NO993776D0 - Gitte dinukleotider og deres anvendelse som modulatorer av mukociliaer renselse og ciliaer stötfrekvens - Google Patents
Gitte dinukleotider og deres anvendelse som modulatorer av mukociliaer renselse og ciliaer stötfrekvensInfo
- Publication number
- NO993776D0 NO993776D0 NO993776A NO993776A NO993776D0 NO 993776 D0 NO993776 D0 NO 993776D0 NO 993776 A NO993776 A NO 993776A NO 993776 A NO993776 A NO 993776A NO 993776 D0 NO993776 D0 NO 993776D0
- Authority
- NO
- Norway
- Prior art keywords
- sub
- useful
- treatment
- dinucleotides
- mucocilia
- Prior art date
Links
- 210000004081 cilia Anatomy 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 230000035939 shock Effects 0.000 title 1
- 206010036790 Productive cough Diseases 0.000 abstract 2
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 201000003883 Cystic fibrosis Diseases 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010033078 Otitis media Diseases 0.000 abstract 1
- 102100037601 P2X purinoceptor 4 Human genes 0.000 abstract 1
- 206010048705 Paraneoplastic cerebellar degeneration Diseases 0.000 abstract 1
- 208000017787 Paraneoplastic neurologic syndrome Diseases 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 108010080192 Purinergic Receptors Proteins 0.000 abstract 1
- 206010038848 Retinal detachment Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000035559 beat frequency Effects 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 230000001886 ciliary effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 208000000617 lacrimal duct obstruction Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003097 mucus Anatomy 0.000 abstract 1
- 208000032307 premature centromere division Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000009266 primary ciliary dyskinesia Diseases 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 230000004264 retinal detachment Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 201000009890 sinusitis Diseases 0.000 abstract 1
- 210000003802 sputum Anatomy 0.000 abstract 1
- 208000024794 sputum Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/797,472 US5900407A (en) | 1997-02-06 | 1997-02-06 | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US08/798,508 US5837861A (en) | 1997-02-10 | 1997-02-10 | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| PCT/US1998/002702 WO1998034942A2 (en) | 1997-02-06 | 1998-02-06 | Dinucleotides and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO993776D0 true NO993776D0 (no) | 1999-08-04 |
| NO993776L NO993776L (no) | 1999-10-06 |
| NO326718B1 NO326718B1 (no) | 2009-02-02 |
Family
ID=27121880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19993776A NO326718B1 (no) | 1997-02-06 | 1999-08-04 | Dinukleotider og farmasøytiske preparater omfattende slike, og anvendelser derav for fremstilling av medikamenter. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6348589B1 (no) |
| EP (1) | EP0981534B1 (no) |
| JP (1) | JP4531867B2 (no) |
| KR (1) | KR100606131B1 (no) |
| CN (1) | CN1262556C (no) |
| AT (1) | ATE325129T1 (no) |
| AU (1) | AU738907C (no) |
| BR (1) | BR9807169A (no) |
| CA (1) | CA2279963C (no) |
| DE (1) | DE69834392T2 (no) |
| DK (1) | DK0981534T3 (no) |
| ES (1) | ES2264197T3 (no) |
| NO (1) | NO326718B1 (no) |
| NZ (1) | NZ337225A (no) |
| PT (1) | PT981534E (no) |
| WO (1) | WO1998034942A2 (no) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673779B2 (en) | 1996-03-27 | 2004-01-06 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| ES2264197T3 (es) | 1997-02-06 | 2006-12-16 | Inspire Pharmaceuticals, Inc. | Dinucleotidos y sus usos. |
| US7223744B2 (en) * | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| US6818629B2 (en) * | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
| US7078391B2 (en) * | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
| US6596725B2 (en) * | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
| US6548658B2 (en) * | 1997-07-25 | 2003-04-15 | Inspire Pharmaceuticals, Inc. | Di-(uridine 5′)-tetraphosphate and salts thereof |
| DK1012154T3 (da) | 1997-07-25 | 2004-07-26 | Inspire Pharmaceuticals Inc | Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf |
| US6872710B2 (en) * | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| ATE288273T1 (de) * | 1997-08-29 | 2005-02-15 | Univ North Carolina | Verwendung von uridin-5'-diphosphat und analoge zur behandlung von lungenerkrankungen |
| JP4633927B2 (ja) * | 1998-05-22 | 2011-02-16 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 治療用ジヌクレオチドおよび誘導体 |
| WO2000039145A1 (en) * | 1998-12-23 | 2000-07-06 | The University Of North Carolina At Chapel Hill | Targeted gene transfer using g protein coupled receptors |
| AU3612600A (en) | 1999-02-26 | 2000-09-14 | Inspire Pharmaceuticals, Inc. | Method of promoting mucosal hydration with certain uridine, adenine and cytidine diphosphates and analogs thereof |
| EA004707B1 (ru) * | 1999-06-30 | 2004-06-24 | Ямаса Корпорейшн | Кристаллы динуклеотида |
| AU6551800A (en) * | 1999-08-17 | 2001-03-13 | Adani, Alexander | Dinucleoside 5',5'-tetraphosphates as inhibitors of viral reverse transcriptasesand viruses |
| MXPA02005161A (es) * | 1999-12-22 | 2002-12-09 | Inspire Pharmaceuticals Inc | Metodo para tratamiento de enfermedades del aparato gastrointestinal con agonistas de los receptores purinergicos. |
| RU2161982C1 (ru) * | 2000-01-20 | 2001-01-20 | Общество с ограниченной ответственностью "Клиника Института биорегуляции и геронтологии" | Тетрапептид, стимулирующий функцию сетчатой оболочки глаза, фармакологическое средство на его основе и способ его применения |
| US6864243B1 (en) | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
| EP1428538B1 (en) | 2000-05-30 | 2013-08-14 | Santen Pharmaceutical Co., Ltd | Ectocornea extension promoters |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7452870B2 (en) | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
| US6555675B2 (en) * | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
| US7132408B2 (en) * | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
| EP1366055A2 (en) * | 2000-12-15 | 2003-12-03 | Pharmasset Limited | Antiviral agents for treatment of flaviviridae infections |
| US20040122223A1 (en) * | 2001-02-07 | 2004-06-24 | Davis Jeremy Martin | Non-natural nucleotides and dinucleotides |
| US7109181B2 (en) | 2001-06-25 | 2006-09-19 | Inspire Pharmaceuticals, Inc. | Joint lubrication with P2Y purinergic receptor agonists |
| EP1409503A1 (en) * | 2001-07-25 | 2004-04-21 | Celltech R & D Limited | Non-natural carbon-linked nucleotides and dinucleotides |
| US20030109488A1 (en) * | 2001-10-11 | 2003-06-12 | Alcon, Inc. | Methods for treating dry eye |
| US7256183B2 (en) | 2001-11-06 | 2007-08-14 | Inspire Pharmaceuticals, Inc. | Method for treating or preventing inflammatory diseases |
| US7084128B2 (en) | 2002-01-18 | 2006-08-01 | Inspire Pharmaceuticals, Inc. | Method for reducing intraocular pressure |
| WO2004037167A2 (en) * | 2002-10-18 | 2004-05-06 | Molichem Medicines, Inc. | Methods of treating dry eye disease with lantibiotics |
| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
| EP1750740A4 (en) * | 2004-05-06 | 2009-06-10 | Molichem Medicines Inc | TREATMENT OF MEMBRANE-ASSOCIATED DISEASES AND DISORDERS USING COMPOSITIONS CONTAINING LANTIBIOTICS |
| WO2005115432A2 (en) * | 2004-05-06 | 2005-12-08 | Molichem Medicines, Inc. | Treatment of ocular diseases and disorders using lantibiotic compositions |
| GB0417886D0 (en) * | 2004-08-11 | 2004-09-15 | Univ Cardiff | Method and means for enhanced pulmonary delivery |
| GB0502250D0 (en) * | 2005-02-03 | 2005-03-09 | Ic Vec Ltd | Use |
| US7368439B2 (en) * | 2005-06-15 | 2008-05-06 | Bar - Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
| US7851456B2 (en) * | 2005-06-29 | 2010-12-14 | Inspire Pharmaceuticals, Inc. | P2Y6 receptor agonists for treating lung diseases |
| US20090306009A1 (en) | 2005-12-06 | 2009-12-10 | P2-Science Aps | Modulation of the P2Y2 Receptor Pathway |
| US20070249556A1 (en) * | 2006-04-21 | 2007-10-25 | Brubaker Kurt E | Method of treating inflammation |
| EP2045257B1 (en) | 2006-07-26 | 2016-08-17 | Yamasa Corporation | Process for producing di(pyrimidine nucleoside 5'-)polyphosphate |
| EP2049665A2 (en) * | 2006-07-28 | 2009-04-22 | Applera Corporation | Dinucleotide mrna cap analogs |
| EP2211956A4 (en) | 2007-10-10 | 2014-07-09 | Parion Sciences Inc | DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA |
| US8168597B2 (en) * | 2008-10-22 | 2012-05-01 | Inspire Pharmaceuticals, Inc. | Method for treating cystic fibrosis |
| US9067964B2 (en) | 2008-12-18 | 2015-06-30 | Oligomer Sciences Ab | Complex and method for enhancing nuclear delivery |
| US9011909B2 (en) | 2010-09-03 | 2015-04-21 | Wisconsin Pharmacal Company, Llc | Prebiotic suppositories |
| BR112013005438B1 (pt) | 2010-09-10 | 2021-09-21 | Santen Pharmaceutical Co., Ltd | Agente para o tratamento de olho ressecado caracterizado por combinar o agonista do receptor de p2y2 e ácido hialurônico ou um sal do mesmo, método para o tratamento de olho ressecado, e uso do agonista do receptor de p2y2, e ácido hialurônico ou um sal do mesmo |
| JP6219271B2 (ja) | 2011-06-07 | 2017-10-25 | パリオン・サイエンシィズ・インコーポレーテッド | 治療の方法 |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| KR101875845B1 (ko) | 2012-03-26 | 2018-07-06 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 함유 점안액 |
| BR112014029329A2 (pt) | 2012-05-29 | 2017-06-27 | Parion Sciences Inc | aminoamidas semelhantes ao dendrímero possuindo atividade bloqueadora de canal de sódio para o tratamento de olho seco e outras doenças mucosais |
| HUE032891T2 (hu) | 2012-12-17 | 2017-11-28 | Parion Sciences Inc | Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| EP2931712B8 (en) | 2012-12-17 | 2018-05-23 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| US10323058B2 (en) | 2014-07-24 | 2019-06-18 | W. R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| AU2016229319B2 (en) | 2015-03-09 | 2020-05-07 | W.R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| US20180125876A1 (en) * | 2015-05-20 | 2018-05-10 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages |
| US11414407B2 (en) | 2017-12-22 | 2022-08-16 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
| EP3919062A1 (en) | 2020-06-02 | 2021-12-08 | Institut Gustave-Roussy | Modulators of purinergic receptors and related immune checkpoint for treating acute respiratory distress syndrom |
| US20230302031A1 (en) | 2020-06-02 | 2023-09-28 | Institut Gustave-Roussy | Modulators Of Purinergic Receptors and Related Immune Checkpoint For Treating Acute Respiratory Distress Syndrome |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855304A (en) | 1985-01-10 | 1989-08-08 | Repligen Corporation | Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals |
| US5049550A (en) | 1987-11-05 | 1991-09-17 | Worcester Foundation For Experimental Biology | Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| IL114520A0 (en) | 1994-07-15 | 1995-11-27 | Lepetit Spa | Dinucleoside-5',5',-pyrophosphates |
| US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5681823A (en) | 1996-05-02 | 1997-10-28 | Prp Inc. | P1, P4 -dithio-P2 -P3 -monochloromethylene 5', 5'"-diadenosine P1, P4 -tetraphosphate as antithrombotic agent |
| US5789391A (en) | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| ES2225958T3 (es) | 1996-10-09 | 2005-03-16 | Pharmasset, Ltd. | Compuestos bisfonato micofenolicos. |
| ES2264197T3 (es) | 1997-02-06 | 2006-12-16 | Inspire Pharmaceuticals, Inc. | Dinucleotidos y sus usos. |
-
1998
- 1998-02-06 ES ES98907435T patent/ES2264197T3/es not_active Expired - Lifetime
- 1998-02-06 KR KR1019997007070A patent/KR100606131B1/ko not_active Expired - Fee Related
- 1998-02-06 AU AU63242/98A patent/AU738907C/en not_active Ceased
- 1998-02-06 DK DK98907435T patent/DK0981534T3/da active
- 1998-02-06 JP JP53505598A patent/JP4531867B2/ja not_active Expired - Fee Related
- 1998-02-06 US US09/101,395 patent/US6348589B1/en not_active Expired - Lifetime
- 1998-02-06 CN CNB988032597A patent/CN1262556C/zh not_active Expired - Fee Related
- 1998-02-06 AT AT98907435T patent/ATE325129T1/de active
- 1998-02-06 CA CA002279963A patent/CA2279963C/en not_active Expired - Fee Related
- 1998-02-06 EP EP98907435A patent/EP0981534B1/en not_active Expired - Lifetime
- 1998-02-06 WO PCT/US1998/002702 patent/WO1998034942A2/en not_active Ceased
- 1998-02-06 BR BR9807169-6A patent/BR9807169A/pt active Search and Examination
- 1998-02-06 PT PT98907435T patent/PT981534E/pt unknown
- 1998-02-06 DE DE69834392T patent/DE69834392T2/de not_active Expired - Lifetime
- 1998-02-06 NZ NZ337225A patent/NZ337225A/en not_active IP Right Cessation
-
1999
- 1999-08-04 NO NO19993776A patent/NO326718B1/no not_active IP Right Cessation
-
2001
- 2001-11-06 US US10/007,451 patent/US6977246B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000070807A (ko) | 2000-11-25 |
| EP0981534B1 (en) | 2006-05-03 |
| JP2001526635A (ja) | 2001-12-18 |
| ES2264197T3 (es) | 2006-12-16 |
| US20020082417A1 (en) | 2002-06-27 |
| AU738907B2 (en) | 2001-09-27 |
| AU738907C (en) | 2002-05-16 |
| WO1998034942A3 (en) | 2000-01-06 |
| NO326718B1 (no) | 2009-02-02 |
| DK0981534T3 (da) | 2006-09-04 |
| CN1262556C (zh) | 2006-07-05 |
| CN1292795A (zh) | 2001-04-25 |
| US6348589B1 (en) | 2002-02-19 |
| ATE325129T1 (de) | 2006-06-15 |
| DE69834392T2 (de) | 2007-02-08 |
| CA2279963A1 (en) | 1998-08-13 |
| AU6324298A (en) | 1998-08-26 |
| US6977246B2 (en) | 2005-12-20 |
| KR100606131B1 (ko) | 2006-07-31 |
| JP4531867B2 (ja) | 2010-08-25 |
| CA2279963C (en) | 2008-04-22 |
| WO1998034942A2 (en) | 1998-08-13 |
| NZ337225A (en) | 2002-03-28 |
| EP0981534A2 (en) | 2000-03-01 |
| DE69834392D1 (de) | 2006-06-08 |
| PT981534E (pt) | 2006-09-29 |
| BR9807169A (pt) | 2000-06-06 |
| NO993776L (no) | 1999-10-06 |
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Legal Events
| Date | Code | Title | Description |
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| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: MERCK SHARP & DOHME CORP, US |
|
| MM1K | Lapsed by not paying the annual fees |