NZ744238B2

NZ744238B2 - Fermented formula with non-digestible oligosaccharides

Info

Publication number: NZ744238B2
Application number: NZ744238A
Authority: NZ
Inventors: Houkje Bouritius; Jan Knol; Alma Jildou Nauta; Akhtar Raish Oozeer
Original assignee: Nv Nutricia
Filing date: 2016-12-29
Publication date: 2025-05-01

Abstract

fermented formula comprising non digestible oligosaccharides synergistically stimulates secretory IgA in infants. In particular, the invention provides the use of a composition comprising 0.02-1.5 wt% lactic acid bacteria and lactate combined, produced from a fermented lactic acid bacteria and 2.5-15 wt% non-digestible oligosaccharides to increase IgA secretion and improve mucosal immune defense in infants or babies.

Claims

WHAT WE CLAIM IS:

1. Use of a fermented ingredient and gestible oligosaccharide in the manufacture of a nutritional composition for preventing or treating a disorder that is prevented or treated by increasing IgA secretion in a human subject with an age of 0 to 36 months, wherein the fermented ingredient is a composition that is fermented by lactic acid producing bacteria and wherein the ional composition comprises 0.02 to 1.5 wt% of the sum of lactic acid and lactate based on dry weight of the nutritional composition and comprises 2.5 to 15 wt% non-digestible oligosaccharide based on dry weight of the nutritional composition.

2. Use of a fermented ingredient and non-digestible oligosaccharide in the manufacture of a nutritional composition for use in improving l immune defense in a human subject with an age of 0 to 36 months, wherein the fermented ingredient is a ition that is ted by lactic acid producing bacteria and wherein the nutritional composition comprises 0.02 to 1.5 wt% of the sum of lactic acid and lactate based on dry weight of the nutritional composition and comprises 2.5 to 15 wt% nondigestible oligosaccharide based on dry weight of the nutritional composition.

3. The use according to any one of the preceding claims wherein the fermented ingredient is a milk substrate that is fermented by lactic acid producing bacteria, and said milk ate comprises at least one selected from the group consisting of milk, whey, whey protein, whey protein hydrolysate, casein, casein hydrolysate, and lactose or mixtures thereof.

4. The use ing to any one of the preceding claims, wherein the nutritional composition is an infant formula, a follow on formula or a g up milk.

5. The use according to any one of the preceding claims, wherein the gestible oligosaccharide is selected from the group consisting of fructo-oligosaccharide, non- digestible dextrin, galacto-oligosaccharide, xylo-oligosaccharide, arabinooligosaccharide , ogalacto-oligosaccharide, gluco-oligosaccharide, gentiooligosaccharide , glucomanno-oligosaccharide, galactomanno-oligosaccharide, mannan-oligosaccharide, isomalto-oligosaccharide, nigero-oligosaccharide, glucomanno-oligosaccharide, chito-oligosaccharide, soy oligosaccharide, uronic acid oligosaccharide, sialyloligosaccharide, and fuco-oligosaccharide, and mixtures thereof.

6. The use ing to any one of the preceding , wherein the non-digestible oligosaccharide comprises galacto-oligosaccharide and/or fructo-oligosaccharide.

7. The use according to any one of the preceding claims, wherein at least 90 wt% of the sum of lactic acid and lactate is L(+)-lactic acid and/or L(+)-lactate.

8. The use according to any one of the preceding claims, wherein the fermented ingredient is fermented by Bifidobacterium and/or ococcus.

9. The use according to any one of the preceding claims n the nutritional composition comprises Bifidobacterium breve and/or ococcus thermophilus.

10. The use according to any one of the preceding claims wherein the lactic acid producing bacteria are inactivated to a level below 105, more preferably below 103 cfu/g dry weight of the nutritional composition.

11. The use according to any one of the preceding claims wherein the nutritional composition comprises protein, digestible carbohydrate and lipid and wherein the protein provides 1.6 to 4 g per 100 kcal, the digestible carbohydrates provides 5 to 20 g per 100 kcal and the lipid es 3 to 7 g lipid per 100 kcal of the nutritional composition.

12. Use according to claim 1, substantially as herein described or ified.

13. Use according to claim 2, substantially as herein described or exemplified.