AP2783A - Uracyl spirooxetane nucleosides - Google Patents

Uracyl spirooxetane nucleosides

Info

Publication number: AP2783A
Authority: AP; ARIPO
Prior art keywords: spirooxetane nucleosides; uracyl spirooxetane; uracyl; nucleosides; spirooxetane
Prior art date: 2009-05-14

Application number

AP2011005958A

Other languages

English (en)

Other versions

AP2011005958A0 (en

Inventor

Tim Hugo Maria Jonckers

Pierre Jean-Marie Bernard Raboisson

Koen Vandyck

Original Assignee

Janssen Products Lp

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-14

Filing date

2010-05-11

Publication date

2013-10-31

2010-05-11 Application filed by Janssen Products Lp, Medivir Ab filed Critical Janssen Products Lp

2011-10-31 Publication of AP2011005958A0 publication Critical patent/AP2011005958A0/xx

2013-10-31 Application granted granted Critical

2013-10-31 Publication of AP2783A publication Critical patent/AP2783A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Virology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AP2011005958A 2009-05-14 2010-05-11 Uracyl spirooxetane nucleosides AP2783A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP09160215		2009-05-14
PCT/EP2010/056438 WO2010130726A1 (en)	2009-05-14	2010-05-11	Uracyl spirooxetane nucleosides

Publications (2)

Publication Number	Publication Date
AP2011005958A0 AP2011005958A0 (en)	2011-10-31
AP2783A true AP2783A (en)	2013-10-31

Family

ID=40823307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2011005958A AP2783A (en)	2009-05-14	2010-05-11	Uracyl spirooxetane nucleosides

Country Status (38)

Country	Link
US (2)	US8481510B2 (es)
EP (2)	EP2430035B1 (es)
JP (2)	JP5778135B2 (es)
KR (1)	KR101806837B1 (es)
CN (1)	CN102439024B (es)
AP (1)	AP2783A (es)
AR (1)	AR076579A1 (es)
AU (1)	AU2010247439B2 (es)
BR (1)	BRPI1010579A2 (es)
CA (1)	CA2760329C (es)
CL (1)	CL2011002859A1 (es)
CO (1)	CO6440533A2 (es)
CR (1)	CR20120297A (es)
CY (2)	CY1114081T1 (es)
DK (2)	DK2511282T3 (es)
EA (1)	EA022084B1 (es)
EC (1)	ECSP11011461A (es)
ES (2)	ES2411086T3 (es)
HN (1)	HN2011003014A (es)
HR (2)	HRP20130554T1 (es)
IL (1)	IL215955A (es)
JO (1)	JO3027B1 (es)
ME (1)	ME01478B (es)
MX (1)	MX2011012027A (es)
MY (1)	MY157018A (es)
NI (1)	NI201100197A (es)
NZ (1)	NZ596073A (es)
PL (2)	PL2430035T3 (es)
PT (2)	PT2511282E (es)
RS (1)	RS52822B (es)
SG (1)	SG175981A1 (es)
SI (2)	SI2430035T1 (es)
SM (2)	SMT201300078B (es)
TW (1)	TWI461432B (es)
UA (1)	UA105790C2 (es)
UY (1)	UY32642A (es)
WO (1)	WO2010130726A1 (es)
ZA (1)	ZA201108309B (es)

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US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
WO2010075554A1 (en)	2008-12-23	2010-07-01	Pharmasset, Inc.	Synthesis of purine nucleosides
JO3027B1 (ar) *	2009-05-14	2016-09-05	Janssen Products Lp	نيوكليوسيدات يوراسيل سبيرواوكسيتان
US9006209B2 (en) *	2010-11-10	2015-04-14	Janssen Products, Lp	Uracyl spirooxetane nucleoside phosphoramidates
WO2012062870A1 (en) *	2010-11-10	2012-05-18	Janssen Products, Lp	Uracyl spirooxetane nucleoside phosphoramidates
CA2818853A1 (en) *	2010-11-30	2012-06-07	Gilead Pharmasset Llc	2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus
AU2015252113B2 (en) *	2010-11-30	2017-05-04	Gilead Pharmasset Llc	Compounds
WO2012142523A2 (en) *	2011-04-13	2012-10-18	Gilead Sciences, Inc.	1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment
HK1203075A1 (en)	2011-12-22	2015-10-16	艾丽奥斯生物制药有限公司	Substituted phosphorothioate nucleotide analogs
AR091156A1 (es)	2012-05-25	2015-01-14	Jansen R & D Ireland	Nucleosidos de espirooxetano de uracilo
EP2940031B1 (en) *	2013-03-08	2017-09-27	Nanjing Sanhome Pharmaceutical Co., Ltd.	Nucleoside phosphoramidate compounds for use in the treatment of hcv
WO2014169278A1 (en)	2013-04-12	2014-10-16	Achillion Pharmaceuticals, Inc.	Highly active nucleoside derivative for the treatment of hcv
WO2014194826A1 (zh) *	2013-06-06	2014-12-11	南京圣和药业有限公司	三环稠杂环类核苷氨基磷酸酯化合物、其制备方法及应用
RU2016125445A (ru) *	2013-11-28	2018-01-10	Янссен Сайенсиз Айрлэнд Юси	Кристаллическая форма нуклеозидного ингибитора hcv
GEP20237502B (en)	2015-03-06	2023-04-25	Atea Pharmaceuticals Inc	B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
US10711029B2 (en)	2016-07-14	2020-07-14	Atea Pharmaceuticals, Inc.	Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
EA202190602A3 (ru)	2016-09-07	2021-11-30	Атеа Фармасьютикалс, Инк.	2'-замещенные-n6-замещенные пуриновые нуклеотиды для лечения вызванных рнк-вирусом заболеваний
GEP20237457B (en)	2017-02-01	2023-01-10	Atea Pharmaceuticals Inc	Nucleotide hemi-sulfate salt for treatment of hepatitis c virus
AU2019207626B2 (en)	2018-01-10	2023-10-05	Nucorion Pharmaceuticals, Inc.	Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
JP2021521118A (ja)	2018-04-10	2021-08-26	アテアファーマシューティカルズ，インコーポレイテッド	肝硬変を伴うｈｃｖ感染患者の治療
CA3143349A1 (en)	2019-07-17	2021-01-21	Nucorion Pharmaceuticals, Inc.	Cyclic deoxyribonucleotide compounds
US10874687B1 (en)	2020-02-27	2020-12-29	Atea Pharmaceuticals, Inc.	Highly active compounds against COVID-19
BR112022020810A2 (pt) *	2020-04-14	2022-11-29	Janssen Pharmaceuticals Inc	Análogos de nucleosídeos espirocíclicos para o tratamento de hepatite e
KR20240022574A (ko)	2021-06-17	2024-02-20	아테아 파마슈티컬즈, 인크.	유리한 항-hcv 조합 요법

Citations (2)

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Publication number	Priority date	Publication date	Assignee	Title
WO2007020193A2 (en) *	2005-08-15	2007-02-22	F. Hoffmann-La Roche Ag	Antiviral phosphoramidates of 4 ' -substituted pronucleotides
WO2007095269A2 (en) *	2006-02-14	2007-08-23	Merck & Co., Inc.	Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection

Family Cites Families (4)

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Publication number	Priority date	Publication date	Assignee	Title
SI1355916T1 (sl) *	2001-01-22	2007-04-30	Merck & Co Inc	Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
CN1972696B (zh) *	2004-06-24	2010-08-11	默沙东公司	用于治疗rna依赖性rna病毒感染的核苷氨基磷酸芳基酯
PA8852101A1 (es) *	2008-12-08	2010-07-27	Medivir Ab	Nucleótidos uracil ciclopropílicos
JO3027B1 (ar) *	2009-05-14	2016-09-05	Janssen Products Lp	نيوكليوسيدات يوراسيل سبيرواوكسيتان

2010
- 2010-05-04 JO JOP/2010/0138A patent/JO3027B1/ar active
- 2010-05-11 EP EP10718207A patent/EP2430035B1/en active Active
- 2010-05-11 SI SI201030246T patent/SI2430035T1/sl unknown
- 2010-05-11 AU AU2010247439A patent/AU2010247439B2/en not_active Ceased
- 2010-05-11 PL PL10718207T patent/PL2430035T3/pl unknown
- 2010-05-11 US US13/319,735 patent/US8481510B2/en not_active Expired - Fee Related
- 2010-05-11 NZ NZ596073A patent/NZ596073A/xx not_active IP Right Cessation
- 2010-05-11 PL PL12176402T patent/PL2511282T3/pl unknown
- 2010-05-11 RS RS20130213A patent/RS52822B/sr unknown
- 2010-05-11 PT PT121764021T patent/PT2511282E/pt unknown
- 2010-05-11 EA EA201171406A patent/EA022084B1/ru not_active IP Right Cessation
- 2010-05-11 SI SI201030667T patent/SI2511282T1/sl unknown
- 2010-05-11 JP JP2012510269A patent/JP5778135B2/ja not_active Expired - Fee Related
- 2010-05-11 ES ES10718207T patent/ES2411086T3/es active Active
- 2010-05-11 KR KR1020117029826A patent/KR101806837B1/ko not_active Expired - Fee Related
- 2010-05-11 SG SG2011082757A patent/SG175981A1/en unknown
- 2010-05-11 CN CN201080021188.8A patent/CN102439024B/zh not_active Expired - Fee Related
- 2010-05-11 AP AP2011005958A patent/AP2783A/xx active
- 2010-05-11 EP EP12176402.1A patent/EP2511282B1/en active Active
- 2010-05-11 ES ES12176402.1T patent/ES2477598T3/es active Active
- 2010-05-11 ME MEP-2013-47A patent/ME01478B/me unknown
- 2010-05-11 PT PT107182073T patent/PT2430035E/pt unknown
- 2010-05-11 DK DK12176402.1T patent/DK2511282T3/da active
- 2010-05-11 BR BRPI1010579A patent/BRPI1010579A2/pt active Search and Examination
- 2010-05-11 MX MX2011012027A patent/MX2011012027A/es active IP Right Grant
- 2010-05-11 WO PCT/EP2010/056438 patent/WO2010130726A1/en not_active Ceased
- 2010-05-11 HR HRP20130554AT patent/HRP20130554T1/hr unknown
- 2010-05-11 MY MYPI2011005445A patent/MY157018A/en unknown
- 2010-05-11 CA CA2760329A patent/CA2760329C/en active Active
- 2010-05-11 DK DK10718207.3T patent/DK2430035T3/da active
- 2010-05-12 TW TW099115051A patent/TWI461432B/zh not_active IP Right Cessation
- 2010-05-13 AR ARP100101670A patent/AR076579A1/es unknown
- 2010-05-14 UY UY0001032642A patent/UY32642A/es unknown
- 2010-11-05 UA UAA201112920A patent/UA105790C2/uk unknown
2011
- 2011-10-26 IL IL215955A patent/IL215955A/en not_active IP Right Cessation
- 2011-10-27 CO CO11145588A patent/CO6440533A2/es not_active Application Discontinuation
- 2011-11-11 ZA ZA2011/08309A patent/ZA201108309B/en unknown
- 2011-11-11 NI NI201100197A patent/NI201100197A/es unknown
- 2011-11-14 EC EC2011011461A patent/ECSP11011461A/es unknown
- 2011-11-14 CL CL2011002859A patent/CL2011002859A1/es unknown
- 2011-11-14 HN HN2011003014A patent/HN2011003014A/es unknown
2012
- 2012-05-30 CR CR20120297A patent/CR20120297A/es unknown
2013
- 2013-03-15 US US13/836,465 patent/US8933052B2/en active Active
- 2013-05-22 CY CY20131100408T patent/CY1114081T1/el unknown
- 2013-07-04 SM SM201300078T patent/SMT201300078B/xx unknown
2014
- 2014-06-26 HR HRP20140605AT patent/HRP20140605T1/hr unknown
- 2014-06-30 SM SM201400085T patent/SMT201400085B/xx unknown
- 2014-07-01 CY CY20141100491T patent/CY1115383T1/el unknown
2015
- 2015-07-06 JP JP2015135001A patent/JP2015180692A/ja not_active Withdrawn

Patent Citations (2)

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Publication number	Priority date	Publication date	Assignee	Title
WO2007020193A2 (en) *	2005-08-15	2007-02-22	F. Hoffmann-La Roche Ag	Antiviral phosphoramidates of 4 ' -substituted pronucleotides
WO2007095269A2 (en) *	2006-02-14	2007-08-23	Merck & Co., Inc.	Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection

Non-Patent Citations (1)

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Title
BABU, B. RAVINDRA ET AL: "2'-Spiro ribo- and arabinonucleosides: synthesis, molecular modelling and incorporation into oligodeoxynucleotides" ORGANIC & BIOMOLECULAR CHEMISTRY , 1(20), 3514-3526 CODEN: OBCRAK; ISSN: 1477-0520, 2003, XP002536360 *

Also Published As

Publication number	Publication date
AU2010247439A1 (en)	2011-12-01
CA2760329A1 (en)	2010-11-18
ES2411086T3 (es)	2013-07-04
MX2011012027A (es)	2012-02-28
JO3027B1 (ar)	2016-09-05
RS52822B (sr)	2013-10-31
TWI461432B (zh)	2014-11-21
IL215955A0 (en)	2012-01-31
AU2010247439B2 (en)	2014-09-25
EP2430035A1 (en)	2012-03-21
IL215955A (en)	2015-03-31
CL2011002859A1 (es)	2012-07-20
HK1166326A1 (en)	2012-10-26
EP2511282A1 (en)	2012-10-17
HRP20140605T1 (hr)	2014-09-26
SI2430035T1 (sl)	2013-08-30
EA201171406A1 (ru)	2012-05-30
CA2760329C (en)	2017-10-31
ZA201108309B (en)	2013-04-24
US20120065156A1 (en)	2012-03-15
CY1114081T1 (el)	2016-07-27
CN102439024A (zh)	2012-05-02
SG175981A1 (en)	2011-12-29
ME01478B (me)	2014-04-20
US8481510B2 (en)	2013-07-09
HRP20130554T1 (xx)	2013-07-31
BRPI1010579A2 (pt)	2016-03-15
EP2430035B1 (en)	2013-04-03
NI201100197A (es)	2012-05-28
KR20120018355A (ko)	2012-03-02
JP2015180692A (ja)	2015-10-15
ECSP11011461A (es)	2012-02-29
MY157018A (en)	2016-04-15
US8933052B2 (en)	2015-01-13
WO2010130726A1 (en)	2010-11-18
PT2511282E (pt)	2014-07-11
SMT201400085B (it)	2014-09-08
JP5778135B2 (ja)	2015-09-16
CN102439024B (zh)	2014-09-17
NZ596073A (en)	2013-02-22
KR101806837B1 (ko)	2017-12-08
CR20120297A (es)	2012-10-25
CO6440533A2 (es)	2012-05-15
ES2477598T3 (es)	2014-07-17
TW201100442A (en)	2011-01-01
EP2511282B1 (en)	2014-04-02
SMT201300078B (it)	2013-09-06
UY32642A (es)	2010-11-30
EA022084B1 (ru)	2015-10-30
UA105790C2 (uk)	2014-06-25
DK2511282T3 (da)	2014-07-07
CY1115383T1 (el)	2017-01-04
JP2012526764A (ja)	2012-11-01
PL2430035T3 (pl)	2013-08-30
DK2430035T3 (da)	2013-05-27
AP2011005958A0 (en)	2011-10-31
PT2430035E (pt)	2013-05-22
US20130217648A1 (en)	2013-08-22
PL2511282T3 (pl)	2014-09-30
AR076579A1 (es)	2011-06-22
HN2011003014A (es)	2014-06-30
SI2511282T1 (sl)	2014-09-30

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ZA201104231B (en)	2012-11-28	Uracyl cyclopropyl nucleotides
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