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NZ502175A - Selective regulation of adenovirus packaging with COUP-TF or lac repressor - Google Patents

Selective regulation of adenovirus packaging with COUP-TF or lac repressor

Info

Publication number
NZ502175A
NZ502175A NZ502175A NZ50217599A NZ502175A NZ 502175 A NZ502175 A NZ 502175A NZ 502175 A NZ502175 A NZ 502175A NZ 50217599 A NZ50217599 A NZ 50217599A NZ 502175 A NZ502175 A NZ 502175A
Authority
NZ
New Zealand
Prior art keywords
packaging
coup
adenovirus
lac repressor
adenovirus packaging
Prior art date
Application number
NZ502175A
Inventor
Patrick Hearing
Susanne I Schmid
Philomena H Ostapchuk
Ece Erturk
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Publication of NZ502175A publication Critical patent/NZ502175A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Wrapping Of Specific Fragile Articles (AREA)

Abstract

A method of regulating adenovirus packaging comprising the steps of :(a) obtaining an adenovirus vector containing an adenovirus packaging repressor binding site, said binding site being located between, within or surrounding an adenovirus packaging sequence; and (b) propagating said vector in the absence of said packaging repressor; and (c) repressing packaging of said vector in the presence of said packaging repressor.
NZ502175A 1998-04-15 1999-04-15 Selective regulation of adenovirus packaging with COUP-TF or lac repressor NZ502175A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8186798P 1998-04-15 1998-04-15
US8832198P 1998-06-05 1998-06-05
PCT/US1999/008294 WO1999053085A2 (en) 1998-04-15 1999-04-15 Selective regulation of adenovirus production

Publications (1)

Publication Number Publication Date
NZ502175A true NZ502175A (en) 2002-12-20

Family

ID=26766062

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ502175A NZ502175A (en) 1998-04-15 1999-04-15 Selective regulation of adenovirus packaging with COUP-TF or lac repressor

Country Status (6)

Country Link
EP (1) EP0994958A2 (en)
JP (1) JP2002506355A (en)
AU (1) AU770005B2 (en)
IL (1) IL133510A0 (en)
NZ (1) NZ502175A (en)
WO (1) WO1999053085A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020136708A1 (en) 1993-06-24 2002-09-26 Graham Frank L. System for production of helper dependent adenovirus vectors based on use of endonucleases
WO2000049166A2 (en) * 1999-02-18 2000-08-24 Merck & Co., Inc. Production of helper dependent adenovirus vectors based on use of endonucleases
US6821512B1 (en) 1999-12-03 2004-11-23 The Trustees Of The University Of Pennsylvania Compositions and methods for increasing packaging and yield of recombinant adenoviruses using multiple packaging signals
EP1234048A2 (en) * 1999-12-03 2002-08-28 The Trustees Of The University Of Pennsylvania Compositions and methods for increasing packaging and yields of recombinant adenoviruses using multiple packaging signals
US6867022B1 (en) * 2000-01-21 2005-03-15 Regents Of The University Of Michigan Replication deficient adenovirus vectors and methods of making and using them
US6916635B2 (en) 2000-10-02 2005-07-12 The Research Foundation Of State University Of New York Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
WO2003027271A2 (en) * 2001-09-25 2003-04-03 The Research Foundation Of The State University Of New York Regulation of adenovirus dna packaging by iptg
EP2377882A1 (en) * 2004-10-28 2011-10-19 University of Pittsburgh of the Commonwealth System of Higher Education Peripherally delivered glutamatic acid decarboxylase gene therapy for spinal cord injury pain
BR112019027765A2 (en) 2017-07-25 2020-07-14 Oxford Genetics Limited adenoviral vectors
TW202323529A (en) 2021-10-18 2023-06-16 美商再生元醫藥公司 Eukaryotic cells comprising adenovirus-associated virus polynucleotides

Also Published As

Publication number Publication date
EP0994958A2 (en) 2000-04-26
WO1999053085A3 (en) 2000-01-27
IL133510A0 (en) 2001-04-30
AU3563699A (en) 1999-11-01
JP2002506355A (en) 2002-02-26
AU770005B2 (en) 2004-02-12
WO1999053085A2 (en) 1999-10-21

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Legal Events

Date Code Title Description
PSEA Patent sealed