NO992875D0 - Preparation of enantiomerically enriched threo-methylphenidate - Google Patents
Preparation of enantiomerically enriched threo-methylphenidateInfo
- Publication number
- NO992875D0 NO992875D0 NO992875A NO992875A NO992875D0 NO 992875 D0 NO992875 D0 NO 992875D0 NO 992875 A NO992875 A NO 992875A NO 992875 A NO992875 A NO 992875A NO 992875 D0 NO992875 D0 NO 992875D0
- Authority
- NO
- Norway
- Prior art keywords
- methylphenidate
- preparation
- enantiomerically enriched
- threo
- enriched threo
- Prior art date
Links
- DUGOZIWVEXMGBE-OLZOCXBDSA-N methyl (S)-phenyl[(R)-piperidin-2-yl]acetate Chemical compound C([C@@H]1[C@@H](C(=O)OC)C=2C=CC=CC=2)CCCN1 DUGOZIWVEXMGBE-OLZOCXBDSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9625972.6A GB9625972D0 (en) | 1996-12-13 | 1996-12-13 | Bioresolution |
| GBGB9712298.0A GB9712298D0 (en) | 1997-06-12 | 1997-06-12 | Crystallisation |
| PCT/GB1997/003418 WO1998025902A1 (en) | 1996-12-13 | 1997-12-11 | The preparation of enantiomerically-enriched threo-methylphenidate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO992875D0 true NO992875D0 (en) | 1999-06-11 |
| NO992875L NO992875L (en) | 1999-06-14 |
Family
ID=26310627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO992875A NO992875L (en) | 1996-12-13 | 1999-06-11 | Preparation of enantiomerically enriched threo-methylphenidate |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0948484A1 (en) |
| JP (1) | JP2001506621A (en) |
| AU (1) | AU7847098A (en) |
| CA (1) | CA2272373A1 (en) |
| CZ (1) | CZ206299A3 (en) |
| HU (1) | HUP0001604A3 (en) |
| NO (1) | NO992875L (en) |
| PL (1) | PL334136A1 (en) |
| WO (1) | WO1998025902A1 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US6486177B2 (en) | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| US6962997B1 (en) | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| US6100401A (en) * | 1998-04-20 | 2000-08-08 | Novartris Ag | Process for preparing the d-threo isomer of methylphenidate hydrochloride |
| US6162919A (en) * | 1998-12-03 | 2000-12-19 | Novartis Ag | Process for preparing the d-threo isomer of methylphenidate hydrochloride |
| US6127385A (en) * | 1999-03-04 | 2000-10-03 | Pharmaquest Limited | Method of treating depression using l-threo-methylphenidate |
| US6395752B1 (en) * | 1999-03-04 | 2002-05-28 | Pharmaquest Limited | Method of treating depression using 1-threo-methylphenidate |
| US6025502A (en) * | 1999-03-19 | 2000-02-15 | The Trustees Of The University Of Pennsylvania | Enantopselective synthesis of methyl phenidate |
| US6221883B1 (en) * | 2000-04-12 | 2001-04-24 | Ross Baldessarini | Method of dopamine inhibition using l-threo-methylphenidate |
| DE60027282T2 (en) * | 2000-06-17 | 2007-04-12 | Pharmaquest Ltd., Hamilton | Use of l-threo-methylphenidate for the manufacture of a medicament for the treatment of depression |
| WO2004080959A2 (en) * | 2003-03-07 | 2004-09-23 | Isp Investments Inc. | Process for the preparation of dexmethylphenidate hydrochloride |
| US7897777B2 (en) | 2007-01-05 | 2011-03-01 | Archimica, Inc. | Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate |
| US8552030B2 (en) | 2009-05-07 | 2013-10-08 | Malladi Drugs & Pharmaceuticals Ltd. | Process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid |
| BR112013015072A2 (en) | 2010-12-17 | 2016-07-12 | Rhodes Technologies | low temperature methylphenidate hydrochloride synthesis |
| US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
| US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| DK3272342T3 (en) | 2011-03-23 | 2021-06-07 | Ironshore Pharmaceuticals & Dev Inc | Methods and compositions for treating attention deficit disorder |
| US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9233924B2 (en) | 2014-03-11 | 2016-01-12 | Ampac Fine Chemicals Llc | Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof |
| EP3160937B1 (en) | 2014-06-27 | 2020-12-30 | Embio Limited | A novel method for synthesis of optically pure beta-amino alcohols |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02190195A (en) * | 1989-01-19 | 1990-07-26 | Rikagaku Kenkyusho | Production of optically active propionic acid ester compound |
| JPH02273196A (en) * | 1989-03-08 | 1990-11-07 | Wisconsin Alumni Res Found | Method for improving enantioselectivity in biocatalytic resolution of racemic compounds |
| JP3431204B2 (en) * | 1993-04-22 | 2003-07-28 | 塩野義製薬株式会社 | Norbornane type ester hydrolase |
| BE1007297A3 (en) * | 1993-07-19 | 1995-05-09 | Dsm Nv | OPTICAL METHOD FOR THE PREPARATION OF ACTIVE alcohols and esters, alcohols and esters APPLIED AND WILLING TO SUCH METHODS. |
| DE4420751A1 (en) * | 1994-06-15 | 1995-12-21 | Basf Ag | Process for the preparation of enantiomerically pure lactams |
-
1997
- 1997-12-11 CZ CZ992062A patent/CZ206299A3/en unknown
- 1997-12-11 EP EP97949034A patent/EP0948484A1/en not_active Withdrawn
- 1997-12-11 HU HU0001604A patent/HUP0001604A3/en unknown
- 1997-12-11 AU AU78470/98A patent/AU7847098A/en not_active Abandoned
- 1997-12-11 PL PL97334136A patent/PL334136A1/en unknown
- 1997-12-11 WO PCT/GB1997/003418 patent/WO1998025902A1/en not_active Ceased
- 1997-12-11 JP JP52637898A patent/JP2001506621A/en active Pending
- 1997-12-11 CA CA002272373A patent/CA2272373A1/en not_active Abandoned
-
1999
- 1999-06-11 NO NO992875A patent/NO992875L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0948484A1 (en) | 1999-10-13 |
| HUP0001604A3 (en) | 2003-03-28 |
| CA2272373A1 (en) | 1998-06-18 |
| JP2001506621A (en) | 2001-05-22 |
| WO1998025902A1 (en) | 1998-06-18 |
| CZ206299A3 (en) | 1999-09-15 |
| HUP0001604A2 (en) | 2000-10-28 |
| PL334136A1 (en) | 2000-02-14 |
| AU7847098A (en) | 1998-07-03 |
| NO992875L (en) | 1999-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |