NZ236736A - Preparation of controlled-release granules containing a pesticide and water and/or a polyhydroxy compound by coating them by reacting with a liquid polyisocyanate - Google Patents

Description

New Zealand Paient Spedficaiion for Paient Number £36736 23G73G Priority Datefs}: . .(?r. [ Complete Speci;"'- • .

Class: J9Q\ M'Z-S \u& ....... 26 HAft'1993' Publication Date: . P.O. Journal, No: m n&fcVflN 61 ij Patents Form No. 5 PROCESS FOR PREPARING CONTROLLED REtE&SE GRANULES WE, E.I. DU PONT DE NEMOURS AND COMPANY, a company organized and existing under the laws of the State of Delaware, U.S.A. of 10th & Market Streets, Wilmington, Delaware 19898, United States of America, hereby declare the invention, for which We pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement: (followed by Page la) 23673G 1 a TITLE BA-8820 PROCESS FOR PREPARING CONTROLLED RELEASE GRANULES 5 BACKGROUND OF THE INVENTION This invention relates to a simplified process for preparing controlled release granules of pesticides.

Controlled release pesticides in granular 10 formulations have been well known in the art for quite some time.

U.K. Patent Application No. 2,007,095-A discloses a process for making slow release biologically active granules by mixing an active with 15 a polyisocyanate and one or more compounds having an active hydrogen atom and then granulating. The granulation operation requires specialized equipment such as a fluidized bed or spray dryer.

U.S. 4,223,070 discloses a process for making 20 slow release granules involving overcoating inert porous granules with a solution of active and an organic polyisocyanate followed by applying an aqueous solution of polymerization catalyst as an additional step.

Japanese Patent Application No. 58-82303 (Kokai No. 59-206302) (copy of translation available upon request) discloses a process involving coating an active component on a granular carrier with a hydroxyl-containing organic compound or water, a "non-ionic surfactant" of the formula 30 R0(CHoCH?0)nC0NHX where R is Ct-C^ alkyl, nr-i-s—i-d-20", ~T . . . i N.Z.PATEWTOFFK& and X is a di- or polyisocyanate residue, and—a " polyisocyanate. I 28 JAN 1933 A need still exists, however, for impii©^ed- i RECEIVED controlled release granules prepared by a si!mp-le process in conventional mixing equipment. (followed by page 2) V V ' t.J i r; w According to the instant invention, an improved process for preparing controlled release granules has 5 been found which is much more versatile and convenient than the processes mentioned above. No adjuvants or solvents are required in the process of this invention. Treatment with aqueous catalyst solution as taught in U.S. 4,223,070 is not required, O 10 and such treatment could lead to non-uniform polymeric coatings because of non-uniform wetting. The process of the present invention can be applied to porous or nonporous granules whereas the process of U.S. 4,223,070 is applicable only to the former. 15 Also, the process of U.S. 4,223,070 requires that the active component be dissolved in the polyisocyanate whereas the process of this invention does not have this requirement. Many pesticides do not dissolve in polyisocyanates and in some cases, the biologically 20 active material can be destroyed by reaction with the polyisocyanate.

SUMMARY OF THE INVENTION • This invention relates to a process for preparing controlled release granules of pesticides 25 for direct application consisting essentially of overcoating a granular carrier containing a pesticide and a polyhydroxylated compound or water with a liquid polyisocyanate and a polymerization catalyst, optionally at elevated temperatures, resulting in 30 interfacial polymerization to a solid cross-linked polyurethane or polyurea barrier.

The term pesticide refers to water-soluble or water-insoluble chemicals commonly known as herbicides, fungicides, insecticides, nematocides, 35 acaricides, miticides, virucides, algiciflgLS, bactericides, plant growth regulants, and their*"-.. agriculturally suitable salts. Preferred are those pesticides which lend themselves to direct soil application. More preferred are herbicides selected from the classes of herbicideal sulfonylureas, imidazolinones, uracils and dinitroanilines; and insecticides selected from the classes of insecticidal carbamates and phosphonates.

Specifically preferred are the following: methyl 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)-amino]carbonyl]amino]su!fonyl]methyl-benzoate (bensulfuron); 5-bromo-3-sec-butyl-6-methyluracil (bromaci1); a,cc,a-trif luoro-2,6-dinitro-N,N-dipropyl-p- toluidine (trifluralin); N,N-dimethyl-2-methylcarbamoyloxyimino-2- (rnethylthio)acetarnide (oxamyl); S-tert-butylthiomethyl 0,0-diethylphosphoro- dithioate (terbufos); and 0,0-diethyl 0-(l,2,2,2-tetrachloroethyl)~ phosphorothioate.

Granular carrier refers to any inert porous or nonporous solid material, examples of which include sand, aggregated clays such as kaolinite, bentonite and attapulgite, vermiculite and granular salts or organic compounds such as sugars, urea, potassium or calcium carbonate, ammonium nitrate, and other granular fertilizers. The term granular carrier also includes water-dispersible granules, examples of which are Glean® 75 DF, Pinnacle® DF and Londax® 60 DF, products of E. I. du Pont de Nemours and Company, Wilmington, DE. Preferred granule sizelis about 150 to 4000 microns with 250 to 2000 microns beiTDg—mQre preferred.

The term polyhydroxylated compound refers to organic chemicals containing two or more free hydroxy1 substituents, examples of which include glycols, glycerin or other polyhydric alcohols or mixtures thereof which are liquids or low-melting solids. Preferred are ethylene glycol or propylene glycol.

The term polyisocyanate refers to any aliphatic, alicyclic or aromatic organic compound with two or more isocyanato substituents (-NCO) present, which is either a low-melting solid or is a liquid at ambient temperature and pressure. Examples of suitable polyisocyanates include the following: hexamethylene-1,6-diisocyanate; m-phenylene diisocyanate;-p-phenylene diisocyanate; 2.4-toluene diisocyanate; 2,6-toluene diisocyanate; 1.5-naphthalene diisocyanate; cyclohexane 2,4-diisocyanate; 1-methylcyclohexyl 2,6-diisocyanate; and 2,4, 6-triisocyanato toluene; or mixtures thereof that are liquids.

Preferred are methylene-1inked polyphenyl-isocyanates, examples of which include those sold under the trade names "Mondur MRS®" (Mobay Chemical Co.) and "PAPI®" (Dow Chemical Co.); the latter is more preferred.

Suitable polymerization catalysts are organic tertiary amines and alkyltin carboxylic esters. Preferred catalysts are triethylamine, trimethylamine, triethylenediamine, tri-n-butylamine, N-rnethyl-morpholine, triethanolamine, dibutyltin dilaurate, dibutyltin diacetate, tributyltin acetate, dibutyltin laurate and dibutyltin maleate. More preferred is dibutyltin dilaurate.

The process is carried out by adding the polyisocyanate and polymerization catalyst to the granules containing the pesticide and water or polyhydroxylated compound at ambient temperature or above. The preferred temperature range is about 23°C to 35°C. The amounts of polyisocyanate and polymerization catalyst employed in the reaction are about 1 to 20% and 0-5% by weight, respectively; a more preferred amount of catalyst is 0.05-1%. More than 20% by weight of the polyisocyanate can be added to the granule if it is applied stepwise, e.g., in layers. The water or polyhydroxylated material must be present in an amount sufficient to ensure that all of the polyisocyanate has reacted. Although reaction time is not critical, it is preferred that the granules can be easily handled (i.e., are nonaggregating) after about 20-30 minutes; a more preferred length of time is about 20 minutes.

The granular bases used in the process of this invention can be aggregated minerals, clays and other inorganic substances or organic mixtures prepared by known methods such as granulating, prilling, tableting, extrusion or compacting. The granular bases can also be naturally occurring granules such as .sands. Examples of suitable inorganic granular bases include kaolinite, bentonite, attapulgite, vermiculite crushed brick and granular salts. Nonlimiting examples of suitable organic granular bases include sugars, urea, potassium carbonate and calcium carbonate. Other suitable materials include granulated corn cobs. The process of this invention DETAILED DESCRIPTION OF THE INVENTION 9 '•> ( "■" l o u ( o is also applicable to commercial water dispersible granules prepared by granulation of powdered premizes ^ 5 of biologically active materials and formulation adjuvants such as binders and dispersants. Preferred are inert aggregated mineral granules which are impregnated with active material. Preferred granule size is about 150 to 4000 microns with 250 to 2000 ^ 10 microns being more preferred. \ j The active material used in the process of this invention can be a mixture of compounds or a single compound, and can be in the form of a solid or liquid. The active material can be an integral part 15 of the granule matrix or can be added at any time during the processing as will be apparent to one skilled in the art. It is preferred that the active material be a component of the granular material used or be mixed with or impregnated into the granular 20 matrix prior to overcoating with polymer. One advantage of pre-incorporation is that there would be less opportunity for the active material to react with the polyisocyanate in cases where the active material is a compound containing hydroxyl, amino, 25 carboxylic acid or other similarly reactive functional groups. Also, by integrating the active material present in or placing it on the granular base before the polymer barrier is formed, superior barrier characteristics are attainable with 30 relatively small amounts of polymer. In this manner, the polymer barrier is not diluted or weakened by the presence of a non-polymeric material. However, when desired, non-volatile organic material or the active material can sometimes be advantageously added to the polyisocyanate for adjustment of release rate. ——— o o / 7 Suitable active materials are selected from the group consisting of herbicides, fungicides, 5 insecticides, nematocides, acaricides, miticides, virucides, algicides, bactericides and plant growth regulants, and their agriculturally suitable salts. Preferred are those active materials which lend themselves to direct soil application. More ! ' J preferred are herbicides selected from the classes of sulfonylureas, imidazolinones, uracils and dinitroanilines; and insecticides selected from the classes of carbamates and phosphonates. Specific examples of preferred active materials are the 15 following: methyl 2-1[[[(4, 6-dimethoxy-2-pyrimidinyl)-amino]carbonyl]amino]sulfonyl]methyl-benzoate; -bromo-3-sec-butyl-6-methyluracil; 20 a,a,a-trifluoro-2,6-dinitro-N,N-dipropyl-p- toluidine; N,N-dimethyl-2-methylcarbamoyloxyimino-2- (methylthio)acetamide; S-tert-butylthiomethyl 0,0-diethylphosphoro-25 dithioate; and 0,0-diethyl 0-(l,2,2,2-tetrachloroethyl)- phosphorothioate.

The term "polyhydroxyl compound" as used in the (v) context of this invention is meant to include organic compounds containing at least two free hydroxyl (-OH) substituents. Examples of suitable polyhydroxyl compounds include glycols, glycerin and other polyhydroxylated alcohols or mixtures thereof, or mixtures thereof with water, which are either liquids 35 or solids. Preferred polyhydroxyl compounds are ethylene glycol and propylene glycol. Water can be n ^-s, O O fi <) i■•" *')/*'> U U { O U 8 used in place of some or all of the polyhydroxyl compound or mixture or polyhydroxyl compounds. While 5 solid polyhydroxyl compounds are operable in the process of this invention, it is preferred that they be used in liquid form by dissolution in a second, liquid polyhydroxyl compound.

The term "polyisocyanate" as used in the 10 context of this invention is meant to include any organic compound containing at least two isocyanato (-NCO) substituents. When solid polyisocyanates are employed in the process of this invention, it is preferred that they be pre-dissolved in a second, 15 liquid polyisocyanate.

Preferred polyisocyanates are methylene-1inked polyphenylisocyanates, nonlimiting examples of which include those sold under the trade names "Mondur MRS®" (Mobay Chemical Co.) and "PAPI®" (Dow Chemical 20 Co.); the latter is more preferred.

While the polymerization reaction requires no catalyst and can be accelerated solely by heating, it is preferred that the process be completed in under 60 minutes, most preferred under 30 minutes at room 25 temperature. The polymerization reaction can be accelerated to provide this result by addition of known catalysts for preparing ureas and urethanes, such as organic tertiary amines or alkyltin carboxylic esters to the polyisocyanate before 30 application to the granular substrate. Preferred catalysts are triethylamine, trimethylamine, triethylenediamine, tri-n-butylamine, N-methylmorpholine, triethanolamine, dibutyltin dilaurate, dibutyltin diacetate, tributyltin acetate, 35 dibutyltin laurat^ and dibutyltin maleate. More preferred is dibutyltin dilaurate. 7\r The process of this invention is carried out by-adding the polyisocyanate and optional polymerization catalyst to the granules containing the active material and water or polyhydroxyl compound at ambient temperature or above. The preferred temperature range is about 23°C to 35°C. The amount of polyisocyanate employed in the process is' about 1 to 20% by weight based on the amount of granular material. Greater than 20% by weight of polyisocyanate can be added to the granules if it is applied in sequential layers wherein sufficient time is allowed for each layer to polymerize before the next coating is applied. When a polymerization catalyst is used, the preferred amount is up to about 5% by weight relative to the amount of polyisocyanate; a more preferred amount of catalyst is 0.05 to 1%. The catalyst is most advantageously applied in solution with the polyisocyanate or polyhydroxyl material to achieve a uniform polymerization reaction. The water or polyhydroxyl compound must be present in an amount sufficient to insure that all of the polyisocyanate has reacted. The barrier-forming reaction occurs at the interface between the top layer of the isocyanate phase and the underlying water or hydroxyl material and generally continues until all the isocyanate functionality is consumed. The presence of excess water or hydroxyl functionality does not normally affect the barrier since such material can be entrapped under the barrier formed. Although reaction time is not critical, it is preferred that the granules can be easily handled (i.e., are nonaggregating) after about 20 to 30 minutes; a more preferred length of time is about 20 minutes. - - f-r i ;,x Where water is the coreactant with the polyisocyanate, some of the isocyanate groups hydrolyze to form amino functionality, followed by self-polycondensation by reaction with the unaffected isocyanate groups. Under these conditions, a polyurea is formed. Where a polyhydroxyl compound is used, a polyurethane is produced as barrier. When the polyhydroxyl or polyisocyanate compounds have more than two hydroxyl or isocyanate groups, cross-linked polymeric barrier coatings are formed. If a mixture of water and at least one organic polyhydroxyl compound is used, the polymeric barrier produced is a polyurea-urethane.

Reduction of the release rate is generally achieved by use of aromatic polyisocyanates instead of alphatic polyisocyanates or by increasing the amount of polymer forming ingredients (which governs the thickness of the shell). Reduction of release rate can also be achieved by increasing the degree of cross-linking by using reactants containing more than two hydroxyl or isocyanate groups to process cross-linking and using no diluents.

In the Examples below, which are further illustrative of the process of this invention, release rates were measured in pH 7 buffered water at room temperature under static conditions. In all cases, sufficient water was used to greatly exceed the quantity needed to dissolve all the active material. The water was agitated just prior to sampling to insure an even concentration of dissolved active. The concentration of active was measured by HPLC. Percentages are meant to be weight percentages unless otherwise indicated.

(J •; I i— QO o O i o u 11 EXAMPLE 1 Granules of the insecticide 0,0-diethyl 5 0-(l,2,2,2-tetrachloroethyl)phosphorothioate (4.08 g) containing 4% propylene glycol and 10% of the active ingredient were mixed with 1.0 g of a solution of 0.01 g dibutyltin dilaurate in PAPI® 901 (Dow Chemical Co.). After 30 minutes, the granules were 10 free-flowing. The volatility of 0,0-diethyl 0-(l,2,2,2-tetrachloroethyl)phosphorothioate in these coated granules was compared with unmodified granules at 45°C-60°C in an air oven. After 44 hours, the overcoated granules lost 0.12 g active ingredient 15 while the uncoated sample lost 0.27 g thereby showing that the polymeric coating retarded volatilization of the active ingredient.

EXAMPLE 2 Water-dispersible granules containing 60% of 20 methyl 2-[[[[4,6-dimethoxy-2-pyrimidinyl)amino]-carbonyl]amino]sulfonyl]methylbehzoate (9.0 g; Londax® 60 DF; E. I. du Pont de Nemours and Company) were mixed with 0.3 g propylene glycol followed by a solution of 1.0 g PAPI® 901 (Dow Chemical Co.) and 25 0.01 g dibutyltin dilaurate. After standing in an open beaker for about 30 minutes, the somewhat sticky mixture became free-flowing, indicating that polymerization to polyurethane coating had occurred. The granules were added to 500 mL water and were 30 allowed to stand 3 days. The granules maintained their integrity while slowly releasing some of the active ingredient: 12% in 21 hours, 31% in 46 hours, and 100% in 300 hours. The uncoated granules completely disintegrated in excess water in about 2 35 minutes and released 100% of the active in under 2 S-, f t ■) I. ,) ►- o u t 6 b 12 EXAMPLE 3.

Florex® LVM 8-16 mesh attapulgite granules 5 (Florex LVM) (Floridin Co.) were preimpregnated with polymer, to reduce porosity, by mixing 120 g of the material with 5 g propylene glycol followed by 10 g of PAPI® 901 containing 0.5% dibutyltin dilaurate. After allowing 1 hour for curing to a crosslinked ' 10 polyurethane containing, 16.6 g of the precoated granules were mixed with 0.627 g technical 2-[[[[4, 6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-amino]sulfonyljmethylbenzoate (95.7%), 0.39 g propylene glycol followed by 0.8 g PAPI® 901 15 (Dow Chemical Co.) containing 0.02 g dibutyltin dilaurate. The sample was allowed to cure in an open vessel giving a product having 3% active ingredient with crosslinked polyurethane urea overcoat. The release rate in excess pK 7 buffered water was 15% in 20 162 hours and 24% in 451 hours.

EXAMPLE 4 Sand (76.4 g, diameter 250 to 840 microns) was mixed with 0.2 g propylene glycol followed by 0.6 g PAPI® 901 containing 0.063 g dibutyltin dilaurate. 25 Then 2.5 g of 2-[[[[4,6-dimethoxy-2-pyrimidinyl)- amino]carbonyl]amino]sulfonyljmethylbenzoate powder was added with stirring to give a mixture containing 3% active ingredient. After curing had occurred, the release rate in excess pH 7 buffered water was found 30 to be 42% in 67 hours and 96% in 499 hours.

EXAMPLE 5 Example 4 was repeated, except that the PAPI® 901 solution was added last, giving granules that released somewhat slower, 35% in 114 hours and 74% in 35 525 hours. 281)730 13 EXAMPLE 6 Example 4 was repeated except for the 5 substitution of propylene glycol by 0.16 g water. Release rates for the polyurea coating were 63% in 305 hours and 100% in 665 hours.

EXAMPLE 7 Sand (17.3 g), 0.627 g 2-[[[[4,6-dimethoxy-10 2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]methyl-benzoate and 0.46 propylene glycol were mixed and 2.02 g technical toluene diisocyanate (80% 2,4-isomer and 20% 2,6-isomer) containing 0.039 g dibutyltin dilaurate was added. The cured product contained 15 2.9% active ingredient. The release rates were 10% in 162 hours and 16% in 451 hours. Similar results were obtained when 2.0 g of a solution of 50% technical toluene-2,4-diisocyanate and PAPI® 901 was used instead of technical toluene-2,4-diisocyanate 20 alone.

EXAMPLE 8 Krovar® I (9.0 g) water-dispersible granules (E. I. du Pont de Nemours & Co.), containing 40% bromacil and 40% diuron, was treated successively 25 with 0.2 g propylene glycol and 0.51 g PAPI® 901 containing 0.4% dibutyltin dilaurate. The release rate of the bromacil in the granules in excess water was 76% in 21 hours and 83% in 46 hours. The granules maintained their integrity over one month in 30 excess water while continuing to release bromacil. The uncoated control granules disintegrated and released all of their bromacil in less than one hour. <»ou J >_> c O 14 BA-8820

Claims (24)

WHAT WE CLAIM IS:

1. A process for preparing controlled release granules of pesticides for direct application consisting essentially of overcoating a granular carrier containing a pesticide and a polyhydroxylated 10 compound, mixtures of polyhydroxylated compounds, or mixtures of water and at least one polyhydroxylated compound or water alone with a liquid polyisocyanate or mixture of polyisocyanates and, optionally, a polymerization catalyst, resulting in an interfacial 15 polymerization reaction to a solid cross-linked polyurethane or polyurea barrier.

2. The process of Claim 1 which takes place at elevated temperature. 20

3. The process of Claim 1 wherein the pesticide is a herbicide or insecticide.

4. The process of Claim 3 wherein the 25 herbicide is selected from sulfonylureas, imidazolinones, uracils, dinitroanilines and the insecticide is a phosphorothioate.

5. The process of Claim 1 wherein the 30 granular carrier is selected from sand or aggregated.— * p.J 7 A TV E '* J' clays. \ 2tuAN193'j

6. The process of Claim 5 wherein thef granular carrier size is ; 150 to 4,000 mi i-rnps iV£■ 35 W 5 10 15 20 o 25 30 225136 15

7. The process of Claim 1 wherein said polyhydroxylated compound is selected from ethylene glycol or propylene glycol.

8. The process of Claim 1 wherein the polyisocyanate is a methylene-linked polypheny1isocyanate.

9. The process of Claim 1 wherein the polyisocyanate is a toluene diisocyanate.

10. The process of Claim 1 wherein the polyisocyanate is a mixture of methylene-linked polyphenylisocyanate and a toluene-2,4-diisocyanate.

11. The process of Claim 1 wherein the polymerization catalyst is selected from organic tertiary amines and alkyltin carboxylic esters.

12. A process for preparing controlled release granules of pesticides for direct application consisting essentially of adding a polyisocyanate or polyisocyanate mixture and a polymerization catalyst to granules containing a pesticide and water or polyhydroxylated compounds or mixtures thereof at at least about ambient temperature wherein the amount of polyisocyanate and polymerization catalyst employed . are 1 to 20% and 0 to 5% by weight, ; respectively, resulting in an interfacial i polymerization reaction to a solid cross-linljfed polyurethane or polyurea barrier whereby the amount" of said water or polyhydroxylated material is present in an amount to insure that all of the polyisocyanate has reacted. ass®*,. 236736 X. 16 ^*—Sj

13. The process of Claim 10 wherein the """" 5 reaction time is 20 to 30 minutes.

14. The process of Claim 10 wherein the pesticide is a herbicide. 10

15. The process of Claim 12 wherein the herbicide is selected from sulfonylureas, imidazolinones, uracils or dinitroanilines.

16. The process of Claim 10 wherein the 15 pesticide is an insecticide.

17. The process of Claim 10 wherein the insecticide is a phosphorothioate. 20 18. The process of Claim 10 wherein the granular carrier is selected from sand or aggregated clays.

18. O

19. The process of Claim 14 wherein the 25 granular carrier size is 150 to 4,000 microns.

20. The process of Claim 10 wherein said polyhydroxylated compound is selected from ethylene -glycol or propylene glycol. 30

21. The process of Claim 10 wherein the ; L ''/trp polyisocyanate is a methylene-linked polypheny!-""" isocyanate, or a toluene diisocyanate or mixtures thereof. 35 (J o /' ■' J ') /■> ... o iWOO 17

22. The process of Claim 10 wherein the polymerization catalyst is -selected from organic tertiary amines and alkyltin carboxylic esters.

23. A process for preparing controlled release granules of pesticides for direct application substantially as herein described with reference to any one of the Examples.

24. Controlled release granules when obtained by a process as claimed in any one of the preceding claims. E.I. DU PONT DE' NEMOURS AND COMPANY /. L .ATUIMAJD a,/By theiir attorneys (7 BALDWIN, SON & CAREY U