NZ194206A - Hair conditioning composition - Google Patents

Description

New Zealand Paient Spedficaiion for Paient Number 1 94206 1 94206 NEW ZEALAND PATENTS ACT, 1953 COMPLETE SPECIFICATION HAIR CONDITIONING COMPOSITION AND METHOD ifcriorfty Date(s): & .1: t .V. ?■?.. Complete Specification Filed: I.7.

Ciass: . i*v 71 PP..

Publication Date: Q. Journal, Wo: ..

B'f'JUL'i£84 No.: Date: i/We' BRISTOL-MYERS COMPANY, a corporation organized under the laws of the State of Delaware, having its principal office at 345 Park Avenue, New York, County and State of New York, United States of America hereby declare the invention for which "SSS/ we pray that a patent may be granted to^gg/us, and the method by which it is to be perfor to be particularly described in and by the following statement:- - 1 - ft,y | ^ 194203 HAIR CONDITIONING COMPOSITION I. Description: This invention relates to compositions that are useful in conditioning hair.

It is known in the prior art to treat hair with certain quaternary amine compounds for the purpose of conditioning hair i.e. to improve its combability, manageability, softness, etc. Although such prior art compositions have proven to be effective in varying degrees, one of the chief drawbacks has been the fact that the effect has not been long-lasting i.e. it does not survive repeated shampooings.

It is accordingly an object of the present invention to provide a hair conditioning composition that retains its conditioning effect through repeated hair shampooings. 194206 Other and more detailed objects of this invention i will be apparent from the following .description and claims.

The present invention relates to composition for conditioning hair, which includes, based on the total weight of the composition, from substantially 0.4% to substantially 10% of at least one cationic polymer, from substantially 0.2% to substantially 20% of an amphoteric surfactant other than a betaine; and sufficient acid to give the composition a pH in the range frcm substantially 1 to substantially 6; the ratio: _ [polymer(mer) ] Idetergent (mol)] being from substantially 0.2 to substantially 5; in an aqueous carrier. Optionally the composition also includes an effective amount, such as from substantially 0.1% to substantially 5% of a betaine having the formula: ch3 r n+ ch2c00* ch3 wherein R is a long chain aliphatic radical containing from 10 to 24 carbon atoms. The present in vention also involves a method for conditioning hair which has been previously treated with an agent having an alkaline pH, by applying thereto the composition of this invention.

The cationic polymers that are useful for the purposes of the present invention can vary somewhat.

Three classes of polymers that have been found to be -\ APR »82 1 particularly useful are those sold under the trade names MERQUAT (e.g. MERQUAT 100), ONAMER (e.g. ONAMER M) and quaternized polyvinylpiridine. The MERQUAT 100 is a polymer of dimethyldiallyl ammonium chloride and are probably mixtures of compounds having the following formula: ch, \ k2c (a) CH ch. ch / 'N ch.

\ X N / \ h3c ch.

CI ch, n) (B) ch. ch ch ch: ch I ch, n+' ch.

CI n Wherein n is a cardinal number dependent on molecular weight. These can vary in molecular weight, however, ordinarily the polymers of this class that will be employed have a 10 molecular weight in the range of from 4,000 to 550,000 and preferably in the range of from about 20,000 to about 100,000.

The ONAMER type polymers that are useful for the present purposes are poly(dimehtyl butenyl ammonium 15 chloride)-a>u)-bis (triethanol ammonium chlorides) that may be described by the formula: 194206 OH-Cf^CI^ \ + OH-CH2CH2 - N - C^-CH = CH-CH2 on-cupi^ CH3 .+ - CH2 -CH = CH-CH2 - GHa CI* N+ - O^O^OH n CH2CH2OH Wherein n is a cardinal number dependent on molecular weight.

The molecular weights of these ONAMER type polymers that may be employed herein can also vary somewhat. For the 5 most part, however, this will be in the range of from about 800 to about 5,000 and preferably, in the range of from about 1,000 to about 3,000.

The polymers and copolymers of quaternized polyvinyl-pyridine that can be used in accordance with this inven-10 tion are described by the general formula: "I ch. ch or n ch. n Where n is a cardinal number depending on molecular / _ weight, R is an alkyl radical of C^-C2q and the X is a cosmetically acceptable anion such as halide, sulfate or carboxylate. These also will have a weight average molecular weight in the range of from substantially 5,000 to substantially 100,000.

As an example of the cationic polymer of this group, the following may be mentioned: V i94206 CH, CH 3 n polyvinyl methyl pyridinium iodide Where n is a cardinal number depending on molecular weight. The weight average molecular weight is suitably about 50,000.

The quantity of cationic polymer contained in the present aqueous solutions will depend on the particular results that are desired. Ordinarily, this will constitute between substantially 0.4% to substantially 10% by weight based on the total weight of the aqueous composition with the optimal range being between substantially 1% to substantially 5% on the same weight basis.

The second essential component of the compositions of this invention are the amphoteric surfactants. A characteristic of these materials is that many assume 15 the character of an anionic or a cationic surfactant compound depending upon the pH of the solution in which it may be contained. There are a number of amphoteric detergents that are suitable for use in the present invention. However, two classes of detergents have been 20 found to be especially effective. The first class can be defined by the formula: C Vo' -1 APR 1982 <1 *// \ v 194206 III n ch.

CE2COONa n ch2ch2och2cco' \ / ch. in which R is a long chain fatty radical containing from 10 to 18 carbon atoms. A typical example of such a compound or compounds is the case in which R represents coconut fatty radicals. A material of this character is sold under the trade name MIRANOL C2MSF and is described in the CTFA Cosmetic Ingredient Dictionary (1973) under the name AMPHOTERIC-2.

A second class of amphoteric detergents that is particularly effective for the purposes of the present invention can be defined by the formula: r- nh — ch2— ce2—cooh wherein R is a long chain fatty alkyl group having from 10 to 18 carbon atoms. An example of such a detergent is marketed under the trade name DERIPHAT 170C in which the R in formula IV is a mixture of lauryl and myristyl fatty alkyl groups. This material is described in the CTFA Cosmetic Ingredient Dictionary (19 73) as Lauramino-propionic Acid.

The quantity of amphoteric detergent which will be contained in the composition of this invention will vary somewhat again depending on the economics and the results 1 9420 sought. However, usually this will be in the range of from substantially 0.2 to substantially 20% by weight and ideally in the range of from substantially 1% to substantially 5% by weight based on the total weight of the composition.

Another essential feature of the present composition is that the solution have an acid pH that is a pH that falls in the range of from substantially 1 to 6. Any of a variety of acids may be used in adjusting the pH of these compositions to the proper level, hydrochloric, citric, and 10 phosphoric acids were found to be particularly useful and suitable.

The betaines that are optionally useful for the purposes of the present invention are of the formula: ch i+ (d r n — ch2cgo CH3 in which R is a long chain aliphatic radical containing 15 10 to 24 atoms. As used herein, the term long chain aliphatic radical includes saturated and unsaturated straight chain and branched chain radicals, hydrocarbon radicals as well as chain radicals that include other atoms in addition to carbon atoms in the chain (e.g. 20 oxygen, nitrogen, etc.).

By way of illustrating typical betaines that may be used in this invention, mention may be made of cocamidopropyl betaine, oleyl betaine, cetyl betaine, coco betaine, etc. Cocamidopropyl betaine is described 25 by the formula: 194£6# CH O I 3 II ' + (II) S- C -NH — {CH2)3—| — CH2-COQ 0 CH_ li ^ . 3 wherein RC- is the coco fatty acid acyl radical. Coco fatty acid is a mixture of fatty acids obtained from Cocunut Oil which are predominantly C^ acids. Oleyl betaine, on the other hand, has the formula: Z3 (III) CH3(CH2)7CH = CH(CH2)7— CH2— N —CH2"-COO CH3 Structurally the coco betaine and cetyl betaine re semble the oleyl betain shown in formula III above excepting that the oleyl radical is replaced with coco fatty radicals or the cetyl radical respectively. A number of betaines that are useful for the purposes of the present invention 10 are available commercially. Among these mention may be made of CHEMADENE NA 30, LONZAINE 12C, LONZAINE 14C, LONZAINE 165, etc.

The quantity of the betaine. that may be incorporated in the composition of the present invention may vary. 15 Usually, it will comprise between substantially 0.1% to substantially 5% by weight and preferably between substantially 0.3% to substantially 3% by weight based on the total weight of the composition.

Although the cationic polymers, the amphoteric surfactants and the acids mentioned above are the essential 20 active ingredients in the present compositions, the compositions contemplated by the present invention may also contain other ingredients which may serve to improve the organoleptic character of the product or its ease of application. Thus, it is within the purview of this 25 invention to incorporate in the present compositions I94206 one or more of such materials as fragrances, thickening agents, fragrance solubilizers, .bactericides, etc.

Optionally a variety of solvents can be employed in the compositions of this invention. These will usually 5 take the form of an aliphatic alcohol, either a monohydric or polyhydric, preferably having from 1 to 6 carbon atoms. As employed herein, the term "aliphatic alcohol" is used in its generic sense and includes such alcohols as straight chain and branched chain alkyl alcohols that can be 10 monohydric or polyhydric (e.g. dihydroxy) ether alcohols, ester alcohols, etc. By way of illustrating the solvents that may be useful for the present composition, mention may be made of ethanol, carbitol, hexylene glycol, propylene glycol. The solvents may be used at levels from 15 0% to about 50% and preferably in the range of from 0% to 5% by weight based on the total weight of the composition.

Optionally, a non-ionic surfactant may also be incorporated in the compositions of this invention. These will 20 constitute between 0% to 10% by weight based on the total weight of the composition but more often, a range of 0% to 2% is preferred. Suitable examples of such^ne-utral surfactants are Igepal CO-630 (CTFA name nonoxynol-9); Arlasolve 200 (polyoxyethylene(20)isohexadecyl ether); 25 Tween 20 (CTFA name polysorbate 20).

To facilitate the application of the present compositions to the hair it is often useful to increase its viscosity somewhat. Many thickening agents can be used for this purpose. Among these mention may be made of 30 hydroxethyl cellulose, carboxymethyl cellulose, the Carbopols e.g. Carbopol 940. However, hydroxethyl cellulose has been found to be particularly suitable. The & % -1 APR 1982 1 * * - 194206 concentration of the thickening agerit may bary somewhat depending on the results desired. Usually, this will be present in the range of from 0% to about 10% by weight based on the total weight of the composition.

It is often useful to incorporate a bactericide in the compositions of this invention. A variety of materials are known in the prior art that will serve this purpose. By way of illustration, mention may be made of a material sold under the trade name DOWICIL 200. This is iden-10 tified in the CTFA Cosmetic Ingredient Dictionary, second edition, as quaternium-15 and chemically as l-(3-chloro-allyl)-3,5,7-triaza-l-azoniaadamantane chloride. The quantity of bactericide that will be contained in the present compositions will vary somewhat depending on the 15 nature of the particular composition. Usually, however, it will comprise between 0% to about 10% by weight based on the total weight of the composition.

Aside from the absolute quantities of the cationic polymer and amphoteric detergent contained in the present 20 compositions, it has been found that their conditioning effectiveness is highly dependent upon the "molar ratio" of polymer to detergent. The term "molar ratio" as used herein is designated by the letter a and is defined as: _ [ Polymer (mer) ] a ~[ Detergent (mol) J* In the above expression and elsewhere in the specification and claims, the term [Polymer (mer)] refers to the number of mols of the repeating units of the polymer I94206 contained in the composition and bearing a positive charge.. The term iDetergent (mol)] in the aforesaid expression and elsewhere is defined as the number of mols of detergent contained in the composition. The ratio a may vary somewhat. Ordinarily, this will be in the range of from substantially 0.2 to substantially 5 and preferably in the range of from substantially 1 to substantially 2.

The compositions of this invention may be applied to hair in any suitable manner. One typical procedure involves applying the conditioning composition, such as described in Example 1 below to freshly dyed or bleached hair, working it gently into the hair mass, leaving the said composition on hair for one to three minutes and rinsing the hair thoroughly with water prior to combing and drying. Amount of the conditioning composition applied to hair may vary but, in general, should not be less than 1% of the hair weight and does not need to exceed 2 0% of hair weight.

It is generally visualized that the compositions of this invention will be applied to hair that has previously been given a treatment that leaves the hair somewhat alkaline. Typical of such treatment are treatments with oxidation hair dye systems or bleaching systems. One such treatment involves mixing a dye base containing among other things the oxidation dye intermediates with an aqueous vehicle containing an oxidizing agent such as hydrogen peroxide and then shampooing this mixture into the hair. These mixtures before being applied to the hair usually have an alkaline pH e.g. in the range of from 7 to 12 and preferably 8 to 11. Another such treatment involves for example treating the hair with an alkaline bleaching solution which contains the usual oxidizing agent (e.g. aqueous hydrogen peroxide), boosters (e.g. potassium persulfate and ammonium persulfate), alkalizing agents, etc. 1942 When the compositions of this invention are applied to hair that has been previously treated as indicated above the combination of amphoteric detergent and cationic polymer precipitates out on the hair forming a 5 conditioning complex that is retained on the hair throughout repeated shampooings.

The pH of the hair conditioning compositions that are employed in the present invention will be selected to some extent on the basis of the alkalinity of the hair 10 to be treated and the relative amounts of cationic polymers and amphoteric detergent. In general, the pH is selected so that after the composition is applied to the hair and comes under the influence of the alkalinity of the hair that the pH of the composition is increased 15 by approximately 1 pH unit above which the precipitation of the complex takes place. Generally, under these conditions the optimum precipitation of the conditioning complex appears to take place.

The following Examples are given to further illustrate 20 the present invention. It is to be understood, however, that the invention is not limited thereto.

Where the CTFA name is given herein, reference is made to the name given to the material in the CTFA Cosmetic Ingredient Dictionary of 19 73 or the 2nd Edition 25 of 1977. 194206 EXAMPLE 1 Ingredient % by Wt.

*Merquat 100 2.00 **Miranol C2MSF 4.00 Hydroxyethyl cellulose 2.00 Phosphoric acid 1.60 Fragrance 0.10 Water QS to 100.00 pH 4.5 CTFA name Quaternium-40 *CTFA name Amphoteric-2 EXAMPLE 2 Ingredient % by Wt.

***Onamer M 1.00 Miranol C2MSF 2.0 0 Hydroxyethyl cellulose 2.00 Phosphoric acid 0.90 Fragrance 0.10 Water QS to 100.00 pH 4.5 **poly(dimethyl butenyl ammonium chloride)-a,1-bis(tri-ethanol ammonium chloride) Av. M.W. about 1,000-2,000 EXAMPLE 3 Ingredient % by Wt.

Poly-4-vinyl methyl 2.00 pyridinium iodide Miranol C2MSF 4.00 Hydroxyethyl cellulose 2.00 Phosphoric acid 1.60 Fragrance 0.10 Water QS to 100.0 0 pH 4.5 194206 EXAMPLE 4 Ingredient % by Wt.

Poly-4-vinyl lauryl 1. 00 pyridininium sulfate Merquat 100 1.00 Miranol C2MSF 4.00 Hydroxyethyl cellulose 2.00 Phosphoric acid 1.60 Fragrance 0.10 Water QS to 100.00 pH 4.5 EXAMPLE 5 Ingredient % by Wt.

Merquat 100 3.50 Miranol C2MSF 1.75 Hydroxyethyl cellulose 2.00 Sodium hydroxide 0.01 Phosphoric acid 0.07 Ethanol 4.00 Chemadene NA-30"'" 2.00 Water QS to 100.00 pH 4.5 Made by the Richardson Chemical Company. Its CTFA name is Cocamidopropyl betaine.

EXAMPLE 6 Same as Example 5 except that 2.00% oleyl betaine is used in place of the cocamidopropyl betaine used in Example 5. This composition had a pH of 4.5. 1 94206 Ingredient Merquat 100 Hydroxethyl cellulose Phosphoric Acid Sodium hydroxide Miranol C2MSF Sorbic acid Dowicil 200* Carbitol Cocamidopropyl betaine Fragrance Tween 20** Arlasolve 200*** Water to 100% PH % by Wt.

Ex. 7 .00 2.250 0. 450 0.015 2.560 0. 100 0.100 3.00 0.600 0. 400 Ex. 8 Ex. 9 . 001 001 4.8 4.5 4.5 *CTFA name Quaternium-15 **CTFA name Polysorbate-20 ***Polyoxyethylene(20)isohexadecyl ether 1942 Ingredient Merquat 100 Hydroxyethyl cellulose Sodium hydroxide Phosphoric acid Deriphat 170C^ Miranol C2MSF Sorbic acid Dowicil 200 Carbitol Fragrance 3 Chemadene NA-30 Merquat 550^ Onamer M^ Lonzaine 12C^ Lonzaine 14 8 Lonzaine 16S Water to 100% pH 4.5 % by Wt.

Ex. Ex. Ex. Ex. Ex. Ex. 10 11 12 13 14 15 5.0 — ~ 5.0 5.0 5.0 2.25 0.15 ' .2 0.46 2.0 — — ■ 2.56 0.1 0.10 __ .10 0.10 3.0 .40 2.0 2.0 2.0 — 12.5 — .0 — 2.0 — — 2.0 — 2.0 2 CTFA name Lauramopropionic acid 3 CTFA name Cocamidopropyl betaine 4 CTFA name Quaternium-41 Poly(dimethyl butenyl ammonium chloride)a,w-bis(tri-ethanol ammonium chloride) 6 CTFA name Coco betaine 7 CTFA name Lauryl betaine 8 CTFA name Cetyl betaine 19420 Conditioning formulations of this invention are not only effective in improving wet and dry combing of hair, imparting manageability, softness, etc. but unlike the conventional products, their conditioning effects are 5 stable to repeated shampooings. This conditioning o durability is illustrated in the following experiment, the dyed hair being used as the test substrate.

Swatches of intact Caucasian hair were colored with Composition A below for 20 minutes, in accordance with 10 the procedure of the instructions. The ratio of the amount of solution to weight of hair, temperature and quantity of water used for rinsing after treatment, were all maintained so as to simulate conditions on the head. After rinsing, a conventional hair condition in which the 15 conditioning ingredient was Stearelkonium chloride (CTFA name) and on another similarly treated swatch the conditioning material of Example 1 and on a similarly treated swatch the composition of Example 5 above was applied to hair (0.1 g of each product per 1 g of hair). Both were worked 20 in for 30 seconds and left on the hair for additional 1 minute after which time the hair was rinsed and combed. The combing measurements were performed by the procedure described in the paper by Garcia and Diaz (J. Soc. Cosmt. Chem. 21_, 379-398, 1976). The test essentially involves 25 passing of a hair tress through a comb attached to a strain gauge which in turn is connected to a recording device.

Work is expended to accomplish the passage of the hair tress through the comb, and this work, read off the integrator, is the objective measure of combing ease/difficulty.

Having determined the combing properties of hair after coloring and conditioning treatement, the swatches TM were shampooed with HERBAL ESSENCE shampoo three or 19 4-2 06' more times and again tested for combing. The shampooing procedure involved application of the shampoo (0.1 g per 1 g of hair), working it into the hair over the period of 60 seconds to produce a copious lather and rinsing the 5 shampooed hair for at least 1 minute. Each shampoo step consisted of two lathering/rinsing sequences.

The results of combability tests are summarized in Table I below. In the Table, the "Work of Combing' is expressed in units of work (gem). The higher the values, 10 the harder it was to comb the hair.

COMPOSITION A % by Wt. based on total Ingredient weight of composition p-Phenylenediamine 0.35 N,N-bis(2-hydroxyethyl0-p- phenylenediamine sulfate 0.17 Resorcinol 0.31 1-Naphthol 0.08 Oleic acid 7.50 Propylene glycol 4.40 Isopropanol 4.35 Hydrogen peroxide 3.00 *Octoxynol-l 3.50 Sulfated Castor Oil 1.50 Ammonium hydroxide 1.15 *Cocamide DEA 0.75 Fragrance 0.15 Sodium sulfite 0.05 EDTA 0.01 Water QS to 100.00 pH 9.8 *CTFA name (See CTFA Cosmetic Ingredient Dictionary, 2nd Edition, 19 77) I CjlfZO io TABLE I Treatment with Average combing work (gem) on wet hair No +3 +4 +5 +6 5 shampooing shampoos shampoos shampoos sham- poo's (A) After dyeing 2,800 (A) + Con-10 ventional conditioner 625 7,350 (A) + Conditioner of Example 1 346 769 (A) + Conditioner of Example 5 228 349 438 531 (A) + Conditioner of Example 7 580 641 809 916 The last two results in Table I have been further confirmed in experiments on live heads.

It should be noted that betaines by themselves do not effect any conditioning when applied in a formulation in 25 combination iwth the cationic polymer e.g. MERQUAT 100 or ONAMER M. It is only when other amphoterics, such as the ones described above, are alos present in the formula that additional conditioning is obtained from the use of the betaine. 194206 The following procedures illustrate the use of the conditioning agent of this invention after a hair bleaching treatment. It has been found that treatment of bleached hair with the present compositions also improves its feel 5 and combability.

Two 3 gram swatches of brown Caucasian hair were bleached for 1 hour at 30° C with 20 grams of the following bleach composition.

COMPOSITION B % by Wt. based on total weight of composition Potassium persulfate Ammonium persulfate Sodium stearate 11.0 6.0 3.5 3.5 3.5 2.5 0.5 0.8 Sodium metasilicate Hydrogen peroxide Cab-O-Sil EDTA Methocel Water QS to pH 10.3 100.0 After bleaching, the hair was thoroughly rinsed and one of the bleached tresses was treated for 3 minutes with 1.5 g of the following composition: 21 19420 6 EXAMPLE 16 ingredient Merquat 100 % by Wt 2.0 2.4 3.5 1. 1 *Deriphat 170C Benzyl alcohol Phosphoric acid (85%) Water QS to 100.0 *Lauraminopropionic acid The other tress was exposed for the same length of 10 time to the same conventional hair conditioner as above.

Both tresses were thoroughly rinsed and found to be soft and silky to feel and easy to comb. Both tresses were then shampooed once and compared again. This time the conventionally conditioned tress felt sticky, rubbery and dif-15 ficult to comb; while the tress that had been treated with conditioning composition given in Example 16 retained the softness of feel and ease of combing. These conditioning attributes were still much in evidence for this tress after as many as 4 shampooings.

Although the invention has been described with reference to specific forms thereof, it will be understood that many changes and modifications may be made without departing from the spirit of this invention. 194206

Claims (13)

WHAT WE CLAIM IS:

1. A composition for conditioning hair consisting essentially of based on the total weight of the composition: (a) from substantially 0.4% to substantially 10% of at least one cationic polymer; (b) from substantially 0.2% to substantially 20% of an amphoteric surfactant other than a betaine; and (c) sufficient acid to give the composition a pH in the range of from substantially 1 to substantially 6; the ratio = [ polymer (mer) ] 1 detergent (mol)] being from substantially 0.2 to substantially 5; in (d) an aqueous carrier.

2. A composition according to claim 1 in which said ratio is in the range of from substantially 1 to substantially 2.

3. The composition of claim 1 or claim 2, further comprising from substantially 1.0% to substantially 5% of at least one betaine of the formula: CH, l+ R N CH-C00 I CH3 wherein R is a long chain aliphatic radical containing from 10 to 24 carbon atoms. j 1 APR 1982* f - 23 - 194206

4. The composition of claim 3 in which said betaine is at least one of cocamidopropyl betaine, lauryl betaine, oleyl betaine, cetyl betaine and coco betaine.

5. A composition according to any of claims 1 - 4,in which said cationic polymer is homopolymer of dimethyl diallyl ammonium chloride.

6. A composition according to any of claims 1-4, in which said cationic polymer is homo- or copolymer of a quaternized polyvinyl pyridine having monomeric units of the formula: CH. Or CH. 1—CH—CH, where R is an alkyl radical of C^-C2Q and the X is a cosmetically acceptable anion and having a weight average molecular weight in the range of from substantially 5000 to substantially 100,000.

7. The composition of claim 6, wherein said anion is a halide, sulfate or carboxylate.

8. A composition according to any of claims 1 - 4, in which said cationic polymer is a poly(dimethyl butenyl jjnonium chloride)-a ,o)-bis (triethanol ammonium chloride). [* APR 1982 194206 - 24 -

9. A composition according to any of claims 1-8, wherein said amphoteric detergent is of the formula: CH2COONa R C N' CK CH OCH COO* !| 2 2 2 N CH_ \ / ch*2 in which R is a long chain fatty radical containing 10 to 18 carbon atoms.

10. A composition according to claim 9, wherein R is a coco fatty radical.

11. A composition according to any of claims 1 to 8 in which said amphoteric detergent is of the formula: R — NH — CR2~ CH2 C00H in which R is a long chain fatty alkyl radical having from 10 to 18 carbon atoms.

12. A composition according to any of claims 1-11, further including aliphatic monohydric or polyhydric alcohol solvent, suitably having between 1 and 6 carbon atoms. i o a ^ n ?' Jl o J G -25-

13. A composition according to claim 1 and substantially as hereinbefore described with particular reference to any of the foregoing Examples 1 to 12. •tflWTHIS bcho* W A. J. PARK* $©N flU I/&L^V—- • imH |0k fM AMISAPfTt