической активностью
RU2168986C1 (ru) *	2000-08-03	2001-06-20	Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин"	Фармацевтическая композиция, обладающая противотуберкулезным действием
NZ518216A (en) *	2000-08-09	2004-11-26	Panacea Biotec Ltd	Pharmaceutical compositions of anti-tubercular drugs and process for their preparation
RU2185170C1 (ru) *	2001-01-29	2002-07-20	Уральский научно-исследовательский институт фтизиопульмонологии	Туберкулостатическое средство
BR0116994A (pt) *	2001-04-27	2004-03-02	Lupin Ltd	Um processo aperfeiçoado para a preparação de uma composição que abrange uma combinação de dose fixa (fdc) de quatro drogas antituberculose
US20030152622A1 (en) *	2001-10-25	2003-08-14	Jenny Louie-Helm	Formulation of an erodible, gastric retentive oral diuretic
RU2265014C1 (ru) *	2004-05-13	2005-11-27	Открытое Акционерное Общество "Фармасинтез"	Способ получения перхлората 4-тиоуреидоиминометилпиридиния, обладающего туберкулостатической активностью
WO2009004249A1 (fr) *	2007-06-20	2009-01-08	France Telecom	Procédé et système d'authentification d'un objet muni d'un dispositif de traitement de données, terminal de communication et programmes d'ordinateur correspondants
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2010
- 2010-04-20 RU RU2010115705/15A patent/RU2423977C1/ru active
2011
- 2011-04-12 CA CA2794439A patent/CA2794439C/en not_active Expired - Fee Related
- 2011-04-12 PE PE2012002038A patent/PE20130202A1/es not_active Application Discontinuation
- 2011-04-12 EA EA201201308A patent/EA023213B1/ru unknown
- 2011-04-12 WO PCT/IB2011/051566 patent/WO2011132114A2/en not_active Ceased
- 2011-04-12 CN CN201510519250.0A patent/CN105147679A/zh active Pending
- 2011-04-12 BR BR112012027000A patent/BR112012027000A2/pt not_active Application Discontinuation
- 2011-04-12 KR KR1020127028910A patent/KR20130079387A/ko not_active Ceased
- 2011-04-12 AU AU2011244054A patent/AU2011244054A1/en not_active Abandoned
- 2011-04-12 MX MX2012011907A patent/MX339367B/es active IP Right Grant
- 2011-04-12 UA UAA201211533A patent/UA102970C2/ru unknown
- 2011-04-12 EP EP11755438A patent/EP2560630A2/en not_active Withdrawn
- 2011-04-12 CN CN2011800052814A patent/CN102844024A/zh active Pending
- 2011-04-12 PH PH1/2012/502094A patent/PH12012502094A1/en unknown
- 2011-04-12 AP AP2012006486A patent/AP3382A/xx active
2012
- 2012-09-26 ZA ZA2012/07189A patent/ZA201207189B/en unknown
- 2012-10-19 CL CL2012002924A patent/CL2012002924A1/es unknown
- 2012-10-22 US US13/657,168 patent/US9750727B2/en not_active Expired - Fee Related
2016
- 2016-11-28 AU AU2016265974A patent/AU2016265974A1/en not_active Abandoned

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SILVEIRA J ET AL: "[THE COMBINATION INH AND ISONICOTINYLADEHYDE-THIOSEMICARBAZONE IN THE TREATMENT OF TUBERCULOSIS IN CHILDHOOD].", HOSPITAL (RIO DE JANEIRO, BRAZIL) SEP 1963 LNKD- PUBMED:14112139, vol. 64, September 1963 (1963-09), pages 561-586, XP008144265 *

Also Published As

Publication number	Publication date
CN102844024A (zh)	2012-12-26
KR20130079387A (ko)	2013-07-10
CA2794439A1 (en)	2011-10-27
AU2011244054A1 (en)	2012-12-06
US9750727B2 (en)	2017-09-05
PE20130202A1 (es)	2013-02-28
US20130052265A1 (en)	2013-02-28
PH12012502094A1 (en)	2016-07-08
WO2011132114A9 (en)	2012-01-26
CL2012002924A1 (es)	2013-04-12
BR112012027000A2 (pt)	2016-07-19
EP2560630A2 (en)	2013-02-27
CA2794439C (en)	2015-03-31
AP2012006486A0 (en)	2012-10-31
UA102970C2 (ru)	2013-08-27
RU2423977C1 (ru)	2011-07-20
MX2012011907A (es)	2013-03-07
CN105147679A (zh)	2015-12-16
WO2011132114A3 (en)	2012-03-22
EA023213B1 (ru)	2016-05-31
EA201201308A1 (ru)	2013-02-28
WO2011132114A2 (en)	2011-10-27
ZA201207189B (en)	2013-05-29
MX339367B (es)	2016-05-20
AU2016265974A1 (en)	2016-12-15

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AP3382A (en)	2015-07-31	Tuberculosis drug based on 4-thioureido-iminomethylpyridinium perchlorate: method of preparation andtreatment
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