[go: up one dir, main page]

NO991051L - Et mikrostr°mningssystem for partikkelseparasjon og analyse - Google Patents

Et mikrostr°mningssystem for partikkelseparasjon og analyse

Info

Publication number
NO991051L
NO991051L NO991051A NO991051A NO991051L NO 991051 L NO991051 L NO 991051L NO 991051 A NO991051 A NO 991051A NO 991051 A NO991051 A NO 991051A NO 991051 L NO991051 L NO 991051L
Authority
NO
Norway
Prior art keywords
flow channel
fluid
flow
particles
field
Prior art date
Application number
NO991051A
Other languages
English (en)
Other versions
NO317958B1 (no
NO991051D0 (no
Inventor
Gert Blankenstein
Original Assignee
Univ Denmark Tech Dtu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Denmark Tech Dtu filed Critical Univ Denmark Tech Dtu
Publication of NO991051D0 publication Critical patent/NO991051D0/no
Publication of NO991051L publication Critical patent/NO991051L/no
Publication of NO317958B1 publication Critical patent/NO317958B1/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/028—Non-uniform field separators using travelling electric fields, i.e. travelling wave dielectrophoresis [TWD]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1023—Microstructural devices for non-optical measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Electrochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Fluid Mechanics (AREA)
  • Environmental & Geological Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Optical Measuring Cells (AREA)
NO19991051A 1996-09-04 1999-03-03 Et mikrostromningssystem for partikkelseparasjon og analyse NO317958B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK95396 1996-09-04
DK15097 1997-02-10
PCT/DK1997/000368 WO1998010267A1 (en) 1996-09-04 1997-09-04 A micro flow system for particle separation and analysis

Publications (3)

Publication Number Publication Date
NO991051D0 NO991051D0 (no) 1999-03-03
NO991051L true NO991051L (no) 1999-04-27
NO317958B1 NO317958B1 (no) 2005-01-17

Family

ID=26063406

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19991051A NO317958B1 (no) 1996-09-04 1999-03-03 Et mikrostromningssystem for partikkelseparasjon og analyse

Country Status (10)

Country Link
US (3) US6432630B1 (no)
EP (1) EP0925494B1 (no)
JP (1) JP2002503334A (no)
AT (1) ATE211258T1 (no)
AU (1) AU4113297A (no)
CA (1) CA2264389A1 (no)
DE (1) DE69709377T2 (no)
DK (1) DK0925494T3 (no)
NO (1) NO317958B1 (no)
WO (1) WO1998010267A1 (no)

Families Citing this family (499)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69830598T2 (de) 1997-01-31 2006-05-18 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
CA2230653A1 (en) 1998-02-27 1999-08-27 The Governors Of The University Of Alberta Microchip based enzymatic analysis
EP1066531A1 (en) * 1998-03-25 2001-01-10 OSTERGAARD, Steen Micro system and method for field manipulation of particules
DE19815882A1 (de) 1998-04-08 1999-10-14 Fuhr Guenther Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
AU3771599A (en) 1998-05-18 1999-12-06 University Of Washington Liquid analysis cartridge
JP2002528699A (ja) * 1998-05-22 2002-09-03 カリフォルニア インスティチュート オブ テクノロジー 微細製作細胞分類器
DE19847952C2 (de) 1998-09-01 2000-10-05 Inst Physikalische Hochtech Ev Fluidstromschalter
US6858439B1 (en) * 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
WO2000056444A2 (en) * 1999-03-24 2000-09-28 Torsana Biosensor A/S Spatially directed interaction on a solid surface
EP1179087B1 (en) * 1999-05-17 2019-03-27 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6613211B1 (en) 1999-08-27 2003-09-02 Aclara Biosciences, Inc. Capillary electrokinesis based cellular assays
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6790328B2 (en) 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US6323040B1 (en) 2000-02-15 2001-11-27 Ryan S. Raz System for biological specimen preparation
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
JP4504501B2 (ja) * 2000-03-15 2010-07-14 株式会社東海理化電機製作所 粒子移動／固定装置
US20030186426A1 (en) * 2000-03-15 2003-10-02 The Regents Of The University Of California Multichannel flow cell for interacting single optically trapped, DNA molecules with different chemical species
JP2001281233A (ja) * 2000-03-28 2001-10-10 Inst Of Physical & Chemical Res 水性分配用マイクロチップおよびそれを用いた水性分配方法
US7682837B2 (en) * 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
DE10025699A1 (de) * 2000-05-23 2001-12-06 Merck Patent Gmbh Emulgier- und Trennvorrichtung für flüssige Phasen
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
WO2001096857A2 (en) * 2000-06-14 2001-12-20 Board Of Regents, The University Of Texas System Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures
AU2001272012A1 (en) * 2000-06-19 2002-01-02 Arizona Board Of Regents Rapid flow-based immunoassay microchip
GB0016247D0 (en) * 2000-06-30 2000-08-23 Torsana Biosensor Diagnostics Flow cell assemblies and methods of spatially directed interaction between liquids and solid surfaces
AU2000274922A1 (en) * 2000-08-08 2002-02-18 Aviva Biosciences Corporation Methods for manipulating moieties in microfluidic systems
AU2002210291A1 (en) * 2000-08-21 2002-03-22 Oleg N. Darashkevitch Method and device for simultaneous detection of multiple components in a mixture
US20020031836A1 (en) * 2000-09-11 2002-03-14 Feldstein Mark J. Fluidics system
CA2424941A1 (en) * 2000-10-10 2002-04-18 Aviva Biosciences Corporation An integrated biochip system for sample preparation and analysis
US6623984B1 (en) * 2000-11-01 2003-09-23 The Cleveland Clinic Foundation MEMS-based integrated magnetic particle identification system
AU2002237689B2 (en) 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
FR2817343B1 (fr) 2000-11-29 2003-05-09 Commissariat Energie Atomique Procede et dispositifs de transport et de concentration d'un analyte present dans un echantillon
US6736978B1 (en) * 2000-12-13 2004-05-18 Iowa State University Research Foundation, Inc. Method and apparatus for magnetoresistive monitoring of analytes in flow streams
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
CN100494360C (zh) * 2001-03-22 2009-06-03 博奥生物有限公司 细胞分离方法及其应用
JP3538777B2 (ja) * 2001-03-26 2004-06-14 独立行政法人産業技術総合研究所 微小化学反応装置
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
FR2826882B1 (fr) * 2001-07-09 2003-09-12 Bio Merieux Procede de traitement de particules magnetiques et configurations d'aimants permettant la mise en oeuvre de ce procede
AU2002320507A1 (en) * 2001-07-13 2003-01-29 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
US20030110840A1 (en) * 2001-07-24 2003-06-19 Arriaga Edgar A. Systems and methods for detecting a particle
US20030095897A1 (en) * 2001-08-31 2003-05-22 Grate Jay W. Flow-controlled magnetic particle manipulation
US20050148085A1 (en) * 2001-09-16 2005-07-07 Chemometec A/S Method and a system for detecting and optinally isolating a rare event particle
GB0126281D0 (en) * 2001-11-01 2002-01-02 Astrazeneca Ab A chemical reactor
US20040214314A1 (en) * 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
US20030119177A1 (en) * 2001-11-15 2003-06-26 Lewis Gruber Sample chip
US20030186465A1 (en) * 2001-11-27 2003-10-02 Kraus Robert H. Apparatus used in identification, sorting and collection methods using magnetic microspheres and magnetic microsphere kits
US7232691B2 (en) * 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7252987B2 (en) * 2001-12-06 2007-08-07 Islet Technology, Inc. System for analysis and selection of encapsulated cellular materials
GB0129374D0 (en) * 2001-12-07 2002-01-30 Univ Brunel Test apparatus
ES2217208T3 (es) * 2002-02-01 2004-11-01 Leister Process Technologies Componente microfluido y procedimiento para la clasificacion de particulas en un fluido.
US7318902B2 (en) 2002-02-04 2008-01-15 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
AU2003219836A1 (en) * 2002-02-27 2003-09-09 The Regents Of The University Of Michigan Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
JP2004000144A (ja) * 2002-03-29 2004-01-08 Aisin Seiki Co Ltd 細胞分離選別装置、細胞整列用基板
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003085379A2 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
FI118611B (fi) * 2002-04-15 2008-01-15 Labmaster Oy Eriste-elektrodilaitteet
US6877528B2 (en) 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US20070065808A1 (en) * 2002-04-17 2007-03-22 Cytonome, Inc. Method and apparatus for sorting particles
US7157274B2 (en) * 2002-06-24 2007-01-02 Cytonome, Inc. Method and apparatus for sorting particles
US6808075B2 (en) * 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
KR100975438B1 (ko) * 2002-04-17 2010-08-11 사이토놈/에스티, 엘엘씨 입자 분류 방법 및 장치
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
WO2003099440A1 (de) * 2002-05-24 2003-12-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum überführen von molekülen aus einem chemisch reagierenden ersten strom in einen benachbarten chemisch reagierenden zweiten strom
JP2006507921A (ja) * 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20040018611A1 (en) * 2002-07-23 2004-01-29 Ward Michael Dennis Microfluidic devices for high gradient magnetic separation
US7745203B2 (en) 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
EP2889879B1 (en) 2002-07-31 2017-09-06 Premium Genetics (UK) Limited System and method of sorting materials using holographic laser steering
US7118676B2 (en) * 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
JP4057967B2 (ja) * 2002-07-31 2008-03-05 株式会社東芝 塩基配列自動解析装置
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US7699767B2 (en) * 2002-07-31 2010-04-20 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
JP4595067B2 (ja) 2002-08-01 2010-12-08 エックスワイ，エルエルシー 低圧精子細胞分離システム
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
BRPI0313476B1 (pt) 2002-08-15 2015-06-23 Xy Llc Citômetro de fluxo de alta resolução
JP3898103B2 (ja) * 2002-08-26 2007-03-28 独立行政法人科学技術振興機構 細胞分析分離装置
WO2004024300A1 (en) 2002-09-11 2004-03-25 The Regents Of The University Of Michigan Ultrafiltration membrane, device, bioartificial organ and methods
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP1581350A4 (en) * 2002-09-16 2009-09-23 Cytonome Inc METHOD AND DEVICE FOR SORTING PARTICLES
WO2004028955A2 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
WO2004029221A2 (en) 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
AU2003301322A1 (en) 2002-10-16 2004-05-04 Yoshiro Okami Apparatus for introducing biological material, method of introducing biological material and magnetic support for introducing biological material
KR20040044336A (ko) * 2002-11-12 2004-05-28 마쯔시다덴기산교 가부시키가이샤 특이결합반응 측정방법과 이에 이용하는 시약키트 및특이결합반응 측정장치
WO2004061446A1 (en) 2002-12-18 2004-07-22 Aclara Biosciences, Inc. Single cell analysis of membrane molecules
WO2004068553A2 (en) * 2003-01-29 2004-08-12 The Regents Of The University Of Michigan Method for forming nanoscale features
US20050064137A1 (en) * 2003-01-29 2005-03-24 Hunt Alan J. Method for forming nanoscale features and structures produced thereby
US7190450B2 (en) * 2003-02-20 2007-03-13 Yale University Systems and methods for sorting aerosols
WO2004077021A2 (en) * 2003-02-27 2004-09-10 Lesko Stephen A Standardized evaluation of therapeutic efficacy based on cellular biomarkers
EP1602623B1 (en) * 2003-03-07 2011-08-17 Tosoh Corporation Method of moulding a microfluidic structure and mould
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
CA2518667C (en) 2003-03-14 2011-07-19 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
DE10311716A1 (de) 2003-03-17 2004-10-14 Evotec Oai Ag Verfahren und Vorrichtung zur Trennung von Partikeln in einer Flüssigkeitsströmung
DK2959774T3 (da) 2003-03-28 2019-05-13 Inguran Llc Fremgangsmåde til kryokonservering af sædceller
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
CA2521862C (en) 2003-04-10 2012-10-16 President And Fellows Of Harvard College Formation and control of fluidic species
JP2006522940A (ja) * 2003-04-10 2006-10-05 ユー．エス． ジェノミクス， インコーポレイテッド マイクロチャネルにおけるポリマーの操作
WO2004100175A1 (en) 2003-05-08 2004-11-18 The University Court Of The University Of St Andrews Fractionation of particles
DE10320869A1 (de) * 2003-05-09 2004-12-16 Evotec Technologies Gmbh Verfahren und Vorrichtungen zur Flüssigkeitsbehandlung suspendierter Partikel
JP3711988B2 (ja) * 2003-05-12 2005-11-02 株式会社日立製作所 微粒子アレー分析システム、微粒子アレーキットおよび化学分析方法
WO2004104178A2 (en) 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
WO2004101731A1 (ja) * 2003-05-19 2004-11-25 Japan Science And Technology Agency 細胞分離装置
GB0313197D0 (en) * 2003-06-09 2003-07-16 Imp College Innovations Ltd Free flow electrophoresis microchip, system and method
EP1655363A1 (en) * 2003-06-20 2006-05-10 Nitto Denko Corporation Cell microchip
ATE405591T1 (de) * 2003-08-26 2008-09-15 Univ Danmarks Tekniske Kontinuierliches verfahren zur anordnung von makromolekulären substanzen und die anschliessende aufnahme und isolierung einer makromolekulären anordnung, sowie ein für dieses verfahren geeignetes system
EP2662135A3 (en) * 2003-08-27 2013-12-25 President and Fellows of Harvard College Method for mixing droplets in a microchannel
CA2536360C (en) 2003-08-28 2013-08-06 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
TW200523534A (en) * 2003-09-04 2005-07-16 Arryx Inc Multiple laminar flow-based particle and cellular separation with laser steering
FR2860006B1 (fr) * 2003-09-24 2006-12-22 Commissariat Energie Atomique Dispositif pour separer et/ou analyser plusieurs cibles moleculaires en solution dans un melange complexe
JP3787578B2 (ja) * 2003-10-29 2006-06-21 アイダエンジニアリング株式会社 マイクロチップの微細流路における液体送液方法
FR2863626B1 (fr) * 2003-12-15 2006-08-04 Commissariat Energie Atomique Procede et dispositif de division d'un echantillon biologique par effet magnetique
WO2005069015A1 (ja) * 2004-01-15 2005-07-28 Japan Science And Technology Agency 化学分析装置及び化学分析方法
US20050178700A1 (en) * 2004-01-21 2005-08-18 David Tyvoll Sorting particles in parallel
US20050282293A1 (en) * 2004-03-03 2005-12-22 Cosman Maury D System for delivering a diluted solution
US20060121624A1 (en) * 2004-03-03 2006-06-08 Huang Lotien R Methods and systems for fluid delivery
US8058056B2 (en) * 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
US7258716B2 (en) * 2004-03-22 2007-08-21 Joseph Gerard Birmingham Microimpactor system having optimized impactor spacing
US20050205483A1 (en) * 2004-03-22 2005-09-22 Birmingham Joseph G Microimpactor system for collection of particles from a fluid stream
JP4643921B2 (ja) * 2004-03-26 2011-03-02 独立行政法人科学技術振興機構 流路における流体の通過を検出する方法および流体の流れを制御する方法
DK2801363T3 (en) 2004-03-29 2018-05-28 Inguran Llc PROCEDURE FOR STORING SORTED SPERMATOZOES
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP2006010529A (ja) * 2004-06-25 2006-01-12 Canon Inc 磁性粒子分離装置および分離方法
JP2006010535A (ja) * 2004-06-25 2006-01-12 Canon Inc 標的物質捕捉方法および装置
JP2006007146A (ja) * 2004-06-28 2006-01-12 Canon Inc 粒子分離装置
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
AR049732A1 (es) 2004-07-22 2006-08-30 Monsanto Co Proceso para enriquecer una poblacion de celulas de esperma
US7156365B2 (en) * 2004-07-27 2007-01-02 Kelsey-Hayes Company Method of controlling microvalve actuator
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US7595170B2 (en) * 2004-08-05 2009-09-29 Modrovich Ivan E Apparatus and method for measuring concentrations of molecules through a barrier
DE102004040785B4 (de) * 2004-08-23 2006-09-21 Kist-Europe Forschungsgesellschaft Mbh Mikrofluidisches System zur Isolierung biologischer Partikel unter Verwendung der immunomagnetischen Separation
JP2006087336A (ja) * 2004-09-22 2006-04-06 Shimadzu Corp 細胞分析装置
ITBO20040601A1 (it) * 2004-09-30 2004-12-30 Ima Spa Metodo per il controllo di capsule
DE102004047953A1 (de) * 2004-10-01 2006-04-20 Rudolf Rigler Selektion von Partikeln im laminaren Fluss
DE102004048443B3 (de) * 2004-10-02 2005-12-01 C.D. Wälzholz-Brockhaus GmbH Verfahren zur walztechnischen Verformung von draht- und stabförmigem Vormaterial, Vorrichtung zur Durchführung des Verfahrens sowie nach dem Verfahren hergestelltes Flachprofil
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7534097B2 (en) * 2004-10-15 2009-05-19 Nanyang Technological University Method and apparatus for controlling multi-fluid flow in a micro channel
DE102004055662A1 (de) * 2004-11-18 2006-06-01 Evotec Technologies Gmbh Mikrofluidisches System mit einer Kanalaufweitung
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
JP4601423B2 (ja) * 2004-12-28 2010-12-22 独立行政法人科学技術振興機構 細胞計測および分離チップ
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US8158410B2 (en) 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
JP2008526251A (ja) 2005-01-18 2008-07-24 バイオセプト インコーポレイティッド パターン化されたポストを有するマイクロチャネルを用いた細胞分離
JP4047336B2 (ja) * 2005-02-08 2008-02-13 独立行政法人科学技術振興機構 ゲル電極付セルソーターチップ
JP2008535644A (ja) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 多重エマルジョンの形成のための方法および装置
US20070054119A1 (en) * 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
FR2882939B1 (fr) * 2005-03-11 2007-06-08 Centre Nat Rech Scient Dispositif de separation fluidique
GB2427468B (en) * 2005-04-05 2011-03-02 Cellpoint Diagnostics Cell separation device and method for the detection of EpCAM positive cells
US20060223178A1 (en) * 2005-04-05 2006-10-05 Tom Barber Devices and methods for magnetic enrichment of cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
DE112005003572T5 (de) * 2005-05-13 2008-03-27 Agilent Technologies Inc., Santa Clara Flusszelle mit Hüllfluss
WO2006128098A2 (en) * 2005-05-27 2006-11-30 Applera Corporation Cytometric system including nucleic acid sequence amplification, and method
EP2703499A1 (en) * 2005-06-02 2014-03-05 Fluidigm Corporation Analysis using microfluidic partitioning devices to generate single cell samples
CA2611743C (en) 2005-06-15 2019-12-31 Callida Genomics, Inc. Nucleic acid analysis by forming and tracking aliquoted fragments of a target polynucleotide
US20070015292A1 (en) * 2005-07-18 2007-01-18 Barry Ruddick Apparatus, System and Method for Evaluating Fluid Systems
US20070128083A1 (en) * 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
ITBO20050481A1 (it) * 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US20070025879A1 (en) * 2005-07-27 2007-02-01 Dakocytomation Denmark A/S Method and apparatus for syringe-based sample introduction within a flow cytometer
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7858307B2 (en) 2005-08-09 2010-12-28 Maxwell Sensors, Inc. Light transmitted assay beads
US20090201504A1 (en) * 2005-08-09 2009-08-13 Maxwell Sensors, Inc. Hydrodynamic focusing for analyzing rectangular microbeads
US8232092B2 (en) * 2005-08-09 2012-07-31 Maxwell Sensors, Inc. Apparatus and method for digital magnetic beads analysis
DE102005039175A1 (de) * 2005-08-18 2007-02-22 Qiagen Gmbh Vorrichtung und Verfahren zum Abtrennen von magnetischen Partikeln aus einer Flüssigkeit
WO2007024914A2 (en) * 2005-08-22 2007-03-01 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
JP4745755B2 (ja) * 2005-08-23 2011-08-10 セイコーインスツル株式会社 分画マイクロチップ及び分画装置
US20070059782A1 (en) * 2005-09-13 2007-03-15 Graham Henry A Magnetic particle tagged blood bank reagents and techniques
US9488665B2 (en) * 2005-09-13 2016-11-08 Chrome Red Technologies, Llc Magnetic particle tagged reagents and techniques
EP1931800A4 (en) * 2005-09-15 2011-06-15 Artemis Health Inc SYSTEMS AND METHOD FOR ENRICHING ANALYTES
JP4692200B2 (ja) * 2005-10-06 2011-06-01 横河電機株式会社 化学処理用カートリッジおよびその使用方法
WO2007044642A2 (en) * 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
US20070178067A1 (en) * 2005-11-09 2007-08-02 John Maier System and method for cytological analysis by raman spectroscopic imaging
US7540206B2 (en) * 2005-11-14 2009-06-02 Parker-Hannifin Corporation Self-cleaning sample extraction system
US20080241910A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for pathogen detection
US20080241000A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for pathogen detection
US20080241909A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Microfluidic chips for pathogen detection
US20080179255A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic devices
US20080178692A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US20080210748A1 (en) * 2005-11-30 2008-09-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware, Systems and methods for receiving pathogen related information and responding
US20080193919A1 (en) * 2005-11-30 2008-08-14 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and methods for receiving pathogen related information and responding
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
CA2636855C (en) 2006-01-11 2016-09-27 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US7695956B2 (en) * 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
CN101004423B (zh) * 2006-01-19 2011-12-28 博奥生物有限公司 流体样品分析用卡盒系统
JP5000666B2 (ja) * 2006-01-25 2012-08-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体を分析する装置
WO2007085300A1 (en) * 2006-01-26 2007-08-02 Ecole Polytechnique Federale De Lausanne (Epfl) Magnetic bead retention apparatus and method
ATE484335T1 (de) * 2006-01-27 2010-10-15 Harvard College Koaleszenz fluider tröpfchen
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
US20090181864A1 (en) * 2006-03-31 2009-07-16 Nam Trung Nguyen Active control for droplet-based microfluidics
US8293524B2 (en) * 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
ATE504354T1 (de) * 2006-05-11 2011-04-15 Corning Inc Modulares halte- und verbindungssystem für microfluidische vorrichtungen
EP4190448A3 (en) 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Microfluidic devices
JP5032792B2 (ja) * 2006-05-22 2012-09-26 浜松ホトニクス株式会社 細胞選別装置
MX2008014732A (es) 2006-05-22 2009-04-07 Univ Columbia Sistemas y metodos de intercambio sin membrana microfluidica usando filtracion de corrientes de salida de fluidos de extraccion.
WO2008016414A2 (en) * 2006-06-01 2008-02-07 The Trustees Of Princeton University Apparatus and method for continuous particle separation
US8296088B2 (en) * 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080070792A1 (en) * 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080124721A1 (en) * 2006-06-14 2008-05-29 Martin Fuchs Analysis of rare cell-enriched samples
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
GB0612825D0 (en) * 2006-06-28 2006-08-09 Iti Scotland Ltd Analyte detection
GB0614297D0 (en) * 2006-07-19 2006-08-30 Shaw Water Engineering Ltd Apparatus, system and method for detecting particles
KR100846491B1 (ko) * 2006-07-25 2008-07-17 삼성전자주식회사 미세유동 장치 내에서 표적 생체분자의 분리 및 정제를 위한 자성 비드 추출 장치
EP2077912B1 (en) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
GB0616508D0 (en) * 2006-08-18 2006-09-27 Iti Scotland Ltd Analyte manipulation and detection
KR101419312B1 (ko) 2006-09-01 2014-07-14 도소 가부시키가이샤 미소유로 구조 및 그것을 사용한 미소입자 제조 방법
GB0618606D0 (en) 2006-09-21 2006-11-01 Univ St Andrews Optical sorting
GB0618605D0 (en) 2006-09-21 2006-11-01 Univ St Andrews Optical sorting
US20120122731A1 (en) * 2006-10-18 2012-05-17 Hyongsok Soh Screening molecular libraries using microfluidic devices
US7807454B2 (en) * 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
JP4984849B2 (ja) * 2006-11-27 2012-07-25 パナソニック株式会社 成分分離デバイスと、この成分分離デバイスを用いた化学分析デバイス
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US8999636B2 (en) 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
WO2008086477A1 (en) 2007-01-10 2008-07-17 The Regents Of The University Of Michigan Ultrafiltration membrane, device, bioartificial organ, and related methods
GB0701641D0 (en) * 2007-01-29 2007-03-07 Iti Scotland Ltd Analyte manipulation and detection
US20080181821A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Microfluidic chips for allergen detection
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US20080180259A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for allergen detection
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US20090050569A1 (en) * 2007-01-29 2009-02-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US8617903B2 (en) * 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US20100108578A1 (en) * 2007-02-07 2010-05-06 Koninklijke Philips Electronics N.V. Means for the separation of magnetic particles
US20090081750A1 (en) * 2007-02-14 2009-03-26 Bio-Rad Laboratories, Inc. Transfection in magnetically driven continuous flow
US20090215157A1 (en) * 2007-03-27 2009-08-27 Searete Llc Methods for pathogen detection
EP2136786B8 (en) * 2007-03-28 2012-11-14 President and Fellows of Harvard College Apparatus for forming droplets
US20080237044A1 (en) * 2007-03-28 2008-10-02 The Charles Stark Draper Laboratory, Inc. Method and apparatus for concentrating molecules
EP2479552B1 (en) 2007-04-02 2015-09-02 Acoustic Cytometry Systems, Inc. Methods for enhanced analysis of acoustic field focused cells and particles
CN101765762B (zh) 2007-04-16 2013-08-14 通用医疗公司以马萨诸塞州通用医疗公司名义经营 使粒子在微通道中聚集的系统和方法
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2008130618A1 (en) * 2007-04-19 2008-10-30 The Charles Stark Draper Laboratory, Inc. Method and apparatus for separating particles, cells, molecules and particulates
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
WO2009014792A2 (en) * 2007-05-11 2009-01-29 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Electrical detection using confined fluids
ATE554859T1 (de) * 2007-05-24 2012-05-15 Univ California Integrierte fluidische vorrichtungen mit magnetischer sortierung
US8921121B2 (en) * 2007-06-29 2014-12-30 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for chemiluminescence-based microfluidic cell counting
US8431090B2 (en) 2007-06-29 2013-04-30 The Trustees Of Columbia University In The City Of New York Microfluidic device for counting biological particles
GB2463839B (en) * 2007-08-09 2012-09-26 Agilent Technologies Inc Fluid flow control in a microfluidic device
WO2009021215A1 (en) * 2007-08-09 2009-02-12 Celula, Inc. Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material
ITBO20070588A1 (it) 2007-08-13 2009-02-14 Silicon Biosystems Spa Metodo per legare uno strato di silicone ad un substrato di polimero metacrilico
EP2178646A1 (en) * 2007-08-23 2010-04-28 Cynvenio Biosystems, LLC Trapping magnetic sorting system for target species
US20110195852A1 (en) 2007-08-30 2011-08-11 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US8835184B2 (en) * 2007-09-14 2014-09-16 Biosensia Patents Limited Analysis system
EP2215441A2 (en) * 2007-10-25 2010-08-11 The Research Foundation of the State University of New York Single photon spectrometer
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
BRPI0819296A2 (pt) * 2007-11-22 2015-05-12 Koninkl Philips Electronics Nv Cartucho de sensor, sensor, métodos para fabricar um cartucho de sensor e para determinar frações alvo em uma amostra de fluido, uso de um cartucho de sensor, dispositivo descartável, e, dispositivo leitor
KR101338349B1 (ko) * 2007-11-30 2013-12-06 연세대학교 산학협력단 미세입자 분리 장치 및 이의 제작 방법
US9656271B2 (en) * 2007-12-04 2017-05-23 Headway Technologies, Inc. Guided transport of magnetically labeled biological molecules and cells
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
KR100907213B1 (ko) 2007-12-07 2009-07-10 한국과학기술원 등자기영동 기술을 이용한 미세입자 분리 장치 및등자기영동 기술을 이용한 미세입자 분리 방법
WO2009076560A2 (en) * 2007-12-12 2009-06-18 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for magnetic separation of cells
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
KR101384142B1 (ko) * 2007-12-28 2014-04-14 삼성디스플레이 주식회사 표시기판, 이의 제조방법 및 이를 갖는 표시장치
US8001855B2 (en) * 2008-01-14 2011-08-23 Medi Medical Engineering Corp. Fluid transferring apparatus
JP2009168650A (ja) * 2008-01-17 2009-07-30 Sekisui Chem Co Ltd カートリッジ式電気化学分析装置及び方法
JP2011514182A (ja) 2008-02-04 2011-05-06 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 流体分離装置、システム、及び方法
KR100965399B1 (ko) 2008-02-14 2010-06-24 연세대학교 산학협력단 전자석의 주울열을 이용하여 채널내 세포의 최적온도조절이 가능한 자성세포분리장치
NL2001322C2 (nl) * 2008-02-27 2009-08-31 Univ Delft Tech Werkwijze en inrichting voor het scheiden van vaste deeltjes met een onderling dichtheidsverschil.
WO2009117611A2 (en) * 2008-03-19 2009-09-24 Cynvenio Biosystems, Llc Trapping magnetic cell sorting system
WO2009129415A1 (en) * 2008-04-16 2009-10-22 Cynvenio Biosystems, Llc Magnetic separation system with pre and post processing modules
WO2009132151A2 (en) * 2008-04-23 2009-10-29 The Regents Of The University Of California Microfluidic devices and methods of using same
JP4661942B2 (ja) 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
JP4572973B2 (ja) * 2008-06-16 2010-11-04 ソニー株式会社 マイクロチップ及びマイクロチップにおける送流方法
GB0812781D0 (en) * 2008-07-11 2008-08-20 Deltadot Ltd Material separation device
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US9180453B2 (en) * 2008-08-15 2015-11-10 University Of Washington Method and apparatus for the discretization and manipulation of sample volumes
LT2334812T (lt) 2008-09-20 2017-04-25 The Board Of Trustees Of The Leland Stanford Junior University Neinvazinis fetalinės aneuploidijos diagnozavimas sekvenavimu
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
EP2346607A2 (en) * 2008-10-10 2011-07-27 Cnrs-Dae Microfluidic integrated device for sample processing
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
JP2010151777A (ja) * 2008-11-19 2010-07-08 Sony Corp 微小粒子解析装置、微小粒子解析用マイクロチップ及び微小粒子解析方法
WO2010123594A2 (en) 2009-01-15 2010-10-28 Children's Medical Center Corporation Device for filtration of fluids there through and accompanying method
US8162149B1 (en) 2009-01-21 2012-04-24 Sandia Corporation Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
DE102009005925B4 (de) 2009-01-23 2013-04-04 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zur Handhabung von Biomolekülen
US20100298453A1 (en) * 2009-01-26 2010-11-25 Invista North America S.A R.L. Board stock foam having biobased content
JP5382852B2 (ja) 2009-02-06 2014-01-08 株式会社オンチップ・バイオテクノロジーズ 使い捨てチップ型フローセルとそれを用いたフローサイトメーター
US8828715B2 (en) * 2009-03-06 2014-09-09 Cfd Research Corporation Particle adhesion assay for microfluidic bifurcations
SG174459A1 (en) * 2009-03-17 2011-10-28 Silicon Biosystems Spa Microfluidic device for isolation of cells
ITBO20090154A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Sistema microfluidico
EP2411148B1 (en) 2009-03-23 2018-02-21 Raindance Technologies, Inc. Manipulation of microfluidic droplets
JP5333752B2 (ja) * 2009-03-27 2013-11-06 セイコーエプソン株式会社 細胞分離装置および細胞分離方法
US8343440B2 (en) 2009-03-27 2013-01-01 Seiko Epson Corporation Cell separating apparatus and cell separating method
JP4893794B2 (ja) * 2009-09-14 2012-03-07 セイコーエプソン株式会社 細胞分離装置
JP5248394B2 (ja) * 2009-03-30 2013-07-31 シャープ株式会社 被検体物質の固定化方法およびマイクロ分析装置
NL2002736C2 (en) 2009-04-09 2010-10-12 Univ Delft Tech Method for separating magnetic pieces of material.
US8689981B2 (en) 2009-04-10 2014-04-08 President And Fellows Of Harvard College Manipulation of particles in channels
ES2945686T3 (es) 2009-05-13 2023-07-05 Sartorius Bioanalytical Instr Inc Medición y control de flujo para cuantificación mejorada de partículas en citometría de flujo
US8790916B2 (en) * 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
JP2011013208A (ja) * 2009-06-05 2011-01-20 Advance Co Ltd 生物学的操作システム及び工業的操作システム
SMT201700421T1 (it) 2009-06-10 2017-11-15 Cynvenio Biosystems Inc Dispositivi e metodi a flusso di guaina
WO2010151776A2 (en) 2009-06-26 2010-12-29 President And Fellows Of Harvard College Fluid injection
DE102009030688A1 (de) 2009-06-26 2010-12-30 Carl Zeiss Ag Mikroskopische Detektion von Objekten in einem Fluidstrom
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
US8202486B2 (en) * 2009-08-12 2012-06-19 Caliper Life Sciences, Inc. Pinching channels for fractionation of fragmented samples
US8834807B2 (en) 2009-08-12 2014-09-16 Caliper Life Sciences, Inc. Device and method for improving sample injection and stacking
CA2772020A1 (en) 2009-08-31 2011-03-03 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
JP5869482B2 (ja) 2009-09-02 2016-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ ジェッティングおよび他の技術を使用して生成された多重エマルジョン
US9625454B2 (en) * 2009-09-04 2017-04-18 The Research Foundation For The State University Of New York Rapid and continuous analyte processing in droplet microfluidic devices
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
SG170702A1 (en) * 2009-10-20 2011-05-30 Agency Science Tech & Res Microfluidic system for trapping and detection of a biological entity in a sample
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
EP2525209B1 (en) 2010-01-15 2020-03-11 On-chip Biotechnologies Co., Ltd. Disposable chip flow cell and cell sorter using same
CA2787135C (en) 2010-01-21 2018-11-20 Biocep Ltd. Magnetic separation of rare cells
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (en) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Digital analyte analysis
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
ES2544635T3 (es) * 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
WO2011124991A2 (en) 2010-04-07 2011-10-13 Biosensia Patents Limited Flow control device for assays
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
JP2011237201A (ja) * 2010-05-06 2011-11-24 Sony Corp 微小粒子分取装置、マイクロチップ及びマイクロチップモジュール
JP5268989B2 (ja) * 2010-05-11 2013-08-21 株式会社日立ハイテクノロジーズ 核酸分析反応セルおよび核酸分析装置
GB2482658A (en) 2010-07-08 2012-02-15 Univ Dublin Non-linear magnetophoresis system
ITBO20100505A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
ITBO20100503A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
WO2012016357A1 (en) 2010-08-06 2012-02-09 Capitalbio Corporation Microarray-based assay integrated with particles for analyzing molecular interactions
US8468680B2 (en) 2010-08-24 2013-06-25 Roche Diagnostics Operations, Inc. Biosensor test member and method for making the same
KR20120026959A (ko) 2010-09-10 2012-03-20 인제대학교 산학협력단 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
DE102010042737A1 (de) * 2010-10-21 2012-04-26 Siemens Aktiengesellschaft Magnetische Durchflusszytometrie
US9090865B2 (en) * 2010-10-29 2015-07-28 The Regents Of The University Of California Systems and methods for particle classification and sorting
JP2012095550A (ja) * 2010-10-29 2012-05-24 Sony Corp 細胞分取装置、細胞分取チップ及び細胞分取方法
CN102019277B (zh) * 2010-10-29 2013-05-22 北京惟馨雨生物科技有限公司 一种用于细胞和颗粒分离的分选仪及分选方法
JP5732816B2 (ja) * 2010-10-29 2015-06-10 ソニー株式会社 細胞分取装置及び細胞分取チップ
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US9815060B2 (en) 2010-11-18 2017-11-14 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspensions
US9522344B2 (en) 2010-11-18 2016-12-20 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspension
BR112013013884A2 (pt) * 2010-12-06 2016-09-13 Pall Corp métodos de processamento contínuo para produtos biológicos
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
US8371683B2 (en) 2010-12-23 2013-02-12 Palo Alto Research Center Incorporated Particle removal device for ink jet printer
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20120214224A1 (en) * 2011-02-01 2012-08-23 Chan Eugene Y Flow based clinical analysis
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US20130000738A1 (en) * 2011-02-28 2013-01-03 Pathogenetix, Inc. Method and system for transferring and/or concentrating a sample
DE102011015321A1 (de) 2011-03-28 2012-10-04 Ralph Heindrichs Verfahren zur kontinuierlichen selektiven Separation von Partikeln mittels Magnetismus
AU2012236128A1 (en) * 2011-04-01 2013-10-31 Children's Medical Center Corporation Dialysis like therapeutic (DLT) device
US9494557B2 (en) 2011-04-05 2016-11-15 Purdue Research Foundation Micro-fluidic system using micro-apertures for high throughput detection of cells
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2012148648A2 (en) 2011-04-27 2012-11-01 Becton Dickinson & Co. Devices and methods for separating magnetically labeled moieties in a sample
EP2701851B1 (en) * 2011-04-29 2024-04-24 Becton Dickinson and Company Fluidic in-line particle immobilization and collection system and method for using the same
DE102011076051A1 (de) * 2011-05-18 2012-11-22 Siemens Aktiengesellschaft Magnetophoretische Analytselektion und -anreicherung
JP6122843B2 (ja) 2011-05-23 2017-04-26 プレジデント アンド フェローズ オブ ハーバード カレッジ 多重エマルジョンを含むエマルジョンの制御
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
JP2014522718A (ja) 2011-07-06 2014-09-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 多相エマルションおよび多相エマルション形成法
US10240186B2 (en) 2011-07-14 2019-03-26 Fluxion Biosciences, Inc. Devices, systems, and methods for magnetic separation
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US20130029355A1 (en) * 2011-07-28 2013-01-31 Electronics And Telecommunications Research Institute Multiple analysis device and method for analyzing cancer cells in blood
GB201113007D0 (en) * 2011-07-28 2011-09-14 Q Chip Ltd Bead collection device and method
US20130075318A1 (en) * 2011-09-23 2013-03-28 Xiaojing Zhang Apparatus for Isolating Rare Cells from Blood Samples
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
EP2644258A1 (en) * 2012-03-29 2013-10-02 Roche Diagniostics GmbH Micro flow filtration system and flow filtration method for a fluid sample
EP2644259A1 (en) 2012-03-29 2013-10-02 Roche Diagniostics GmbH Micro flow filtration system and flow filtration method
US9556412B2 (en) * 2012-04-17 2017-01-31 Regents Of The University Of Minnesota Inlet and outlet geometries for a vertical three-stream microfluidic device
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9517474B2 (en) * 2012-05-18 2016-12-13 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
JP2015519900A (ja) 2012-05-21 2015-07-16 フリューダイム・コーポレイション 粒子集団の単粒子解析方法及び単粒子単離方法
DE102012211626A1 (de) * 2012-07-04 2014-01-09 Siemens Aktiengesellschaft Anordnung zur Quantifizierung von Zellen einer Zellsuspension
US9874556B2 (en) 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
JP5910412B2 (ja) * 2012-08-16 2016-04-27 ソニー株式会社 微小粒子分取方法及び微小粒子分取用マイクロチップ
CN110595987A (zh) 2012-10-26 2019-12-20 贝克顿·迪金森公司 用于操纵流体样品中的组分的装置和方法
US20140151229A1 (en) * 2012-12-05 2014-06-05 Caliper Life Sciences, Inc. Manipulation of objects in microfluidic devices using external electrodes
US20140168328A1 (en) * 2012-12-18 2014-06-19 Palo Alto Research Center Incorporated Non-spherical particle separator for ink jet printer
KR101356933B1 (ko) * 2012-12-28 2014-01-29 고려대학교 산학협력단 표면탄성파를 이용한 미세유동 크로마토 그래피 기반 미세입자 분리 장치 및 방법
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
FR3001038B1 (fr) * 2013-01-17 2018-02-09 Centre National De La Recherche Scientifique (Cnrs) Procede de capture, procede de detection et kit de capture d'une molecule dans un echantillon
US9322013B2 (en) * 2013-02-25 2016-04-26 Los Alamos National Security, Llc Magnetic separation of algae
US9599615B2 (en) 2013-03-13 2017-03-21 Symbolics, Llc Lateral flow assays using two dimensional test and control signal readout patterns
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
US20160296945A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for active particle separation
WO2014145765A1 (en) 2013-03-15 2014-09-18 Ancera, Inc. Systems and methods for bead-based assays in ferrofluids
CN103217311B (zh) * 2013-03-26 2015-04-01 上海交通大学 生物复合物的分离与收集方法
CN103194371B (zh) * 2013-03-26 2014-12-24 上海交通大学 生物复合物的分离与收集装置
CN103196725B (zh) * 2013-03-26 2015-07-08 上海交通大学 制备与富集单个微纳米珠携带单根多聚物分子的方法
CN103305603B (zh) * 2013-03-26 2015-05-20 上海交通大学 单分子生物反应器制备单微纳米珠携带单根多聚物的方法
CN103194370B (zh) * 2013-03-26 2014-12-24 上海交通大学 制备与富集单个微纳米珠携带单根多聚物分子的装置
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
JP5780274B2 (ja) * 2013-07-31 2015-09-16 セイコーエプソン株式会社 細胞回収方法
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9815059B2 (en) * 2013-10-07 2017-11-14 Devrim PESEN OKVUR Microfluidic device for investigation of distance dependent interactions in cell biology
EP3058316B1 (en) * 2013-10-18 2019-03-13 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
GB201320146D0 (en) * 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
US9939362B2 (en) * 2014-02-20 2018-04-10 Malvern Instruments Limited Heterogeneous fluid sample characterization
DE102014203285A1 (de) * 2014-02-24 2015-08-27 Miltenyi Biotec Gmbh Hydrodynamische Fokussierungseinheit
US20170074870A1 (en) 2014-03-14 2017-03-16 Northeastern University Microfluidic System and Method for Real-Time Measurement of Antibody-Antigen Binding and Analyte Detection
US8820538B1 (en) * 2014-03-17 2014-09-02 Namocell LLC Method and apparatus for particle sorting
DE102014205949A1 (de) * 2014-03-31 2015-10-01 Siemens Aktiengesellschaft Durchflusskammer für einen Durchflusszytometer sowie Durchflusszytometer
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
US10031104B2 (en) * 2014-06-13 2018-07-24 Yes Way Intellectual Holdings, Llc Mobile micro-lab for chemical analysis of fluids
SI3183568T1 (sl) * 2014-08-20 2023-02-28 Stem Sel S.R.L. Naprava za frakcioniranje objektov in postopek frakcioniranja
DE102014112270B3 (de) 2014-08-27 2015-04-23 Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. Verfahren zur Messung der Thrombozytenfunktion
EP3187854B1 (en) * 2014-08-28 2020-08-19 Sysmex Corporation Particle image-capturing device and particle image-capturing method
DE102014116567A1 (de) * 2014-11-12 2016-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zum Sortieren von Mikropartikeln in einem Fluidstrom
EP3259579B1 (en) 2015-02-19 2022-09-14 1087 Systems, Inc. Scanning infrared measurement system
US10167502B2 (en) 2015-04-03 2019-01-01 Fluxion Biosciences, Inc. Molecular characterization of single cells and cell populations for non-invasive diagnostics
WO2016183032A1 (en) 2015-05-08 2016-11-17 Biomagnetic Solutions Llc Apparatus and method for immunomagnetic cell separation
US11725179B2 (en) 2015-05-12 2023-08-15 On-Chip Biotechnologies Co., Ltd. Single-particle analysis method, and system for performing said analysis
US11285490B2 (en) 2015-06-26 2022-03-29 Ancera, Llc Background defocusing and clearing in ferrofluid-based capture assays
ES2599056B2 (es) * 2015-07-31 2017-07-07 Pablo ALBERTOS SÁNCHEZ Dispositivo para ensayar una muestra de células
US10676719B2 (en) 2015-07-31 2020-06-09 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
DE102015218177B4 (de) 2015-09-22 2022-09-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Isolation und Anreicherung magnetisch markierter Zellen im Durchfluss
CN108369224B (zh) * 2015-10-02 2021-12-14 小利兰·斯坦福大学托管委员会 利用磁性悬浮的生物和非生物组分分选
ES2757076T3 (es) * 2015-11-30 2020-04-28 Rqmicro Ag Dispositivo microfluídico, conjuntos y procedimiento para extraer partículas de una muestra
CN105536664B (zh) * 2015-12-12 2017-06-20 西安交通大学 一种用于可控筛选流体中粒子的微反应器的制备方法
KR101855490B1 (ko) * 2016-01-22 2018-05-08 한국과학기술원 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법
US10962527B2 (en) * 2016-02-05 2021-03-30 The Broad Institute, Inc. Multi-stage, multiplexed target isolation and processing from heterogeneous populations
US20170259262A1 (en) * 2016-03-09 2017-09-14 Intelligent Bio-Systems, Inc. Laminar fluidic separation in flowcells for minimal reagent usage
EP3440186A4 (en) 2016-04-04 2019-12-11 Cytequest, Inc. SYSTEM, APPARATUS AND METHOD FOR THE ELECTROPORATION OF CELLS
WO2017181258A1 (en) * 2016-04-21 2017-10-26 Duane Hewitt Continuous flow system
US10189029B2 (en) * 2016-06-30 2019-01-29 United Arab Emirates University Magnetic particle separator
US9968943B2 (en) * 2016-06-30 2018-05-15 United Arab Emirates University Magnetic particle separator
WO2018052137A1 (ja) 2016-09-16 2018-03-22 株式会社オンチップ・バイオテクノロジーズ 微粒子分注装置、微粒子解析装置、及び反応検出装置、並びにそれらを用いる方法
US20200171509A1 (en) * 2017-04-01 2020-06-04 Biomagnetic Solutions Llc Devices and methods for one-step static or continuous magnetic separation
GB201706947D0 (en) * 2017-05-02 2017-06-14 Cytosight Ltd Fluid sample enrichment system
US10350611B2 (en) * 2017-06-27 2019-07-16 General Electric Company Apparatus and methods for particle separation by ferrofluid constriction
WO2019017875A1 (en) * 2017-07-17 2019-01-24 Hewlett-Packard Development Company, L.P. DIELECTROPHORESIS SEPARATORS WITH CELL EJECTION DEVICES
CN107340226A (zh) * 2017-08-03 2017-11-10 江苏大学 一种油液中悬浮微粒计数检测装置及其应用
US11292000B2 (en) 2017-08-04 2022-04-05 University Of Georgia Research Foundation, Inc. Devices and methods for separating circulating tumor cells from biological samples
CA3071593A1 (en) * 2017-08-04 2019-02-07 University Of Georgia Research Foundation, Inc. Devices and methods for separating circulating tumor cells from biological samples
US11648559B2 (en) 2017-08-04 2023-05-16 University Of Georgia Research Foundation, Inc. Devices and methods for separating circulating tumor cells from biological samples
KR20190016011A (ko) * 2017-08-07 2019-02-15 울산과학기술원 자성 입자를 이용한 유체 분리 시스템 및 방법
KR102327920B1 (ko) * 2017-12-28 2021-11-17 인하대학교 산학협력단 결정성 나노셀룰로오스의 길이별 분리장치
KR102260437B1 (ko) * 2017-12-28 2021-06-02 인하대학교 산학협력단 결정성 나노셀룰로오스의 길이별 분리장치
DE102018104669A1 (de) * 2018-03-01 2019-09-05 Dionex Softron Gmbh Verwendung einer akustischen Welle in einem Chromatographiesystem
WO2019167510A1 (ja) * 2018-03-02 2019-09-06 ソニー株式会社 微小粒子の吸引条件の最適化方法、微小粒子分取用装置、微小粒子分取用システム及び微小粒子分取用プログラム
KR20210002450A (ko) * 2018-04-23 2021-01-08 앤팩 바이오-메디컬 사이언스 시오., 엘티디. 질환 검출을 위한 새로운 장치 및 방법들
WO2019212989A1 (en) * 2018-04-30 2019-11-07 United Therapeutics Corporation Apparatus and method for controlling fluid flow
WO2019216887A1 (en) 2018-05-08 2019-11-14 Biomagnetic Solutions Llc A rigid chamber for cell separation from a flexible disposable bag
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
US12180440B2 (en) * 2018-06-01 2024-12-31 Sony Corporation Microchip and sample sorting kit
CN108680403B (zh) * 2018-06-21 2024-03-29 重庆交通大学 附加压流式多级亚微米粒子采集器
US12239981B2 (en) * 2018-07-11 2025-03-04 The University Of Hong Kong Automatic microfluidic system for continuous and quantitive collection of droplets
ES2967515T3 (es) 2018-08-01 2024-04-30 Sartorius Bioanalytical Instr Inc Métodos, kits y composiciones de tinción para la evaluación de citometría de flujo de partículas del tamaño de un virus no asociadas utilizando múltiples colorantes fluorogénicos
CN109174445B (zh) * 2018-08-23 2020-03-31 山东路友再生资源设备有限公司 一种飞秒激光涡流磁选机
US20210205812A1 (en) 2018-09-24 2021-07-08 Hewlett-Packard Development Company, L.P. Particle separation from whole blood
WO2020072303A1 (en) * 2018-10-03 2020-04-09 Verily Life Sciences Llc Systems and methods for maintaining constant volumetric flow rates in a fluid channel
US11137337B2 (en) 2019-01-21 2021-10-05 Essen Instruments, Inc. Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation
CN109856398B (zh) * 2019-01-31 2022-04-29 京东方科技集团股份有限公司 疫苗检测装置及其检测方法
KR102279854B1 (ko) * 2019-02-13 2021-07-21 인제대학교 산학협력단 자기영동을 이용한 음성수집 방식의 미세입자 분리장치 및 그 분리방법
ES2871925T3 (es) 2019-03-19 2021-11-02 Ace Medical Tech Co Ltd Dispositivo para clasificar biopartículas utilizando una fuerza generada a partir de dielectroforesis inducida por luz y su método de funcionamiento
EP3948279B1 (en) 2019-03-26 2025-06-18 Sartorius BioAnalytical Instruments, Inc. Flow cytometry evaluation for unassociated non-enveloped viral particles
EP4245140A3 (en) 2019-04-18 2024-01-17 ABS Global, Inc. System and process for continuous addition of cryoprotectant
GB2587061B (en) * 2019-06-05 2023-09-13 Jaguar Land Rover Ltd Device for manipulating a substance
CN110438000B (zh) * 2019-07-24 2021-10-12 中山大学 双频驻波声场分离循环肿瘤细胞及其微栓的装置与方法
WO2021022050A1 (en) 2019-07-31 2021-02-04 CytoVale Inc. System and method for immune activity determination
US12031895B2 (en) 2019-10-28 2024-07-09 Op-Hygiene Ip Gmbh Method of identifying biologic particles
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US11709116B2 (en) 2020-02-04 2023-07-25 Sartorius Bioanalytical Instruments, Inc. Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods
IT202000006031A1 (it) * 2020-03-20 2021-09-20 Celldynamics I S R L Dispositivo fluidico per analisi di corpuscoli e relativo metodo
US20220088604A1 (en) * 2020-09-24 2022-03-24 Micareo Taiwan Co., Ltd. Microfluidic chip and device
EP3978119A1 (en) * 2020-09-30 2022-04-06 Levitas, Inc. Particle separator system, materials, and methods of use
US11951476B2 (en) * 2020-11-19 2024-04-09 Rutgers, The State University Of New Jersey Electronic-sensing and magnetic-modulation (ESMM) biosensor for phagocytosis quantification in pathogenic infections and methods of use thereof
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
CN112871750B (zh) * 2021-01-26 2022-12-02 华南师范大学 基于级联式微型热源的颗粒分选芯片及其颗粒分选方法
US20230131266A1 (en) * 2021-10-21 2023-04-27 Hewlett-Packard Development Company, L.P. Alignment and fusion of cells with an electrical field
WO2023153331A1 (ja) * 2022-02-08 2023-08-17 京セラ株式会社 流路デバイスの準備方法
US11802870B1 (en) * 2022-12-13 2023-10-31 Panazee Kinetic immunoassay systems and methods
US12030053B1 (en) 2023-05-05 2024-07-09 Panazee Inc. Multi-step kinetic immunoassay systems and methods
CN116493057B (zh) * 2023-02-16 2025-07-18 河海大学常州校区 一种精准分离微纳米颗粒的微流控装置及其操控方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1894146A (en) * 1931-04-30 1933-01-10 John S Baker Score card holder or writing tablet
US3560754A (en) * 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3827555A (en) 1973-03-05 1974-08-06 Bio Physics Systems Inc Particle sorter with segregation indicator
US4279345A (en) * 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
DE3574617D1 (de) 1984-09-11 1990-01-11 Partec Ag Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln.
EP0196205A2 (en) 1985-03-27 1986-10-01 The Standard Oil Company Improved apparatus for segregating particulate matter
DE3522365A1 (de) 1985-06-22 1987-01-02 Bayer Ag Trenngeraet fuer magnetische partikel aus fluessiger phase
US4894146A (en) 1986-01-27 1990-01-16 University Of Utah Thin channel split flow process and apparatus for particle fractionation
NO162946C (no) 1987-08-21 1990-03-14 Otto Soerensen Anordning for magnetisk separasjon av celler.
US5053344A (en) * 1987-08-04 1991-10-01 Cleveland Clinic Foundation Magnetic field separation and analysis system
US5123901A (en) 1988-02-25 1992-06-23 Carew E Bayne Method for separating pathogenic or toxic agents from a body fluid and return to body
US5039426A (en) 1988-05-17 1991-08-13 University Of Utah Process for continuous particle and polymer separation in split-flow thin cells using flow-dependent lift forces
DE3827252A1 (de) 1988-08-11 1990-02-15 Unkelbach Karl Heinz Dr Verfahren und vorrichtung zum kontinuierlichen trennen von biologische mikrosysteme und zellen enthaltenden mischungen
US5092973A (en) 1990-01-26 1992-03-03 The Board Of Trustees Of The Leland Stanford Junior University Rectangular capillaries for capillary electrophoresis
GB9008044D0 (en) 1990-04-09 1990-06-06 Hatfield Polytechnic Higher Ed Microfabricated device for biological cell sorting
US5460797A (en) * 1991-05-08 1995-10-24 Streck Laboratories, Inc. Method for fixing tissues and cells for analysis using oxazolidine compounds
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
JP3207424B2 (ja) 1992-05-01 2001-09-10 トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 微細加工した分析装置における流体の取扱い
TW239881B (no) 1992-12-22 1995-02-01 Sienna Biotech Inc
JPH08506664A (ja) * 1993-02-01 1996-07-16 セック，リミテッド Ｄｎａ配列決定の方法および装置
US5483469A (en) 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
JPH07232097A (ja) 1994-02-24 1995-09-05 Power Reactor & Nuclear Fuel Dev Corp 磁気クロマトグラフィー法による群分離方法
JPH10507632A (ja) * 1994-09-20 1998-07-28 ミルテニー バイオテック，インコーポレイティド 母体からの胎児血液の濃縮
US5528045A (en) 1995-04-06 1996-06-18 Becton Dickinson And Company Particle analyzer with spatially split wavelength filter

Also Published As

Publication number Publication date
NO317958B1 (no) 2005-01-17
US7138269B2 (en) 2006-11-21
US20070207548A1 (en) 2007-09-06
DK0925494T3 (da) 2002-07-01
CA2264389A1 (en) 1998-03-12
ATE211258T1 (de) 2002-01-15
DE69709377D1 (de) 2002-01-31
DE69709377T2 (de) 2002-08-14
US20030044832A1 (en) 2003-03-06
WO1998010267A1 (en) 1998-03-12
US6432630B1 (en) 2002-08-13
JP2002503334A (ja) 2002-01-29
NO991051D0 (no) 1999-03-03
EP0925494B1 (en) 2001-12-19
AU4113297A (en) 1998-03-26
EP0925494A1 (en) 1999-06-30

Similar Documents

Publication Publication Date Title
NO991051D0 (no) Et mikrostr°mningssystem for partikkelseparasjon og analyse
ATE287761T1 (de) Verfahren und vorrichtung zum mischen kleinster flüssigkeitsmengen
US4515274A (en) Particle analyzing and sorting apparatus
WO1998058725A8 (en) Apparatus for separation and concentration of particles from a fluid stream
EP0753154A1 (en) Analysis method and analysis apparatus
WO2003037491A3 (en) Microfluidic micromixer
EP0840886A4 (en) SYSTEM FOR TRANSFERRING MICRO-AMOUNTS OF FLUID
DE69839709D1 (de) Vorrichtung und Verfahren zur Lyse
EP2299256A3 (en) Microfabricated crossflow devices and methods
WO1993022055A3 (en) Fluid handling in microfabricated analytical devices
DE69937353D1 (de) Instrument zur analyse und selektiven verteilung von objektproben
EP0753153A1 (en) Analysis method and analysis apparatus
DK0925115T3 (da) Fremgangsmåder til analyse/seperation
MX9700845A (es) Aparato y metodo para llevar a cabo manipulaciones de microfluidos para analisis y sintesis quimicos.
DE3860159D1 (de) Rotierender teilchenabscheider.
CA2176672A1 (en) Improved Sample Card
US20030108452A1 (en) Method and device for withdrawing suspended microparticles from a fluidic microsystem
KR910700464A (ko) 화학공정의 순차실행을 위한 장치 및 방법
ATE502391T1 (de) Vorrichtung zur einführung von flüssigen proben in ein massenspektrometer unter verwendung eines schnellen ventilsystems zur synchronisation mehrerer paraleller probenströmen
AU1275295A (en) Fast continuous gas mixture analysis method and device
US20090148937A1 (en) Micro-fluidic system comprising an expanded channel
AU2018326394B2 (en) Sample collection system and parts thereof
HU9600742D0 (en) Liquid nozzle for vehicles
SE9703477D0 (sv) Anordning vid gasflödescell
ATE167571T1 (de) Prüfröhrchen und gerät zur durchführung von immunohämatologischen analyse von blut und anderen biologischen flüssigkeiten

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees