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NZ732700A - Microencapsulated cannabinoid compositions - Google Patents

Microencapsulated cannabinoid compositions

Info

Publication number
NZ732700A
NZ732700A NZ732700A NZ73270015A NZ732700A NZ 732700 A NZ732700 A NZ 732700A NZ 732700 A NZ732700 A NZ 732700A NZ 73270015 A NZ73270015 A NZ 73270015A NZ 732700 A NZ732700 A NZ 732700A
Authority
NZ
New Zealand
Prior art keywords
cannabinoid
compound
containing composition
rule
substitute sheet
Prior art date
Application number
NZ732700A
Other versions
NZ732700B2 (en
Inventor
William Kleidon
Justin Kirkland
Original Assignee
Ojai Energetics Pbc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ojai Energetics Pbc filed Critical Ojai Energetics Pbc
Publication of NZ732700A publication Critical patent/NZ732700A/en
Publication of NZ732700B2 publication Critical patent/NZ732700B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/001—Spread compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A23G9/52—Liquid products; Solid products in the form of powders, flakes or granules for making liquid products ; Finished or semi-finished solid products, frozen granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
    • A—HUMAN NECESSITIES
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    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
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    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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Abstract

The present invention relates to cannabinoid compositions. These compositions can be encapsulated (e.g., microencapsulated). In particular, these compositions can be administered to a subject, such as through oral consumption or topical treatment.

Claims (16)

1. A cannabinoid-containing composition comprising a plurality of droplets in an emulsion, wherein an individual droplet of said plurality has a size less than or equal to about 500 nanometers and comprises: (i) at least one cannabinoid compound in addition to tetrahydrocannabinol (THC); (ii) at least one terpene compound; and (iii) a compound that counteracts tetrahydrocannabinol (THC) intoxication, wherein the compound is pregnenolone, wherein said composition comprises: (1) at least one terpene compound present in an amount of at least one microgram, and (2) a natural or naturally-derived surfactant present in an amount such that said composition comprising said plurality of droplets has a shelf half-life of at least 1 week, wherein said individual droplet has a THC content of more than 0% and less than 0.3% by weight, wherein said at least one cannabinoid compound in said emulsion has a bioavailability of at least twice that of said at least one cannabinoid compound in non-droplet-encapsulated form.
2. The cannabinoid-containing composition of claim 1, wherein said individual droplet has a size between about 10 nanometers and about 200 nanometers.
3. The cannabinoid-containing composition of claim 1 or claim 2, wherein said natural or naturally-derived surfactant is a saponin or rice bran.
4. The cannabinoid-containing composition of any one of claims 1-3, wherein said at least one cannabinoid compound comprises cannabidiol (CBD).
5. The cannabinoid-containing composition of any one of claims 1-4, further comprising a pharmaceutically acceptable excipient.
6. The cannabinoid-containing composition of any one of claims 1-5, further comprising a stabilizer.
7. The cannabinoid-containing composition of claim 6, wherein said stabilizer is alginate.
8. The cannabinoid-containing composition of any one of claims 1-7, further comprising at least one agent selected from the group consisting of an herb, an essential oil, a food product, a mushroom, fulvic acid, L-Theanine, Fish Oil, phenyl ethyl amine (PEA), tulsi, lemon balm, passion flower, blue lotus, cacao, maca, schizandra, Siberian ginseng, kava, skullcap, valerian, hops, California poppy, catuba, epidmedium, pao d'arco, ashwaganda, ginko, albiza, reishi, lion's mane, maitake, chaga, vitamin C, turmeric, CBD oil, bioperine, and xanthohumol.
9. The cannabinoid-containing composition of claim 1, wherein said individual droplet of said plurality of droplets is characterized by at least one of: (i) a sigmoidal release profile of said at least one cannabinoid compound; (ii) a plasma half-life of said at least one cannabinoid compound greater than twice that of said at least one cannabinoid compound in non-encapsulated form; (iii) a first pass metabolism of said at least one cannabinoid compound reduced by at least 50% compared to said at least one cannabinoid compound in non- encapsulated form; (iv) a rate of excretion of said at least one cannabinoid compound from a subject's body reduced by at least 20% compared to said at least one cannabinoid compound in non-encapsulated form; and (v) a degradation rate at an ambient temperature of at least 20° C. of said at least one cannabinoid compound of less than about 50% of a degradation rate of said at least one cannabinoid compound in non-encapsulated form.
10. The cannabinoid-containing composition of any one of the preceding claims, wherein said at least one cannabinoid compound is present at a concentration of from about 0.03% to about 5% by weight.
11. The cannabinoid-containing composition of claim 9, wherein said individual droplet in said emulsion is stable over a period of at least 1 month.
12. The cannabinoid-containing composition of any one of the preceding claims, wherein said emulsion is free of a synthetic surfactant.
13. The cannabinoid-containing composition of any one of the preceding claims, wherein said composition exists in an emulsion state for a period of at least 1 month.
14. The cannabinoid-containing composition of any one of the preceding claims, wherein said individual droplet has a THC content of at most 0.1% by weight.
15. The cannabinoid-containing composition of any one of the preceding claims, wherein said composition comprises pregnenolone or a derivative thereof present at an amount of between about 1 milligram (mg) to 50 mg.
16. The cannabinoid-containing composition of claim 1, wherein said at least one cannabinoid compound is present at a concentration between about 0.03% to 10% by weight. 1 / 9 w'SS: SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SKS • m SUBSTITUTE SHEET (RULE 26)
NZ732700A 2015-12-11 Microencapsulated cannabinoid compositions NZ732700B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462091445P 2014-12-12 2014-12-12
US201562128761P 2015-03-05 2015-03-05
PCT/US2015/065268 WO2016094810A2 (en) 2014-12-12 2015-12-11 Microencapsulated cannabinoid compositions

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NZ732700A true NZ732700A (en) 2024-07-05
NZ732700B2 NZ732700B2 (en) 2024-10-08

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