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AP2006003849A0 - 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors - Google Patents

3-Aminocyclopentanecarboxamides as modulators of chemokine receptors

Info

Publication number
AP2006003849A0
AP2006003849A0 AP2006003849A AP2006003849A AP2006003849A0 AP 2006003849 A0 AP2006003849 A0 AP 2006003849A0 AP 2006003849 A AP2006003849 A AP 2006003849A AP 2006003849 A AP2006003849 A AP 2006003849A AP 2006003849 A0 AP2006003849 A0 AP 2006003849A0
Authority
AP
ARIPO
Prior art keywords
aminocyclopentanecarboxamides
modulators
chemokine receptors
chemokine
receptors
Prior art date
Application number
AP2006003849A
Other languages
English (en)
Inventor
Chu-Biao Xue
Chang-Sheng Zheng
Michael Xia
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AP2006003849A0 publication Critical patent/AP2006003849A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2006003849A 2004-06-28 2005-06-27 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors AP2006003849A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58348204P 2004-06-28 2004-06-28
US62437404P 2004-11-01 2004-11-01
PCT/US2005/022793 WO2006004684A2 (fr) 2004-06-28 2005-06-27 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de la chimiokine

Publications (1)

Publication Number Publication Date
AP2006003849A0 true AP2006003849A0 (en) 2006-12-31

Family

ID=35783293

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003849A AP2006003849A0 (en) 2004-06-28 2005-06-27 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors

Country Status (21)

Country Link
US (2) US7449467B2 (fr)
EP (1) EP1763351B9 (fr)
JP (2) JP4116670B2 (fr)
KR (1) KR100856156B1 (fr)
AP (1) AP2006003849A0 (fr)
AR (1) AR049559A1 (fr)
AU (1) AU2005260013A1 (fr)
BR (1) BRPI0512352A (fr)
CA (1) CA2571019C (fr)
CR (1) CR8775A (fr)
EA (1) EA011487B1 (fr)
EC (1) ECSP067120A (fr)
ES (1) ES2614117T3 (fr)
GE (1) GEP20094843B (fr)
IL (1) IL179910A0 (fr)
MA (1) MA28680B1 (fr)
MX (1) MXPA06014672A (fr)
NO (1) NO20070487L (fr)
SG (1) SG156691A1 (fr)
TW (1) TW200608966A (fr)
WO (1) WO2006004684A2 (fr)

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EP1565436B1 (fr) * 2002-11-27 2012-04-25 Incyte Corporation Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine
HU229709B1 (en) * 2004-04-13 2014-05-28 Incyte Corp Wilmington Piperazinyilpiperidine derivatives as chemokine receptor antagonists
JP4116671B2 (ja) * 2004-06-28 2008-07-09 インサイト コーポレイション ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド
BRPI0512352A (pt) * 2004-06-28 2008-03-04 Incyte Corp 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas
WO2007053499A2 (fr) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Composés pouvant être employés en tant qu'antagonistes de ccr2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
MEP1008A (xx) * 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina
US7910108B2 (en) 2006-06-05 2011-03-22 Incyte Corporation Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2008109238A1 (fr) * 2007-03-02 2008-09-12 Janssen Pharmaceutica N.V. Cyclopentylpipéridines substituées antagonistes du ccr2
US8536198B2 (en) * 2007-07-24 2013-09-17 Bristol-Myers Squibb Company Piperidine derivatives as modulators of chemokine receptor activity
TWI433838B (zh) 2008-06-25 2014-04-11 必治妥美雅史谷比公司 作為趨化因子受體活性調節劑之六氫吡啶衍生物
HRP20130409T2 (hr) * 2008-11-26 2013-11-22 Pfizer Inc. 3-aminociklopentankarboksamidi kao modulatori kemokinskih receptora
CN101555616B (zh) * 2009-05-13 2012-11-07 大连理工大学 镍钛合金表面羟基磷灰石/二氧化钛复合涂层的制备方法
MX2012013082A (es) 2010-05-12 2013-05-09 Vertex Pharma Derivados de 2-aminopiridina utiles como iinhibidores de cinasa atr.
WO2013010839A1 (fr) * 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Antagonistes de ccr2 nouveaux et sélectifs
MX381819B (es) 2014-08-04 2025-03-13 Nuevolution As Derivados de heterociclico opcionalmente condensados de pirimidina útiles para el tratamiento de enfermedades inflamatorias, metabólicas oncológicas y autoinmunitarias.
US10403890B2 (en) * 2015-11-10 2019-09-03 Nissan Motor Co., Ltd. Negative electrode active material for electric device and electric device using the same
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
JP7746259B2 (ja) 2019-12-20 2025-09-30 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性の化合物
WO2021198955A1 (fr) 2020-03-31 2021-10-07 Nuevolution A/S Composés actifs vis-à-vis des récepteurs nucléaires
EP4126875A1 (fr) 2020-03-31 2023-02-08 Nuevolution A/S Composés actifs vis-à-vis des récepteurs nucléaires
WO2022077034A1 (fr) * 2020-10-09 2022-04-14 Napa Therapeutics Ltd. Inhibiteurs amides hétéroaryles de cd38
EP4289431A4 (fr) 2020-11-19 2024-09-18 Gliacelltech Inc. Composition pour la prévention ou le traitement d'une maladie neuro-inflammatoire comprenant de la didanosine

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US6500844B1 (en) * 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US6977265B2 (en) 2001-11-30 2005-12-20 Roche Palo Alto Llc Piperidine CCR-3 receptor antagonists
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TWI262077B (en) 2002-04-29 2006-09-21 Merck & Co Inc Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
CA2483843A1 (fr) 2002-04-29 2003-11-13 Merck & Co. Inc. Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline
JP2006514003A (ja) * 2002-10-30 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルベンジルアミド調節剤
JP2006511500A (ja) 2002-10-30 2006-04-06 メルク　エンド　カムパニー　インコーポレーテッド γ−アミノアミド系のケモカイン受容体活性調節剤
JP2006508948A (ja) 2002-10-30 2006-03-16 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性のヘテロアリールピペリジンモジュレーター
EP1558253A4 (fr) 2002-10-30 2007-07-25 Merck & Co Inc Modulateur piperidinyl-alpha-aminoamide de l'activite de recepteurs de la chimiokine
CA2503713A1 (fr) 2002-10-30 2004-05-21 Merck & Co., Inc. Composes de piperidinyl cyclopentyl aryl benzylamide modulateurs de l'activite du recepteur de chimiokine
EP1565436B1 (fr) * 2002-11-27 2012-04-25 Incyte Corporation Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine
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WO2005040109A1 (fr) * 2003-10-22 2005-05-06 Neurocrine Biosciences, Inc. Ligands du recepteur de la melanocortine et compositions et methodes associees
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EP1696919B1 (fr) 2003-12-18 2013-10-02 Incyte Corporation Derives 3-cycloalkylaminopyrrolidine utilises en tant que modulateurs des recepteurs de chimiokine
EP1701724A4 (fr) 2004-01-02 2007-11-14 Merck & Co Inc Modulateurs d'amide cyclopentyle d'alkylamino, arylamino et sulfonamido de l'activite des recepteurs de la chimiokine
EP1732552A4 (fr) 2004-01-20 2007-12-19 Merck & Co Inc Piperidines disubstituees en 2,6, modulatrices de l'activite du recepteur de la chemokine
JP2007519734A (ja) 2004-01-28 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
JP2007534758A (ja) 2004-04-26 2007-11-29 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性調節物質であるテトラヒドロピラニルシクロペンチル１−置換及び１，１−二置換テトラヒドロイソキノリン
AP2314A (en) * 2004-05-11 2011-10-31 Incyte Corp 3- 4-heteroarylcyclohexylamino cyclopentanecarboxamides as modulators of chemokine receptors.
BRPI0512352A (pt) * 2004-06-28 2008-03-04 Incyte Corp 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas
JP4116671B2 (ja) * 2004-06-28 2008-07-09 インサイト コーポレイション ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド
UY29219A1 (es) * 2004-11-22 2006-04-28 Incyte Corp Sales de la n-(2- (((3r)-1-(trans-4-hidroxi-4-(6-metoxipiridin-3-il)-cilohexil) pirrolidin-3-il)amino)-2-oxoetil)-3- (trifluorometil) benzamida
MEP1008A (xx) * 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina

Also Published As

Publication number Publication date
JP2008504293A (ja) 2008-02-14
EA200602242A1 (ru) 2007-04-27
AR049559A1 (es) 2006-08-16
EP1763351B9 (fr) 2017-05-31
IL179910A0 (en) 2007-05-15
US7449467B2 (en) 2008-11-11
JP4116670B2 (ja) 2008-07-09
EP1763351A2 (fr) 2007-03-21
US8470827B2 (en) 2013-06-25
WO2006004684A8 (fr) 2007-01-04
CR8775A (es) 2007-01-04
CA2571019A1 (fr) 2006-01-12
AU2005260013A1 (en) 2006-01-12
CA2571019C (fr) 2012-06-05
WO2006004684A2 (fr) 2006-01-12
EP1763351A4 (fr) 2009-08-12
JP2008074877A (ja) 2008-04-03
BRPI0512352A (pt) 2008-03-04
NO20070487L (no) 2007-03-05
ECSP067120A (es) 2007-01-26
MXPA06014672A (es) 2007-03-26
TW200608966A (en) 2006-03-16
EP1763351B1 (fr) 2016-11-30
US20060004018A1 (en) 2006-01-05
ES2614117T3 (es) 2017-05-29
KR100856156B1 (ko) 2008-09-03
EA011487B1 (ru) 2009-04-28
US20100119503A1 (en) 2010-05-13
GEP20094843B (en) 2009-11-25
MA28680B1 (fr) 2007-06-01
KR20070026660A (ko) 2007-03-08
SG156691A1 (en) 2009-11-26
WO2006004684A3 (fr) 2006-10-05

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