[go: up one dir, main page]

AP2008A - Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them - Google Patents

Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them

Info

Publication number
AP2008A
AP2008A AP2005003424A AP2005003424A AP2008A AP 2008 A AP2008 A AP 2008A AP 2005003424 A AP2005003424 A AP 2005003424A AP 2005003424 A AP2005003424 A AP 2005003424A AP 2008 A AP2008 A AP 2008A
Authority
AP
ARIPO
Prior art keywords
inflammatory
preparation
treatment
pharmaceutical compositions
compositions containing
Prior art date
Application number
AP2005003424A
Other languages
English (en)
Other versions
AP2005003424A0 (en
Inventor
Balasubramanian Gopalan
Laxmikant Arat
Aftab Lakdawala
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of AP2005003424A0 publication Critical patent/AP2005003424A0/xx
Application granted granted Critical
Publication of AP2008A publication Critical patent/AP2008A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2005003424A 2003-04-11 2004-02-11 Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them AP2008A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN363MU2003 2003-04-11
US51996703P 2003-11-13 2003-11-13
PCT/IB2004/000355 WO2004089940A1 (fr) 2003-04-11 2004-02-11 Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
AP2005003424A0 AP2005003424A0 (en) 2005-12-31
AP2008A true AP2008A (en) 2009-06-29

Family

ID=36947516

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2005003424A AP2008A (en) 2003-04-11 2004-02-11 Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (4) US7223789B2 (fr)
EP (1) EP1620429B1 (fr)
JP (1) JP2006522789A (fr)
KR (1) KR20060017494A (fr)
CN (1) CN1829711B (fr)
AP (1) AP2008A (fr)
AR (1) AR043199A1 (fr)
AT (1) ATE427308T1 (fr)
AU (1) AU2004228453B2 (fr)
BR (1) BRPI0409747A (fr)
CA (1) CA2522023A1 (fr)
CL (1) CL2004000526A1 (fr)
CO (1) CO5700824A2 (fr)
DE (1) DE602004020332D1 (fr)
DK (1) DK1620429T3 (fr)
EA (1) EA010634B1 (fr)
ES (1) ES2320888T3 (fr)
GE (1) GEP20084526B (fr)
HR (1) HRP20050944A2 (fr)
IS (1) IS8123A (fr)
MA (1) MA27801A1 (fr)
MX (1) MXPA05010948A (fr)
MY (1) MY136516A (fr)
NO (1) NO20055316L (fr)
NZ (1) NZ542882A (fr)
OA (1) OA13154A (fr)
PL (1) PL378813A1 (fr)
PT (1) PT1620429E (fr)
SI (1) SI1620429T1 (fr)
TN (1) TNSN05252A1 (fr)
TW (1) TW200508212A (fr)
UA (1) UA79558C2 (fr)
WO (1) WO2004089940A1 (fr)
ZA (1) ZA200508240B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI474282B (zh) * 2008-10-03 2015-02-21 Himax Tech Ltd 深度相關的影像加強

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003269317B2 (en) * 2002-10-23 2009-10-29 Glenmark Pharmaceuticals Ltd. Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2004089940A1 (fr) * 2003-04-11 2004-10-21 Glenmark Pharmaceuticals S.A. Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant
JP2009519206A (ja) * 2004-10-13 2009-05-14 グレンマーク・ファーマシューティカルズ・エスエー Ｎ−（３，５−ジクロロピリジン−４−イル）−４−ジフルオロメトキシ−８−メタンスルホンアミド−ジベンゾ［ｂ，ｄ］フラン−１−カルボキサミドの製造法
WO2006051390A1 (fr) * 2004-11-10 2006-05-18 Glenmark Pharmaceuticals S.A. Composes heterocycliques utilises pour le traitement de troubles inflammatoires et allergiques, compositions pharmaceutiques contenant ces composes et procedes permettant de les preparer
AR066386A1 (es) * 2004-12-17 2009-08-19 Glenmark Pharmaceuticals Sa Compuestos heterociclicos condensados, metodos e intermediarios para su preparacion, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por la inhibicion de la pde-4
ES2417491T3 (es) * 2004-12-17 2013-08-08 Glenmark Pharmaceuticals S.A. Novedosos compuestos heterocíclicos útiles para el tratamiento de trastornos inflamatorios y alérgicos
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
RS53461B (sr) * 2006-07-05 2014-12-31 Takeda Gmbh Kombinacija inhibitora hmg-coa reduktaze atorvastatina ili simvastatina sa fosfodiesteraza 4 inhibitorom, kao što je roflumilast za lečenje inflamatornih pulmonarnih oboljenja
US7511150B2 (en) * 2006-07-06 2009-03-31 Forest Laboratories Holdings Limited Synthesis of heterocyclic compounds
JPWO2008026687A1 (ja) 2006-09-01 2010-01-21 杏林製薬株式会社 ピラゾロピリジンカルボキサミド誘導体及びそれらを含有するホスホジエステラーゼ（ｐｄｅ）阻害剤
EP2060572A4 (fr) * 2006-09-06 2010-11-17 Kyorin Seiyaku Kk Dérivé de pyrazolopyridine et inhibiteur de la phosphodiestérase (pde) qui le contient en tant que matière active
WO2008032171A1 (fr) * 2006-09-11 2008-03-20 Matrix Laboratories Ltd. Nouveaux composés hétérocycliques utiles pour traiter les maladies allergiques et inflammatoires, compositions pharmaceutiques les contenant et procédés servant à les préparer
WO2008057254A2 (fr) * 2006-10-27 2008-05-15 Wyeth Composés tricycliques servant d'inhibiteurs des métalloprotéases matricielles
WO2008065522A2 (fr) * 2006-11-29 2008-06-05 Glenmark Pharmaceuticals S.A. Procédé de synthèse du 4-difluorométhoxy-8-nitro-1-formyl-dibenzo[b,d]furane, un intermédiaire d'inhibiteurs de la pde4
CN101657460A (zh) * 2006-12-13 2010-02-24 基利得科学公司 用于治疗肺炎症和支气管收缩的作为抗炎性信号转导调节剂(AISTM’S)和β-激动剂的相互前药的单磷酸酯
JP2010518114A (ja) * 2007-02-09 2010-05-27 フォレスト・ラボラトリーズ・ホールディングス・リミテッド 複素環式化合物の生物学的利用能を備えた製剤
US8524905B2 (en) 2007-05-22 2013-09-03 Glenmark Pharmaceuticals S.A. Processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of PDE IV inhibitors
US20110171195A1 (en) * 2007-06-15 2011-07-14 Duke University Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp
EP2070913A1 (fr) * 2007-12-14 2009-06-17 CHIESI FARMACEUTICI S.p.A. Dérivés d'ester en tant qu'inhibiteurs de la phosphodiestérase
WO2009147476A1 (fr) * 2008-06-02 2009-12-10 Matrix Laboratories Ltd. Nouveaux inhibiteurs de phosphodiestérases, compositions pharmaceutiques les contenant et leurs procédés de préparation
SG171815A1 (en) 2008-12-19 2011-07-28 Bristol Myers Squibb Co Carbazole carboxamide compounds useful as kinase inhibitors
WO2011132051A2 (fr) * 2010-04-19 2011-10-27 Glenmark Pharmaceuticals S.A. Composés tricycliques en tant qu'inhibiteurs de la phosphodiestérase-10
MY192981A (en) * 2010-12-15 2022-09-20 Contravir Pharmaceuticals Inc Cyclosporine analogue molecules modified at amino acid 1 and 3
WO2014133020A1 (fr) * 2013-02-28 2014-09-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 Agent permettant de prévenir et de traiter une maladie respiratoire
CN104177612A (zh) * 2013-05-28 2014-12-03 韩文毅 一种新的非线性聚合物及其制备和用途
CN104211947A (zh) * 2013-05-31 2014-12-17 韩文毅 一种非线性聚合物及其制备和用途
CN104211949A (zh) * 2013-06-04 2014-12-17 韩文毅 一种非线性聚合物及其制备与用途
CN104211950A (zh) * 2013-06-04 2014-12-17 韩文毅 一种非线性聚合物及其制备与用途
TW201718581A (zh) 2015-10-19 2017-06-01 英塞特公司 作為免疫調節劑之雜環化合物
SG10202004618TA (en) 2015-11-19 2020-06-29 Incyte Corp Heterocyclic compounds as immunomodulators
US20170174671A1 (en) 2015-12-17 2017-06-22 Incyte Corporation Heterocyclic compounds as immunomodulators
SI3394033T1 (sl) 2015-12-22 2021-03-31 Incyte Corporation Heterociklične spojine kot imunomodulatorji
RU2616617C1 (ru) * 2016-04-12 2017-04-18 Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук 5-(9-этил-9Н-карбазол-3-ил)-4-[5-(9-этил-9Н-карбазол-3-ил)-тиофен-2-ил]-пиримидин
AR108396A1 (es) 2016-05-06 2018-08-15 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
MA45116A (fr) 2016-05-26 2021-06-02 Incyte Corp Composés hétérocycliques comme immunomodulateurs
ES2927984T3 (es) 2016-06-20 2022-11-14 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
ES2930092T3 (es) 2016-07-14 2022-12-07 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
US20180057486A1 (en) 2016-08-29 2018-03-01 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2018119221A1 (fr) 2016-12-22 2018-06-28 Incyte Corporation Dérivés pyridine utilisés en tant qu'immunomodulateurs
MX391981B (es) 2016-12-22 2025-03-21 Incyte Corp Derivados de benzooxazol como inmunomoduladores.
EP3558963B1 (fr) 2016-12-22 2022-03-23 Incyte Corporation Composés hétéroaromatiques bicycliques utilisés en tant qu'immunomodulateurs
WO2018119236A1 (fr) 2016-12-22 2018-06-28 Incyte Corporation Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs
SMT202300065T1 (it) 2018-03-30 2023-05-12 Incyte Corp Composti eterociclici come immunomodulatori
PL3790877T3 (pl) 2018-05-11 2023-06-12 Incyte Corporation Pochodne tetrahydroimidazo[4,5-c]pirydyny jako immunomodulatory pd-l1
CN109651232A (zh) * 2018-12-12 2019-04-19 河北华清光电材料有限公司 制备4-溴咔唑及其衍生物的方法
WO2021030162A1 (fr) 2019-08-09 2021-02-18 Incyte Corporation Sels d'un inhibiteur de pd-1/pd-l1
IL291471B2 (en) 2019-09-30 2025-04-01 Incyte Corp Pyrimido[3,2–D]pyrimidine compounds as immunomodulators
CN114829366A (zh) 2019-11-11 2022-07-29 因赛特公司 Pd-1/pd-l1抑制剂的盐及结晶形式
WO2022099018A1 (fr) 2020-11-06 2022-05-12 Incyte Corporation Procédé de préparation d'un inhibiteur de pd-1/pd-l1
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式
US11866434B2 (en) 2020-11-06 2024-01-09 Incyte Corporation Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof
CN114163417B (zh) * 2021-12-06 2023-08-04 郑州海阔光电材料有限公司 一种3-溴硫芴的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285398A (en) * 1969-06-25 1972-08-16 Merck & Co Inc Hydroxy-substituted tricyclic carboxylic acids and derivatives and pharmaceutical compositions containing them
US4222944A (en) * 1978-07-31 1980-09-16 Hoffmann-La Roche Inc. Halo-3-dibenzofuran alkanonitriles
WO2002060867A2 (fr) * 2001-01-29 2002-08-08 Insight Strategy And Marketing Ltd Derives de carbazole et leur utilisation en tant qu'inhibiteurs d'heparanase

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1041861A (en) 1962-03-14 1966-09-07 Organon Labor Ltd Pyrrolidone derivatives and pharmaceutical preparations containing them
US3759948A (en) * 1969-06-25 1973-09-18 Merck & Co Inc Non-steroid anti-inflammatory compounds
US3846553A (en) * 1969-12-03 1974-11-05 Merck & Co Inc 3-substituted-2-pyridones in the treatment of pain, fever or inflammation
NL7016899A (fr) 1969-12-03 1971-06-07
JPS62158253A (ja) 1985-12-28 1987-07-14 Kirin Brewery Co Ltd ４−アミノピリジンアミド誘導体
JPH0812430B2 (ja) 1986-07-07 1996-02-07 キヤノン株式会社 電子写真感光体
US5202344A (en) 1990-12-11 1993-04-13 G. D. Searle & Co. N-substituted lactams useful as cholecystokinin antagonists
IE71647B1 (en) 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
MX9301903A (es) 1992-04-02 1994-08-31 Smithkline Beecham Corp Compuestos.
PL307265A1 (en) 1992-07-28 1995-05-15 Rhone Poulenc Rorer Ltd Compounds containing a phenyl group bonded with aryl or heteroaryl group through their bonding aliphatic group or that containing heteroatom
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
US5814651A (en) 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
GB9304920D0 (en) 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
PL178314B1 (pl) 1993-07-02 2000-04-28 Byk Gulden Lomberg Chem Fab Benzamidy podstawione grupą fluoroalkoksylową, hamujące fosfodiesterazę cyklicznych nukleotydów, sposób ich otrzymywania i lek zawierający podstawione benzamidy
GB9315595D0 (en) 1993-07-28 1993-09-08 Res Inst Medicine Chem New compounds
WO1995009837A1 (fr) 1993-10-01 1995-04-13 Smithkline Beecham Corporation Composes cyano
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
GB9404706D0 (en) 1994-03-11 1994-04-27 Smithkline Beecham Corp Compounds
CN1166169A (zh) 1994-07-27 1997-11-26 三共株式会社 用作毒蕈碱性受体别构效应物的杂环化合物
CA2256716A1 (fr) * 1996-09-04 1998-03-12 Warner-Lambert Company Inhibiteurs de metalloproteinases matricielles et leurs utilisations pharmaceutiques
EP2261235A3 (fr) 1998-03-19 2011-04-20 Vertex Pharmaceuticals Incorporated Inhibiteurs de caspase
US6110962A (en) * 1998-05-12 2000-08-29 American Home Products Corporation 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
CN1308627A (zh) 1998-05-12 2001-08-15 美国家用产品公司 可用于治疗胰岛素抗性和高血糖的11－芳基－苯并[b]萘并[2,3－d]呋喃和11－芳基－苯并[b]萘并[2,3－d]噻吩
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
CZ20023033A3 (cs) 2000-03-17 2003-01-15 Bristol-Myers Squibb Pharma Company Deriváty cyklických beta-aminokyselin jako inhibitory matrixových metaloproteáz a TNF-alfa
US6924292B2 (en) 2000-03-23 2005-08-02 Takeda Chemical Industries, Ltd. Furoisoquinoline derivatives, process for producing the same and use thereof
KR20090090406A (ko) * 2000-12-18 2009-08-25 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 염증성 사이토카인 생산 유리 억제제
AU2002306687A1 (en) 2001-03-13 2002-09-24 Glenmark Pharmaceuticals Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
WO2003064389A1 (fr) * 2002-01-31 2003-08-07 Ono Pharmaceutical Co., Ltd. Composes bicycliques contenant de l'azote et medicaments contenant ces composes en tant qu'ingredient actif
WO2004016596A1 (fr) 2002-08-19 2004-02-26 Glenmark Pharmaceuticals Limited Composes condenses heterocycliques utilises comme inhibiteurs de pde-iv dans le traitement de troubles inflammatoires et allergiques
WO2004022536A1 (fr) 2002-09-04 2004-03-18 Glenmark Pharmaceuticals Limited Nouveaux composes amides heterocycliques utilises pour le traitement d'affections inflammatoires et allergiques; procede permettant de les fabriquer et compositions pharmaceutiques les contenant
AU2003269317B2 (en) * 2002-10-23 2009-10-29 Glenmark Pharmaceuticals Ltd. Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2004089940A1 (fr) * 2003-04-11 2004-10-21 Glenmark Pharmaceuticals S.A. Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant
ES2417491T3 (es) * 2004-12-17 2013-08-08 Glenmark Pharmaceuticals S.A. Novedosos compuestos heterocíclicos útiles para el tratamiento de trastornos inflamatorios y alérgicos

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285398A (en) * 1969-06-25 1972-08-16 Merck & Co Inc Hydroxy-substituted tricyclic carboxylic acids and derivatives and pharmaceutical compositions containing them
US4222944A (en) * 1978-07-31 1980-09-16 Hoffmann-La Roche Inc. Halo-3-dibenzofuran alkanonitriles
WO2002060867A2 (fr) * 2001-01-29 2002-08-08 Insight Strategy And Marketing Ltd Derives de carbazole et leur utilisation en tant qu'inhibiteurs d'heparanase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI474282B (zh) * 2008-10-03 2015-02-21 Himax Tech Ltd 深度相關的影像加強

Also Published As

Publication number Publication date
AU2004228453B2 (en) 2010-08-19
EP1620429A1 (fr) 2006-02-01
WO2004089940A1 (fr) 2004-10-21
PT1620429E (pt) 2009-04-28
IS8123A (is) 2005-11-10
US20050027129A1 (en) 2005-02-03
JP2006522789A (ja) 2006-10-05
DK1620429T3 (da) 2009-05-18
MY136516A (en) 2008-10-31
US20070105855A1 (en) 2007-05-10
SI1620429T1 (sl) 2009-08-31
TNSN05252A1 (en) 2007-07-10
ES2320888T3 (es) 2009-05-29
DE602004020332D1 (de) 2009-05-14
US7393846B2 (en) 2008-07-01
EP1620429B1 (fr) 2009-04-01
EA200501617A1 (ru) 2006-04-28
OA13154A (en) 2006-12-13
NO20055316D0 (no) 2005-11-10
US7223789B2 (en) 2007-05-29
US20090182143A1 (en) 2009-07-16
NZ542882A (en) 2007-10-26
CL2004000526A1 (es) 2005-03-18
AR043199A1 (es) 2005-07-20
BRPI0409747A (pt) 2006-05-09
US7384962B2 (en) 2008-06-10
TW200508212A (en) 2005-03-01
AU2004228453A1 (en) 2004-10-21
US20070105854A1 (en) 2007-05-10
KR20060017494A (ko) 2006-02-23
ATE427308T1 (de) 2009-04-15
CO5700824A2 (es) 2006-11-30
MA27801A1 (fr) 2006-03-01
HRP20050944A2 (en) 2006-02-28
EA010634B1 (ru) 2008-10-30
UA79558C2 (en) 2007-06-25
NO20055316L (no) 2006-01-11
PL378813A1 (pl) 2006-05-29
MXPA05010948A (es) 2006-05-31
AP2005003424A0 (en) 2005-12-31
GEP20084526B (en) 2008-11-10
CA2522023A1 (fr) 2004-10-21
ZA200508240B (en) 2006-05-31
CN1829711A (zh) 2006-09-06
CN1829711B (zh) 2010-06-16

Similar Documents

Publication Publication Date Title
AP2008A (en) Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them
AU2003263393A1 (en) New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
PL376769A1 (pl) Nowe związki tricykliczne użyteczne w leczeniu chorób zapalnych i alergicznych, sposób ich wytwarzania i kompozycje farmaceutyczne je zawierające
ZA200610055B (en) Chemical compounds and pharmaceutical compositions containing them for the treatment of inflammatory disorders
IL183827A0 (en) Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
HUP0600781A2 (en) Compounds for the treatment of metabolic disorders and pharmaceutical compositions containing them
WO2005063766A3 (fr) Inhibiteurs heterocycliques bicycliques des kinases p-38
NO20050741D0 (no) Ny fremgangsmate for syntesen og ny krystallinsk form av agomelatin og farmasoytiske sammensetninger inneholdende den
IL157734A0 (en) Pharmaceutical compositions for the treatment of urogenital disorders
PL374542A1 (en) Benzofused heteroaryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
PL1644021T3 (pl) Sposoby i kompozycje do leczenia zaburzeń żołądkowo-jelitowych
WO2004046120A3 (fr) Diaminotriazoles convenant comme inhibiteurs de proteine kinases
IL172621A0 (en) Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
IL190137A (en) Lacquinimod crystalline mixtures, pharmaceutical compositions containing them and ways to prepare them
GB0312832D0 (en) 2-amino-pyridine derivatives useful for the treatment of diseases
IL166108A0 (en) Novel compounds pharmaceutical compositions containing same and methods of use for same
IL175529A0 (en) Methods and compositions for the treatment of metabolic disorders
EP1615664A4 (fr) Composition pharmaceutique utile dans le traitement de troubles immunologiques
HUP0303751A3 (en) Use of n-phenyl-2-pyrimidineamine derivatives for preparation of pharmaceutical compositions suitable for treating mast cell-based diseases like allergic disorders
IL166054A0 (en) Novel compounds pharmaceutical compositions containing same and methods of use for same
AU2003253130A1 (en) Condensed heterocyclic compounds as pde-iv inhibitors for the treatment of inflammatory and allergic disorders
GB0407025D0 (en) Novel compounds
SI1831227T1 (sl) Nove heterociklične spojine uporabne za zdravljenje vnetnih in alergijskih motenj
EP1694242A4 (fr) Preparations pharmaceutiques de camptothecines et leur procede d'obtention
HK1101908A (en) Chemical compounds and pharmaceutical compositions containing them for the treatment of inflammatory disorders