NO994408L - Dolastatin-15 derivater i kombinasjon med taxaner - Google Patents

Dolastatin-15 derivater i kombinasjon med taxaner

Info

Publication number: NO994408L
Authority: NO; Norway
Prior art keywords: combination; dolastatin; taxanes; derivatives; compounds
Prior art date: 1997-03-13

Application number

NO994408A

Other languages

English (en)

Other versions

NO323894B1 (no

NO994408D0 (no

Inventor

Teresa Barlozzari

Andreas Haupt

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-13

Filing date

1999-09-10

Publication date

1999-11-10

1999-09-10 Application filed by Basf Ag filed Critical Basf Ag

1999-09-10 Publication of NO994408D0 publication Critical patent/NO994408D0/no

1999-11-10 Publication of NO994408L publication Critical patent/NO994408L/no

2007-07-16 Publication of NO323894B1 publication Critical patent/NO323894B1/no

Links

229940123237 Taxane Drugs 0.000 title 1
LQKSHSFQQRCAFW-CCVNJFHASA-N [(2s)-1-[(2s)-2-benzyl-3-methoxy-5-oxo-2h-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2s)-1-[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxyl Chemical class C([C@@H]1N(C(=O)C=C1OC)C(=O)[C@@H](OC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)C1=CC=CC=C1 LQKSHSFQQRCAFW-CCVNJFHASA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
229940063683 taxotere Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Epoxy Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

NO19994408A 1997-03-13 1999-09-10 Farmasoytisk blanding og sammensetning av dolastatinderivater, samt anvendelse og fremstilling derav. NO323894B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/819,101 US6103698A (en)	1997-03-13	1997-03-13	Dolastatin-15 derivatives in combination with taxanes
PCT/US1998/004594 WO1998040092A1 (en)	1997-03-13	1998-03-09	Dolastatin-15 derivatives in combination with taxanes

Publications (3)

Publication Number	Publication Date
NO994408D0 NO994408D0 (no)	1999-09-10
NO994408L true NO994408L (no)	1999-11-10
NO323894B1 NO323894B1 (no)	2007-07-16

Family

ID=25227196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19994408A NO323894B1 (no)	1997-03-13	1999-09-10	Farmasoytisk blanding og sammensetning av dolastatinderivater, samt anvendelse og fremstilling derav.

Country Status (29)

Country	Link
US (2)	US6103698A (no)
EP (1)	EP0981358B1 (no)
JP (1)	JP2001514659A (no)
KR (1)	KR100555604B1 (no)
CN (1)	CN1157223C (no)
AT (1)	ATE241376T1 (no)
AU (1)	AU728027B2 (no)
BG (1)	BG64338B1 (no)
BR (1)	BR9808249A (no)
CA (1)	CA2282720C (no)
CO (1)	CO4940498A1 (no)
CZ (1)	CZ293905B6 (no)
DE (1)	DE69815100T2 (no)
DK (1)	DK0981358T3 (no)
ES (1)	ES2200317T3 (no)
HR (1)	HRP980125A2 (no)
HU (1)	HU228860B1 (no)
ID (1)	ID23900A (no)
IL (2)	IL131597A0 (no)
NO (1)	NO323894B1 (no)
NZ (1)	NZ337416A (no)
PL (1)	PL197834B1 (no)
PT (1)	PT981358E (no)
RU (1)	RU2218174C2 (no)
SK (1)	SK285133B6 (no)
TR (1)	TR199902244T2 (no)
TW (1)	TWI277426B (no)
WO (1)	WO1998040092A1 (no)
ZA (1)	ZA982093B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20010009901A1 (en)	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
EP2289549A3 (en)	1999-10-01	2011-06-15	Immunogen, Inc.	Immunoconjugates for treating cancer
AU2002214876A1 (en) *	2000-11-08	2002-05-21	Lorus Therapeutics Inc.	Combination preparation of a biological response modifier and an anticancer agent and uses thereof
US20050192443A1 (en) *	2000-11-08	2005-09-01	Lorus Therapeutics Inc.	Biological response modifier for the treatment of cancer
CA2607940C (en)	2005-05-18	2009-12-15	Aegera Therapeutics Inc.	Bir domain binding compounds
EP2024362A4 (en)	2006-05-16	2012-01-25	Pharmascience Inc	BINDING COMPOUNDS TO THE IAP BIR DOMAIN
WO2011100403A1 (en)	2010-02-10	2011-08-18	Immunogen, Inc	Cd20 antibodies and uses thereof
US9284350B2 (en)	2010-02-12	2016-03-15	Pharmascience Inc.	IAP BIR domain binding compounds
US20230295221A1 (en) *	2020-06-03	2023-09-21	Chugai Seiyaku Kabushiki Kaisha	Efficient peptide condensation method for difficult sequences
US20250281630A1 (en)	2021-09-03	2025-09-11	Toray Industries, Inc.	Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (25)

* Cited by examiner, † Cited by third party
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US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US5676978A (en)	1989-02-14	1997-10-14	Amira, Inc.	Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent
US4879278A (en) *	1989-05-16	1989-11-07	Arizona Board Of Regents	Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
US5278324A (en) *	1990-08-28	1994-01-11	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
MX9102128A (es)	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
AU662551B2 (en)	1991-08-09	1995-09-07	Teikoku Hormone Mfg. Co., Ltd.	Novel tetrapeptide derivative
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5272171A (en) *	1992-02-13	1993-12-21	Bristol-Myers Squibb Company	Phosphonooxy and carbonate derivatives of taxol
FR2688518B1 (fr) *	1992-03-13	1994-05-06	Rhone Poulenc Rorer Sa	Procede de preparation de derives du taxane.
US5831002A (en) *	1992-05-20	1998-11-03	Basf Aktiengesellschaft	Antitumor peptides
US5248796A (en) *	1992-06-18	1993-09-28	Bristol-Myers Squibb Company	Taxol derivatives
US5254580A (en) *	1993-01-19	1993-10-19	Bristol-Myers Squibb Company	7,8-cyclopropataxanes
FR2697752B1 (fr) *	1992-11-10	1995-04-14	Rhone Poulenc Rorer Sa	Compositions antitumorales contenant des dérivés du taxane.
AU679479B2 (en) *	1992-12-16	1997-07-03	Basf Aktiengesellschaft	Dolostatin analog
US5484612A (en) *	1993-09-22	1996-01-16	The Board Of Trustees Of The Leland Stanford Junior University	Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin
CA2129282A1 (en)	1993-09-29	1995-03-30	George Weber	Method for the treatment of neoplastic disease utilizing taxol and tiazofurin
US5447936A (en) *	1993-12-22	1995-09-05	Bionumerik Pharmaceuticals, Inc.	Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5565478A (en) *	1994-03-14	1996-10-15	The United States Of America As Represented By The Department Of Health & Human Services	Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs
US5494930A (en) *	1994-06-02	1996-02-27	Shimizu; Yuzuru	Caribenolide I
US5525613A (en) *	1994-06-16	1996-06-11	Entropin, Inc.	Covalently coupled benzoylecgonine ecgonine and ecgonidine
US5504191A (en) *	1994-08-01	1996-04-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) *	1994-08-01	1996-06-25	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory peptide amides
US5543423A (en) *	1994-11-16	1996-08-06	Vertex Pharmaceuticals, Incorporated	Amino acid derivatives with improved multi-drug resistance activity
ATE306927T1 (de)	1994-12-15	2005-11-15	Baker Norton Pharma	Verfahren und mittel zur verminderung der tumorentwicklung mittels einer kombination aus einer taxanverbindung und einer tellur und/oder selenverbindung

1997
- 1997-03-13 US US08/819,101 patent/US6103698A/en not_active Expired - Lifetime
1998
- 1998-03-09 HU HU0001381A patent/HU228860B1/hu not_active IP Right Cessation
- 1998-03-09 IL IL13159798A patent/IL131597A0/xx active IP Right Grant
- 1998-03-09 PT PT98909066T patent/PT981358E/pt unknown
- 1998-03-09 CN CNB988033089A patent/CN1157223C/zh not_active Expired - Fee Related
- 1998-03-09 BR BR9808249-3A patent/BR9808249A/pt not_active IP Right Cessation
- 1998-03-09 NZ NZ337416A patent/NZ337416A/en not_active IP Right Cessation
- 1998-03-09 PL PL335579A patent/PL197834B1/pl unknown
- 1998-03-09 CA CA002282720A patent/CA2282720C/en not_active Expired - Fee Related
- 1998-03-09 ID IDW991020A patent/ID23900A/id unknown
- 1998-03-09 EP EP98909066A patent/EP0981358B1/en not_active Expired - Lifetime
- 1998-03-09 CZ CZ19993211A patent/CZ293905B6/cs not_active IP Right Cessation
- 1998-03-09 WO PCT/US1998/004594 patent/WO1998040092A1/en not_active Ceased
- 1998-03-09 ES ES98909066T patent/ES2200317T3/es not_active Expired - Lifetime
- 1998-03-09 SK SK1251-99A patent/SK285133B6/sk not_active IP Right Cessation
- 1998-03-09 DK DK98909066T patent/DK0981358T3/da active
- 1998-03-09 KR KR1019997008305A patent/KR100555604B1/ko not_active Expired - Fee Related
- 1998-03-09 DE DE69815100T patent/DE69815100T2/de not_active Expired - Lifetime
- 1998-03-09 TR TR1999/02244T patent/TR199902244T2/xx unknown
- 1998-03-09 AU AU66945/98A patent/AU728027B2/en not_active Ceased
- 1998-03-09 JP JP53967998A patent/JP2001514659A/ja active Pending
- 1998-03-09 AT AT98909066T patent/ATE241376T1/de active
- 1998-03-09 RU RU99122032/14A patent/RU2218174C2/ru not_active IP Right Cessation
- 1998-03-10 HR HR08/819,101A patent/HRP980125A2/hr not_active Application Discontinuation
- 1998-03-12 ZA ZA9802093A patent/ZA982093B/xx unknown
- 1998-03-12 CO CO98013903A patent/CO4940498A1/es unknown
- 1998-03-13 TW TW087103777A patent/TWI277426B/zh not_active IP Right Cessation
1999
- 1999-08-26 IL IL131597A patent/IL131597A/en not_active IP Right Cessation
- 1999-09-10 NO NO19994408A patent/NO323894B1/no not_active IP Right Cessation
- 1999-09-13 BG BG103728A patent/BG64338B1/bg unknown
2000
- 2000-03-07 US US09/520,254 patent/US6632795B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HK1026851A1 (en)	2000-12-29
BR9808249A (pt)	2000-05-16
PL335579A1 (en)	2000-05-08
CZ293905B6 (cs)	2004-08-18
AU728027B2 (en)	2001-01-04
WO1998040092A1 (en)	1998-09-17
CN1157223C (zh)	2004-07-14
ZA982093B (en)	1999-09-12
EP0981358A1 (en)	2000-03-01
US6632795B1 (en)	2003-10-14
TWI277426B (en)	2007-04-01
CA2282720C (en)	2009-12-29
CO4940498A1 (es)	2000-07-24
EP0981358B1 (en)	2003-05-28
NZ337416A (en)	2001-05-25
KR100555604B1 (ko)	2006-03-03
SK125199A3 (en)	2000-08-14
IL131597A0 (en)	2001-01-28
HRP980125A2 (en)	1999-02-28
HUP0001381A3 (en)	2001-12-28
TR199902244T2 (xx)	1999-12-21
ID23900A (id)	2000-05-25
HU228860B1 (en)	2013-06-28
DE69815100T2 (de)	2004-02-05
IL131597A (en)	2006-06-11
US6103698A (en)	2000-08-15
CN1252728A (zh)	2000-05-10
PL197834B1 (pl)	2008-04-30
BG64338B1 (bg)	2004-10-29
RU2218174C2 (ru)	2003-12-10
AU6694598A (en)	1998-09-29
DK0981358T3 (da)	2003-09-22
JP2001514659A (ja)	2001-09-11
ES2200317T3 (es)	2004-03-01
HUP0001381A2 (hu)	2000-10-28
CZ321199A3 (cs)	2000-02-16
PT981358E (pt)	2003-09-30
ATE241376T1 (de)	2003-06-15
DE69815100D1 (de)	2003-07-03
KR20000076211A (ko)	2000-12-26
BG103728A (en)	2000-04-28
CA2282720A1 (en)	1998-09-17
NO323894B1 (no)	2007-07-16
SK285133B6 (sk)	2006-07-07
NO994408D0 (no)	1999-09-10

Publication	Publication Date	Title
FI952248A7 (fi)	1995-05-09	Kasvainvastaisia koostumuksia, jotka sisältävät taksaanijohdannaisia
EP1181013A4 (en)	2004-07-07	METHOD AND COMPOSITION FOR THE TREATMENT OF CANCER
NZ514409A (en)	2004-03-26	C7 ester substituted taxanes as antitumor agents
HU9602942D0 (en)	1996-12-30	Taxane class derivative based pharmaceutical compositions
WO2002058694A3 (en)	2003-12-04	Method of treating hematologic tumors and cancers using beta lapachone
DK0698018T3 (da)	2003-02-10	Inklusionskomplekser af Taxol eller Taxotere eller Taxus-ekstrakt dannet med cyclodextriner, deres fremstilling og anvendelse
NO994408L (no)	1999-11-10	Dolastatin-15 derivater i kombinasjon med taxaner
CY1110449T1 (el)	2015-04-29	Συνδυασμος δοκεταξελης και φλαβοπιριδinολης
ATE554753T1 (de)	2012-05-15	2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia
EE200200087A (et)	2003-04-15	Kompositsioon hepatotsellulaarse kartsinoomi raviks
DE69430797D1 (de)	2002-07-18	C9 taxanderivate und diese enthaltende pharmazeutische zusammensetzungen
WO2002078690A3 (en)	2002-11-21	Taxoid anti-tumor agents and pharmaceutical compositions thereof
ATE393624T1 (de)	2008-05-15	Verwendung von sesquiterpene enthaltenden zusammenstellungen zur behandlung von krebs
NZ514407A (en)	2004-12-24	C10 carbamoyloxy substituted taxanes as antitumor agents
EP0793499A4 (en)	2000-11-08	METHOD AND MEANS FOR REDUCING TUMOR DEVELOPMENT BY MEANS OF A COMBINATION OF A TAXAN COMPOUND AND A TELLUR AND / OR SELENIUM COMPOUND
DK1287854T3 (da)	2006-04-03	Kombinationer, der modvirker kræft
HUP0103246A2 (hu)	2003-07-28	C10 karbonát szubsztituált taxánok
ATE327240T1 (de)	2006-06-15	2ß OXO-VORUSCHARIN UND DERIVATEN
HUP0103247A2 (hu)	2003-07-28	C7 észter szubsztituált taxánok

Legal Events

Date	Code	Title	Description
2014-06-02	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: ABBVIE DEUTSCHLAND GMBH & CO AG, DE
2015-10-26	MM1K	Lapsed by not paying the annual fees